CDP-choline treatment induces brain plasticity markers expression in experimental animal stroke

Neurochemistry International

Volumn 60, Issue 3, 2012, Pages 310-317

  Gutiérrez Fernández, María ^a   Rodríguez Frutos, Berta ^a   Fuentes, Blanca ^a   Vallejo Cremades, María Teresa ^a   Álvarez Grech, Julia ^a   Expósito Alcaide, Mercedes ^a   Díez Tejedor, Exuperio ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

Brain plasticity markers; CDP choline; Rats; Recovery; Stroke

Indexed keywords

BROXURIDINE; CITICOLINE; EOSIN; GLIAL FIBRILLARY ACIDIC PROTEIN; HEMATOXYLIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; SODIUM CHLORIDE; SYNAPTOPHYSIN; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE MODEL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL PLASTICITY; NICK END LABELING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; SHAM PROCEDURE; SPRAGUE DAWLEY RAT; STAINING; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; BRAIN CHEMISTRY; BRAIN ISCHEMIA; CELL PROLIFERATION; CYTIDINE DIPHOSPHATE CHOLINE; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INFARCTION, MIDDLE CEREBRAL ARTERY; MAGNETIC RESONANCE IMAGING; MALE; NEURONAL PLASTICITY; NOOTROPIC AGENTS; RATS; RATS, SPRAGUE-DAWLEY; STROKE; SYNAPTOPHYSIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ANIMALIA; RATTUS;

EID: 84856337861     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2011.12.015     Document Type: Article

References (56)

