Design of a conformationally restricted analogue of the antiepilepsy drug vigabatrin that directs its mechanism of inactivation of γ-aminobutyric acid aminotransferase

Journal of the American Chemical Society

Volumn 124, Issue 8, 2002, Pages 1620-1624

  Choi, Sun ^a,c   Storici, Paola ^b   Schirmer, Tilman ^b   Silverman, Richard B ^c  

^a TRIPOS INC   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIEPILEPSY DRUGS;

BIOCHEMISTRY; CARBOXYLIC ACIDS; CONFORMATIONS; CRYSTAL STRUCTURE; PROTEINS;

DRUG PRODUCTS;

3 AMINOCYCLOHEX 4 ENE 1 CARBOXYLIC ACID; 4 AMINOBUTYRATE AMINOTRANSFERASE INHIBITOR; ANION; CARBOXYLIC ACID DERIVATIVE; LYSINE; UNCLASSIFIED DRUG; VIGABATRIN;

ARTICLE; COMPUTER MODEL; CONJUGATION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG MECHANISM; ENZYME INACTIVATION; PROTON TRANSPORT;

4-AMINOBUTYRATE TRANSAMINASE; ANTICONVULSANTS; ENZYME ACTIVATION; ENZYME INHIBITORS; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYRIDOXAL; THERMODYNAMICS; VIGABATRIN;

EID: 0037181037     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja011968d     Document Type: Article

References (25)