Subamolide A, a component isolated from Cinnamomum subavenium, induces apoptosis mediated by mitochondria-dependent, p53 and ERK1/2 pathways in human urothelial carcinoma cell line NTUB1

Journal of Ethnopharmacology

Volumn 137, Issue 1, 2011, Pages 503-511

  Liu, Chiung Hui ^a   Chen, Chung Yi ^b   Huang, A Mei ^a   Li, Jih Heng ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b FOOYIN UNIVERSITY   (Taiwan)

Author keywords

Chemotherapeutic drugs; Cinnamomum subavenium; Human urothelial carcinoma; Mitochondria mediated apoptosis; Subamolide A

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CASPASE 3; CISPLATIN; CYTOCHROME C; GEMCITABINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT MEDICINAL PRODUCT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SUBAMOLIDE A; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CHEMICAL COMPOSITION; CINNAMOMUM SUBAVENIUM; CONTROLLED STUDY; CYTOTOXICITY; DRUG MEGADOSE; EPITHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOASSAY; MEDIATOR; MEDICINAL PLANT; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOLECULE; PLANT STEM; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; STRESS; TRADITIONAL MEDICINE; TRANSITIONAL CELL CARCINOMA; UROEPITHELIAL CELL; WESTERN BLOTTING;

4-BUTYROLACTONE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CARCINOMA; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; CINNAMOMUM; CISPLATIN; CYTOCHROMES C; DEOXYCYTIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FLOW CYTOMETRY; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PLANT PREPARATIONS; PLANT STEMS; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53; UROLOGIC NEOPLASMS; UROTHELIUM;

CINNAMOMUM SUBAVENIUM;

EID: 80052024322     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.06.001     Document Type: Article

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