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Volumn , Issue , 2016, Pages 141-166

Considerations of design and data when developing physiologically based pharmacokinetic models

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EID: 84856217942     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (2)

References (48)
  • 1
    • 0024948957 scopus 로고
    • Biologically motivated models for chemical risk assessment
    • Clewell HJ III, Andersen ME. Biologically motivated models for chemical risk assessment. Health Phys 1989; 57:129-137.
    • (1989) Health Phys , vol.57 , pp. 129-137
    • Clewell, H.J.1    Andersen, M.E.2
  • 2
    • 0021279862 scopus 로고
    • A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans
    • Ramsey JC, Andersen ME. A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol Appl Pharmacol 1984; 73:159-175.
    • (1984) Toxicol Appl Pharmacol , vol.73 , pp. 159-175
    • Ramsey, J.C.1    Andersen, M.E.2
  • 3
    • 0023158895 scopus 로고
    • Physiologically-based pharmaco-kinetics and risk assessment process for methylene chloride
    • Andersen ME, Clewell HJ, Gargas ML, et al. Physiologically-based pharmaco-kinetics and risk assessment process for methylene chloride. Toxicol Appl Pharmacol 1987; 87:185-205.
    • (1987) Toxicol Appl Pharmacol , vol.87 , pp. 185-205
    • Andersen, M.E.1    Clewell, H.J.2    Gargas, M.L.3
  • 4
    • 0026321636 scopus 로고
    • Hepatic modeling and risk assessment: Compartmental versus tube models and interspecies scaling
    • Robinson PJ. Hepatic modeling and risk assessment: compartmental versus tube models and interspecies scaling. Drug Metab Rev 1991; 23:381-398.
    • (1991) Drug Metab Rev , vol.23 , pp. 381-398
    • Robinson, P.J.1
  • 5
    • 0034103008 scopus 로고    scopus 로고
    • Sensitivity analysis of a physiological model for 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD): Assessing the impact of specific model parameters on sequestration in liver and fat in the rat
    • Evans MV, Andersen ME. Sensitivity analysis of a physiological model for 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD): assessing the impact of specific model parameters on sequestration in liver and fat in the rat. Toxicol Sci 2000; 54:71-80.
    • (2000) Toxicol Sci , vol.54 , pp. 71-80
    • Evans, M.V.1    Andersen, M.E.2
  • 6
    • 0002252722 scopus 로고
    • Physiologically based pharmacokinetic modeling in 'toxicology'
    • Hayes AW, ed. 3rd ed. New York
    • Krishnan K, Andersen ME. Physiologically based pharmacokinetic modeling in 'toxicology'. In: Hayes AW, ed. Principles and Methods of Toxicology. 3rd ed. New York, 1994:149-188.
    • (1994) Principles and Methods of Toxicology , pp. 149-188
    • Krishnan, K.1    Andersen, M.E.2
  • 7
    • 0035384499 scopus 로고    scopus 로고
    • The use of physiologically based models to integrate diverse data sets and reduce uncertainty in the prediction of per-chlorate and iodide kinetics across life stages and species
    • Clewell RA, Merrill EA, Robinson PJ. The use of physiologically based models to integrate diverse data sets and reduce uncertainty in the prediction of per-chlorate and iodide kinetics across life stages and species. Toxicol Ind Health 2001; 17:210-222.
    • (2001) Toxicol Ind Health , vol.17 , pp. 210-222
    • Clewell, R.A.1    Merrill, E.A.2    Robinson, P.J.3
  • 8
    • 0038278532 scopus 로고    scopus 로고
    • Quantitative structure-property relationships for interspecies extrapolation of the inhalation pharmacokinetics of organic chemicals
    • Beliveau M, Tardiff R, Krishnan K. Quantitative structure-property relationships for interspecies extrapolation of the inhalation pharmacokinetics of organic chemicals. Toxicol Appl Pharmacol 2003; 189:221-232.
    • (2003) Toxicol Appl Pharmacol , vol.189 , pp. 221-232
    • Beliveau, M.1    Tardiff, R.2    Krishnan, K.3
  • 9
    • 15344349015 scopus 로고    scopus 로고
    • Quantitative structure-property relationships for interspecies extrapolation of the inhalation pharmacokinetics of organic chemicals
    • Beliveau M, Lipscomb JC, Tordiff R, et al. Quantitative structure-property relationships for interspecies extrapolation of the inhalation pharmacokinetics of organic chemicals. Chem Res Toxicol 2005; 18:475-485.
