Current trends in the treatment of infantile spasms

Neuropsychiatric Disease and Treatment

Volumn 5, Issue 1, 2009, Pages 289-299

  Tsao, Chang Yong ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Adrenocorticotropic hormone; Infantile spasms; Oral corticosteroids; Vigabatrin

Indexed keywords

ANTICONVULSIVE AGENT; CLONAZEPAM; CORTICOSTEROID; CORTICOTROPIN; DEXAMETHASONE 21 PALMITATE; ETIRACETAM; FELBAMATE; GANAXOLONE; HYDROCORTISONE; IMMUNOGLOBULIN; LAMOTRIGINE; NITRAZEPAM; PHENYLALANINE; PLACEBO; PREDNISONE; PROTIRELIN; PYRIDOXINE; STEROID; SULTIAME; TETRACOSACTIDE; TOPIRAMATE; UNCLASSIFIED DRUG; VALPROIC ACID; VIGABATRIN; ZONISAMIDE;

ADD ON THERAPY; ADRENAL DISEASE; AGGRESSION; AGITATION; AGRANULOCYTOSIS; ANOREXIA; ANXIETY; APLASTIC ANEMIA; ASPIRATION PNEUMONIA; ATAXIA; BIOTINIDASE DEFICIENCY; BRAIN ATROPHY; CLINICAL FEATURE; CLINICAL TRIAL; CLOSED ANGLE GLAUCOMA; COGNITIVE DEFECT; CONFUSION; DEPRESSION; DERMATITIS; DIARRHEA; DISEASE ASSOCIATION; DISEASE COURSE; DIZZINESS; DRESS SYNDROME; DRUG CHOICE; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG ERUPTION; DRUG FATALITY; DRUG INDUCED HEADACHE; DRUG MECHANISM; DRUG MEGADOSE; DRUG RESPONSE; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; DYSPHAGIA; ELECTROENCEPHALOGRAPHY; FATIGUE; FOCAL EPILEPSY; FOOD COMPOSITION; HAIR LOSS; HUMAN; HYPERSALIVATION; HYPERTENSION; HYPERTHERMIA; HYPSARRHYTHMIA; INCIDENCE; INFANT; INFANTILE SPASM; INFECTION; INSOMNIA; IRRITABILITY; KETOGENIC DIET; LIVER FAILURE; LOW DRUG DOSE; MONOTHERAPY; MUSCLE HYPOTONIA; MYOCLONUS SEIZURE; NAUSEA; NEPHROLITHIASIS; NEUROSURGERY; NEUROTOXICITY; OPTIMAL DRUG DOSE; PANCREATITIS; PARESTHESIA; PHENYLKETONURIA; PREVALENCE; RESTLESSNESS; REVIEW; SEDATION; SEIZURE; SEPSIS; SERUM SICKNESS; SIDE EFFECT; SINGLE DRUG DOSE; SKIN BRUISING; SOMNOLENCE; STEVENS JOHNSON SYNDROME; THYROID DISEASE; TREATMENT DURATION; TREMOR; TUBEROUS SCLEROSIS; VISUAL FIELD DEFECT; VOMITING; WEIGHT GAIN; WEIGHT REDUCTION; WEST SYNDROME;

EID: 70449714191     PISSN: 11766328     EISSN: 11782021     Source Type: Journal    
DOI: 10.2147/ndt.s4488     Document Type: Review

References (123)

1. Lux AL, Osborne JP. A proposal for case definitions and outcome measures in studies of infantile spasms and West syndrome: consensus statement of the West Delphi group. Epilepsia. 2004;45:1416-1428.
