CD40 engagement of CD4 +CD40 + T cells in a neo-self antigen disease model ablates CTLA-4 expression and indirectly impacts tolerance

European Journal of Immunology

Volumn 42, Issue 2, 2012, Pages 424-435

  Carter, Jessica ^a   Vaitaitis, Gisela M ^a   Waid, Dan M ^a   Wagner, David H ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmunity; CD40; CTLA 4; Diabetes; Tolerance; Treg cells

Indexed keywords

AUTOANTIGEN; CD40 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; OVALBUMIN; OVALBUMIN[323-339]PEPTIDE; PEPTIDE DERIVATIVE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DIABETES; AUTOIMMUNE DISEASE; AUTOREGULATION; CD4+ CD40+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE EXACERBATION; ENGRAFTMENT; EPITHELIUM CELL; IMMUNOLOGICAL TOLERANCE; LYMPH NODE; MEDULLARY THYMIC EPITHELIAL CELL; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PANCREAS; PANCREAS ISLET BETA CELL; PANCREAS LYMPH NODE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; THYMOCYTE; THYMUS; TRANSGENIC ANIMAL;

ANIMALS; ANTIGENS, CD40; AUTOANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; CTLA-4 ANTIGEN; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; DOWN-REGULATION; HUMANS; IMMUNE TOLERANCE; IMMUNOMODULATION; MICE; MICE, INBRED NOD; MICE, TRANSGENIC; SIGNAL TRANSDUCTION;

EID: 84856054869     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201141880     Document Type: Article

References (52)