    • (2005) Chem Res Toxicol , vol.18 , pp. 475-485
    • Beliveau, M.1    Lipscomb, J.C.2    Tordiff, R.3
  • 11
    • 0030806348 scopus 로고    scopus 로고
    • Physiological parameter values for physiologically based pharmacokinetic modelsPhysiological parameter values for physiologically based pharmacokinetic models
    • Brown RP, Delp MD, Lindstedt SL, et al. Physiological parameter values for physiologically based pharmacokinetic modelsPhysiological parameter values for physiologically based pharmacokinetic models. Toxicol Ind Health 1997; 13:407-484.
    • (1997) Toxicol Ind Health , vol.13 , pp. 407-484
    • Brown, R.P.1    Delp, M.D.2    Lindstedt, S.L.3
  • 12
    • 0027275566 scopus 로고
    • Physiological parameters in laboratory animals and humans
    • Davies B, Morris T. Physiological parameters in laboratory animals and humans. Pharm Res 1993; 10:1093-1095.
    • (1993) Pharm Res , vol.10 , pp. 1093-1095
    • Davies, B.1    Morris, T.2
  • 14
    • 0036978894 scopus 로고    scopus 로고
    • Application of a physiologically based pharmacokinetic model for isopropanol in the derivation of a reference dose and reference concentration
    • Gentry PR, Covington TR, Anderson ME, Clewell HJ. Application of a physiologically based pharmacokinetic model for isopropanol in the derivation of a reference dose and reference concentration. Regul Toxicol Pharmacol 2002; 36:51-68.
    • (2002) Regul Toxicol Pharmacol , vol.36 , pp. 51-68
    • Gentry, P.R.1    Covington, T.R.2    Anderson, M.E.3    Clewell, H.J.4
  • 15
    • 0026533396 scopus 로고
    • A physiologically based kinetic model of rat and mouse gestation: Disposition of a weak acid
    • O'Flaherty EJ, Scott W, Schreiner C, Beliles RP. A physiologically based kinetic model of rat and mouse gestation: disposition of a weak acid. Toxicol Appl Pharmacol 1992; 112:245-256.
    • (1992) Toxicol Appl Pharmacol , vol.112 , pp. 245-256
    • O'Flaherty, E.J.1    Scott, W.2    Schreiner, C.3    Beliles, R.P.4
  • 16
    • 0038172567 scopus 로고    scopus 로고
    • Predicting fetal Perchlorate dose and inhibition of iodide kinetics during gestation: A physiologically-based pharmacokinetic analysis of perchlorate and iodide kinetics in the rat
    • Clewell HJ III, Merill EM, Yu KO, et al. Predicting fetal Perchlorate dose and inhibition of iodide kinetics during gestation: a physiologically-based pharmacokinetic analysis of perchlorate and iodide kinetics in the rat. Toxicol Sci 2003; 73:235-255.
    • (2003) Toxicol Sci , vol.73 , pp. 235-255
    • Clewell, H.J.1    Merill, E.M.2    Yu, K.O.3
  • 18
    • 0024524118 scopus 로고
    • Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues
    • Gargas ML, Burgess RJ, Voisard DE, et al. Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues. Toxicol Appl Pharmacol 1989; 98:87-99.
    • (1989) Toxicol Appl Pharmacol , vol.98 , pp. 87-99
    • Gargas, M.L.1    Burgess, R.J.2    Voisard, D.E.3
  • 19
    • 0034659425 scopus 로고    scopus 로고
    • Empirical relations predicting human and rat tissue: Air partition coefficients of volatile organic compounds
    • Meulenberg CJW, Vijverberg HP. Empirical relations predicting human and rat tissue: air partition coefficients of volatile organic compounds. Toxicol Appl Pharmacol 2000; 165:206-216.