1. R.M. Adibhatla, J.F. Hatcher, and R.J. Dempsey Effects of citicoline on phospholipid and glutathione levels in transient cerebral ischemia Stroke 32 2001 2376 2381 (Pubitemid 32954811)
2. R.M. Adibhatla, J.F. Hatcher, and R.J. Dempsey Citicoline: neuroprotective mechanisms in cerebral ischemia J. Neurochem. 80 2002 12 23 (Pubitemid 34614573)
3. R.M. Adibhatla, J.F. Hatcher, E.C. Larsen, X. Chen, D. Sun, and F.H. Tsao CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke J. Biol. Chem. 281 2006 6718 6725 (Pubitemid 43847607)
4. R.M. Adibhatla, J.F. Hatcher, and K. Tureyen CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke Brain Res. 1058 2005 193 197 (Pubitemid 41416815)
5. M. Alonso de Leciñana, M. Gutiérrez, J.M. Roda, F. Carceller, and E. Díez-Tejedor Effect of combined therapy with thrombolysis and citicoline in a rat model of embolic stroke J. Neurol. Sci. 247 2006 121 129
6. J. Aronowski, R. Strong, and J.C. Grotta Citicoline for treatment of experimental focal ischemia: histologic and behavioral outcome Neurol. Res. 18 1996 570 574 (Pubitemid 27009396)
7. A. Arvidsson, T. Collin, D. Kirik, Z. Kokaia, and O. Lindvall Neuronal replacement from endogenous precursors in the adult brain after stroke Nat. Med. 8 2002 963 970 (Pubitemid 35033700)
8. S.T. Carmichael Themes and strategies for studying the biology of stroke recovery in the poststroke epoch Stroke 39 2008 1380 1388 (Pubitemid 351440722)
9. J. Chen, and M. Chopp Neurorestorative treatment of stroke: cell and pharmacological approaches NeuroRx. 3 2006 466 473 (Pubitemid 44443015)
10. J. Chen, Z.G. Zhang, Y. Li, Y. Wang, L. Wang, H. Jiang, C. Zhang, M. Lu, M. Katakowski, C.S. Feldkamp, and M. Chopp Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke Ann. Neurol. 53 2003 743 751 (Pubitemid 36622511)
11. S.T. Chen, C.Y. Hsu, E.L. Hogan, H. Maricq, and J.D. Balentine A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction Stroke 17 1986 738 743 (Pubitemid 16066549)
12. Y.H. Chen, H.L. Wu, C.K. Chen, Y.H. Huang, B.C. Yang, and L.W. Wu Angiostatin antagonizes the action of VEGF-A in human endothelial cells via two distinct pathways Biochem. Biophys. Res. Commun. 310 2003 804 810
13. A. Dávalos, J. Castillo, J. Alvarez-Sabin, J.J. Secades, J. Mercadal, S. López, E. Cobo, S. Warach, D. Sherman, W.M. Clark, and R. Lozano Oral citicoline in acute ischemic stroke: an individual patient data pooling analysis of clinical trials Stroke 33 2002 2850 2857 (Pubitemid 35462855)
14. M.W. Decker, L.E. Rueter, and R.S. Bitner Nicotinic acetylcholine receptor agonists: a potential new class of analgesics Curr. Top. Med. Chem. 4 2004 369 384 (Pubitemid 38842575)
15. R.V. Dorman, Z. Dabrowiecki, and L.A. Horrocks Effects of CDPcholine and CDPethanolamine on the alterations in rat brain lipid metabolism induced by global ischemia J. Neurochem. 40 1983 276 279 (Pubitemid 13151637)
16. Durukan, A., Tatlisumak, T., 2009. Animal models of ischemic stroke in: M. Fisher (3rd series), Handbook of Clinical Neurology, Stroke, Part 1 Basic and epidemiological aspects, Vol. 92, New York, pp. 1-464.
17. H.F. Dvorak Discovery of vascular permeability factor (VPF) Exp. Cell. Res. 312 2006 522 526 (Pubitemid 43290329)
18. C.M. Flores The promise and pitfalls of a nicotinic cholinergic approach to pain management Pain 88 2000 1 6
19. M. Gutiérrez-Fernández, B. Rodríguez-Frutos, J. Álvarez-Grech, M.T. Vallejo-Cremades, M. Expósito-Alcaide, J. Merino, J.M. Roda, and E. Díez-Tejedor Functional recovery after hematic administration of allogenic mesenchymal stem cells in acute ischemic stroke in rats Neuroscience 175 2011 394 405
20. Gutiérrez, M., Díez Tejedor, E., Alonso de Leciñana, M., Fuentes, B., Carceller, F., Roda, J.M., 2006. Thrombolysis and neuroprotection in cerebral ischemia. Cerebrovasc. Dis. 21(Suppl. 2), 118-126.
21. W. Hacke, M. Kaste, E. Bluhmki, M. Brozman, A. Dávalos, D. Guidetti, V. Larrue, K.R. Lees, Z. Medeghri, T. Machnig, D. Schneider, R. von Kummer, N. Wahlgren, and D. Toni Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke N. Engl. J. Med 359 2008 1317 1329
22. E. Hamurtekin, and M.S. Gurun The antinociceptive effects of centrally administered CDP-choline on acute pain models in rats: the involvement of cholinergic system Brain Res. 1117 2006 92 100 (Pubitemid 44573100)
23. B.T. Hawkins, and T.P. Davis The blood-brain barrier/neurovascular unit in health and disease Pharmacol. Rev. 57 2005 173 185 (Pubitemid 41043883)
24. O. Hurtado, A. Cárdenas, J.M. Pradillo, J.R. Morales, F. Ortego, T. Sobrino, J. Castillo, M.A. Moro, and I. Lizasoain A chronic treatment with CDP-choline improves functional recovery and increases neuronal plasticity after experimental stroke Neurobiol. Dis. 26 2007 105 111 (Pubitemid 46436490)
25. O. Hurtado, M.A. Moro, A. Cárdenas, V. Sánchez, P. Fernández-Tome, J.C. Leza, P. Lorenzo, J.J. Secades, R. Lozano, A. Dávalos, J. Castillo, and I. Lizasoain Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport Neurobiol. Dis. 18 2005 336 345 (Pubitemid 40431117)
26. K. Jaquet, K. Krause, M. Tawakol-Khodai, S. Geidel, and K.H. Kuck Erythropoietin and VEGF exhibit equal angiogenic potential Microvasc. Res. 64 2002 326 333
27. E.P. Kennedy, and S.B. Weiss The function of cytidine coenzymes in the biosynthesis of phospholipides J. Biol. Chem. 222 1956 193 214
28. T. Kobayashi, T. Kawamata, N. Shibata, Y. Okada, M. Kobayashi, and T. Hori Angiotensin II type 1 receptor blocker telmisartan reduces cerebral infarct volume and peri-infarct cytosolic phospholipase A(2) level in experimental stroke J. Neurotrauma 26 2009 2355 2364
