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Volumn 46, Issue 3, 2010, Pages 265-278

Humanization of a mouse monoclonal antibody directed against a cell surface-exposed epitope of membrane-associated heat shock protein 70 (Hsp70)

Author keywords

Cancer; CDR grafting; Chimeric antibody; Heat shock protein; Humanization

Indexed keywords

CANCER; CDR GRAFTING; CHIMERIC ANTIBODY; HEAT SHOCK PROTEIN; HUMANIZATION;

EID: 77958103554     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12033-010-9298-x     Document Type: Article
Times cited : (6)

References (51)
  • 1
    • 0024151897 scopus 로고
    • The heat-shock proteins
    • 10.1146/annurev.ge.22.120188.003215
    • S Linquist EA Craig 1988 The heat-shock proteins Annual Review of Genetics 22 631 677 10.1146/annurev.ge.22.120188.003215
    • (1988) Annual Review of Genetics , vol.22 , pp. 631-677
    • Linquist, S.1    Craig, E.A.2
  • 2
    • 26044433779 scopus 로고    scopus 로고
    • Message in a bottle: Role of the 70-kDa heat shock protein family in anti-tumor immunity
    • DOI 10.1002/eji.200535002
    • SK Calderwood JR Theriault J Gong 2005 Message in a bottle: Role of the 70-kDa heat shock protein family in anti-tumor immunity European Journal of Immunology 35 2518 2527 1:CAS:528:DC%2BD2MXhtVOqsL%2FP 10.1002/eji.200535002 (Pubitemid 41404034)
    • (2005) European Journal of Immunology , vol.35 , Issue.9 , pp. 2518-2527
    • Calderwood, S.K.1    Theriault, J.R.2    Gong, J.3
  • 3
    • 17044387386 scopus 로고    scopus 로고
    • Hsp70 chaperones: Cellular functions and molecular mechanisms
    • 1:CAS:528:DC%2BD2MXktlymt78%3D 10.1007/s00018-004-4464-6
    • MP Mayer B Bukau 2005 Hsp70 chaperones: Cellular functions and molecular mechanisms Cellular and Molecular Life Sciences 62 670 684 1:CAS:528: DC%2BD2MXktlymt78%3D 10.1007/s00018-004-4464-6
    • (2005) Cellular and Molecular Life Sciences , vol.62 , pp. 670-684
    • Mayer, M.P.1    Bukau, B.2
  • 4
    • 35548970287 scopus 로고    scopus 로고
    • Heat shock proteins in cancer
    • DOI 10.1196/annals.1391.030, Stress Responses
    • M Sherman G Multhoff 2007 Heat shock proteins in cancer Annals of the New York Academy of Sciences 1113 192 201 1:CAS:528:DC%2BD2sXhsVanurfE 10.1196/annals.1391.030 (Pubitemid 350015025)
    • (2007) Annals of the New York Academy of Sciences , vol.1113 , pp. 192-201
    • Sherman, M.1    Multhoff, G.2
  • 5
    • 44849084963 scopus 로고    scopus 로고
    • Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages
    • 1:CAS:528:DC%2BD1cXisl2jtLc%3D
    • VL Vega M Rodríguez-Silva T Frey M Gehrmann JC Diaz C Steinem G Multhoff N Arsipe A De Maio 2008 Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages Journal of Immunology 180 4299 4307 1:CAS:528:DC%2BD1cXisl2jtLc%3D
    • (2008) Journal of Immunology , vol.180 , pp. 4299-4307
