Th17 cells in autoimmune disease: Changing the verdict

Immunotherapy

Volumn 1, Issue 2, 2009, Pages 199-203

  Haak, Stefan ^a   Gyülveszi, Gabor ^a   Becher, Burkhard ^a  

^a INSTITUTE OF EXPERIMENTAL IMMUNOLOGY   (Switzerland)

Author keywords

Autoimmunity; CNS; Experimental autoimmune encephalomyelitis; IL 17; Multiple sclerosis; Th cells

Indexed keywords

INTERLEUKIN 17;

ADAPTIVE IMMUNITY; ALLERGIC ENCEPHALOMYELITIS; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; IMMUNE RESPONSE; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH17 CELL;

ADAPTIVE IMMUNITY; ANIMALS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HUMANS; INFLAMMATION; INTERLEUKIN-17; MICE; NEUROIMMUNOMODULATION; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS;

EID: 77953433348     PISSN: 1750743X     EISSN: None     Source Type: Journal    
DOI: 10.2217/1750743X.1.2.199     Document Type: Article

References (30)

1. Mosmann TR, Cherwinski H, Bond MW et al: Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136(7), 2348-2357 (1986).
2. Gutcher I, Becher B: APC-derived cytokines and T cell polarization in autoimmune inflammation. J. Clin. Invest 117(5), 1119-1127 (2007). (Pubitemid 46718396)
3. Bettelli E, Korn T, Kuchroo VK: Th17: the third member of the effector T cell trilogy. Curr. Opin. Immunol. 19(6), 652-657 (2007).
4. Williams KC, Ulvestad E, Hickey WF: Immunology of multiple sclerosis. Clin. Neurosci. 2(3-4), 229-245 (1994).
5. Wang J, Fathman JW, Lugo-Villarino G et al: TF T-bet regulates inflammatory arthritis through its function in dendritic cells. J. Clin. Invest. 116(2), 414-421 (2006).
6. Becher B, Durell BG, Noelle RJ: Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J. Clin. Invest. 110(4), 493-497 (2002).
7. Cua DJ, Sherlock J, Chen Y et al: Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421(6924), 744-748 (2003). (Pubitemid 36227625)
8. Chen Y, Langrish CL, McKenzie B et al: Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J. Clin. Invest. 116(5), 1317-1326 (2006).
9. McGeachy MJ, Cua DJ: Th17 cell differentiation: the long and winding road. Immunity 28(4), 445-453 (2008).
10. Eugster HP, Frei K, Kopf M et al: IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. Eur. J. Immunol. 28(7), 2178-2187 (1998).
11. Steinman L: A rush to judgment on Th17. J. Exp. Med. 205(7), 1517-1522 (2008).
12. Langrish CL, Chen Y, Blumenschein WM et al: IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201(2), 233-240 (2005).
13. Hofstetter HH, Ibrahim SM, Koczan D et al: Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis. Cell. Immunol. 237(2), 123-130 (2005).
14. Komiyama Y, Nakae S, Matsuki T et al: IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol. 177(1), 566-573 (2006). (Pubitemid 43939170)
15. Haak S, Croxford AL, Kreymborg K et al: IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J. Clin. Invest. doi: 10.1172/JC135997 (2008).
16. Ivanov II, McKenzie BS, Zhou L et al: The orphan nuclear receptor RORyt directs the differentiation program of proinflammatory IL-17'T helper cells. Cell 126(6), 1121-1133 (2006). (Pubitemid 44380299)
17. Eberl G, Marmon S, Sunshine MJ et al: An essential function for the nuclear receptor RORγ (t) in the generation of fetal lymphoid tissue inducer cells. Nat. Immunol. 5(1), 64-73 (2004).
18. Sun Z, Unutmaz D, Zou YR et al: Requirement for RORγ in thymocyte survival and lymphoid organ development. Science 288(5475), 2369-2373 (2000). (Pubitemid 30448162)
19. Kroenke MA, Carlson TJ, Andjelkovic AV et al: IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J. Exp. Med. 205(7), 1535-1541 (2008).
20. Luger D, Silver PB, Tang J et al: Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J. Exp. Med. 205(4), 799-810 (2008).
21. O'Connor RA, Prendergast CT, Sabatos CA et al: Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis. J. Immunol. 181(6), 3750-3754 (2008).
22. Ferber IA, Brocke S, Taylor-Edwards C et al: Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 156(1), 5-7 (1996). (Pubitemid 3024744)
23. Stromnes IM, Cerretti LM, Liggitt D et al: Differential regulation of central nervous system autoimmunity by Th1 and Th17 cells. Nat. Med. 14(3), 337-342 (2008).
24. Lee JW, Wang P, Kattah MG et al: Differential regulation of chemokines by IL-17 in colonic epithelial cells. J. Immunol. 181(9), 6536-6545 (2008).
25. + CXC chemokine pathway is essential for the development of central nervous system autoimmune disease. J. Exp. Med. 205(4), 811-823 (2008).
26. Kobayashi Y: Neutrophil infiltration and chemokines. Crit. Rev. Immunol. 26(4), 307-316 (2006).
27. Bechmann I, Galea I, Perry VH: What is the blood-brain barrier (not)? Trends Immunol. 28(1), 5-11 (2007).
28. Kebir H, Kreymborg K, Ifergan I et al: Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat. Med. 13(10), 1173-1175 (2007).
29. McGeachy MJ, Bak-Jensen KS, Chen Y et al: TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain Th-17 cell-mediated pathology. Nat. Immunol. 8(12), 1390-1397 (2007).
30. Segal BM, Constantinescu CS, Raychaudhuri A, Kim L, Fidelus-Gort R et al: LH: Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a Phase II, double-blind, placebo-controlled, randomised, dose-ranging study. Lancet Neurol. 7(9), 796-804 (2008).