Alpha-particle carcinogenesis in Thorotrast® patients: Epidemiology, dosimetry, pathology, and molecular analysis

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 20, Issue 4, 2001, Pages 311-315

  Ishikawa, Yuichi ^a   Wada, Ikuo ^a   Fukumoto, Manabu ^b  

^a CANCER INSTITUTE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Alpha particle; Cholangiocarcinoma; Hemangiosarcoma; Hepatocellular carcinoma; Leukemia; Liver cancer; Radiation; Radon; Thorotrast

Indexed keywords

CONTRAST MEDIUM; RADIOISOTOPE; RADON; THORIUM 232; THORIUM DIOXIDE;

ALPHA RADIATION; ANGIOSARCOMA; BILE DUCT CARCINOMA; CANCER; CARCINOGENESIS; CONFERENCE PAPER; CONTROLLED STUDY; DOSIMETRY; DRUG ELIMINATION; GENE MUTATION; HUMAN; LEUKEMIA; LIVER CANCER; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MOLECULAR BIOLOGY; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 0035688284     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: 10.1615/jenvironpatholtoxicoloncol.v20.i4.70     Document Type: Conference Paper

References (20)

1. Proceedings of the International Workshop on the health effects of Thorotrast, radium, radon and other alpha-emitters, 1999
2. Summary of entire Japanese Thorotrast follow-up study: Updated 1998
3. The German Thorotrast study: Recent results and assessment of risks
4. Long-term effects of internally deposited alpha-particle emitting radionuclides: Epidemiological, pathological and molecular biological studies of Danish Thorotrast-administered patients and their offspring
5. Mortality in the Portuguese Thorotrast study
6. Mortality after long-term exposure to radioactive Thorotrast: A forty-year follow-up survey in Sweden
7. Lack of apparent excess of malignant mesothelioma but increased overall malignancies of peritoneal cavity in Japanese autopsies with Thorotrast injection into blood vessels
8. Alpha-particle dose to the liver and spleen tissues of Japanese Thorotrast patients
9. Lung cancers associated with Thorotrast exposure: High incidence of small-cell carcinoma and implications for estimation of radon risk
10. Tissue dose in Thorotrast patients
11. Revised organ partition of thorium-232 in Thorotrast patients
12. Late effects of alpha-particles on Thorotrast patients
13. Portable Rn-220 detector used to assess Thorotrast exposure
14. Results of measurements of exhaled radon-220 from Thorotrast patients
15. 1998 Results of the first series of follow-up studies on Japanese Thorotrast patients and their relationships to an autopsy series
16. Pathomorphological characteristics of 102 cases of Thorotrast-related hepatocellular carcinoma, cholangiocarcinoma, and hepatic angiosarcoma
17. Clinicopathological study of hematological disorders after Thorotrast administration in Japan
18. Systemic deposits of thorium in Thorotrast patients with particular reference to sites of minor storage
19. Effects of preconceptional irradiation on mortality and cancer incidence in the offspring of patients injected with thorium dioxide
20. High rate of small p53 mutations and infrequent loss of heterozygosity in malignant liver tumors associated with Thorotrast: Implications for alpha-particle carcinogenesis