2. Rima Nabbout and Olivier Dulac. Epileptic syndromes in infancy and childhood. Curr Opin Neurol. 2008;21:161-166.
3. Cowan LD, Hudson LS. The epidemiology and natural history of infantile spasms. J Child Neurol. 1991;6:355-364.
4. Sidenvall R, Eeg-Olofsson O. Epidemiology of infantile spasms in Sweden. Epilepsia. 1995;36:572-574.
5. Riikonen R, Donner M. Incidence and aetiology of infantile spasms from 1960-1976: a population study in Findland. Dev Med Child Neurol. 1979;21:333-343.
6. Ludvigsson P, Olafsson E, Siguroardottir S, Hauser WA. Epidemiologic features of infantile spasms in Iceland. Epilepsia. 1994;35:802-805. (Pubitemid 24278034)
7. Rantala H, Putkonen T. Occurrence, outcome, and prognostic factors of infantile spasms and Lennox-Gastaut syndrome. Epilepsia. 1999;40:286-289. (Pubitemid 29164790)
8. Trevathan E, Murphy CC, Yeargin-Allsopp M. The descriptive epidemiology of infantile spasms among Atlanta children. Epilepsia 1999;40:748-751. (Pubitemid 29260714)
9. Cowan LD, Bodensteiner JB. Prevalence of the epilepsies in children and adolescents. Epilepsia. 1989;30:94-106.
10. Lacy Jr, Penry JK. Infantile spasms. New York, NY: Raven Press;1976.
11. Mackay MT, Weiss SK, Adams-Webber T, et al. Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society. Neurology. 2004;62:1668-1681. (Pubitemid 38661719)
12. Poirier K, Eisermann M, Caubel I, Kaminska A, et al. Combination of infantile spasms, non-epileptic seizures and complex movement disorder: a new case of ARX-related epilepsy. Epilepsy Res. 2008;80:224-228.
13. Watanabe K, Negoro T, Okumura A. Symptomatology of infantile spasms. Brain Dev. 2001;23:453-466.
14. Kellaway P, Hrachovy RA, Frost JD, Zion T. Precise characterization and quantification of infantile spasms. Ann Neurol. 1979;6:214-218. (Pubitemid 9253590)
15. Hattori H. Spontaneous remission of spasms in West syndrome-implications of viral infection. Brain Dev. 2001;23:705-707. (Pubitemid 32999153)
16. Hrachovy RA, Glaze DG, Frost JD Jr. A retrospective study of spontaneous remission and long-term outcome in patients with infantile spasms. Epilepsia. 1991;32:212-214.
17. Gibbs EL, Anderson EM, Gibbs FA. Diagnosis and prognosis of hypsarrhythmia and infantile spasms. Pediatrics. 1954;13:66-73.
18. Glaze DG, Hrachovy RA, Frost JD Jr, Kellaway PR, Zion TE. Prospective study of outcome of infants with infantile spasms treated during controlled studies of ACTH and prednisone. J Pediatr. 1988;112:389-396.
19. Lombroso CT. A prospective study of infantile spasms: clinical andtherapeutic correlations. Epilepsia. 1983;24:135-158.
20. Riikonen R. Topical review: infantile spasms: therapy and outcome. J Child Neurol. 2004;19:401-404.
21. Kivity S, Lerman P, Ariel R, et al. Long-term cognitive outcomes of a cohort of children with cryptogenic infantile spasms treated with high-dose adrenocorticotropic hormone. Epilepsia. 2004;45:255-262. (Pubitemid 38332752)
22. Hrachovy RA, Frost JD Jr, Kellaway P, Zion TE. Double-blind study of ACTH vs prednisone therapy in infantile spasms. J Pediatr. 1983;103:641-645.
