Half-life extension of a single-chain diabody by fusion to domain B of staphylococcal protein A

Protein Engineering, Design and Selection

Volumn 25, Issue 2, 2012, Pages 81-88

  Unverdorben, Felix ^a   Färber Schwarz, Aline ^a   Richter, Fabian ^a   Hutt, Meike ^a   Kontermann, Roland E ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

Author keywords

immunoglobulin binding domain; pharmacokinetics; protein A; serum half life; single chain diabody

Indexed keywords

AMINO ACID RESIDUES; ANTIGEN-BINDING ACTIVITIES; C-TERMINUS; DIABODY; ENZYME LINKED IMMUNOSORBENT ASSAY; FUSION PROTEINS; HEK293 CELLS; IMMUNOGLOBULIN-BINDING DOMAIN; MOUSE IGG; NEONATAL FC RECEPTORS; PH-DEPENDENT; PLASMA PROTEIN; PROTEIN A; RECOMBINANT ANTIBODY; REVERSIBLE BINDING; SERUM HALF-LIFE; STAPHYLOCOCCAL PROTEIN; THERAPEUTIC PROTEIN;

AMINO ACIDS; ANTIBODIES; ENZYME ACTIVITY; FLOW CYTOMETRY; PHARMACOKINETICS;

MAMMALS;

AMINO ACID; HYBRID PROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; PLASMA PROTEIN; RECOMBINANT ANTIBODY; STAPHYLOCOCCUS PROTEIN A;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANTIGEN BINDING; ARTICLE; CELL STRAIN HEK293; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HALF LIFE TIME; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE, TUMOR; HALF-LIFE; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; JURKAT CELLS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SINGLE-CHAIN ANTIBODIES; STAPHYLOCOCCAL PROTEIN A;

BACTERIA (MICROORGANISMS); MUS;

EID: 84856300610     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzr061     Document Type: Article

References (41)

