(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction

Journal of Medicinal Chemistry

Volumn 55, Issue 1, 2012, Pages 357-366

  Pan, Yue ^a   Gerasimov, Madina R ^b   Kvist, Trine ^c   Wellendorph, Petrine ^c   Madsen, Karsten K ^c   Pera, Elena ^d   Lee, Hyunbeom ^a   Schousboe, Arne ^c   Chebib, Mary ^d   Bräuner Osborne, Hans ^c   Craft, Cheryl M ^e   Brodie, Jonathan D ^f   Schiffer, Wynne K ^b   Dewey, Stephen L ^b   Miller, Steven R ^g   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF SYDNEY   (Australia)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g Catalyst Pharmaceutical Partners Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 4 DIFLUOROMETHYLENYL 1 CYCLOPENTANOIC ACID; 4 AMINOBUTYRATE AMINOTRANSFERASE INHIBITOR; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; COCAINE; CPP 115; DOPAMINE; RACLOPRIDE C 11; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE; VIGABATRIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG ELIMINATION; DRUG RECEPTOR BINDING; DRUG STABILITY; ELECTRORETINOGRAPHY; FEMALE; GABAERGIC TRANSMISSION; HUMAN; HUMAN CELL; IN VIVO STUDY; LYMPHOCYTE; MALE; MICRODIALYSIS; MICROPOSITRON EMISSION TOMOGRAPHY; NONHUMAN; NUCLEUS ACCUMBENS; PLACE PREFERENCE; POSITRON EMISSION TOMOGRAPHY; RAT; SYNAPSE;

4-AMINOBUTYRATE TRANSAMINASE; ANIMALS; BIOLOGICAL AVAILABILITY; CARBOXYLIC ACIDS; COCAINE-RELATED DISORDERS; CYCLOPENTANES; DOGS; DOPAMINE; ELECTRORETINOGRAPHY; FEMALE; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GABA UPTAKE INHIBITORS; HUMANS; MALE; MICE; MICRODIALYSIS; NUCLEUS ACCUMBENS; OOCYTES; POSITRON-EMISSION TOMOGRAPHY; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, GABA; RETINA; STEREOISOMERISM; TISSUE DISTRIBUTION; VIGABATRIN; XENOPUS LAEVIS;

EID: 84862907915     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201231w     Document Type: Article

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