23. Riikonen R. A long-term follow-up study of 214 children with the syndrome of infantile spasms. Neuropediatrics. 1982;13:14-23. (Pubitemid 12192677)
24. Snead OC III, Benton JW, Myers GJ. ACTH and prednisone in childhood seizure disorders. Neurology. 1983;33:966-970.
25. Riikonen R. Long-term outcome of West syndrome: A study of adults with a history of infantile spasms. Epilepsia 1996;37:367-372. (Pubitemid 26100830)
26. Matsumoto A, Watanabe K, Negoro T, et al. Long-term prognosis after infantile spasms: A statistical study of prognositic factors in 200 cases. Dev Med Child Neurol. 1981;23:51-65. (Pubitemid 11179349)
27. Wong M, Trevathan E. Infantile spasms. Pediatr Neurol. 2001;24:89-98.
28. Jeavons PM, Bower BD, Dimatrkoudi M. Long-term prognosis of 150 cases of "West syndrome." Epilepsia. 1973;14:153-164.
29. Appleton RE, Peters ACB, Mumford JP, Shaw DE. Randomised, placebo controlled study of vigabatrin as first-line treatment of infantile spasms. Epilepsia. 1999;40:1627-1633. (Pubitemid 29518094)
30. Bobele GB, Bodensteiner JB. The treatment of infantile spasms by childneurologists. J Child Neurol. 1994;9:432-435.
31. Ito M, Seki T, Takuma Y. Current therapy for West syndrome in Japan. J Child Neurol. 2000;15:424-428. (Pubitemid 30418065)
32. Tsuji T, Okumura A, Ozawa H, et al. Current treatment of West syndrome. J Child Neurol. 2007;22:560-564.
33. Wheless JW, Clarke DF, Carpenter D. Treatment of pediatric epilepsy: expert opinion, 2005. J Child Neurol. 2005;20:S1-S56. (Pubitemid 43230877)
34. Wheless JW, Clarke DF, Arzimanoglou A, Carpenter D. Treatment of pediatric epilepsy: European expert opinion. Epileptic Disord. 2007;9:353-412. (Pubitemid 351147653)
35. Brunson KL, Avishai-Eliner S, Baram TZ. ACTH treatment of infantile spasms: mechanisms of its effects in modulation of neuronal excitability. Int Rev Neurobiol. 2002;49:185-197.
36. Baram TZ. Pathophysiology of massive infantile spasms: perspective on the putative role of the brain adrenal axis. Ann Neurol. 1993;33:231-236.
37. Holmes GL. Effect of non-sex hormones on neuronal excitability, seizures, and the electroencephalogram. Epilepsia. 1991; 2(Suppl 6):S11-S18.
38. Sorel L, Dusaucy-Bauloye A. A propos de 21 cas d'hypsarhythmia de Gibbs. Son traitment spectaculaire par L'ACTH. Acta Neurol Psychiatr Berg. 1958;58:130-141.
39. Hrachovy RA, Frost JD Jr, Glaze DG. High-dose, long-duration versus low-dose, short-duration corticotropin therapy for infantile spasms. J Pediatr. 1994;124:803-806.
40. Yanagaki S, Oguni H, Hayashi K, et al. A comparative study of highdose and low-dose ACTH therapy for West syndrome. Brain Dev. 1999;21:461-467. (Pubitemid 29428075)
41. Baram TZ, Mitchell WG, Tournay A, et al. High-dose corticotrophin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study. Pediatrics. 1996;97:375-379. (Pubitemid 26076265)
42. Levy RH, Mattson RH, Meldrum BS, Perucca E. Antiepileptic drugs. 5th ed. Philadelphia: Lippincott Williams and Wilkins; 2002.
