Maternal consumption of high-fat diet disturbs hypothalamic neuronal function in the offspring: Implications for the genesis of obesity

Endocrinology

Volumn 153, Issue 2, 2012, Pages 543-545

  Velloso, Licio A ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID;

BRAIN FUNCTION; DIETARY INTAKE; GENE EXPRESSION; HUMAN; HYPOTHALAMUS; INFLAMMATION; LACTATION; LIPID DIET; MOLECULAR MECHANICS; NEUROPHYSIOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PREGNANCY; PRIORITY JOURNAL; PROGENY; SHORT SURVEY;

ANIMALS; DIETARY FATS; FEMALE; GLUCOSE; HYPOTHALAMUS; I-KAPPA B KINASE; MITOGEN-ACTIVATED PROTEIN KINASE 8; PREGNANCY;

EID: 84856118514     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-2077     Document Type: Short Survey

References (19)

1. Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW 2006 Central nervous system control of food intake and body weight. Nature 443:289-295 (Pubitemid 44435142)
2. Friedman JM 2002 The function of leptin in nutrition, weight, and physiology. Nutr Rev 60:S1-S14
3. Thaler JP, Schwartz MW 2010 Inflammation and obesity pathogenesis: the hypothalamus heats up. Endocrinology 151:4109-4115
4. Myers MG, Cowley MA, Münzberg H 2008 Mechanisms of leptin action and leptin resistance. Annu Rev Physiol 70:537-556 (Pubitemid 351738191)
5. Velloso LA, Schwartz MW 2011 Altered hypothalamic function in diet-induced obesity. Int J Obes (Lond) 35:1455-1465
6. Hotamisligil GS 2006 Inflammation and metabolic disorders. Nature 444:860-867 (Pubitemid 46024993)
7. Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjørbaek C, Flier JS 2004 Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med 10:734-738 (Pubitemid 38937639)
8. De Souza CT, Araujo EP, Bordin S, Ashimine R, Zollner RL, Boschero AC, Saad MJ, Velloso LA 2005 Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146:4192-4199 (Pubitemid 41324012)
9. Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D 2008 Hypothalamic IKKβ/NF-≲καππα∀B and ER stress link overnutrition to energy imbalance and obesity. Cell 135:61-73
10. Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ 2009 Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents. J Clin Invest 119:2577-2589
11. Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, Kahn BB 2008 Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem 283:14230-14241
12. Picardi PK, Calegari VC, Prada Pde O, Moraes JC, Araújo E, Marcondes MC, Ueno M, Carvalheira JB, Velloso LA, Saad MJ 2008 Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats. Endocrinology 149:3870-3880
13. Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra DE, Tsukumo DM, Anhe G, Amaral ME, Takahashi HK, Curi R, Oliveira HC, Carvalheira JB, Bordin S, Saad MJ, Velloso LA 2009 Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci 29:359-370
14. Ainge H, Thompson C, Ozanne SE, Rooney KB 2011 A systematic review on animal models of maternal high fat feeding and offspring glycaemic control. Int J Obes (Lond) 35:325-335
15. Ashino NG, Saito KN, Souza FD, Nakutz FS, Roman EA, Velloso LA, Torsoni AS, Torsoni MA 2 May 2011 Maternal high-fat feeding through pregnancy and lactation predisposes mouse offspring to molecular insulin resistance and fatty liver. J Nutr Biochem 10.1016/j.jnutbio.2010.12.011
16. Rother E, Kuschewski R, Alcazar MA, Oberthuer A, Bae-Gartz I, Vohlen C, Roth B, Dötsch J 2012 Hypothalamic JNK1 and IKKâactivation and impaired early postnatal glucose metabolism after maternal perinatal high-fat feeding. Endocrinology 153:770-781
17. Lee JY, Ye J, Gao Z, Youn HS, Lee WH, Zhao L, Sizemore N, Hwang DH 2003 Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids. J Biol Chem 278:37041-37051 (Pubitemid 37175218)
18. Lien E, Chow JC, Hawkins LD, McGuinness PD, Miyake K, Espevik T, Gusovsky F, Golenbock DT 2001 A novel synthetic acyclic lipid A-like agonist activates cells via the lipopolysaccharide/toll-like receptor 4 signaling pathway. J Biol Chem 276:1873-1880 (Pubitemid 32111740)
19. Mouihate A, Galic MA, Ellis SL, Spencer SJ, Tsutsui S, Pittman QJ 2010 Early life activation of toll-like receptor 4 reprograms neural anti-inflammatory pathways. J Neurosci 30:7975-7983