The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1 S,3 S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile Spasms

Journal of Medicinal Chemistry

Volumn 55, Issue 2, 2012, Pages 567-575

  Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 4 DIFLUOROMETHYLENYL 1 CYCLOPENTANOIC ACID; 4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRIC ACID; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CPP 115; DOPAMINE; PHENYTOIN; PYRIDOXAL 5 PHOSPHATE; SCHIFF BASE; SUCCINIC SEMIALDEHYDE; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE; VIGABATRIN;

4 AMINOBUTYRIC ACID BRAIN LEVEL; ANTICONVULSANT ACTIVITY; BLOOD BRAIN BARRIER; CONCENTRATION (PARAMETERS); CRYSTAL STRUCTURE; DOG; DOPAMINE RELEASE; DRUG DEPENDENCE; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; EPILEPSY; HUMAN; HYDROLYSIS; IC 50; INFANTILE SPASM; MICHAEL ADDITION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SEIZURE; TAUTOMERIZATION; TREATMENT DURATION; VISUAL FIELD DEFECT;

4-AMINOBUTYRATE TRANSAMINASE; ANIMALS; ANTICONVULSANTS; AWARDS AND PRIZES; COCAINE-RELATED DISORDERS; HUMANS; INFANT; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROLINE; RATS; SPASMS, INFANTILE; SUBSTANCE-RELATED DISORDERS; UNITED STATES; VIGABATRIN;

EID: 84856367692     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201650r     Document Type: Review

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