43. Elterman RD, Shields WD, Mansfield KA, et al. Randomised trial of vigabatrin in patients with infantile spasms. Neurology. 2001;57:1416-1421. (Pubitemid 32995722)
44. Aicardi J, Hauser E, Steinbock H, et al. Vigabatrin as initial therapy for infantile spasms: a European retrospective survey. Epilepsia. 1996;37:638-642. (Pubitemid 26249996)
45. Covanis A, Theodorou V, Lada C, et al. The first-line use of vigabatrin to achieve complete control of infantile spasms. J Epilepsy. 1998;11:265-269. (Pubitemid 28436451)
46. Fejerman N, Cersosimo R, Caraballo R, et al. Vigabatrin as a firstchoice drug in the treatment of West syndrome. J Child Neurol. 2000;15:161-165. (Pubitemid 30202242)
47. Granstrom ML, Gaily E, Liukkonen E. Treatment of infantile spasms: results of a population-based study with vigabatrin as the first drug for spasms. Epilepsia. 1999;40:950-957. (Pubitemid 29316050)
48. Vigevano F, Cilio MR. Vigabatrin versus ACTH as first-line treatment for infantile spasms: a randomized, prospective study. Epilepsia 1997;38:1270-1274. (Pubitemid 28007515)
49. Vles JSH, Van der Heyden AMHG, Ghijs A, et al. Vigabatrin in the treatment of infantile spasms. Neuropediatrics. 1993;24:230-231.
50. Cossette P, Riviello JJ, Carmant L. ACTH versus vigabatrin therapy in infantile spasms: a retrospective study. Neurology. 1999;52:1691-1694. (Pubitemid 29220650)
51. Lux AL, Edwards SW, Hancock E, et al. The United Kingdom Infantile Spasms Study (UKISS) comparing hormone treatment with vigabatrin on developmental and epilepsy outcomes to age 14 months: a multicentre randomised trial. Lancet Neurol. 2005;4:712-717. (Pubitemid 41457286)
52. Gross-Tsur V, Banin E, Shahar E, et al. Visual impairment in children with epilepsy treated with vigabatrin. Ann Neurol. 2000;48:60-64. (Pubitemid 30432431)
53. Iannetti P, Spalice A, Perla FM, et al. Visual field constriction in children with epilepsy on vigabatrin treatment. Pediatrics. 2000;106:838-842. (Pubitemid 30769215)
54. Krauss GL, Johnson MA, Miller NR. Vigabatrin-associated retinal cone dysfunction. Electroretinogram and ophthalmologic findings. Neurology. 1997;50:614-618. (Pubitemid 28146139)
55. Siemes H, Spohr HL, Michael T, et al. Therapy of infantile spasms with valproate: results of a prospective study. Epilepsia. 1988;29:553-560. (Pubitemid 18240138)
56. Fisher E, Siemes H, Pund R, et al. Valproate metabolites in serum and urine during antiepileptic therapy in children with infantile spasms: abnormal metabolite pattern associated with reversible hepatotoxicity. Epilepsia. 1992;33:165-171.
57. Schachter SC. Currently available antiepileptic drugs. Neurotherapeutics. 2007;4:4-11.
58. Nabbout R. A risk-benefit assessment of treatment for infantile spasms. Drug Saf. 2001;24:813-828. (Pubitemid 32937973)
59. Chamberlain MC. Nitrazepam for refractory infantile spasms and the Lennox-Gastaut syndrome. J Child Neurol. 1996;11:31-34. (Pubitemid 26051067)
60. Volzke E, Doose H, Stephan E. The treatment of infantile spasms and hypsarrhythmia with mogadon. Epilepsia. 1967;8:64-70.
61. Dreifuss F, Farwell J, Holmes G, et al. Infantile spasms, comparative trial of nitrazepam and corticotropin. Arch Neurol. 1986;43:1107-1110. (Pubitemid 17174436)
62. Murphy JV, Sawasky F, Marquardt KM, Harris DJ. Deaths in young children receiving nitrazepam. J Pediatr. 1987;111:145-147. (Pubitemid 17092667)
63. Rintahaka PJ, Nakagawa JA, Shewmon DA, et al. Incidence of death in patients with intractable epilepsy during nitrazepam treatment. Epilepsia. 1999;40:492-496.
64. Chung SH, Cox RA. Determination of pyridoxal phosphate levels in the brains of audiogenic and normal mice. Neurochem Res. 1983;8:1245-1259.