    • (2000) Toxicol Appl Pharmacol , vol.165 , pp. 206-216
    • Meulenberg, C.J.W.1    Vijverberg, H.P.2
  • 20
    • 0001300382 scopus 로고    scopus 로고
    • Molecular structure-based prediction of the partition coefficients of organic chemicals for physiological pharmacokinetic models
    • Poulin P, Krishnan K. Molecular structure-based prediction of the partition coefficients of organic chemicals for physiological pharmacokinetic models. Toxicol Methods 1996; 6:117-137.
    • (1996) Toxicol Methods , vol.6 , pp. 117-137
    • Poulin, P.1    Krishnan, K.2
  • 21
    • 0018693845 scopus 로고
    • Partition coefficients of some aromatic hydrocarbons and ketones in water, blood and oil
    • Sato A, Nakajima T. Partition coefficients of some aromatic hydrocarbons and ketones in water, blood and oil. Br J Ind Med 1979; 36:231-234.
    • (1979) Br J Ind Med , vol.36 , pp. 231-234
    • Sato, A.1    Nakajima, T.2
  • 22
    • 0027300555 scopus 로고
    • Variability of physiologically-based pharmacokinetic (PB-PK) model parameters and their effects on PB-PK model predictions in a risk assessment for perchloroethylene (PCE)
    • Gearhart JM, Mahle DA, Grene RJ, et al. Variability of physiologically-based pharmacokinetic (PB-PK) model parameters and their effects on PB-PK model predictions in a risk assessment for perchloroethylene (PCE). Toxicol Lett 1993; 68:131-144.
    • (1993) Toxicol Lett , vol.68 , pp. 131-144
    • Gearhart, J.M.1    Mahle, D.A.2    Grene, R.J.3
  • 24
    • 70350730621 scopus 로고
    • A partition coefficient determination method for nonvolatile chemicals in biological tissues
    • Jepson GW, Hoover DK, Black RK, et al. A partition coefficient determination method for nonvolatile chemicals in biological tissues. Fund Appl Toxicol 1994; 22:519-524.
    • (1994) Fund Appl Toxicol , vol.22 , pp. 519-524
    • Jepson, G.W.1    Hoover, D.K.2    Black, R.K.3
  • 25
    • 0018411081 scopus 로고
    • Estimation of tissue-to-plasma partition coefficients used in physiological pharmacokinetic models
    • Chen HS, Gross JF. Estimation of tissue-to-plasma partition coefficients used in physiological pharmacokinetic models. J Pharmacokinet Biop 1979; 7:117-125.
    • (1979) J Pharmacokinet Biop , vol.7 , pp. 117-125
    • Chen, H.S.1    Gross, J.F.2
  • 26
    • 0004061014 scopus 로고
    • Physiologic pharmacokinetic models
    • In: New York, NY: Marcel Dekker
    • Gibaldi M. Physiologic pharmacokinetic models. In: Pharmacokinetics. New York, NY: Marcel Dekker, 1982; 9:355-384.
    • (1982) Pharmacokinetics , vol.9 , pp. 355-384
    • Gibaldi, M.1
  • 27
    • 85122906508 scopus 로고    scopus 로고
    • Comparison of partition coefficients for a mixture of volatile organic compounds in rats and humans at different life stages
    • Mahle DA, Grisgsby CC, Godfrey RL, et al. Comparison of partition coefficients for a mixture of volatile organic compounds in rats and humans at different life stages Toxicol Sci 2004; 78:22.
    • (2004) Toxicol Sci , vol.78 , pp. 22
    • Mahle, D.A.1    Grisgsby, C.C.2    Godfrey, R.L.3
  • 29
    • 0014805690 scopus 로고
    • Kinetics of distribution of radioactive perchlorate in rat and guinea-pig thyroid glands
    • Chow SY, Woodbury DM. Kinetics of distribution of radioactive perchlorate in rat and guinea-pig thyroid glands. J Endocrinol 1970; 47:207-218.
    • (1970) J Endocrinol , vol.47 , pp. 207-218
    • Chow, S.Y.1    Woodbury, D.M.2
  • 30
    • 0037834743 scopus 로고    scopus 로고
    • PBPK predictions of perchlorate distribution and its effect on thyroid uptake of radioiodide in the male rat
    • Merrill EA, Clewell RA, Gearhart JM, et al. PBPK predictions of perchlorate distribution and its effect on thyroid uptake of radioiodide in the male rat Toxicol Sci 2003; 73:256-269.
