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Volumn 58, Issue 5, 1998, Pages 464-477

Specific heat flow rate: An on-line monitor and potential control variable of specific metabolic rate in animal cell culture that combines microcalorimetry with dielectric spectroscopy

Author keywords

Animal cell culture; Calorimetry; Capacitance; Metabolic activity; On line biosensor; Specific metabolic rate

Indexed keywords

BIOSENSORS; CALORIMETRY; CHEMICAL VARIABLES CONTROL; GENETIC ENGINEERING; GROWTH KINETICS; METABOLISM; ONLINE SYSTEMS; PROBES; SPECIFIC HEAT; SPECTROSCOPY; THERMAL CONDUCTIVITY; THERMAL VARIABLES MEASUREMENT;

EID: 0032486513     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19980605)58:5<464::AID-BIT2>3.0.CO;2-B     Document Type: Article
Times cited : (53)

References (62)
  • 1
    • 0022327666 scopus 로고
    • Metabolism in lymphocytes and its importance in the immune response
    • Ardawi, M. S. M., Newsholme, E. A. 1985. Metabolism in lymphocytes and its importance in the immune response. Essays Biochem. 21: 1-44.
    • (1985) Essays Biochem. , vol.21 , pp. 1-44
    • Ardawi, M.S.M.1    Newsholme, E.A.2
  • 2
    • 0025953953 scopus 로고
    • Cell-growth experiments using a microcalorimetric vessel equipped with oxygen and pH electrodes
    • Bäckman, P., Wadsö, I. 1991. Cell-growth experiments using a microcalorimetric vessel equipped with oxygen and pH electrodes. J. Biochem. Biophys. Methods 23: 283-293.
    • (1991) J. Biochem. Biophys. Methods , vol.23 , pp. 283-293
    • Bäckman, P.1    Wadsö, I.2
  • 3
    • 0002627791 scopus 로고
    • Growth and metabolism in bacteria
    • A. E. Beezer (ed.). Academic Press, London
    • Belaich, J. P. 1980. Growth and metabolism in bacteria, pp. 1-42. In: A. E. Beezer (ed.), Biological microcalorimetry. Academic Press, London.
    • (1980) Biological Microcalorimetry , pp. 1-42
    • Belaich, J.P.1
  • 4
    • 0028518802 scopus 로고
    • Multichannel flow-injection-analysis biosensor system for online monitoring of glucose, lactate, glutamine, glutamate, and ammonia in animal-cell culture
    • Blankenstein, G., Spohn, U., Preuschoff, F., Thommes, J., Kula, M.-R. 1994. Multichannel flow-injection-analysis biosensor system for online monitoring of glucose, lactate, glutamine, glutamate, and ammonia in animal-cell culture. Biotechnol. Appl. Biochem. 20: 291-307.
    • (1994) Biotechnol. Appl. Biochem. , vol.20 , pp. 291-307
    • Blankenstein, G.1    Spohn, U.2    Preuschoff, F.3    Thommes, J.4    Kula, M.-R.5
  • 5
    • 0029256482 scopus 로고
    • Determination of the respiration of the respiration quotient in mammalian-cell culture in bicarbonate buffered media
    • Bonarius, H. P. J., De Gooijer, C. D., Tramper, J., Schmid, G. 1995. Determination of the respiration of the respiration quotient in mammalian-cell culture in bicarbonate buffered media. Biotechnol Bioeng. 45: 524-535.
    • (1995) Biotechnol Bioeng. , vol.45 , pp. 524-535
    • Bonarius, H.P.J.1    De Gooijer, C.D.2    Tramper, J.3    Schmid, G.4
  • 8
    • 0027870467 scopus 로고
    • Dielectric spectroscopy of mammalian cells. 1. Evaluation of the biomass of HeLa cell and CHO cell in suspension by low-frequency dielectric spectroscopy
    • Cerckel, I., Garcia, A., Degouys, V., Dubois, D., Fabry, L., Miller, A. O. A. 1993. Dielectric spectroscopy of mammalian cells. 1. Evaluation of the biomass of HeLa cell and CHO cell in suspension by low-frequency dielectric spectroscopy. Cytotechnol. 13: 185-193.