65. Ito M, Mikawa H, Taniguchi T, et al. Cerebrospinal fluid GABA levels in children with infantile spasms. Neurology. 1984;4:234-238. (Pubitemid 14185376)
66. Watanabe K. Medical treatment of West syndrome in Japan. J Child Neurol. 1995;10:143-147.
67. Ohtsuka Y, Matsuda M, Ogino T, et al. Treatment of the West syndrome with high-dose pyridoxal phosphate. Brain Dev. 1987;9:418-421. (Pubitemid 18032030)
68. Pietz J, Benninger C, Schafer H, et al. Treatment of infantile spasms with high-dosage vitamin B6. Epilepsia. 1993;34:757-763. (Pubitemid 23228144)
69. Striano P, Battaglia S, Giordano L, et al. Two novel ALDH7A1 (antiquitin) splicing mutations associated with pyridoxine-dependent seizures. Epilepsia. 2009;50:933-936.
70. Leppik IE. Zonisamide: chemistry, mechanism of action, and pharmacokinetics. Seizure. 2004;13(Suppl 1):S5-S9.
71. Yanai S, Hanai T, Narazaki O. Treatment of infantile spasms with zonisamide. Brain Dev. 1999;21:157-161.
72. Kawawaki H, Tomiwa K, Shiraishi K, et al. Efficacy of zonisamide in West syndrome [abstract]. No To Hattatsu. 1999;31:263-267. (Pubitemid 29256385)
73. Suzuki Y, Nagai T, Ono J, et al. Zonisamide monotherapy in newly diagnosed infantile spasms. Epilepsia. 1997;38:1035-1038. (Pubitemid 27382943)
74. Suzuki Y, Imai K, Toribe Y, et al. Long-term response to zonisamide in patients with West syndrome. Neurology. 2002;58:1556-1559. (Pubitemid 34552971)
75. Lotze TE, Wilfong A. Zonisamide treatment for symptomatic spasms. Neurology. 2004;62:296-298.
76. Privitera MD. Topiramate: a new antiepileptic drug. Ann Pharmacother. 1997;31:1164-1173.
77. Glauser TA, Clark PO, Strawsburg R. A pilot study of topiramate in the treatment of infantile spasms. Epilepsia. 1998;39:1324-1328. (Pubitemid 29005632)
78. Glauser TA, Clark PO, McGee K. Long-term response to topiramate in patients with West syndrome. Epilepsia. 2000;41(Suppl 1):S91-94. (Pubitemid 30202350)
79. Hosain SA, Merchant S, Solomon GE, Chutorian A. Tropiramate for the treatment of infantile spasms. J Child Neurol. 2006;21:17-19.
80. Korinthenberg R, Schreiner A. Topiramate in children with west syndrome: a retrospective multicenter evaluation of 100 patients. J Child Neurol. 2007;22:302-306. (Pubitemid 46860559)
81. Hurst DL, Rolan TD. The use of felbamate to treat infantile spasms. J Child Neurol. 1995;10:134-144.
82. Coppola G, Pascotto A. Felbamate in refractory infantile spasms. Epilepsia. 1997;38 Suppl:37.
83. Veggiotti P, Cieuta C, Rey E, et al. Lamotrigine in infantile spasms [letter]. Lancet. 1994;44:1375-1376.
84. Cianchetti C, Pruna D, Coppola G, Pascotto A. Low-dose lamotrigine in West syndrome. Epilepsy Res. 2002;51:199-200.
85. Lagae L, Buyse G, Deconink A, Ceulemans B. Effect of levetiracetam in refractory childhood epilepsy syndromes. Eur J Paediatr Neurol. 2003;7(3):123-128. (Pubitemid 36700750)