    • Vega, V.L.1    Rodríguez-Silva, M.2    Frey, T.3    Gehrmann, M.4    Diaz, J.C.5    Steinem, C.6    Multhoff, G.7    Arsipe, N.8    De Maio, A.9
  • 6
    • 0028953056 scopus 로고
    • A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells
    • 1:CAS:528:DyaK2MXlsVCmtLY%3D 10.1002/ijc.2910610222
    • G Multhoff C Botzler M Wiesnet E Müller T Meier W Wilmanns RD Issels 1995 A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells International Journal of Cancer 61 272 279 1:CAS:528:DyaK2MXlsVCmtLY%3D 10.1002/ijc.2910610222
    • (1995) International Journal of Cancer , vol.61 , pp. 272-279
    • Multhoff, G.1    Botzler, C.2    Wiesnet, M.3    Müller, E.4    Meier, T.5    Wilmanns, W.6    Issels, R.D.7
  • 7
    • 0034522797 scopus 로고    scopus 로고
    • Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients
    • DOI 10.1379/1466-1268(2000)005<0438:HPMEOP>2.0.CO;2
    • M Hantschel K Pfister A Jordan R Scholz R Andreesen G Schmitz H Schmetzer W Hiddemann G Multhoff 2000 Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients Cell Stress and Chaperones 5 438 442 1:CAS:528:DC%2BD3MXkslyguw%3D%3D 10.1379/1466-1268(2000)005<0438: HPMEOP>2.0.CO;2 (Pubitemid 32057495)
    • (2000) Cell Stress and Chaperones , vol.5 , Issue.5 , pp. 438-442
    • Hantschel, M.1    Pfister, K.2    Jordan, A.3    Scholz, R.4    Andreesen, R.5    Schmitz, G.6    Schmetzer, H.7    Hiddemann, W.8    Multhoff, G.9
  • 10
    • 0038712092 scopus 로고    scopus 로고
    • Membrane-bound heat shock protein 70 (Hsp70) in acute myeloid leukemia: A tumor specific recognition structure for the cytolytic activity of autologous NK cells
    • M Gehrmann H Schmetzer G Eissner T Haferlach W Hiddemann G Multhoff 2003 Membrane-bound heat shock protein 70 (Hsp70) in acute myeloid leukemia: A tumor specific recognition structure for the cytolytic activity of autologous NK cells Haematologica 88 474 476
    • (2003) Haematologica , vol.88 , pp. 474-476
    • Gehrmann, M.1    Schmetzer, H.2    Eissner, G.3    Haferlach, T.4    Hiddemann, W.5    Multhoff, G.6
  • 11
    • 33750354943 scopus 로고    scopus 로고
    • High HSP70-membrane expression on leukemic cells from patients with acute myeloid leukemia is associated with a worse prognosis [19]
    • DOI 10.1038/sj.leu.2404391, PII 2404391
    • K Steiner M Graf K Hecht S Reif L Rossbacher K Pfister HJ Kolb HM Schmetzer G Multhoff 2006 High Hsp70-membrane expression on leukemic cells from patients with acute myeloid leukemia is associated with worse prognosis Leukemia 20 2076 2079 1:CAS:528:DC%2BD28XhtFWnsL3K 10.1038/sj.leu.2404391 (Pubitemid 44614913)
    • (2006) Leukemia , vol.20 , Issue.11 , pp. 2076-2079
    • Steiner, K.1    Graf, M.2    Hecht, K.3    Reif, S.4    Rossbacher, L.5    Pfister, K.6    Kolb, H.-J.7    Schmetzer, H.M.8    Multhoff, G.9
  • 12
    • 34848859541 scopus 로고    scopus 로고
    • Heat shock protein 70 (Hsp70): Membrane location, export and immunological relevance