    • (1993) Cytotechnol. , vol.13 , pp. 185-193
    • Cerckel, I.1    Garcia, A.2    Degouys, V.3    Dubois, D.4    Fabry, L.5    Miller, A.O.A.6
  • 9
    • 0020446049 scopus 로고
    • A test and calibration process for microcalorimeters used as thermal power meters
    • Chen, A.-T., Wadsö, I. 1982. A test and calibration process for microcalorimeters used as thermal power meters. J. Biochem. Biophys. Methods 6: 297-306.
    • (1982) J. Biochem. Biophys. Methods , vol.6 , pp. 297-306
    • Chen, A.-T.1    Wadsö, I.2
  • 10
    • 0029278215 scopus 로고
    • Heterogeneity within populations of recombinant Chinese hamster ovary cells expressing interferon-γ
    • Coppen, S. R., Newsam, R., Bull, A. T., Baines, A. J. 1995. Heterogeneity within populations of recombinant Chinese hamster ovary cells expressing interferon-γ. Biotechnol. Bioeng. 46: 147-158.
    • (1995) Biotechnol. Bioeng. , vol.46 , pp. 147-158
    • Coppen, S.R.1    Newsam, R.2    Bull, A.T.3    Baines, A.J.4
  • 11
    • 0001851857 scopus 로고    scopus 로고
    • Real-time monitoring of the biomass content of animal cell cultures using dielectric spectroscopy
    • K. Funatsu, Y. Shirai, and T. Matsushita (eds.). Kluwer Academic Publishers, Dordrecht, Netherlands
    • Davey, C. L., Guan, Y., Kemp, R. B., Kell, D. B. 1997. Real-time monitoring of the biomass content of animal cell cultures using dielectric spectroscopy, pp. 61-65. In: K. Funatsu, Y. Shirai, and T. Matsushita (eds.). Animal cell technology: Basic and applied aspects, Vol. 8. Kluwer Academic Publishers, Dordrecht, Netherlands.
    • (1997) Animal Cell Technology: Basic and Applied Aspects , vol.8 , pp. 61-65
    • Davey, C.L.1    Guan, Y.2    Kemp, R.B.3    Kell, D.B.4
  • 12
    • 0024140018 scopus 로고
    • On the audio- And radio-frequency dielectric behaviour of anchorage- independent, mouse L929-derived LS fibroblasts. Bioelectrochem
    • Davey, C. L., Kell, D. B., Kemp, R. B., Meredith, R. W. J. 1988. On the audio- and radio-frequency dielectric behaviour of anchorage- independent, mouse L929-derived LS fibroblasts. Bioelectrochem. Bioenerg. 20: 83-98.
    • (1988) Bioenerg. , vol.20 , pp. 83-98
    • Davey, C.L.1    Kell, D.B.2    Kemp, R.B.3    Meredith, R.W.J.4
  • 13
    • 0003122853 scopus 로고
    • On the determination of the size of microbial cells using flow cytometry
    • D. Lloyd (ed.). Springer-Verlag, Berlin
    • Davey, H. M., Davey, C. L., Kell, D. B. 1993a. On the determination of the size of microbial cells using flow cytometry, pp. 49-65. In: D. Lloyd (ed.). Flow cytometry in microbiology. Springer-Verlag, Berlin.
    • (1993) Flow Cytometry in Microbiology , pp. 49-65
    • Davey, H.M.1    Davey, C.L.2    Kell, D.B.3
  • 14
    • 0342393265 scopus 로고
    • Skatgraf: A stand-alone program for the calibration and plotting of flow cytometric data
    • Davey, H. M., Davey, C. L., Kell, D. B. 1993b. Skatgraf: A stand-alone program for the calibration and plotting of flow cytometric data. Binary 5: 165-170.
    • (1993) Binary , vol.5 , pp. 165-170
    • Davey, H.M.1    Davey, C.L.2    Kell, D.B.3
  • 15
    • 0029635979 scopus 로고
    • On-line gas analysis in animal cell cultivation: II. Methods for oxygen uptake rate estimation and its application to controlled feeding of glutamine
    • Eyer, K., Oeggerli, A., Heinzle, E. 1995. On-line gas analysis in animal cell cultivation: II. Methods for oxygen uptake rate estimation and its application to controlled feeding of glutamine. Biotechnol. Bioeng. 45: 54-62.