1. +) T cells promotes diabetes. J. Leukoc. Biol. 2008. 84: 431-439.
2. Haskins, K. and Wegmann, D., Diabetogenic T-cell clones. Diabetes 1996. 45: 1299-1305.
3. + T lymphocytes. Proc. Natl. Acad. Sci. USA 2002. 13: 13.
4. +) T-cell population comprises multiple antigenic specificities. Clin. Immunol. 2002. 105: 332-341.
5. + T-cell clonotypes in peripheral blood and the pancreatic islets are distinct. J. Immunol. 2009. 183: 7585-7591.
6. Li, L., Wang, B., Frelinger, J. A. and Tisch, R., T-cell promiscuity in autoimmune diabetes. Diabetes 2008. 57: 2099-2106.
7. Kishimoto, H. and Sprent, J., A defect in central tolerance in NOD mice. Nat. Immunol. 2001. 2: 1025-1031.
8. + auto-aggressive T-cell expansion during insulin-dependent diabetes mellitus. Eur. J. Immunol. 2004. 34: 1488-1497.
9. Vaitaitis, G. M. and Wagner, D. H., Jr., CD40 glycoforms and TNF-receptors 1 and 2 in the formation of CD40 receptor(s) in autoimmunity. Mol Immunol. 47: 2303-2313.
10. Vaitaitis, G. M. and Wagner, D. H., Jr., High distribution of CD40 and TRAF2 in Th40 T-cell rafts leads to preferential survival of this auto-aggressive population in autoimmunity. PLoS One 2008. 3: e2076-2086.
11. Siebert, J. C., Inokuma, M., Waid, D. M., Pennock, N. D., Vaitaitis, G. M., Disis, M. L., Dunne, J. F. et al., An analytical workflow for investigating cytokine profiles. Cytometry A 2008. 73: 289-298.
12. + T cells (TCD40) in human type 1 diabetes. Clin. Immunol. 2007. 124: 138-148.
13. Vaitaitis, G. M., Poulin, M., Sanderson, R. J., Haskins, K. and Wagner, D. H., Jr., Cutting edge: CD40-induced expression of recombination activating gene (RAG) 1 and RAG2: a mechanism for the generation of autoaggressive T cells in the periphery. J. Immunol. 2003. 170: 3455-3459.
14. Wagner, D. H., Jr., Vaitaitis, G., Sanderson, R., Poulin, M., Dobbs, C. and Haskins, K., Expression of CD40 identifies a unique pathogenic T-cell population in type 1 diabetes. Proc. Natl. Acad. Sci. USA 2002. 99: 3782-3787.
15. + T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1). J. Exp. Med. 1998. 188: 415-420.
16. Gallegos, A. M. and Bevan, M. J., Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J. Exp. Med. 2004. 200: 1039-1049.
17. Holman, P. O., Walsh, E. R. and Hogquist, K. A., The central tolerance response to male antigen in normal mice is deletion and not receptor editing. J. Immunol. 2003. 171: 4048-4053.
18. McGargill, M. A., Mayerova, D., Stefanski, H. E., Koehn, B., Parke, E. A., Jameson, S. C., Panoskaltsis-Mortari, A. and Hogquist, K. A., A spontaneous CD8 T cell-dependent autoimmune disease to an antigen expressed under the human keratin 14 promoter. J. Immunol. 2002. 169: 2141-2147.
19. McGargill, M. A., Derbinski, J. M. and Hogquist, K. A., Receptor editing in developing T cells. Nat. Immunol. 2000. 1: 336-341.
20. Lohr, J., Knoechel, B., Kahn, E. C. and Abbas, A. K., Role of B7 in T-cell tolerance. J. Immunol. 2004. 173: 5028-5035.
21. Oosterwegel, M. A., Mandelbrot, D. A., Boyd, S. D., Lorsbach, R. B., Jarrett, D. Y., Abbas, A. K. and Sharpe, A. H., The role of CTLA-4 in regulating Th2 differentiation. J. Immunol. 1999. 163: 2634-2639.
22. Eggena, M. P., Walker, L. S., Nagabhushanam, V., Barron, L., Chodos, A. and Abbas, A. K., Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an isleT-cell antigen. J. Exp. Med. 2004. 199: 1725-1730.
23. Schatz, D. G. and Spanopoulou, E., Biochemistry of V(D)J recombination. Curr. Top. Microbiol. Immunol. 2005. 290: 49-85.
24. Yamaguchi, T., Hirota, K., Nagahama, K., Ohkawa, K., Takahashi, T., Nomura, T. and Sakaguchi, S., Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity 2007. 27: 145-159.
25. Walker, L. S., Ausubel, L. J., Chodos, A., Bekarian, N. and Abbas, A. K., CTLA-4 differentially regulates T-cell responses to endogenous tissue protein versus exogenous immunogen. J. Immunol. 2002. 169: 6202-6209.
26. Balasa, B., Krahl, T., Patstone, G., Lee, J., Tisch, R., McDevitt, H. O. and Sarvetnick, N., CD40 Ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice. J. Immunol. 1997. 159: 4620-4627.
27. Vaitaitis, G. and Wagner, D. H., Jr., CD40 glycoforms and TNF-receptors 1 and 2 in the formation of CD40 receptor(s) in autoimmunity. Mol. Immunol. 2010. 47: 2303-2313.
28. Vaitaitis, G., Waid, D. M. and Wagner, D. H., Jr., The expanding role of TNF-receptor super family member CD40 (tnfrsf5) in autoimmune disease: focus on Th40 cells. Curr. Immunol. Rev. 2010. 6: 130-136.
29. Vaitaitis, G. M., Poulin, M., Sanderson, R. J., Haskins, K. J. and Wagner, D. H., Jr., CD40-induced expression of recombination activating gene (RAG) 1 and RAG2: a mechanism for the generation of autoaggressive T cells in the periphery. Cutting edge. J. Immunol. 2003. 170: 3455-3459.
30. Gallegos, A. M. and Bevan, M. J., Central tolerance: good but imperfect. Curr. Immunol. Rev. 2006. 209: 290-296.
31. Baker, R. L., Wagner, D. H., Jr. and Haskins, K., CD40 on NOD CD4 T cells contributes to their activation and pathogenicity. J. Autoimmun. 2008. 31: 385-392.
32. Egan, R. M., Yorkey, C., Black, R., Loh, W. K., Stevens, J. L. and Woodward, J. G., Peptide-specific T-cell clonal expansion in vivo following immunization in the eye, an immune-privileged site. J. Immunol. 1996. 157: 2262-2271.
33. + cells in the absence of CD5 signaling. Eur. J. Immunol. 2009. 39: 2233-2247.
34. Koelsch, U., Schraven, B. and Simeoni, L., SIT and TRIM determine T-cell fate in the thymus. J. Immunol. 2008. 181: 5930-5939.
35. + T cells. Immunity 2000. 13: 59-71.
36. Maggi, E., Cosmi, L., Liotta, F., Romagnani, P., Romagnani, S. and Annunziato, F., Thymic regulatory T cells. Autoimmun. Rev. 2005. 4: 579-586.
37. + regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 2005. 6: 345-352.
38. Ryan, G. A., Wang, C. J., Chamberlain, J. L., Attridge, K., Schmidt, E. M., Kenefeck, R., Clough, L. E. et al., B1 cells promote pancreas infiltration by autoreactive T cells. J. Immunol. 2011, 185: 2800-2807.
39. + regulatory T cells in vivo. J. Exp. Med. 2003. 198: 249-258.
40. Lohr, J., Knoechel, B., Nagabhushanam, V. and Abbas, A. K., T-cell tolerance and autoimmunity to systemic and tissue-restricted self-antigens. Curr. Immunol. Rev. 2005. 204: 116-127.
41. Kersh, G. J., Donermeyer, D. L., Frederick, K. E., White, J. M., Hsu, B. L. and Allen, P. M., TCR transgenic mice in which usage of transgenic α- and β-chains is highly dependent on the level of selecting ligand. J. Immunol. 1998. 161: 585-593.
42. Sakaguchi, S., Yamaguchi, T., Nomura, T. and Ono, M., Regulatory T cells and immune tolerance. Cell 2008. 133: 775-787.
43. + natural regulatory T cells in dominant self-tolerance and autoimmune disease. Curr. Immunol. Rev. 2006. 212: 8-27.
44. Weaver, C. T. and Hatton, R. D., Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective. Nat. Rev. Immunol. 2009. 9: 883-889.
45. Vaitaitis, G. M. and Wagner, D. H., Jr., CD40 glycoforms and TNF-receptors 1 and 2 in the formation of CD40 receptor(s) in autoimmunity. Mol. Immunol. 47: 2303-2313.
46. Goudy, K. S., Johnson, M. C., Garland, A., Li, C., Samulski, R. J., Wang, B. and Tisch, R., Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62L(lo) FoxP3(+) CD4(+) T cells with limited suppressor activity. Eur. J. Immunol. 41: 1480-1490.
47. + regulatory T cells prevent autoimmunity by inhibiting dendritic cells from activating autoreactive T cells. J. Immunol. 2007. 179: 4685-4693.
48. +CD25hi T-regulatory cells. Blood 2006. 108: 253-261.
49. +CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J. Immunol. 2007. 178: 2579-2588.
50. + regulatory T cells. J. Immunol. 2008. 181: 7350-7355.
51. Fife, B. T. and Bluestone, J. A., Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. Curr. Immunol. Rev. 2008. 224: 166-182.
52. + T-cell contact-dependent activation of monocyte interleukin-1 synthesis. Eur. J. Immunol. 1994. 24: 3148-3154.