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Volumn 21, Issue 4, 2012, Pages 874-889

Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ADENOVIRUS VECTOR; BETA ACTIN; DOPAMINE; GREEN FLUORESCENT PROTEIN; TYROSINE 3 MONOOXYGENASE; UBIQUITIN THIOLESTERASE; UBIQUITIN THIOLESTERASE L1; UNCLASSIFIED DRUG;

EID: 84856347615     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddr521     Document Type: Article
Times cited : (31)

References (66)
  • 1
  • 3
    • 34547535639 scopus 로고    scopus 로고
    • The functions of UCH-L1 and its relation to neurodegenerative diseases
    • Setsuie, R. and Wada, K. (2007) The functions of UCH-L1 and its relation to neurodegenerative diseases. Neurochem. Int., 51, 105-111.
    • (2007) Neurochem. Int. , vol.51 , pp. 105-111
    • Setsuie, R.1    Wada, K.2
  • 5
    • 76549084350 scopus 로고    scopus 로고
    • Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction
    • Chen, F., Sugiura, Y., Myers, K.G., Liu, Y. and Lin, W. (2010) Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction. Proc. Natl Acad. Sci. USA, 107, 1636-1641.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 1636-1641
    • Chen, F.1    Sugiura, Y.2    Myers, K.G.3    Liu, Y.4    Lin, W.5
  • 6
    • 69149089036 scopus 로고    scopus 로고
    • Molecular pathogenesis of Parkinson disease: insights from genetic studies
    • Gasser, T. (2009) Molecular pathogenesis of Parkinson disease: insights from genetic studies. Expert Rev. Mol. Med., 11, e22.
    • (2009) Expert Rev. Mol. Med. , vol.11
    • Gasser, T.1
  • 8
    • 0033544368 scopus 로고    scopus 로고
    • Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease
    • Maraganore, D.M., Farrer, M.J., Hardy, J.A., Lincoln, S.J., McDonnell, S.K. and Rocca, W.A. (1999) Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease. Neurology, 53, 1858-1860.
    • (1999) Neurology , vol.53 , pp. 1858-1860
    • Maraganore, D.M.1    Farrer, M.J.2    Hardy, J.A.3    Lincoln, S.J.4    McDonnell, S.K.5    Rocca, W.A.6
  • 11
    • 0035881339 scopus 로고    scopus 로고
    • A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population
    • Satoh, J. and Kuroda, Y. (2001) A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population. J. Neurol. Sci., 189, 113-117.
    • (2001) J. Neurol. Sci. , vol.189 , pp. 113-117
    • Satoh, J.1    Kuroda, Y.2
  • 12
    • 34347257768 scopus 로고    scopus 로고
    • S18Y in ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) associated with decreased risk of Parkinson's disease in Sweden
    • Carmine Belin, A., Westerlund, M., Bergman, O., Nissbrandt, H., Lind, C., Sydow, O. and Galter, D. (2007) S18Y in ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) associated with decreased risk of Parkinson's disease in Sweden. Parkinsonism Relat. Disord., 13, 295-298.
    • (2007) Parkinsonism Relat. Disord. , vol.13 , pp. 295-298
    • Carmine Belin, A.1    Westerlund, M.2    Bergman, O.3    Nissbrandt, H.4    Lind, C.5    Sydow, O.6    Galter, D.7
  • 14
    • 79952184830 scopus 로고    scopus 로고
    • Case-control study of the UCH-L1 S18Y variant in sporadic Parkinson's disease in the Chinese population
    • Wang, L., Guo, J.F., Nie, L.L., Luo, L., Zuo, X., Shen, L., Jiang, H., Yan, X.X., Xia, K., Pan, Q. et al. (2011) Case-control study of the UCH-L1 S18Y variant in sporadic Parkinson's disease in the Chinese population. J. Clin. Neurosci., 18, 541-544.