86. Lawlor KM, Devlin AM. Levetiracetam in the treatment of infantile spasms. Eur J Paediatr Neurol. 2005;9:19-22.
87. Gümüş H, Kumanda S, Per H. Levetiracetam monotherapy in newly diagnosed cryptogenic West syndrome. Pediatr Neurol. 2007;37:350-353. (Pubitemid 47575828)
88. Matsumoto A, Kumagai T, Takeuchi T, Miyazaki S, Watanabe K. Clinical effects of thyrotropin-releasing hormone for severe epilepsy in childhood: a comparative study with ACTH therapy. Epilepsia. 1987;28:49-55. (Pubitemid 17231446)
89. Takeuchi Y, Matsushita H, Kawano H, Sakai H, Yoshimoto K, Sawada T. Thyrotropin-releasing hormone increases cerebrospinal fluid concentration of kynurenine. Neuroreport. 1999 26;10:3601-3603.
90. Takeuchi Y, Takano T, Abe J, Takikita S, Ohno M. Thyrotropin-releasing hormone: role in the treatment of West syndrome and related epileptic encephalopathies. Brain Dev. 2001;23:662-667. (Pubitemid 32999145)
91. Deng PY, Porter JE, Shin HS, Lei S. Thyrotropin-releasing hormone increases GABA release in rat hippocampus. J Physiol. 2006;577:497-511. (Pubitemid 44804008)
92. Kubek MJ, Garg BP. Thyrotropin-releasing hormone in the treatment of intractable epilepsy. Pediatr Neurol. 2002;26:9-17.
93. Gee KW, McCauley LD, Lan NC. A putative receptor for neurosteroids on the GABAA receptor complex: the pharmacological properties and therapeutic potential of epalons. Crit Rev Neurobiol. 1995;9(2 and 3):207-227.
94. Belelli D, Lambert JJ. Neurosteroids: endogenous regulators of the GABAA receptor. Nat Rev Neurosci. 2005;6:565-575. (Pubitemid 40942823)
95. Kerrigan JF, Shields WD, Nelson TY, et al. Ganaxolone for treating intractable infantile spasms: a multicenter, open-label, add-on trial. Epilepsy Res. 2000;42:133-139.
96. Yamamoto H, Asoh M, Murakami H, Kamiyama N, Ohta C. Liposteroid (dexamethasone palmitate) therapy for West syndrome: a comparative study with ACTH therapy. Pediatr Neurol. 1998;18:415-419. (Pubitemid 28308709)
97. Yamamoto H, Fukuda M, Miyamoto Y, Murakami H, Kamiyama N. A new trial liposteroid (dexamethasone palmitate) therapy for intractable epileptic seizures in infancy. Brain Dev. 2007;29:421-424. (Pubitemid 46755533)
98. Debus OM, Kurlemann G; Study group. Sulthiame in the primary therapy of West syndrome: a randomized double-blind placebo-controlled add-on trial on baseline pyridoxine medication. Epilepsia. 2004;45:103-108.
99. Ariizumi M, Baba K, Hibio S, et al. Immunoglobulin therapy in West syndrome. Brain Dev. 1987;9:422-425.
100. Echenne B, Dulac O, Parayre-Chanez MJ, et al. Treatment of infantile spasms with intravenous gammaglobulines. Brain Dev. 1991;13:313-319.
101. Kossoff EH, Pyzik PL, McGrogan JR, Vining EP, Freeman JM. Efficacy of the ketogenic diet for infantile spasms. Pediatrics. 2002;109:780-783.
102. Eun SH, Kang HC, Kim DW, Kim HD. Ketogenic diet for treatment of infantile spasms. Brain Dev. 2006;28:566-571. (Pubitemid 44308691)
103. Kossoff EH, Hedderick EF, Turner Z, Freeman JM. A case-control evaluation of the ketogenic diet versus ACTH for new-onset infantile spasms. Epilepsia. 2008;49:1504-1509.
104. Ballaban-Gil K, Callahan C, O'Dell C, Pappo M, Moshé S, Shinnar S. Complications of the ketogenic diet. Epilepsia. 1998;39:744-748.
