Sorafenib: Complexities of Raf-dependent and Raf-independent signaling are now unveiled

Medical Molecular Morphology

Volumn 44, Issue 4, 2011, Pages 183-189

  Matsuda, Yasunobu ^a   Fukumoto, Manabu ^b  

^a NIIGATA UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Endoplasmic reticulum stress; Hepatocellular carcinoma; Myeloid cell leukemia 1; Raf; Sorafenib

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; 4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; B RAF KINASE; BORTEZOMIB; CD135 ANTIGEN; CETUXIMAB; DOXORUBICIN; ERLOTINIB; OCTREOTIDE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; RAF PROTEIN; RAPAMYCIN; SELUMETINIB; SORAFENIB; STEM CELL FACTOR RECEPTOR; SULFORAPHANE; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VITAMIN K GROUP; ZOLEDRONIC ACID;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; CELL DEATH; CELL STRESS; DRUG EFFICACY; ENDOPLASMIC RETICULUM; HUMAN; INFORMATION RETRIEVAL; INTRACELLULAR SIGNALING; LIVER CELL CARCINOMA; LOW DRUG DOSE; MEDICAL LITERATURE; MOLECULARLY TARGETED THERAPY; MONOTHERAPY; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; BENZENESULFONATES; CARCINOMA, HEPATOCELLULAR; DRUG SYNERGISM; ENDOPLASMIC RETICULUM STRESS; HUMANS; LIVER NEOPLASMS; MAP KINASE SIGNALING SYSTEM; NEOVASCULARIZATION, PATHOLOGIC; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRIDINES; RAF KINASES;

EID: 84856051012     PISSN: 18601480     EISSN: 18601499     Source Type: Journal    
DOI: 10.1007/s00795-011-0558-z     Document Type: Review

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