    • DOI 10.1016/j.ymeth.2007.06.006, PII S1046202307001314, Heat Shock Proteins In Extracellular Signaling
    • G Multhoff 2007 Heat shock protein 70 (Hsp70): Membrane location, export and immunological relevance Methods 43 229 237 1:CAS:528:DC%2BD2sXhtFers7%2FO 10.1016/j.ymeth.2007.06.006 (Pubitemid 47499077)
    • (2007) Methods , vol.43 , Issue.3 , pp. 229-237
    • Multhoff, G.1
  • 13
    • 0031132876 scopus 로고    scopus 로고
    • Heat shock protein 72 on tumor cells: A recognition structure for natural killer cells
    • 1:CAS:528:DyaK2sXivVCksb0%3D
    • G Multhoff C Botzler L Jennen J Schmidt J Ellwart R Issels 1997 Heat shock protein 72 on tumor cells: A recognition structure for natural killer cells Journal of Immunology 158 4341 4350 1:CAS:528:DyaK2sXivVCksb0%3D
    • (1997) Journal of Immunology , vol.158 , pp. 4341-4350
    • Multhoff, G.1    Botzler, C.2    Jennen, L.3    Schmidt, J.4    Ellwart, J.5    Issels, R.6
  • 14
    • 0034569491 scopus 로고    scopus 로고
    • Adoptive transfer of human natural killer cells in mice with severe combined immunodeficiency inhibits growth of Hsp70-expressing tumors
    • 1:CAS:528:DC%2BD3cXot1SqtLk%3D 10.1002/1097-0215(20001201)88:5<791:: AID-IJC17>3.0.CO;2-I
    • G Multhoff K Pfister C Botzler A Jordan R Scholz H Schmetzer R Burgstahler W Hiddemann 2000 Adoptive transfer of human natural killer cells in mice with severe combined immunodeficiency inhibits growth of Hsp70-expressing tumors International Journal of Cancer 88 791 797 1:CAS:528:DC%2BD3cXot1SqtLk%3D 10.1002/1097-0215(20001201)88:5<791::AID-IJC17>3.0.CO;2-I
    • (2000) International Journal of Cancer , vol.88 , pp. 791-797
    • Multhoff, G.1    Pfister, K.2    Botzler, C.3    Jordan, A.4    Scholz, R.5    Schmetzer, H.6    Burgstahler, R.7    Hiddemann, W.8
  • 15
    • 0035205080 scopus 로고    scopus 로고
    • A 14-mer Hsp70 peptide stimulates natural killer (NK) cell activity
    • DOI 10.1379/1466-1268(2001)006<0337:AMHPSN>2.0.CO;2
    • G Multhoff K Pfister M Gehrmann M Hantschel C Gross M Hafner W Hiddemann 2001 A 14-mer Hsp70 peptide stimulates natural killer (NK) cell activity Cell Stress and Chaperones 6 337 344 1:CAS:528:DC%2BD38XivVOiuw%3D%3D 10.1379/1466-1268(2001)006<0337:AMHPSN>2.0.CO;2 (Pubitemid 33123486)
    • (2001) Cell Stress and Chaperones , vol.6 , Issue.4 , pp. 337-344
    • Multhoff, G.1    Pfister, K.2    Gehrmann, M.3    Hantschel, M.4    Gross, C.5    Hafner, M.6    Hiddemann, W.7
  • 16
    • 2542558307 scopus 로고    scopus 로고
    • Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: A clinical phase I trial
    • DOI 10.1158/1078-0432.CCR-03-0683
    • SW Krause R Gastpar R Andreesen C Gross H Ullrich G Thonigs K Pfister G Multhoff 2004 Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: A clinical phase I trial Clinical Cancer Research 10 3699 3707 1:CAS:528: DC%2BD2cXksVKnsbc%3D 10.1158/1078-0432.CCR-03-0683 (Pubitemid 38697603)