    • (1995) Biotechnol. Bioeng. , vol.45 , pp. 54-62
    • Eyer, K.1    Oeggerli, A.2    Heinzle, E.3
  • 16
    • 0011856193 scopus 로고
    • The twin-flow microrespirometer and simultaneous calorimetry
    • E. Gnaiger and H. Forstner (eds.). Springer-Verlag, Berlin
    • Gnaiger, E. 1983. The twin-flow microrespirometer and simultaneous calorimetry, pp. 134-166. In: E. Gnaiger and H. Forstner (eds.), Polarographic oxygen sensors: Aquatic and physiological applications. Springer-Verlag, Berlin.
    • (1983) Polarographic Oxygen Sensors: Aquatic and Physiological Applications , pp. 134-166
    • Gnaiger, E.1
  • 17
    • 0002000539 scopus 로고
    • Concepts on efficiency in biological calorimetry and metabolic flux control
    • Gnaiger, E. 1990. Concepts on efficiency in biological calorimetry and metabolic flux control. Thermochim. Acta 172: 31-52.
    • (1990) Thermochim. Acta , vol.172 , pp. 31-52
    • Gnaiger, E.1
  • 18
    • 0025320078 scopus 로고
    • Anaerobic metabolism in aerobic mammalian cells: Information from the ratio of calorimetric heat flux and respirometric oxygen flux
    • Gnaiger, E., Kemp, R. B. 1990. Anaerobic metabolism in aerobic mammalian cells: Information from the ratio of calorimetric heat flux and respirometric oxygen flux. Biochim. Biophys. Acta 1016: 328-332.
    • (1990) Biochim. Biophys. Acta , vol.1016 , pp. 328-332
    • Gnaiger, E.1    Kemp, R.B.2
  • 20
    • 11944272604 scopus 로고
    • Environmental effects on protein glycosylation
    • Goochee, C. F., Monica, T. 1990. Environmental effects on protein glycosylation. Bio/Technol. 8: 421-427.
    • (1990) Bio/Technol. , vol.8 , pp. 421-427
    • Goochee, C.F.1    Monica, T.2
  • 21
    • 0030698581 scopus 로고    scopus 로고
    • A modified flow microcalorimeter for measuring the heat dissipation by mammalian cells in batch culture
    • Guan, Y., Lloyd, P. C., Evans, P. M., Kemp, R. B. 1997. A modified flow microcalorimeter for measuring the heat dissipation by mammalian cells in batch culture. J. Thermal Anal. 49: 785-794.
    • (1997) J. Thermal Anal. , vol.49 , pp. 785-794
    • Guan, Y.1    Lloyd, P.C.2    Evans, P.M.3    Kemp, R.B.4
  • 22
    • 0041041168 scopus 로고    scopus 로고
    • Medium design with the aid of heat flux measurement in mammalian cell culture
    • H. V. Westerhoff, J. L. Snoep, F. E. Sluse, J. E. Wijker, and B. N. Kholodenko (eds.). BTK, Amsterdam
    • Guan, Y., Kemp, R. B. 1996. Medium design with the aid of heat flux measurement in mammalian cell culture, pp. 387-397. In: H. V. Westerhoff, J. L. Snoep, F. E. Sluse, J. E. Wijker, and B. N. Kholodenko (eds.), BioThermoKinetics of the living cell. BTK, Amsterdam.
    • (1996) BioThermoKinetics of the Living Cell , pp. 387-397
    • Guan, Y.1    Kemp, R.B.2
  • 23
    • 0023306390 scopus 로고
    • The dielectric permittivity of microbial suspensions at radio-frequencies: A novel method for the real-time estimation of microbial biomass
    • Harris, C. M., Todd, R. W., Bungard, S. J., Lovitt, R. W., Morris, J. G., Kell, D. B. 1987. The dielectric permittivity of microbial suspensions at radio-frequencies: A novel method for the real-time estimation of microbial biomass. Enzyme Microb. Technol. 9: 181-186.
    • (1987) Enzyme Microb. Technol. , vol.9 , pp. 181-186
    • Harris, C.M.1    Todd, R.W.2    Bungard, S.J.3    Lovitt, R.W.4    Morris, J.G.5    Kell, D.B.6
  • 27
    • 0028893979 scopus 로고
    • Role of glutamine in hybridoma cell culture: Effects on cell growth, antibody production, and cell metabolism
    • Jeong, Y.-H., Wang, S. S. 1995. Role of glutamine in hybridoma cell culture: Effects on cell growth, antibody production, and cell metabolism. Enzyme Microb. Technol. 17: 47-55.
