Systematic evaluation of the nefopam-paracetamol combination in rodent models of antinociception

Clinical and Experimental Pharmacology and Physiology

Volumn 38, Issue 3, 2011, Pages 170-178

  Girard, Philippe ^a   Niedergang, Betty ^a   Pansart, Yannick ^a   Coppé, Marie Claude ^a   Verleye, Marc ^a  

^a Service de Pharmacologie   (France)

Author keywords

Abdominal writhing; Allodynia; Formalin; Hyperalgesia; Nefopam; Paracetamol

Indexed keywords

CARRAGEENAN; FORMALDEHYDE; NEFOPAM; PARACETAMOL; ANALGESIC AGENT; NARCOTIC ANALGESIC AGENT;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENTIATION; HYPERALGESIA; INFLAMMATION; LICKING; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; RAT; WRITHING TEST; ANIMAL; DISEASE MODEL; DRUG COMBINATION; PAIN; PAIN MEASUREMENT; PROCEDURES; SPRAGUE DAWLEY RAT;

ACETAMINOPHEN; ANALGESICS; ANALGESICS, NON-NARCOTIC; ANALGESICS, OPIOID; ANIMALS; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; HYPERALGESIA; MALE; MICE; NEFOPAM; PAIN; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79952017884     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2011.05477.x     Document Type: Article

References (52)