1. Andersen, J.T., Pehrson, R., Tolmachev, V., Daba, M.B., Abrahmsén, L. and Ekblad, C. (2011) J. Biol. Chem., 286, 5234-5241.
2. Batra, S.K., Jain, M., Wittel, U.A., Chauhan, S.C. and Colcher, D. (2002) Curr. Opin. Biotechnol., 13, 603-608.
3. Benedict, C.A., MacKrell, A.J. and Anderson, W.F. (1997) J. Immunol. Methods, 201, 223-231.
4. Burmeister, W.P., Huber, A.H. and Bjorkman, P.J. (1994) Nature, 372, 379-383.
5. Chaudhury, C., Mehnaz, S., Robsinon, J.M., Hayton, W.L., Pearl, D.K., Roopenian, D.C. and Anderson, C.L. (2003) J. Exp. Med., 197, 315-322.
6. Chuang, V.T.G., Kragh-Hansen, U. and Otagiri, M. (2002) Pharm. Res., 19, 569-577.
7. Claßen, A., Kalali, B.N., Schnopp, C., Andres, C., Aguilar-Pimentel, J.A., Ring, J., Ollert, M. and Mempel, M. (2011) Exp. Dermatol., 20, 48-52.
8. Deisenhofer, J. (1981) Biochemistry, 20, 2361-2370.
9. Evangelidou, M., Tseveleki, V., Vamvakas, S.S. and Probert, L. (2010) Immunol. Cell Biol., 88, 586-595.
10. Flisiak, R. and Flisiak, I. (2010) Exp. Opin. Biol. Ther., 10, 1509-1515.
11. Gebauer, M. and Skerra, A. (2009) Curr. Opin. Chem. Biol., 13, 245-255.
12. Gómez, M.I., O'Seaghdha, M., Magargee, M., Foster, T. and Prince, A.S. (2006) J. Biol. Chem., 281, 20190-20196.
13. Gore, M.G., Ferris, W.F., Popplewel, A.G., Scawen, M. and Atkinson, T. (1992) Protein Eng., 5, 577-582.
14. Gouda, H., Torigoe, H., Saito, A., Sato, M., Arata, Y. and Shimada, I. (1992) Biochemistry, 31, 9665-9672.
15. Holliger, P., Wing, M., Pound, J.D., Bohlen, H. and Winter, G. (1997) Nat. Biotechnol., 15, 632-636.
16. Hopp, J., Hornig, N., Zettlitz, K.A., Schwarz, A., Fuss, N., Müller, D. and Kontermann, R.E. (2010) Protein Eng. Des. Sel., 23, 827-834.
17. Huang, C. (2009) Curr. Opin. Biotechnol., 20, 692-699.
18. Jansson, B., Uhlén, M. and Nygren, P.A. (1998) FEMS Immunol. Med. Microbiol., 20, 69-78.
19. Jovic, M., Sharma, M., Rahajeng, J. and Caplan, S. (2010) Histol. Histopathol., 25, 99-112.
20. Kim, J.K., Tsen, M.F., Ghetie, V. and Ward, E.S. (1994) Eur. J. Immunol., 24, 2429-2434.
21. Kim, J., Hayton, W.L., Robinson, J.M. and Anderson, C.L. (2006) Clin. Immunol., 122, 146-155.
22. Kontermann, R.E. (2009) BioDrugs, 23, 93-109.
23. Kontermann, R.E. (2010) Curr. Opin. Mol. Ther., 12, 176-183.
24. Kontermann, R.E. (2011) Curr. Opin. Biotechnol., 22, 868-876.
25. Kumar, A., Tassopoulos, A.M., Li, Q. and Yu, F.S.X. (2007) Biochem. Biophys. Res. Commun., 354, 955-961.
26. Mazor, Y., Noy, R., Wels, W.S. and Benhar, I. (2007) Cancer Lett., 257, 124-135.
27. Metzner, H.J., Weimer, T., Kronthaler, U., Lang, W. and Schulze, S. (2009) Thromb. Haemost., 102, 634-644.
28. Müller, D., Karle, A., Meissburger, B., Höfig, I., Stork, R. and Kontermann, R.E. (2007) J. Biol. Chem., 282, 12650-12660.
29. Nord, K., Gunneriusson, E., Ringdahl, J., Stahl, S., Uhlén, M. and Nygren, P.A. (1997) Nat. Biotechnol., 15, 772-777.
30. Nuttall, S.D. and Walsh, R.B. (2008) Curr. Opin. Pharmacol., 8, 609-615.
31. Nygren, P.-A., Flodby, P., Andersson, R., Wigzell, H. and Uhlén, M. (1991) Vaccines, 91, 363-368.
32. Pisal, d.S., Kosloski, M.P. and Balu-Iyer, S.V. (2010) J. Pharm. Sci., 99, 2557-2575.
33. Raghavan, M., Chen, M.Y., Gastinel, L.N. and Bjorkman, P.J. (1994) Immunity, 1, 303-315.
34. Rehlaender, B.N. and Cho, M.J. (1998) Pharm. Res., 15, 1652-1656.
35. Sauer-Eriksson, A.E., Kleywegt, G.J., Uhlén, M. and Jones, T.A. (1995) Sturcture, 3, 265-278.
36. Sidorin, E.V. and Solov'eva, T.F. (2011) Biochemistry (Mosc.), 76, 363-378.
37. Stork, R., Müller, D. and Kontermann, R.E. (2007) Protein Eng. Des. Sel., 20, 569-576.
38. Stork, R., Campigna, E., Robert, B., Müller, D. and Kontermann, R.E. (2009) J. Biol. Chem., 284, 25612-25619.
39. Tai, M.-S., Mudgett-Hunter, M., Levinson, D., Wu, G.-M., Haber, E., Oppermann, H. and Huston, J.S. (1990) Biochemistry, 29, 8024-8030.
40. Tashiro, M. and Montelione, G.T. (1995) Curr. Biol., 5, 471-481.
41. Zettlitz, K.A., Seitter, J., Müller, D. and Kontermann, R.E. (2010) Mol. Biotechnol., 46, 265-278.