    • (1995) Enzyme Microb. Technol. , vol.17 , pp. 47-55
    • Jeong, Y.-H.1    Wang, S.S.2
  • 28
    • 0040447256 scopus 로고
    • Heat dissipation and metabolism in isolated tissue cells and whole tissues/organs
    • A. M. James (ed.). Wright, Bristol, UK
    • Kemp, R. B. 1987. Heat dissipation and metabolism in isolated tissue cells and whole tissues/organs, pp. 147-166. In: A. M. James (ed.), Thermal and energetic studies of cellular biological systems. Wright, Bristol, UK.
    • (1987) Thermal and Energetic Studies of Cellular Biological Systems , pp. 147-166
    • Kemp, R.B.1
  • 29
    • 0002657898 scopus 로고
    • Developments in cellular microcalorimetry with particular emphasis on the valuable role of the energy (enthalpy) balance method
    • Kemp, R. B. 1993. Developments in cellular microcalorimetry with particular emphasis on the valuable role of the energy (enthalpy) balance method. Thermochim. Acta. 219: 17-41.
    • (1993) Thermochim. Acta , vol.219 , pp. 17-41
    • Kemp, R.B.1
  • 30
    • 0029174113 scopus 로고
    • Cytotoxicity in an anchorage-independent fibroblast cell line measured by a combination of fluorescent dyes
    • Kemp, R. B. 1995. Cytotoxicity in an anchorage-independent fibroblast cell line measured by a combination of fluorescent dyes. Meth. Mol. Biol. 43: 211-218.
    • (1995) Meth. Mol. Biol. , vol.43 , pp. 211-218
    • Kemp, R.B.1
  • 31
    • 0000393123 scopus 로고
    • A thermochemical study of metabolic pathways in activated and triggered 2C11-12 mouse macrophage hybridoma cells
    • Kemp, R. B., Belicic-Kolsek, A., Hoare, S., Schmalfeldt, M., Townsend, C., Evans, P. M. 1995. A thermochemical study of metabolic pathways in activated and triggered 2C11-12 mouse macrophage hybridoma cells. Thermochim. Acta. 250: 259-276.
    • (1995) Thermochim. Acta , vol.250 , pp. 259-276
    • Kemp, R.B.1    Belicic-Kolsek, A.2    Hoare, S.3    Schmalfeldt, M.4    Townsend, C.5    Evans, P.M.6
  • 32
    • 0030710806 scopus 로고    scopus 로고
    • An enthalpy balance approach to studies of metabolic activity in mammalian cells
    • Kemp, R. B., Evans, P. M., Guan, Y. 1997. An enthalpy balance approach to studies of metabolic activity in mammalian cells. J. Thermal Anal. 49: 755-770.
    • (1997) J. Thermal Anal. , vol.49 , pp. 755-770
    • Kemp, R.B.1    Evans, P.M.2    Guan, Y.3
  • 33
    • 0001254358 scopus 로고    scopus 로고
    • Heat flux and the calorimetric-respirometric ratio as measures of catabolic flux in mammalian cells
    • Kemp, R. B., Guan, Y. 1997. Heat flux and the calorimetric-respirometric ratio as measures of catabolic flux in mammalian cells. Thermochim. Acta 300: 199-211.
    • (1997) Thermochim. Acta , vol.300 , pp. 199-211
    • Kemp, R.B.1    Guan, Y.2
  • 34
    • 0003166310 scopus 로고    scopus 로고
    • Probing the metabolism of genetically-engineered mammalian cells by heat flux
    • in press
    • Kemp, R. B., Guan, Y. 1998. Probing the metabolism of genetically-engineered mammalian cells by heat flux. Thermochim. Acta 309: (in press).
    • (1998) Thermochim. Acta , vol.309
    • Kemp, R.B.1    Guan, Y.2
  • 36
    • 0026206357 scopus 로고
    • Use of microcalorimetric monitoring in establishing continuous energy balances and in continuous determinations of substrate and product concentrations of batch-grown Saccharomyces cerevisiae
    • Larsson, C., Blomberg, A., Gustafsson, L. 1991. Use of microcalorimetric monitoring in establishing continuous energy balances and in continuous determinations of substrate and product concentrations of batch-grown Saccharomyces cerevisiae. Biotechnol. Bioeng. 38: 447-458.