    • (2004) Clinical Cancer Research , vol.10 , Issue.11 , pp. 3699-3707
    • Krause, S.W.1    Gastpar, R.2    Andreesen, R.3    Gross, C.4    Ullrich, H.5    Thonigs, G.6    Pfister, K.7    Multhoff, G.8
  • 17
    • 67949102158 scopus 로고    scopus 로고
    • Activation of natural killer cells by heat shock protein 70
    • 1:CAS:528:DC%2BD1MXlvV2ksLo%3D 10.1080/02656730902902001
    • G Multhoff 2009 Activation of natural killer cells by heat shock protein 70 International Journal of Hyperthermia 25 169 175 1:CAS:528: DC%2BD1MXlvV2ksLo%3D 10.1080/02656730902902001
    • (2009) International Journal of Hyperthermia , vol.25 , pp. 169-175
    • Multhoff, G.1
  • 18
    • 0031945664 scopus 로고    scopus 로고
    • Definition of extracellular localized epitopes of Hsp70 involved in an NK immune response
    • DOI 10.1379/1466-1268(1998)003<0006:DOELEO>2.3.CO;2
    • C Botzler G Li RD Issels G Multhoff 1998 Definition of extracellular localized epitopes of Hsp70 involved in an NK immune response Cell Stress and Chaperones 3 6 11 1:CAS:528:DyaK1cXislCjsL4%3D 10.1379/1466-1268(1998) 003<0006:DOELEO>2.3.CO;2 (Pubitemid 28159674)
    • (1998) Cell Stress and Chaperones , vol.3 , Issue.1 , pp. 6-11
    • Botzler, C.1    Li, G.2    Issels, R.D.3    Multhoff, G.4
  • 19
    • 0036819181 scopus 로고    scopus 로고
    • Inhibition of tumor growth in mice with severe combined immunodeficiency is mediated by heat shock protein 70 (Hsp70)-peptide-activated, CD94 positive natural killer cells
    • DOI 10.1379/1466-1268(2002)007<0365:IOTGIM>2.0.CO;2
    • C Moser C Schmidbauer U Gürtler C Gross M Gehrmann G Thonigs K Pfister G Multhoff 2002 Inhibition of tumor growth in mice with severe combined immunodeficiency is mediated by heat shock protein 70 (Hsp70)-peptide activated, CD94 positive natural killer cells Cell Stress and Chaperones 7 365 373 1:CAS:528:DC%2BD3sXksVyksQ%3D%3D 10.1379/1466-1268(2002)007<0365:IOTGIM>2. 0.CO;2 (Pubitemid 36008749)
    • (2002) Cell Stress and Chaperones , vol.7 , Issue.4 , pp. 365-373
    • Moser, C.1    Schmidbauer, C.2    Gurtler, U.3    Gross, C.4    Gehrmann, M.5    Thonigs, G.6    Pfister, K.7    Multhoff, G.8
  • 20
    • 0142103373 scopus 로고    scopus 로고
    • Cell Surface-bound Heat Shock Protein 70 (Hsp70) Mediates Perforin-independent Apoptosis by Specific Binding and Uptake of Granzyme B
    • DOI 10.1074/jbc.M302644200
    • C Gross W Koelch A DeMaio N Arispe G Multhoff 2003 Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B Journal of Biological Chemistry 278 41173 41181 1:CAS:528:DC%2BD3sXotFWgtbo%3D 10.1074/jbc.M302644200 (Pubitemid 37280943)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.42 , pp. 41173-41181
    • Gross, C.1    Koelch, W.2    DeMaio, A.3    Arispe, N.4    Multhoff, G.5
  • 21
    • 2542462084 scopus 로고    scopus 로고