    • (2011) J. Clin. Neurosci. , vol.18 , pp. 541-544
    • Wang, L.1    Guo, J.F.2    Nie, L.L.3    Luo, L.4    Zuo, X.5    Shen, L.6    Jiang, H.7    Yan, X.X.8    Xia, K.9    Pan, Q.10
  • 16
    • 0034864346 scopus 로고    scopus 로고
    • No genetic association of the ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism with familial Parkinson's disease
    • Levecque, C., Destee, A., Mouroux, V., Becquet, E., Defebvre, L., Amouyel, P. and Chartier-Harlin, M.C. (2001) No genetic association of the ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism with familial Parkinson's disease. J. Neural. Transm., 108, 979-984.
    • (2001) J. Neural. Transm. , vol.108 , pp. 979-984
    • Levecque, C.1    Destee, A.2    Mouroux, V.3    Becquet, E.4    Defebvre, L.5    Amouyel, P.6    Chartier-Harlin, M.C.7
  • 17
    • 0033525009 scopus 로고    scopus 로고
    • Low frequency of pathogenic mutations in the ubiquitin carboxy-terminal hydrolase gene in familial Parkinson's disease
    • Lincoln, S., Vaughan, J., Wood, N., Baker, M., Adamson, J., Gwinn-Hardy, K., Lynch, T., Hardy, J. and Farrer, M. (1999) Low frequency of pathogenic mutations in the ubiquitin carboxy-terminal hydrolase gene in familial Parkinson's disease. Neuroreport, 10, 427-429.
    • (1999) Neuroreport , vol.10 , pp. 427-429
    • Lincoln, S.1    Vaughan, J.2    Wood, N.3    Baker, M.4    Adamson, J.5    Gwinn-Hardy, K.6    Lynch, T.7    Hardy, J.8    Farrer, M.9
  • 18
    • 0034722106 scopus 로고    scopus 로고
    • The ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism does not confer protection against idiopathic Parkinson's disease
    • Mellick, G.D. and Silburn, P.A. (2000) The ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism does not confer protection against idiopathic Parkinson's disease. Neurosci. Lett., 293, 127-130.
    • (2000) Neurosci. Lett. , vol.293 , pp. 127-130
    • Mellick, G.D.1    Silburn, P.A.2
  • 23
    • 0037131567 scopus 로고    scopus 로고
    • The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility
    • Liu, Y., Fallon, L., Lashuel, H.A., Liu, Z. and Lansbury, P.T. Jr. (2002) The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell, 111, 209-218.
    • (2002) Cell , vol.111 , pp. 209-218
    • Liu, Y.1    Fallon, L.2    Lashuel, H.A.3    Liu, Z.4    Lansbury Jr., P.T.5
  • 24
    • 1842581669 scopus 로고    scopus 로고
    • Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases
    • Choi, J., Levey, A.I., Weintraub, S.T., Rees, H.D., Gearing, M., Chin, L.S. and Li, L. (2004) Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. J. Biol. Chem., 279, 13256-13264.
    • (2004) J. Biol. Chem. , vol.279 , pp. 13256-13264
    • Choi, J.1    Levey, A.I.2    Weintraub, S.T.3    Rees, H.D.4    Gearing, M.5    Chin, L.S.6    Li, L.7
  • 25
    • 33847069643 scopus 로고    scopus 로고
    • Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: an initial assessment
    • Butterfield, D.A., Gnjec, A., Poon, H.F., Castegna, A., Pierce, W.M., Klein, J.B. and Martins, R.N. (2006) Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: an initial assessment. J. Alzheimers Dis., 10, 391-397.
    • (2006) J. Alzheimers Dis. , vol.10 , pp. 391-397
    • Butterfield, D.A.1    Gnjec, A.2    Poon, H.F.3    Castegna, A.4    Pierce, W.M.5    Klein, J.B.6    Martins, R.N.7
  • 26
    • 61449148337 scopus 로고    scopus 로고
    • Proteomic and histochemical analysis of proteins involved in the dying-back-type of axonal degeneration in the gracile axonal dystrophy (gad) mouse
    • Goto, A., Wang, Y.L., Kabuta, T., Setsuie, R., Osaka, H., Sawa, A., Ishiura, S. and Wada, K. (2009) Proteomic and histochemical analysis of proteins involved in the dying-back-type of axonal degeneration in the gracile axonal dystrophy (gad) mouse. Neurochem. Int., 54, 330-338.