105. Kang HC, Chung DE, Kim DW, Kim HD. Early- and late-onset complications of the ketogenic diet for intractable epilepsy. Epilepsia. 2004;45:1116-1123.
106. Freeman JM, Kossoff EH, Hartman AL. The ketogenic diet: one decade later. Pediatrics. 2007;119:535-543.
107. Zafeiriou DI, Kontopoulos EE, Tsikoulas IG. Adrenocorticotropic hormone and vigabatrin treatment of children with infantile spasms underlying cerebral palsy. Brain Dev. 1996;18:450-452.
108. Schlumberger E, Dulac O. A simple effective and well-tolerated treatment regime for West syndrome. Dev Med Child Neurol. 1994;36:863-872. (Pubitemid 24294508)
109. Buoni S, Zannolli R, Strambi M, Fois A. Combined treatment with vigabatrin and topiramate in West syndrome. J Child Neurol. 2004;19:385-386. (Pubitemid 38867951)
110. Kalayci O, Coskun T, Tokatli A, et al. Infantile spasms as the initial symptom of biotinidase deficiency. J Pediatr. 1994;124:103-104. (Pubitemid 24027296)
111. Zhongshu Z, Weiming Y, Yukio F, Cheng-LNing Z, Zhixing W. Clinical analysis of West syndrome associated with phenylketonuria. Brain Dev. 2001;23:552-557. (Pubitemid 32999125)
112. Chugani HT, ShieldsWD, Shewmon DA, et al. Infantile spasms. I. PET identifies focal cortical dysgenesis in cryptogenic cases for surgical treatment. Ann Neurol. 1990;27:406-413.
113. Chugani TH, Shewmon AD, Shields DW, et al. Surgery for intractable infantile spasms: neuroimaging perspectives. Epilepsia. 1993;34:764-771.
114. Asarnow RF, LoPresti C, Guthrie D, Elliott T, Cynn V, Shields WD, Shewmon DA, Sankar R, Peacock WJ. Developmental outcomes in children receiving resection surgery for medically intractable infantile spasms. Dev Med Child Neurol. 1997;39:430-440. (Pubitemid 27338552)
115. Chuang MF, Harnod T, Wang PJ, et al. Effect of multiple subpial transection on patients with uncontrolled atypical infantile spasms. Epilepsia. 2006;47:659-660. (Pubitemid 43351575)
116. Kang HC, Jung da E, Kim KM, Hwang YS, Park SK, Ko TS. Surgical treatment of two patients with infantile spasms in early infancy. Brain Dev. 2006;28:453-457.
117. Pinard JM, Delalande O, Chiron C, et al. Callosotomy for epilepsy after West syndrome. Epilepsia. 1999;40:1727-1734.
118. National Institute for Clinical Excellence (NICE): Technology Appraisal Guidance 79, Newer Drugs for Epilepsy in Children (www.nice.org/uk/TA 079 guidance)
119. and Clinical Guideline 20, The Epilepsies: The Diagnosis and Management of the Epilepsies in Adults and Children in Primary and Secondary Care, October 2004. (www.nice.org/uk/CG020NICE guideline).
120. Scottish Intercollegiate Guidelines Network. Diagnosis and management of epilepsies in children and young people: a national clinical guideline. Edinburgh, Scottish Intercollegiate Guidelines Network, March 2005. Available at www.sign.ac.uk/pdf/sign81.pdf.
121. Stafstrom CE, Holmes GL. Infantile spasms: criteria for an animal model. Int Rev Neurobiol. 2002;49:391-411.
122. Philippi H, Wohlrab G, Bettendorf U, et al. Electroencephalographic evolution of hypsarrhythmia: toward an early treatment option. Epilepsia. 2008;49:1859-1864.
123. Hancock EC, Osborne JP, Edwards SW. Treatment of infantile spasms. Cochrane Database Syst Rev. 2008; Issue 4. Art. No.: CD001770.