    • Differential up-regulation of cytosolic and membrane-bound heat shock protein 70 in tumor cells by anti-inflammatory drugs
    • DOI 10.1158/1078-0432.CCR-03-0382
    • M Gehrmann M Brunner K Pfister A Reichle E Kremmer G Multhoff 2004 Differential up-regulation of cytosolic and membrane-bound heat shock protein 70 in tumor cells by anti-inflammatory drugs Clinical Cancer Research 10 3354 3364 1:CAS:528:DC%2BD2cXkt1GhsL8%3D 10.1158/1078-0432.CCR-03-0382 (Pubitemid 38685440)
    • (2004) Clinical Cancer Research , vol.10 , Issue.10 , pp. 3354-3364
    • Gehrmann, M.1    Brunner, M.2    Pfister, K.3    Reichle, A.4    Kremmer, E.5    Multhoff, G.6
  • 22
    • 1642536402 scopus 로고    scopus 로고
    • The cell surface-localized heat shock protein 70 epitope TKD induces migration and cytolytic activity selectively in human NK cells
    • 1:CAS:528:DC%2BD2cXnvVGn
    • R Gastpar C Gross L Rossbacher J Ellwart J Riegger G Multhoff 2004 The cell surface-localized heat shock protein 70 epitope TKD induces migration and cytolytic activity selectively in human NK cells Journal of Immunology 172 972 980 1:CAS:528:DC%2BD2cXnvVGn
    • (2004) Journal of Immunology , vol.172 , pp. 972-980
    • Gastpar, R.1    Gross, C.2    Rossbacher, L.3    Ellwart, J.4    Riegger, J.5    Multhoff, G.6
  • 23
    • 20444431560 scopus 로고    scopus 로고
    • Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells
    • DOI 10.1158/0008-5472.CAN-04-3804
    • R Gastpar M Gehrmann MA Bausero A Asea C Gross JA Schroeder G Multhoff 2005 Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells Cancer Research 65 5238 5247 1:CAS:528:DC%2BD2MXltFemu7w%3D 10.1158/0008-5472.CAN-04-3804 (Pubitemid 40827334)
    • (2005) Cancer Research , vol.65 , Issue.12 , pp. 5238-5247
    • Gastpar, R.1    Gehrmann, M.2    Bausero, M.A.3    Asea, A.4    Gross, C.5    Schroeder, J.A.6    Multhoff, G.7
  • 25
    • 41149097757 scopus 로고    scopus 로고
    • Engineering therapeutic monoclonal antibodies
    • DOI 10.1111/j.1600-065X.2008.00601.x
    • X Liu LM Pop ES Vitella 2008 Engineering therapeutic monoclonal antibodies Immunological Reviews 222 9 27 1:CAS:528:DC%2BD1cXlsFejtr8%3D 10.1111/j.1600-065X.2008.00601.x (Pubitemid 351430363)
    • (2008) Immunological Reviews , vol.222 , Issue.1 , pp. 9-27
    • Liu, X.-Y.1    Pop, L.M.2    Vitetta, E.S.3
  • 26
    • 33646352962 scopus 로고    scopus 로고
    • Potent antibody therapeutics by design
    • 1:CAS:528:DC%2BD28XjslOhu7o%3D 10.1038/nri1837
    • PJ Carter 2006 Potent antibody therapeutics by design Nature Reviews Immunology 6 343 357 1:CAS:528:DC%2BD28XjslOhu7o%3D 10.1038/nri1837
    • (2006) Nature Reviews Immunology , vol.6 , pp. 343-357
    • Carter, P.J.1
  • 27
    • 30344484440 scopus 로고    scopus 로고
    • Antibody engineering for the development of therapeutic antibodies
    • 1:CAS:528:DC%2BD2MXhtVGhtbnL
    • SJ Kim Y Park HJ Hong 2005 Antibody engineering for the development of therapeutic antibodies Molecules and Cells 20 17 29 1:CAS:528:DC%2BD2MXhtVGhtbnL