    • (2009) Neurochem. Int. , vol.54 , pp. 330-338
    • Goto, A.1    Wang, Y.L.2    Kabuta, T.3    Setsuie, R.4    Osaka, H.5    Sawa, A.6    Ishiura, S.7    Wada, K.8
  • 27
    • 1642301524 scopus 로고    scopus 로고
    • Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1, reveals oxidation of key proteins
    • Castegna, A., Thongboonkerd, V., Klein, J., Lynn, B.C., Wang, Y.L., Osaka, H., Wada, K. and Butterfield, D.A. (2004) Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1, reveals oxidation of key proteins. J. Neurochem., 88, 1540-1546.
    • (2004) J. Neurochem. , vol.88 , pp. 1540-1546
    • Castegna, A.1    Thongboonkerd, V.2    Klein, J.3    Lynn, B.C.4    Wang, Y.L.5    Osaka, H.6    Wada, K.7    Butterfield, D.A.8
  • 28
    • 77953912384 scopus 로고    scopus 로고
    • Deficiency of ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) leads to vulnerability to lipid peroxidation
    • Nagamine, S., Kabuta, T., Furuta, A., Yamamoto, K., Takahashi, A. and Wada, K. (2010) Deficiency of ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) leads to vulnerability to lipid peroxidation. Neurochem. Int., 57, 102-110.
    • (2010) Neurochem. Int. , vol.57 , pp. 102-110
    • Nagamine, S.1    Kabuta, T.2    Furuta, A.3    Yamamoto, K.4    Takahashi, A.5    Wada, K.6
  • 29
    • 46249113267 scopus 로고    scopus 로고
    • The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells
    • Kyratzi, E., Pavlaki, M. and Stefanis, L. (2008) The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells. Hum. Mol. Genet., 17, 2160-2171.
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 2160-2171
    • Kyratzi, E.1    Pavlaki, M.2    Stefanis, L.3
  • 30
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: mechanisms and models
    • Dauer, W. and Przedborski, S. (2003) Parkinson's disease: mechanisms and models. Neuron, 39, 889-909.
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 32
    • 0034734772 scopus 로고    scopus 로고
    • A new vector system with inducible E2a cell line for production of higher titer and safer adenoviral vectors
    • Zhou, H. and Beaudet, A.L. (2000) A new vector system with inducible E2a cell line for production of higher titer and safer adenoviral vectors. Virology, 275, 348-357.
    • (2000) Virology , vol.275 , pp. 348-357
    • Zhou, H.1    Beaudet, A.L.2
  • 33
    • 0037297303 scopus 로고    scopus 로고
    • Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain depending on the transduced area
    • Kugler, S., Kilic, E. and Bahr, M. (2003) Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain depending on the transduced area. Gene Ther., 10, 337-347.
    • (2003) Gene Ther , vol.10 , pp. 337-347
    • Kugler, S.1    Kilic, E.2    Bahr, M.3
  • 37
    • 78751522558 scopus 로고    scopus 로고
    • A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2
    • Dusonchet, J., Kochubey, O., Stafa, K., Young, S.M. Jr, Zufferey, R., Moore, D.J., Schneider, B.L. and Aebischer, P. (2011) A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2. J. Neurosci., 31, 907-912.
    • (2011) J. Neurosci. , vol.31 , pp. 907-912
    • Dusonchet, J.1    Kochubey, O.2    Stafa, K.3    Young Jr., S.M.4    Zufferey, R.5    Moore, D.J.6    Schneider, B.L.7    Aebischer, P.8
  • 38
    • 0037713489 scopus 로고    scopus 로고
    • The 1-methyl-4-phenyl-1,2,3 6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease
    • Przedborski, S. and Vila, M. (2003) The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease. Ann. N. Y. Acad. Sci., 991, 189-198.