29. G.W. Kreutzberg Microglia: a sensor for pathological events in the CNS Trends Neurosci. 19 1996 312 318 (Pubitemid 26349059)
30. J. Krupinski, I. Ferrer, M. Barrachina, J.J. Secades, J. Mercadal, and R. Lozano CDP-choline reduces pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat Neuropharmacology 42 2002 846 854 (Pubitemid 34518284)
31. J. Krupinski, J. Kaluza, P. Kumar, S. Kumar, and J.M. Wang Role of angiogenesis in patients with cerebral ischemic stroke Stroke 25 1994 1794 1798 (Pubitemid 24274974)
32. J. Krupinski, P. Stroemer, M. Slevin, E. Marti, P. Kumar, and F. Rubio Three-dimensional structure and survival of newly formed blood vessels after focal cerebral ischemia Neuroreport 14 2003 1171 1176 (Pubitemid 36930268)
33. D.Q. Li, Y. Li, Y. Liu, Y.M. Bao, B. Hu, and L.J. An Catalpol prevents the loss of CA1 hippocampal neurons and reduces working errors in gerbils after ischemia-reperfusion injury Toxicon 46 2005 845 851 (Pubitemid 41735134)
34. T.H. Liu, J.S. Beckman, B.A. Freeman, E.L. Hogan, and C.Y. Hsu Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury Am. J. Physiol. 256 1989 H589 593
35. E.H. Lo, J.P. Broderick, and M.A. Moskowitz TPA and proteolysis in the neurovascular unit Stroke 35 2004 354 356 (Pubitemid 38174404)
36. M.P. Mattson Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity Trends Neurosci. 21 1998 53 57 (Pubitemid 28078902)
37. B. Millauer, S. Wizigmann-Voos, H. Schnurch, R. Martinez, N.P. Moller, W. Risau, and A. Ullrich High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis Cell 72 1993 835 846 (Pubitemid 23110226)
38. C. Plataras, S. Tsakiris, and P. Angelogianni Effect of CDP-choline on brain acetylcholinesterase and Na(+), K(+)-ATPase in adult rats Clin. Biochem. 33 2000 351 357
39. K.H. Plate, H. Beck, S. Danner, P.R. Allegrini, and C. Wiessner Cell type specific upregulation of vascular endothelial growth factor in an MCA-occlusion model of cerebral infarct J. Neuropathol. Exp. Neurol. 58 1999 654 666 (Pubitemid 29264945)
40. R. Polavarapu, M.C. Góngora, H. Yi, S. Ranganthan, D.A. Lawrence, D. Strickland, and M. Yepes Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit Blood 109 2007 3270 3278 (Pubitemid 46572512)
41. P. Ramos-Cabrer, J. Agulla, B. Argibay, M. Perez-Mato, and J. Castillo Serial MRI study of the enhanced therapeutic effects of liposome-encapsulated citicoline in cerebral ischemia Int. J. Pharm. 405 2011 228 233
42. A.M. Rao, J.F. Hatcher, and R.J. Dempsey Lipid alterations in transient forebrain ischemia: possible new mechanisms of CDP-choline neuroprotection J. Neurochem. 75 2000 2528 2535
43. K. Rejdak, R. Rejdak, M. Sieklucka-Dziuba, Z. Stelmasiak, and P. Grieb The effects of citicoline and/or MK-801 on survival, neurological and behavioral outcome of mice exposed to transient hyperglycemia and oligemic hypoxia Eur. Neuropsychopharmacol. 11 2001 333 341 (Pubitemid 32946883)
44. U.I. Richardson, C.J. Watkins, C. Pierre, I.H. Ulus, and R.J. Wurtman Stimulation of CDP-choline synthesis by uridine or cytidine in PC12 rat pheochromocytoma cells Brain Res. 971 2003 161 167 (Pubitemid 36423318)
45. D.C. Rogers, C.A. Campbell, J.L. Stretton, and K.B. Mackay Correlation between motor impairment and infarct volume after permanent and transient middle cerebral artery occlusion in the rat Stroke 28 1997 2060 2066 (Pubitemid 27459019)
46. S. Sahin, T. Alkan, S.G. Temel, K. Tureyen, S. Tolunay, and E. Korfali Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats J. Clin. Neurosci. 17 2010 227 231
47. W.R. Schabitz, F. Li, K. Irie, B.W. Sandage Jr., K.W. Locke, and M. Fisher Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia Stroke 30 1999 427 431 discussion 431-422
48. W.R. Schabitz, J. Weber, K. Takano, B.W. Sandage, K.W. Locke, and M. Fisher The effects of prolonged treatment with citicoline in temporary experimental focal ischemia J. Neurol. Sci. 138 1996 21 25 (Pubitemid 26195858)
49. N.R. Sims, and H. Muyderman Mitochondria, oxidative metabolism and cell death in stroke Biochim. Biophys. Acta 1802 2010 80 91
50. R.P. Stroemer, T.A. Kent, and C.E. Hulsebosch Enhanced neocortical neural sprouting, synaptogenesis, and behavioral recovery with D-amphetamine therapy after neocortical infarction in rats Stroke 29 1998 2381 2393 discussion 2393-2385
51. Y. Sun, K. Jin, L. Xie, J. Childs, X.O. Mao, A. Logvinova, and D.A. Greenberg VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia J. Clin. Invest. 111 2003 1843 1851 (Pubitemid 38057729)
52. R.A. Swanson, M.T. Morton, G. Tsao-Wu, R.A. Savalos, C. Davidson, and F.R. Sharp A semiautomated method for measuring brain infarct volume J. Cereb. Blood. Flow. Metab. 10 1990 290 293 (Pubitemid 20096202)
53. M.T. Tacconi Neuronal death: is there a role for astrocytes? Neurochem. Res. 23 1998 759 765 (Pubitemid 28173583)
54. L. Tarsa, and Y. Goda Synaptophysin regulates activity-dependent synapse formation in cultured hippocampal neurons Proc. Natl. Acad. Sci. USA 99 2002 1012 1016 (Pubitemid 34106627)
55. G. Trovarelli, G.E. de Medio, R.V. Dorman, G.L. Piccinin, L.A. Horrocks, and G. Porcellati Effect of cytidine diphosphate choline (CDP-choline) on ischemia-induced alterations of brain lipid in the gerbil Neurochem. Res. 6 1981 821 833 (Pubitemid 12247640)
56. Z.G. Zhang, and M. Chopp Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic Lancet Neurol. 8 2009 491 500