    • (2005) Molecules and Cells , vol.20 , pp. 17-29
    • Kim, S.J.1    Park, Y.2    Hong, H.J.3
  • 28
    • 17644378667 scopus 로고    scopus 로고
    • Immunogenicity of engineered antibodies
    • DOI 10.1016/j.ymeth.2005.01.001, Humanized Antibodies and their Applications
    • WY Hwang J Foote 2005 Immunogenicity of engineered antibodies Methods 36 3 10 1:CAS:528:DC%2BD2MXjsVegs7o%3D 10.1016/j.ymeth.2005.01.001 (Pubitemid 40558811)
    • (2005) Methods , vol.36 , Issue.1 , pp. 3-10
    • Hwang, W.Y.K.1    Foote, J.2
  • 29
    • 67649843650 scopus 로고    scopus 로고
    • Strategies to extend plasma half-lives of recombinant antibodies
    • 1:CAS:528:DC%2BD1MXovFSnsbs%3D 10.2165/00063030-200923020-00003
    • RE Kontermann 2009 Strategies to extend plasma half-lives of recombinant antibodies Biodrugs 23 93 109 1:CAS:528:DC%2BD1MXovFSnsbs%3D 10.2165/00063030-200923020-00003
    • (2009) Biodrugs , vol.23 , pp. 93-109
    • Kontermann, R.E.1
  • 30
    • 38449104580 scopus 로고    scopus 로고
    • Humanization of antibodies
    • 1:CAS:528:DC%2BD1cXhs1CgsLk%3D
    • JC Almagro J Fransson 2008 Humanization of antibodies Frontiers in Bioscience 13 1619 1633 1:CAS:528:DC%2BD1cXhs1CgsLk%3D
    • (2008) Frontiers in Bioscience , vol.13 , pp. 1619-1633
    • Almagro, J.C.1    Fransson, J.2
  • 32
  • 33
    • 34250361507 scopus 로고    scopus 로고
    • Improved pharmacokinetics of recombinant bispecific antibody molecules by fusion to human serum albumin
    • DOI 10.1074/jbc.M700820200
    • D Müller A Karle B Meissburger I Höfig R Stork RE Kontermann 2007 Improved pharmacokinetics of recombinant bispecific antibody molecules by fusion to human serum albumin Journal of Biological Chemistry 282 12650 12660 10.1074/jbc.M700820200 (Pubitemid 47100581)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.17 , pp. 12650-12660
    • Muller, D.1    Karle, A.2    Meissburger, B.3    Hofig, I.4    Stork, R.5    Kontermann, R.E.6
  • 34
    • 34248170673 scopus 로고    scopus 로고
    • Analyzing the "Degree of Humanness" of Antibody Sequences
    • DOI 10.1016/j.jmb.2007.02.100, PII S0022283607003038
    • KR Abhinandan AC Martin 2007 Analyzing the "degree of humanness" of antibody sequences Journal of Molecular Biology 369 852 862 1:CAS:528:DC%2BD2sXlt1Sgs7Y%3D 10.1016/j.jmb.2007.02.100 (Pubitemid 46709913)
    • (2007) Journal of Molecular Biology , vol.369 , Issue.3 , pp. 852-862
    • Abhinandan, K.R.1    Martin, A.C.R.2
  • 35
    • 79957860276 scopus 로고    scopus 로고
    • Protein sequence and structural analysis of antibody variable domains
    • R.E. Kontermann S. Dübel (eds). Springer Heidelberg
    • Martin, A. C. (2001). Protein sequence and structural analysis of antibody variable domains. In R. E. Kontermann & S. Dübel (Eds.), Antibody engineering (pp. 422-439). Heidelberg: Springer.