    • (2003) Ann. N. Y. Acad. Sci. , vol.991 , pp. 189-198
    • Przedborski, S.1    Vila, M.2
  • 43
    • 13944279784 scopus 로고    scopus 로고
    • Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES-derived cell model of primary Parkinsonism
    • Martinat, C., Shendelman, S., Jonason, A., Leete, T., Beal, M.F., Yang, L., Floss, T. and Abeliovich, A. (2004) Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES-derived cell model of primary Parkinsonism. PLoS Biol., 2, e327.
    • (2004) PLoS Biol , vol.2
    • Martinat, C.1    Shendelman, S.2    Jonason, A.3    Leete, T.4    Beal, M.F.5    Yang, L.6    Floss, T.7    Abeliovich, A.8
  • 45
    • 53649093358 scopus 로고    scopus 로고
    • Genome-wide association studies in neurological disorders
    • Simon-Sanchez, J. and Singleton, A. (2008) Genome-wide association studies in neurological disorders. Lancet Neurol., 7, 1067-1072.
    • (2008) Lancet Neurol , vol.7 , pp. 1067-1072
    • Simon-Sanchez, J.1    Singleton, A.2
  • 49
    • 39049093652 scopus 로고    scopus 로고
    • Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in micewith a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene
    • Sakurai, M., Sekiguchi, M., Zushida, K., Yamada, K., Nagamine, S., Kabuta, T. and Wada, K. (2008) Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in micewith a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene. Eur. J. Neurosci., 27, 691-701.
    • (2008) Eur. J. Neurosci. , vol.27 , pp. 691-701
    • Sakurai, M.1    Sekiguchi, M.2    Zushida, K.3    Yamada, K.4    Nagamine, S.5    Kabuta, T.6    Wada, K.7
  • 52
    • 4644263753 scopus 로고    scopus 로고
    • Two closely related ubiquitin C-terminal hydrolase isozymes function as reciprocal modulators of germ cell apoptosis in cryptorchid testis
    • Kwon, J., Wang, Y.L., Setsuie, R., Sekiguchi, S., Sato, Y., Sakurai, M., Noda, M., Aoki, S., Yoshikawa, Y. and Wada, K. (2004) Two closely related ubiquitin C-terminal hydrolase isozymes function as reciprocal modulators of germ cell apoptosis in cryptorchid testis. Am. J. Pathol., 165, 1367-1374.
    • (2004) Am. J. Pathol. , vol.165 , pp. 1367-1374
    • Kwon, J.1    Wang, Y.L.2    Setsuie, R.3    Sekiguchi, S.4    Sato, Y.5    Sakurai, M.6    Noda, M.7    Aoki, S.8    Yoshikawa, Y.9    Wada, K.10
  • 53
    • 33745035500 scopus 로고    scopus 로고
    • Oxidative stress regulated expression of ubiquitin carboxyl-terminal hydrolase-L1: role in cell survival
    • Shen, H., Sikorska, M., Leblanc, J., Walker, P.R. and Liu, Q.Y. (2006) Oxidative stress regulated expression of ubiquitin carboxyl-terminal hydrolase-L1: role in cell survival. Apoptosis, 11, 1049-1059.
    • (2006) Apoptosis , vol.11 , pp. 1049-1059
    • Shen, H.1    Sikorska, M.2    Leblanc, J.3    Walker, P.R.4    Liu, Q.Y.5
  • 55
    • 34347259269 scopus 로고    scopus 로고
    • Protocol for the MPTP mouse model of Parkinson's disease
    • Jackson-Lewis, V. and Przedborski, S. (2007) Protocol for the MPTP mouse model of Parkinson's disease. Nat. Protoc., 2, 141-151.
    • (2007) Nat. Protoc. , vol.2 , pp. 141-151
    • Jackson-Lewis, V.1    Przedborski, S.2
  • 56
    • 63349090404 scopus 로고    scopus 로고
    • Neurochemical and behavioral alterations in an inflammatory model of depression: sex differences exposed
    • Pitychoutis, P.M., Nakamura, K., Tsonis, P.A. and Papadopoulou-Daifoti, Z. (2009) Neurochemical and behavioral alterations in an inflammatory model of depression: sex differences exposed. Neuroscience, 159, 1216-1232.
