Systemic paracetamol-induced analgesic and antihyperalgesic effects through activation of descending serotonergic pathways involving spinal 5-HT 7 receptors

European Journal of Pharmacology

Volumn 677, Issue 1-3, 2012, Pages 93-101

  Dogrul, Ahmet ^a   Seyrek, Melik ^a   Akgul, Emin Ozgur ^b   Cayci, Tuncer ^b   Kahraman, Serdar ^b   Bolay, Hayrunnisa ^c  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

^b Gulhane Academy of Medicine   (Turkey)

^c Gazi Medical Faculty   (Turkey)

Author keywords

5 HT 7; Acetaminophen; Analgesia; Descending; Hyperalgesia; Incision; Paracetamol; Postoperative pain; Serotonin; Spinal

Indexed keywords

3 [2 [2 (4 METHYL 1 PIPERIDINYL)ETHYL] 1 PYRROLIDINESULFONYL]PHENOL; 5,7 DIHYDROXYTRYPTAMINE; KETANSERIN; ONDANSETRON; PARACETAMOL; SEROTONIN 2A RECEPTOR; SEROTONIN 3 RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN ANTAGONIST;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERALGESIC ACTIVITY; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG DOSE COMPARISON; DRUG EFFICACY; HOT PLATE TEST; HYPERALGESIA; MALE; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SEROTONIN BLOOD LEVEL; SEROTONINERGIC SYSTEM; SPINAL CORD; SYSTEMIC THERAPY; TAIL FLICK TEST;

ACETAMINOPHEN; ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; HYPERALGESIA; MALE; MICE; MICE, INBRED BALB C; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN; SEROTONIN ANTAGONISTS; SPINAL CORD;

EID: 84856250315     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.12.016     Document Type: Article

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