Evidence for an atypical receptor mediating the augmented bronchoconstrictor response to adenosine induced by allergen challenge in actively sensitized Brown Norway rats

British Journal of Pharmacology

Volumn 135, Issue 3, 2002, Pages 685-696

  Hannon, J P ^a   Tigani, B ^a   Wolber, C ^a   Williams, I ^a   Mazzoni, L ^a   Howes, C ^b   Fozard, J R ^a  

^a Novartis Pharma AG   (Switzerland)

^b NOVARTIS HORSHAM RESEARCH CENTRE   (United Kingdom)

Author keywords

Adenosine receptors; Airway hyperresponsiveness; Allergen challenge; Brown Norway rat; Lung parenchymal strip

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 CHLORO 6 N (3 IODOBENZYL) 5' N METHYLCARBOXAMIDOADENOSINE; 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 6 N CYCLOPENTYLADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE DERIVATIVE; ALLERGEN; BETHANECHOL; N (4 CYANOPHENYL) 2 [4 (2,3,6,7 TETRAHYDRO 2,6 DIOXO 1,3 DIPROPYL 1H PURIN 8 YL)PHENOXY]ACETAMIDE; N (4 CYANOPHENYL) 2 [4 (2,6 DIOXO 1,3 DIPROPYL 2,3,4,5,6,7 HEXAHYDRO 1H PURIN 8 YL)PHENOXY]ACETAMIDE; OVALBUMIN; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; BRONCHUS MUSCLE; COLON; CONTROLLED STUDY; DRUG POTENTIATION; DRUG RECEPTOR BINDING; INTESTINE MUSCLE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIZATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTILITY;

ADENOSINE; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ADJUVANTS, IMMUNOLOGIC; AIRWAY RESISTANCE; ALLERGENS; ANIMALS; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTION; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNIZATION; INJECTIONS, SUBCUTANEOUS; INTUBATION, INTRATRACHEAL; LUNG; MALE; OVALBUMIN; RATS; RATS, INBRED BN; RECEPTORS, PURINERGIC P1; VASODILATOR AGENTS;

EID: 0036179646     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704516     Document Type: Article

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