    • (2009) Neuroscience , vol.159 , pp. 1216-1232
    • Pitychoutis, P.M.1    Nakamura, K.2    Tsonis, P.A.3    Papadopoulou-Daifoti, Z.4
  • 59
    • 0033966487 scopus 로고    scopus 로고
    • Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP
    • Vila, M., Vukosavic, S., Jackson-Lewis, V., Neystat, M., Jakowec, M. and Przedborski, S. (2000) Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP. J. Neurochem., 74, 721-729.
    • (2000) J. Neurochem. , vol.74 , pp. 721-729
    • Vila, M.1    Vukosavic, S.2    Jackson-Lewis, V.3    Neystat, M.4    Jakowec, M.5    Przedborski, S.6
  • 60
    • 84985280160 scopus 로고
    • The efficiency of systematic sampling in stereology and its prediction
    • Gundersen, H.J. and Jensen, E.B. (1987) The efficiency of systematic sampling in stereology and its prediction. J. Microsc., 147, 229-263.
    • (1987) J. Microsc. , vol.147 , pp. 229-263
    • Gundersen, H.J.1    Jensen, E.B.2
  • 61
    • 53049098471 scopus 로고    scopus 로고
    • Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    • Vogiatzi, T., Xilouri, M., Vekrellis, K. and Stefanis, L. (2008) Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J. Biol. Chem., 283, 23542-23556.
    • (2008) J. Biol. Chem. , vol.283 , pp. 23542-23556
    • Vogiatzi, T.1    Xilouri, M.2    Vekrellis, K.3    Stefanis, L.4
  • 62
    • 0033178444 scopus 로고    scopus 로고
    • Caspase-dependent and independent death of camptothecin-treated embryonic cortical neurons
    • Stefanis, L., Park, D.S., Friedman, W.J. and Greene, L.A. (1999) Caspase-dependent and -independent death of camptothecin-treated embryonic cortical neurons. J. Neurosci., 19, 6235-6247.
    • (1999) J. Neurosci. , vol.19 , pp. 6235-6247
    • Stefanis, L.1    Park, D.S.2    Friedman, W.J.3    Greene, L.A.4
  • 63
    • 0036432029 scopus 로고    scopus 로고
    • Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination
    • Rideout, H.J. and Stefanis, L. (2002) Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination. Mol. Cell Neurosci., 21, 223-238.
    • (2002) Mol. Cell Neurosci. , vol.21 , pp. 223-238
    • Rideout, H.J.1    Stefanis, L.2
  • 64
    • 0032528153 scopus 로고    scopus 로고
    • Neuroprotective actions of dipyridamole on cultured CNS neurons
    • Farinelli, S.E., Greene, L.A. and Friedman, W.J. (1998) Neuroprotective actions of dipyridamole on cultured CNS neurons. J. Neurosci., 18, 5112-5123.
    • (1998) J. Neurosci. , vol.18 , pp. 5112-5123
    • Farinelli, S.E.1    Greene, L.A.2    Friedman, W.J.3
  • 65
    • 0025939423 scopus 로고
    • Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms
    • Rukenstein, A., Rydel, R.E. and Greene, L.A. (1991) Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms. J. Neurosci., 11, 2552-2563.
    • (1991) J. Neurosci. , vol.11 , pp. 2552-2563
    • Rukenstein, A.1    Rydel, R.E.2    Greene, L.A.3
  • 66
    • 0030984171 scopus 로고    scopus 로고
    • Inhibitors of trypsin-like serine proteases inhibit processing of the caspase Nedd-2 and protect PC12 cells and sympathetic neurons from death evoked by withdrawal of trophic support
    • Stefanis, L., Troy, C.M., Qi, H. and Greene, L.A. (1997) Inhibitors of trypsin-like serine proteases inhibit processing of the caspase Nedd-2 and protect PC12 cells and sympathetic neurons from death evoked by withdrawal of trophic support. J. Neurochem., 69, 1425-1437.
    • (1997) J. Neurochem. , vol.69 , pp. 1425-1437
    • Stefanis, L.1    Troy, C.M.2    Qi, H.3    Greene, L.A.4


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