    • (2001) Antibody Engineering , pp. 422-439
    • Martin, A.C.1
  • 36
    • 0030589039 scopus 로고    scopus 로고
    • Structural families in loops of homologous proteins: Automatic classification, modelling and application to antibodies
    • DOI 10.1006/jmbi.1996.0617
    • AC Martin JM Thornton 1996 Structural families of loops in homologous proteins: Automatic classification, modelling and application to antibodies Journal of Molecular Biology 263 800 815 1:CAS:528:DyaK28XntF2nsr4%3D 10.1006/jmbi.1996.0617 (Pubitemid 26395069)
    • (1996) Journal of Molecular Biology , vol.263 , Issue.5 , pp. 800-815
    • Martin, A.C.R.1    Thornton, J.M.2
  • 37
    • 77954647325 scopus 로고    scopus 로고
    • Bacterial production and functional characterization of the Fab fragment of the murine IgG1/λ monoclonal antibody cmHsp70.1, a reagent for tumour diagnostics
    • 1:CAS:528:DC%2BC3cXjslejtLk%3D 10.1093/protein/gzp095
    • F Friedrich S Stangl H Hahne B Küster P Köhler G Multhoff A Skerra 2010 Bacterial production and functional characterization of the Fab fragment of the murine IgG1/λ monoclonal antibody cmHsp70.1, a reagent for tumour diagnostics Protein Engineering, Design and Selection 23 161 168 1:CAS:528:DC%2BC3cXjslejtLk%3D 10.1093/protein/gzp095
    • (2010) Protein Engineering, Design and Selection , vol.23 , pp. 161-168
    • Friedrich, F.1    Stangl, S.2    Hahne, H.3    Küster, B.4    Köhler, P.5    Multhoff, G.6    Skerra, A.7
  • 38
    • 0039423955 scopus 로고    scopus 로고
    • The periplasmic Escherichia coli peptidylprolyl cis,trans-isomerase FkpA: I. Increased functional expression of antibody fragments with and without cis-prolines
    • DOI 10.1074/jbc.M910233199
    • H Bothmann A Plückthun 2000 The periplasmic Escherichia coli peptidylprolyl cis, trans-isomerase FkpA. I. Increased functional expression of antibody fragments with and without cis-prolines Journal of Biological Chemistry 275 17100 17105 1:CAS:528:DC%2BD3cXjvFCmtrY%3D 10.1074/jbc.M910233199 (Pubitemid 30398954)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.22 , pp. 17100-17105
    • Bothmann, H.1    Pluckthun, A.2
  • 39
    • 77950630983 scopus 로고    scopus 로고
    • Co-expression of Skp and KkpA chaperones improves cell viability and alters the global expression of stress response genes during scFvD1.3 production
    • 10.1186/1475-2859-9-22
    • DS Ow DY Lim PM Nissom A Camattari VV Wong 2010 Co-expression of Skp and KkpA chaperones improves cell viability and alters the global expression of stress response genes during scFvD1.3 production Microb Cell Fact 9 22 10.1186/1475-2859-9-22
    • (2010) Microb Cell Fact , vol.9 , pp. 22
    • Ow, D.S.1    Lim, D.Y.2    Nissom, P.M.3    Camattari, A.4    Wong, V.V.5
  • 40
    • 33947096424 scopus 로고    scopus 로고
    • Framework shuffling of antibodies to reduce immunogenicity and manipulate functional and biophysical properties
    • DOI 10.1016/j.molimm.2006.12.019, PII S0161589006007462
    • MM Damschroder L Widjaja PS Gill V Krasnoperov W Jiang WF Dall'Acqua H Wu 2007 Framework shuffling of antibodies to reduce immunogenicity and manipulate functional and biophysical properties Molecular Immunology 44 3049 3060 1:CAS:528:DC%2BD2sXjtVWrtLo%3D 10.1016/j.molimm.2006.12.019 (Pubitemid 46412478)
    • (2007) Molecular Immunology , vol.44 , Issue.11 , pp. 3049-3060
    • Damschroder, M.M.1    Widjaja, L.2    Gill, P.S.3    Krasnoperov, V.4    Jiang, W.5    Dall'Acqua, W.F.6    Wu, H.7
  • 41
    • 38449112154 scopus 로고    scopus 로고
    • Engineering antibodies for stability and efficient folding
    • Y. Chernajovsky A. Nissim (eds). Springer Heidelberg
    • Honegger, A. (2008). Engineering antibodies for stability and efficient folding. In Y. Chernajovsky & A. Nissim (Eds.), Therapeutic antibodies. Handbook of experimental pharmacology (pp. 47-68). Heidelberg: Springer.