    • (2003) Toxicol Sci , vol.73 , pp. 256-269
    • Merrill, E.A.1    Clewell, R.A.2    Gearhart, J.M.3
  • 31
    • 3042695200 scopus 로고    scopus 로고
    • Emission-particle-induced ventilatory abnormalities in a rat model of pulmonary hypertension
    • Gardner SY, Sarah Y, McGee KJ, et al. Emission-particle-induced ventilatory abnormalities in a rat model of pulmonary hypertension. Environ Health Per-spect 2004; 112:872-878.
    • (2004) Environ Health Per-spect , vol.112 , pp. 872-878
    • Gardner, S.Y.1    Sarah, Y.2    McGee, K.J.3
  • 32
    • 0026792779 scopus 로고
    • The closed chamber technique-uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors
    • Filser JG. The closed chamber technique-uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors. Arch Toxicol 1992; 66:1-10.
    • (1992) Arch Toxicol , vol.66 , pp. 1-10
    • Filser, J.G.1
  • 33
    • 0022872403 scopus 로고
    • A physiologically-based simulation approach for determining metabolic constants from gas uptake data
    • Gargas ML, Andersen ME, Clewell HJ III. A physiologically-based simulation approach for determining metabolic constants from gas uptake data. Toxicol Appl Pharmacol 1986; 86:341-352.
    • (1986) Toxicol Appl Pharmacol , vol.86 , pp. 341-352
    • Gargas, M.L.1    Andersen, M.E.2    Clewell, H.J.3
  • 34
    • 0021272976 scopus 로고
    • Inhalation pharmacokinetics: Evaluating systemic extraction, total in vivo metabolism and the time course of enzyme induction for inhaled styrene in rats based on arterial blood: Inhaled air concentration ratios
    • Andersen ME, Clewell HJ III, Gargas ML, et al. Inhalation pharmacokinetics: evaluating systemic extraction, total in vivo metabolism and the time course of enzyme induction for inhaled styrene in rats based on arterial blood: inhaled air concentration ratios. Toxicol Appl Pharmacol 1984; 73:176-187.
    • (1984) Toxicol Appl Pharmacol , vol.73 , pp. 176-187
    • Andersen, M.E.1    Clewell, H.J.2    Gargas, M.L.3
  • 35
    • 11344264355 scopus 로고    scopus 로고
    • Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment
    • Clark LH, Setzer RW, Barton HA, et al. Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment. Risk Anal 2004; 24:1697-1717.
    • (2004) Risk Anal , vol.24 , pp. 1697-1717
    • Clark, L.H.1    Setzer, R.W.2    Barton, H.A.3
  • 37
    • 2042502449 scopus 로고
    • Allometry: Body size constraints in animal design
    • Washington, DC: National Academy Press
    • Lindstedt SL. Allometry: body size constraints in animal design. In: Pharmacokinetics in Risk Assessment: Drinking Water and Health. Vol. 8. Washington, DC: National Academy Press, 1987:65-79.
    • (1987) Pharmacokinetics in Risk Assessment: Drinking Water and Health , vol.8 , pp. 65-79
    • Lindstedt, S.L.1
  • 38
    • 0033860767 scopus 로고    scopus 로고
    • A model for size and age changes in the pharmacokinetics of paracetamol in neonates, infants and children
    • Anderson BJ, Woollard G, Holford NHG. A model for size and age changes in the pharmacokinetics of paracetamol in neonates, infants and children. Br J Clin Pharmacol 2000; 50:125-134.
    • (2000) Br J Clin Pharmacol , vol.50 , pp. 125-134
    • Anderson, B.J.1    Woollard, G.2    Holford, N.H.G.3
  • 39
    • 0002681105 scopus 로고
    • Physiologically based approaches for examining the pharmacokinetics of inhaled vapors
    • Gardner DE, Crapo JD, Massaro EJ, eds. New York, NY: Raven Press
    • Gargas ML, Andersen ME. Physiologically based approaches for examining the pharmacokinetics of inhaled vapors. In: Gardner DE, Crapo JD, Massaro EJ, eds. Toxicology of the Lung. New York, NY: Raven Press, 1988:449-476.
