Dichloroacetate metabolically targeted therapy defeats cytotoxicity of standard anticancer drugs

Cancer Chemotherapy and Pharmacology

Volumn 67, Issue 3, 2011, Pages 647-655

  Heshe, Dirk ^a   Hoogestraat, Stephanie ^a   Brauckmann, Christine ^b   Karst, Uwe ^b   Boos, Joachim ^a   Lanvers Kaminsky, Claudia ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Cancer; Cisplatin; Cytotoxicity; DCA; Warburg effect

Indexed keywords

CASPASE 3; CASPASE 7; CISPLATIN; DICHLOROACETIC ACID; DOXORUBICIN; TEMOZOLOMIDE; ANTINEOPLASTIC AGENT; DACARBAZINE; DRUG DERIVATIVE; GLUCOSE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG EFFICACY; DRUG TARGETING; ENZYME ACTIVATION; GLUCOSE METABOLISM; GLYCOLYSIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; TUMOR GROWTH; CELL STRAIN HEK293; CELL SURVIVAL; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG INTERACTION; DRUG STABILITY; METABOLISM; NEOPLASM; ORAL DRUG ADMINISTRATION; PATHOLOGY; TUMOR CELL LINE;

ADMINISTRATION, ORAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; DACARBAZINE; DICHLOROACETATE; DOXORUBICIN; DRUG DELIVERY SYSTEMS; DRUG INTERACTIONS; DRUG STABILITY; GLUCOSE; HEK293 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEOPLASMS;

EID: 79953804263     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-010-1361-6     Document Type: Article

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