Proapoptotic protein Bim is differentially required during thymic clonal deletion to ubiquitous versus tissue-restricted antigens

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 3, 2012, Pages 893-898

  Suen, Alexander Y W ^a   Baldwin, Troy A ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Autoimmunity; Thymocyte development

Indexed keywords

BIM PROTEIN; MEMBRANE PROTEIN; OVALBUMIN; T LYMPHOCYTE RECEPTOR; TISSUE ANTIGEN; UBIQUITIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW; CD8+ T LYMPHOCYTE; CELL SELECTION; CELL SURVIVAL; CHICKEN; CHIMERA; CONTROLLED STUDY; GRAFT RECIPIENT; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; ORGAN DONOR; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; THYMOCYTE;

ANIMALS; ANTIGENS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; CHICKENS; CLONAL DELETION; INSULIN; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; ORGAN SPECIFICITY; OVALBUMIN; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; RATS; RECOMBINANT FUSION PROTEINS; THYMUS GLAND;

RATTUS;

EID: 84856403030     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114834109     Document Type: Article

References (33)

1. Hogquist KA, Baldwin TA, Jameson SC (2005) Central tolerance: Learning self-control in the thymus. Nat Rev Immunol 5:772-782. (Pubitemid 41400851)
2. Ueno T, et al. (2004) CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J Exp Med 200:493-505. (Pubitemid 39121906)
3. McCaughtry TM, Wilken MS, Hogquist KA (2007) Thymic emigration revisited. J Exp Med 204:2513-2520. (Pubitemid 350044776)
4. Nitta T, Nitta S, Lei Y, Lipp M, Takahama Y (2009) CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens. Proc Natl Acad Sci USA 106:17129-17133.
5. Gallegos AM, Bevan MJ (2004) Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J Exp Med 200:1039-1049. (Pubitemid 39431128)
6. Baldwin TA, Hogquist KA, Jameson SC (2004) The fourth way? Harnessing aggressive tendencies in the thymus. J Immunol 173:6515-6520. (Pubitemid 39541032)
7. Wirnsberger G, Hinterberger M, Klein L (2011) Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes. Immunol Cell Biol 89:45-53.
8. Ouyang W, Beckett O, Ma Q, Li MO (2010) Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development. Immunity 32:642-653.
9. Labrecque N, Baldwin T, Lesage S (2011) Molecular and genetic parameters defining T-cell clonal selection. Immunol Cell Biol 89:16-26.
10. Baldwin TA, Hogquist KA (2007) Transcriptional analysis of clonal deletion in vivo. J Immunol 179:837-844.
11. Liston A, et al. (2004) Gene dosage-limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity. J Exp Med 200:1015-1026. (Pubitemid 39431126)
12. Strasser A, Puthalakath H, O'Reilly LA, Bouillet P (2008) What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain. Immunol Cell Biol 86:57-66.
13. Bouillet P, et al. (2002) BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 415:922-926. (Pubitemid 34174755)
14. Bouillet P, et al. (1999) Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286:1735-1738. (Pubitemid 129515880)
15. Zucchelli S, et al. (2005) Defective central tolerance induction in NOD mice: Genomics and genetics. Immunity 22:385-396. (Pubitemid 40387479)
16. Hu Q, Sader A, Parkman JC, Baldwin TA (2009) Bim-mediated apoptosis is not necessary for thymic negative selection to ubiquitous self-antigens. J Immunol 183:7761-7767.
17. Kovalovsky D, Pezzano M, Ortiz BD, Sant'Angelo DB (2010) A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway. PLoS ONE 5:e8675.
18. Jorgensen TN, et al. (2007) Bim and Bcl-2 mutually affect the expression of the other in T cells. J Immunol 179:3417-3424.
19. Taniguchi RT, Anderson MS (2011) The role of Aire in clonal selection. Immunol Cell Biol 89:40-44.
20. McCaughtry TM, Baldwin TA, Wilken MS, Hogquist KA (2008) Clonal deletion of thymocytes can occur in the cortexwith no involvement of themedulla. JExpMed205:2575-2584.
21. Ehst BD, Ingulli E, Jenkins MK (2003) Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection. Am J Transplant 3:1355-1362. (Pubitemid 37288079)
22. Kurts C, et al. (1996) Constitutive class I-restricted exogenous presentation of self antigens in vivo. J Exp Med 184:923-930. (Pubitemid 26313550)
23. Anderson MS, et al. (2005) The cellular mechanism of Aire control of T cell tolerance. Immunity 23:227-239. (Pubitemid 41169291)
24. Kurts C, et al. (1997) CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity. J Exp Med 186:2057-2062. (Pubitemid 28013691)
25. Ludwinski MW, et al. (2009) Critical roles of Bim in T cell activation and T cell-mediated autoimmune inflammation in mice. J Clin Invest 119:1706-1713.
26. Prlic M, Bevan MJ (2008) Exploring regulatory mechanisms of CD8+ T cell contraction. Proc Natl Acad Sci USA 105:16689-16694.
27. Zhan Y, et al. (2011) Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells. J Immunol 187:1566-1577.
28. Moran AE, et al. (2011) T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J ExpMed 208:1279-1289.
29. Edelmann SL, Marconi P, Brocker T (2011) Peripheral T cells re-enter the thymus and interfere with central tolerance induction. J Immunol 186:5612-5619.
30. Barron L, Knoechel B, Lohr J, Abbas AK (2008) Cutting edge: Contributions of apoptosis and anergy to systemic T cell tolerance. J Immunol 180:2762-2766.
31. Johnson LD, Jameson SC (2010) Self-specific CD8+ T cells maintain a semi-naive state following lymphopenia-induced proliferation. J Immunol 184:5604-5611.
32. Tsai S, et al. (2010) Reversal of autoimmunity by boosting memory-like autoregulatory T cells. Immunity 32:568-580.
33. Hogquist KA, et al. (1994) T cell receptor antagonist peptides induce positive selection. Cell 76:17-27. (Pubitemid 24035278)