    • (1991) Biotechnol. Bioeng. , vol.38 , pp. 447-458
    • Larsson, C.1    Blomberg, A.2    Gustafsson, L.3
  • 37
    • 0029167271 scopus 로고
    • The use of dielectric permittivity for the control of the biomass level during biotransformations of toxic substrates in continuous-culture
    • Markx, G. H., Kell, D. B. 1995. The use of dielectric permittivity for the control of the biomass level during biotransformations of toxic substrates in continuous-culture. Biotechnol. Prog. 11: 64-70.
    • (1995) Biotechnol. Prog. , vol.11 , pp. 64-70
    • Markx, G.H.1    Kell, D.B.2
  • 39
    • 0002643676 scopus 로고
    • Glutaminolysis in animal cells
    • M. J. Morgan (ed.). Plenum Press, New York
    • McKeehan, W. L. 1986. Glutaminolysis in animal cells, pp. 111-150. In: M. J. Morgan (ed.). Carbohydrate metabolism in cultured cells. Plenum Press, New York.
    • (1986) Carbohydrate Metabolism in Cultured Cells , pp. 111-150
    • McKeehan, W.L.1
  • 40
  • 41
    • 0022196860 scopus 로고
    • Glutamine metabolism in lymphocytes - Its biochemical, physiological and clinical importance
    • Newsholme, E. A., Crabtree, B., Ardawi, M. S. M. 1985. Glutamine metabolism in lymphocytes - Its biochemical, physiological and clinical importance. Quart. J. Exp. Physiol. 70: 473-489.
    • (1985) Quart. J. Exp. Physiol. , vol.70 , pp. 473-489
    • Newsholme, E.A.1    Crabtree, B.2    Ardawi, M.S.M.3
  • 42
    • 0028979470 scopus 로고
    • On-line gas analysis in animal cell cultivation. 1. Control of dissolved oxygen and pH
    • Oeggerli, A., Eyer, K., Heinzle, E. 1995. On-line gas analysis in animal cell cultivation. 1. Control of dissolved oxygen and pH. Biotechnol. Bioeng. 45: 42-53.
    • (1995) Biotechnol. Bioeng. , vol.45 , pp. 42-53
    • Oeggerli, A.1    Eyer, K.2    Heinzle, E.3
  • 43
    • 0027112176 scopus 로고
    • Effects of lactate concentration on hybridoma culture in lactate-controlled fed-batch operation
    • Omasa, T., Higaskiyama, K.-i., Shloya, S., Suga, K.-i. 1992. Effects of lactate concentration on hybridoma culture in lactate-controlled fed-batch operation. Biotechnol. Bioeng. 39: 556-564.
    • (1992) Biotechnol. Bioeng. , vol.39 , pp. 556-564
    • Omasa, T.1    Higaskiyama, K.-I.2    Shloya, S.3    Suga, K.-I.4
  • 45
    • 0018386209 scopus 로고
    • Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells
    • Reitzer, L. J., Wice, B. M., Kennell, D. 1979. Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J. Biol. Chem. 254: 2669-2676.
    • (1979) J. Biol. Chem. , vol.254 , pp. 2669-2676
    • Reitzer, L.J.1    Wice, B.M.2    Kennell, D.3
  • 48
    • 0022801637 scopus 로고
    • Microcalorimetric measurements on tissue-cells attached to microcarriers in stirred suspension
    • Schön, A., Wadsö, I. 1986. Microcalorimetric measurements on tissue-cells attached to microcarriers in stirred suspension. J. Biochem. Biophys. Methods 13: 135-143.
    • (1986) J. Biochem. Biophys. Methods , vol.13 , pp. 135-143
    • Schön, A.1    Wadsö, I.2
  • 49
    • 54949152106 scopus 로고
    • Electrical properties of tissue and cell suspensions
    • Schwan, H. P. 1957. Electrical properties of tissue and cell suspensions. Adv. Biol. Med. Phys. 5: 147-209.
    • (1957) Adv. Biol. Med. Phys. , vol.5 , pp. 147-209
    • Schwan, H.P.1
  • 50
    • 0025257412 scopus 로고
    • Light-scattering measurement in an arc lamp-based flow cytometry
    • Steen, H. B. 1990. Light-scattering measurement in an arc lamp-based flow cytometry. Cytometry 11: 223-230.