1. Fanelli G, Berti M, Baciarello M. Updating postoperative pain management: From multimodal to context-sensitive treatment. Minerva Anestesiol. 2008; 74: 489-500.
2. Schug SA. Combination analgesia in 2005: A rational approach. Focus on paracetamol-tramadol. Clin. Rheumatol. 2006; 25(Suppl. 1): S16-21.
3. White PF. Multimodal analgesia: Its role in preventing postoperative pain. Curr. Opin. Investig. Drugs 2008; 9: 76-82.
4. Korpela R, Korvenoja P, Meretoja OA. Morphine-sparing effect of acetaminophen in pediatric day-case surgery. Anesthesiology 1999; 91: 442-7.
5. Tramoni G, Viale JP, Cazals C, Bhageerutty K. Morphine-sparing effect of nefopam by continuous intravenous injection after abdominal surgery by laparotomy. Eur. J. Anaesthesiol. 2003; 20: 990-2.
6. Conway AC, Mitchell CL. Analgesic studies with nefopam hydrochloride. Arch. Int. Pharmacodyn. Ther. 1977; 226: 156-71.
7. Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS. Nefopam: A review of its pharmacological properties and therapeutic efficacy. Drugs 1980; 19: 249-67.
8. Girard P, Pansart Y, Coppe MC, Gillardin JM. Nefopam reduces thermal hypersensitivity in acute and postoperative pain models in the rat. Pharmacol. Res. 2001; 44: 541-5.
9. Buritova J, Besson JM. Effects of nefopam on the spinal nociceptive processes: A c-Fos protein study in the rat. Eur. J. Pharmacol. 2002; 441: 67-74.
10. Biella GE, Groppetti A, Novelli A, Fernandez-Sanchez MT, Manfredi B, Sotgiu ML. Neuronal sensitization and its behavioral correlates in a rat model of neuropathy are prevented by a cyclic analog of orphenadrine. J. Neurotrauma 2003; 20: 593-601.
11. Guirimand F, Dupont X, Bouhassira D, Brasseur L, Chauvin M. Nefopam strongly depresses the nociceptive flexion (R(III)) reflex in humans. Pain 1999; 80: 399-404.
12. Du Manoir B, Aubrun F, Langlois M et al. Randomized prospective study of the analgesic effect of nefopam after orthopaedic surgery. Br. J. Anaesth. 2003; 91: 836-41.
13. Beloeil H, Delage N, Negre I, Mazoit JX, Benhamou D. The median effective dose of nefopam and morphine administered intravenously for postoperative pain after minor surgery: A prospective randomized double-blinded isobolographic study of their analgesic action. Anesth. Analg. 2004; 98: 395-400.
14. Kapfer B, Alfonsi P, Guignard B, Sessler DI, Chauvin M. Nefopam and ketamine comparably enhance postoperative analgesia. Anesth. Analg. 2005; 100: 169-74.
15. Laboureyras E, Chateauraynaud J, Richebé P, Simonnet G. Long-term pain vulnerability after surgery in rats: Prevention by nefopam, an analgesic with antihyperalgesic properties. Anesth. Analg. 2009; 109: 623-31.
16. Tresnak-Rustad NJ, Wood ME. In vitro biochemical effects of nefopam hydrochloride, a new analgesic agent. Biochem. Pharmacol. 1981; 30: 2847-50.
17. Rosland JH, Hole K. The effect of nefopam and its enantiomers on the uptake of 5-hydroxytryptamine, noradrenaline and dopamine in crude rat brain synaptosomal preparations. J. Pharm. Pharmacol. 1990; 42: 437-8.
18. Ohkubo Y, Nomura K, Yamaguchi I. Involvement of dopamine in the mechanism of action of FR64822, a novel non-opioid antinociceptive compound. Eur. J. Pharmacol. 1991; 204: 121-5.
19. Fuller RW, Snoddy HD. Evaluation of nefopam as a monoamine uptake inhibitor in vivo in mice. Neuropharmacology 1993; 32: 995-9.
20. Piercey MF, Schroeder LA. Spinal and supraspinal sites for morphine and nefopam analgesia in the mouse. Eur. J. Pharmacol. 1981; 74: 135-40.
21. Fernandez-Sanchez MT, Diaz-Trelles R, Groppetti A et al. Novel effect of nefopam preventing cGMP increase, oxygen radical formation and neuronal death induced by veratridine. Neuropharmacology 2001; 41: 935-42.
22. Verleye M, Andre N, Heulard I, Gillardin JM. Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents. Brain Res. 2004; 1013: 249-55.
23. Novelli A, Diaz-Trelles R, Groppetti A, Fernandez-Sanchez MT. Nefopam inhibits calcium influx, cGMP formation, and NMDA receptor-dependent neurotoxicity following activation of voltage sensitive calcium channels. Amino Acids 2005; 28: 183-91.
24. Qiu HX, Liu J, Kong H, Liu Y, Mei XG. Isobolographic analysis of the antinociceptive interactions between ketoprofen and paracetamol. Eur. J. Pharmacol. 2007; 557: 141-6.
25. Matzke GR. Clinical consequences of nonnarcotic analgesic use. Ann. Pharmacother. 1997; 31: 245-8.
26. Botting RM. Inhibitors of cyclooxygenases: Mechanisms, selectivity and uses. J. Physiol. Pharmacol. 2006; 57(Suppl. 5): 113-24.
27. Pini LA, Vitale G, Ottani A, Sandrini M. Naloxone-reversible antinociception by paracetamol in the rat. J. Pharmacol. Exp. Ther. 1997; 280: 934-40.
28. Choi SS, Lee JK. Antinociceptive profiles of aspirin and acetaminophen in formalin, substance P and glutamate pain models. Brain Res. 2001; 921: 233-9.
29. Pelissier T, Alloui A, Caussade F et al. Paracetamol exerts a spinal antinociceptive effect involving an indirect interaction with 5-hydroxytryptamine3 receptors: In vivo and in vitro evidence. J. Pharmacol. Exp. Ther. 1996; 278: 8-14.
30. Pini LA, Sandrini M, Vitale G. The antinociceptive action of paracetamol is associated with changes in the serotonergic system in the rat brain. Eur. J. Pharmacol. 1996; 308: 31-40.
31. 3 receptor subtypes in the antinociceptive effect of paracetamol. Inflamm. Res. 2003; 52: 347-52.
32. 1A receptors differentially influence nociceptive processing according to the nature of the noxious stimulus in rats. Effect of WAY-100635 on the antinociceptive activities of paracetamol, venlafaxine and 5-HT. Pain 2005; 114: 482-90.
33. Le Bars D, Gozariu M, Cadden SW. [Acute pain measurement in animals. Part 1]. Ann. Fr. Anesth. Reanim. 2001; 20: 347-65 (in French).
34. Brennan TJ, Vandermeulen EP, Gebhart GF. Characterization of a rat model of incisional pain. Pain 1996; 64: 493-501.
35. Zahn PK, Gysbers D, Brennan TJ. Effect of systemic and intrathecal morphine in a rat model of postoperative pain. Anesthesiology 1997; 86: 1066-77.
36. Field MJ, Holloman EF, McCleary S, Hughes J, Singh L. Evaluation of gabapentin and S-(+)-3-isobutylgaba in a rat model of postoperative pain. J. Pharmacol. Exp. Ther. 1997; 282: 1242-6.
37. Hargreaves KM, Dubner R, Brown F, Flores C, Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988; 32: 77-88.
38. Yamamoto T, Nozaki-Taguchi N, Sakashita Y. Spinal N-acetyl-alpha-linked acidic dipeptidase (NAALADase) inhibition attenuates mechanical allodynia induced by paw carrageenan injection in the rat. Brain Res. 2001; 909: 138-44.
39. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983; 16: 109-10.
40. Girard P, Pansart Y, Gillardin JM. Nefopam potentiates morphine antinociception in allodynia and hyperalgesia in the rat. Pharmacol. Biochem. Behav. 2004; 77: 695-703.
41. Tabo E, Eisele JH Jr, Carstens E. Force of limb withdrawals elicited by graded noxious heat compared with other behavioral measures of carrageenan-induced hyperalgesia and allodynia. J. Neurosci. Methods 1998; 81: 139-49.
42. Tallarida RJ. Drug synergism. Its detection and applications. J. Pharmacol. Exp. Ther. 2001; 298: 865-72.
43. Tallarida RJ. An overview of drug combination analysis with isobolograms. J. Pharmacol. Exp. Ther. 2006; 319: 1-7.
44. Pinardi G, Pelissier T, Miranda HF. Interactions in the antinociceptive effect of tramadol in mice: An isobolographic analysis. Eur. J. Pain 1998; 2: 343-50.
45. Dahl JB, Rosenberg J, Dirkes WE, Mogensen T, Kehlet H. Prevention of postoperative pain by balanced analgesia. Br. J. Anaesth. 1990; 64: 518-20.
46. Kehlet H. Multimodal approach to control postoperative pathophysiology and rehabilitation. Br. J. Anaesth. 1997; 78: 606-17.
47. Kehlet H, Dahl JB. The value of 'multimodal' or 'balanced analgesia' in postoperative pain treatment. Anesth. Analg. 1993; 77: 1048-56.
48. Miranda HF, Puig MM, Prieto JC, Pinardi G. Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain. Pain 2006; 121: 22-8.
49. Winter L Jr, Post A. Analgesic combinations with orphenadrine in oral post-surgical pain. J. Int. Med. Res. 1979; 7: 240-6.
50. Hunskaar S, Berge OG, Hole K. Orphenadrine citrate increases and prolongs the antinociceptive effects of paracetamol in mice. Acta Pharmacol. Toxicol. 1986; 59: 53-9.
51. Bassett JR, Cairncross KD, Hacket NB, Story M. Studies on the peripheral pharmacology of fenazoxine, a potential antidepressant drug. Br. J. Pharmacol. 1969; 37: 69-78.
52. Guindon J, Walczak JS, Beaulieu P. Recent advances in the pharmacological management of pain. Drugs 2007; 67: 2121-33.