    • (1988) Toxicology of the Lung , pp. 449-476
    • Gargas, M.L.1    Andersen, M.E.2
  • 40
    • 0034769320 scopus 로고    scopus 로고
    • Development of a physiologically based pharmacokinetic model of isopropanol and its metabolite acetone
    • Clewell HJ III, Gentry PR, Gearhart JM, et al. Development of a physiologically based pharmacokinetic model of isopropanol and its metabolite acetone. Toxicol Sci 2001; 63:160-172.
    • (2001) Toxicol Sci , vol.63 , pp. 160-172
    • Clewell, H.J.1    Gentry, P.R.2    Gearhart, J.M.3
  • 41
    • 0029055473 scopus 로고
    • Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
    • Kararli TT. Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals. Biopharm Drug Dispos 1995; 16:351-380.
    • (1995) Biopharm Drug Dispos , vol.16 , pp. 351-380
    • Kararli, T.T.1
  • 42
    • 85122908957 scopus 로고
    • Effect of vehicle on the pharmacokinetics and uptake of four halogenated hydrocarbons from the gastrointestinal tract of the rat
    • Withey JR, Collins BT, Collins PG. Effect of vehicle on the pharmacokinetics and uptake of four halogenated hydrocarbons from the gastrointestinal tract of the rat. J Appl Toxicol 1983; 9:173-177.
    • (1983) J Appl Toxicol , vol.9 , pp. 173-177
    • Withey, J.R.1    Collins, B.T.2    Collins, P.G.3
  • 43
    • 0022972882 scopus 로고
    • Kinetics of protein binding determine rates of uptake of drugs by brain
    • Robinson PJ, Rapoport SI. Kinetics of protein binding determine rates of uptake of drugs by brain. Am J Physiol 1986; 251:R1212-R1220.
    • (1986) Am J Physiol , vol.251 , pp. R1212-R1220
    • Robinson, P.J.1    Rapoport, S.I.2
  • 44
    • 0024390938 scopus 로고
    • Metabolism, toxicity and carcinogenicity of trichloroethylene
    • Bruckner JV, David BD, Blancato JN. Metabolism, toxicity and carcinogenicity of trichloroethylene. Crit Rev Toxicol 1989; 20:31-50.
    • (1989) Crit Rev Toxicol , vol.20 , pp. 31-50
    • Bruckner, J.V.1    David, B.D.2    Blancato, J.N.3
  • 45
    • 0023639556 scopus 로고
    • The metabolism of t-butylcyclo-hexane in Fischer-344 male rats with hyaline droplet nephropathy
    • Henningsen GM, Yu KO, Salomon RA, et al. The metabolism of t-butylcyclo-hexane in Fischer-344 male rats with hyaline droplet nephropathy. Toxicol Lett 1987; 39:313-318.
    • (1987) Toxicol Lett , vol.39 , pp. 313-318
    • Henningsen, G.M.1    Yu, K.O.2    Salomon, R.A.3
  • 46
    • 0024400601 scopus 로고
    • A physiological model for simulation of benzene metabolism by rats and mice
    • Medinsky MA, Sabourin PJ, Lucier G, et al. A physiological model for simulation of benzene metabolism by rats and mice. Toxicol Appl Pharmacol 1989; 99:193-206.
    • (1989) Toxicol Appl Pharmacol , vol.99 , pp. 193-206
    • Medinsky, M.A.1    Sabourin, P.J.2    Lucier, G.3
  • 47
    • 0043092167 scopus 로고    scopus 로고
    • Predicting neonatal perchlorate dose and inhibition of iodide uptake in the rat during lactation using physiologically-based pharmacokinetic modeling
    • Clewell HJ III, Merrill EM, Yu KO, et al. Predicting neonatal perchlorate dose and inhibition of iodide uptake in the rat during lactation using physiologically-based pharmacokinetic modeling. Toxicol Sci 2003; 74:416-436.
    • (2003) Toxicol Sci , vol.74 , pp. 416-436
    • Clewell, H.J.1    Merrill, E.M.2    Yu, K.O.3
  • 48
    • 0035708743 scopus 로고    scopus 로고
    • Perchlorate: Problems, detection, and solutions
    • Motzer WE. Perchlorate: problems, detection, and solutions. Environ Forensics 2001; 2:301-311.
    • (2001) Environ Forensics , vol.2 , pp. 301-311
    • Motzer, W.E.1


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