    • (1990) Cytometry , vol.11 , pp. 223-230
    • Steen, H.B.1
  • 52
    • 0020271758 scopus 로고
    • A multichannel micro-calorimetry system
    • Suurkuusk, J., Wadsö, I. 1982. A multichannel micro-calorimetry system. Chem. Scr. 20: 155-163.
    • (1982) Chem. Scr. , vol.20 , pp. 155-163
    • Suurkuusk, J.1    Wadsö, I.2
  • 54
    • 0000799121 scopus 로고
    • Large-scale calorimetry and biotechnology
    • von Stockar, U., Marison, I. W. 1991. Large-scale calorimetry and biotechnology. Thermochim. Acta. 193: 215-242.
    • (1991) Thermochim. Acta , vol.193 , pp. 215-242
    • Von Stockar, U.1    Marison, I.W.2
  • 55
    • 0001479894 scopus 로고
    • Microcalorimetry of aqueous and biological systems
    • K. N. Marsh and P. A. G. O'Hare (eds.). Blackwell Scientific, London
    • Wadsö, I. 1994. Microcalorimetry of aqueous and biological systems, pp. 267-301. In: K. N. Marsh and P. A. G. O'Hare (eds.). Experimental thermodynamics, Vol. IV, Solution calorimetry. Blackwell Scientific, London.
    • (1994) Experimental Thermodynamics, Vol. IV, Solution Calorimetry , vol.4 , pp. 267-301
    • Wadsö, I.1
  • 57
    • 0029256472 scopus 로고
    • Evaluation and applications of optical-cell density probes in mammalian-cell bioreactors
    • Wu, P., Ozturk, S. S., Blackie, J. D., Thrift, J. C., Figueroa, C., Naveh, D. 1995. Evaluation and applications of optical-cell density probes in mammalian-cell bioreactors. Biotechnol. Bioeng. 45: 495-502.
    • (1995) Biotechnol. Bioeng. , vol.45 , pp. 495-502
    • Wu, P.1    Ozturk, S.S.2    Blackie, J.D.3    Thrift, J.C.4    Figueroa, C.5    Naveh, D.6
  • 58
    • 0001341681 scopus 로고
    • Cell death
    • J. O'D. McGee, P. G. Isaacson, and N. A. Wright (eds.). Oxford University Press, Oxford
    • Wyllie, A. H., Durall, E. 1992. Cell death, pp. 141-157. In: J. O'D. McGee, P. G. Isaacson, and N. A. Wright (eds.), Oxford textbook of pathology, Vol. 1. Oxford University Press, Oxford.
    • (1992) Oxford Textbook of Pathology , vol.1 , pp. 141-157
    • Wyllie, A.H.1    Durall, E.2
  • 59
    • 0028436953 scopus 로고
    • Stoichiometric analysis of animal cell growth and its application in medium design
    • Xie, L., Wang, D. I. C. 1994. Stoichiometric analysis of animal cell growth and its application in medium design. Biotechnol. Bioeng. 43: 1175-1189.
    • (1994) Biotechnol. Bioeng. , vol.43 , pp. 1175-1189
    • Xie, L.1    Wang, D.I.C.2
  • 60
    • 9444286985 scopus 로고    scopus 로고
    • High cell density and high monoclonal antibody production through medium design and rational control in a bioreactor
    • Xie, L., Wang, D. I. C. 1996. High cell density and high monoclonal antibody production through medium design and rational control in a bioreactor. Biotechnol. Bioeng. 51: 725-729.
    • (1996) Biotechnol. Bioeng. , vol.51 , pp. 725-729
    • Xie, L.1    Wang, D.I.C.2
  • 61
    • 0002043589 scopus 로고
    • Recent advances in bioprocess monitoring and control
    • Zhou, W., Mulchandani, A. 1995. Recent advances in bioprocess monitoring and control. ACS Symp. Ser. 613: 88-98.
    • (1995) ACS Symp. Ser. , vol.613 , pp. 88-98
    • Zhou, W.1    Mulchandani, A.2
  • 62
    • 0028454939 scopus 로고
    • On-line characterization of a hybridoma cell-culture process
    • Zhou, W. C., Hu, W. S. 1994. On-line characterization of a hybridoma cell-culture process. Biotechnol. Bioeng. 44: 170-177.
    • (1994) Biotechnol. Bioeng. , vol.44 , pp. 170-177
    • Zhou, W.C.1    Hu, W.S.2


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