    • (2008) Therapeutic Antibodies. Handbook of Experimental Pharmacology , pp. 47-68
    • Honegger, A.1
  • 42
    • 0027198490 scopus 로고
    • Antibody variable region glycosylation: Biochemical and clinical effects
    • 1:CAS:528:DyaK2cXltFymtw%3D%3D 10.1007/BF00201106
    • A Wright SK Morrison 1993 Antibody variable region glycosylation: Biochemical and clinical effects Springer Seminars in Immunopathology 15 259 273 1:CAS:528:DyaK2cXltFymtw%3D%3D 10.1007/BF00201106
    • (1993) Springer Seminars in Immunopathology , vol.15 , pp. 259-273
    • Wright, A.1    Morrison, S.K.2
  • 45
    • 0027434029 scopus 로고
    • Genetically engineered deglycosylation of the variable domain increases the affinity of an anti-CD33 monoclonal antibody
    • 1:CAS:528:DyaK2cXmsVKn 10.1016/0161-5890(93)90097-U
    • MS Co DA Scheinberg NM Avdalovic K McGraw M Vasquez PC Caron C Queen 1993 Genetically engineered deglycosylation of the variable domain increases the affinity of an anti-CD33 monoclonal antibody Molecular Immunology 30 1361 1371 1:CAS:528:DyaK2cXmsVKn 10.1016/0161-5890(93)90097-U
    • (1993) Molecular Immunology , vol.30 , pp. 1361-1371
    • Co, M.S.1    Scheinberg, D.A.2    Avdalovic, N.M.3    McGraw, K.4    Vasquez, M.5    Caron, P.C.6    Queen, C.7
  • 48
    • 27144431943 scopus 로고    scopus 로고
    • Selecting and screening recombinant antibody libraries
    • DOI 10.1038/nbt1126, PII N1126
    • HR Hoogenboom 2005 Selecting and screening recombinant antibody libraries Nature Biotechnology 23 1105 1116 1:CAS:528:DC%2BD2MXpvVyrsb0%3D 10.1038/nbt1126 (Pubitemid 41486392)
    • (2005) Nature Biotechnology , vol.23 , Issue.9 , pp. 1105-1116
    • Hoogenboom, H.R.1
  • 49
    • 33747616656 scopus 로고    scopus 로고
    • Engineering of therapeutic antibodies to minimize immunogenicity and optimize function
    • DOI 10.1016/j.addr.2006.01.026, PII S0169409X06000858
    • LG Presta 2006 Engineering of therapeutic antibodies to minimize immunogenicity and optimize function Advanced Drug Delivery Reviews 58 640 656 1:CAS:528:DC%2BD28XoslKrsLY%3D 10.1016/j.addr.2006.01.026 (Pubitemid 44262411)
    • (2006) Advanced Drug Delivery Reviews , vol.58 , Issue.5-6 , pp. 640-656
    • Presta, L.G.1
  • 50
    • 48549105161 scopus 로고    scopus 로고
    • Molecular engineering and design of therapeutic antibodies
    • 1:CAS:528:DC%2BD1cXpslSltL8%3D 10.1016/j.coi.2008.06.012
    • LG Presta 2008 Molecular engineering and design of therapeutic antibodies Current Opinion in Immunology 20 460 470 1:CAS:528:DC%2BD1cXpslSltL8%3D 10.1016/j.coi.2008.06.012
    • (2008) Current Opinion in Immunology , vol.20 , pp. 460-470
    • Presta, L.G.1
  • 51
    • 77950080700 scopus 로고    scopus 로고
    • Improving effector functions of antibodies for cancer treatment: Enhancing ADCC and CDC
    • 1:CAS:528:DC%2BD1MXoslSmsLc%3D
    • A Natsume R Niwa M Satoh 2009 Improving effector functions of antibodies for cancer treatment: Enhancing ADCC and CDC Drug Design, Development and Therapy 3 7 16 1:CAS:528:DC%2BD1MXoslSmsLc%3D
    • (2009) Drug Design, Development and Therapy , vol.3 , pp. 7-16
    • Natsume, A.1    Niwa, R.2    Satoh, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.