Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation

Journal of Biological Chemistry

Volumn 283, Issue 3, 2008, Pages 1428-1436

  Kondo, Asuka ^a   Hirayama, Naoki ^a   Sugito, Yasuko ^a   Shono, Michihiro ^a   Tanaka, Toshiaki ^a   Kitamura, Naomi ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOPLASMIC DOMAINS; GROWTH FACTORS; HEPATOCYTE GROWTH FACTOR (HGF);

CELL CULTURE; GROWTH KINETICS; MOLECULAR DYNAMICS; MUTAGENESIS;

ENZYME INHIBITION;

CYCLIN DEPENDENT KINASE INHIBITOR 2A; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR RECEPTOR; PROTEIN; PROTEIN GAB1; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; HEPATOMA CELL; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEOMICS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; CLONE CELLS; COS CELLS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GRB2 ADAPTOR PROTEIN; HEPATOCYTE GROWTH FACTOR; HUMANS; LIVER NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MUTANT PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MET; RATS; RECOMBINANT PROTEINS; UP-REGULATION;

EID: 38349168403     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M704999200     Document Type: Article

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