Synthesis and in vitro antimycobacterial activity of compounds derived from (R)- and (S)-2-amino-1-butanol - The crucial role of the configuration

European Journal of Medicinal Chemistry

Volumn 48, Issue , 2012, Pages 45-56

  Dobrikov, Georgi M ^a   Valcheva, Violeta ^b   Stoilova Disheva, Margarita ^b   Momekov, Georgi ^c   Tzvetkova, Pavleta ^a   Chimov, Angel ^a   Dimitrov, Vladimir ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY   (Bulgaria)

^b INSTITUTE OF MICROBIOLOGY   (Bulgaria)

^c MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

2 Amino 1 butanol; Antibacterial; Antimycobacterial; Enantiomers; Ethambutol analogues

Indexed keywords

2 AMINOBUTANOL; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ETHAMBUTOL; FLUCONAZOLE; GENTAMICIN; ITRACONAZOLE; STREPTOMYCIN; TUBERCULOSTATIC AGENT; 2-AMINO-1-BUTANOL; AMINOALCOHOL;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; ENANTIOMER; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY CELL; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; GROWTH, DEVELOPMENT AND AGING; IC 50; MICROBIOLOGICAL EXAMINATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OPTICAL ROTATION; STEREOISOMERISM; SYNTHESIS;

AMINO ALCOHOLS; ANTITUBERCULAR AGENTS; CELL LINE; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; OPTICAL ROTATION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM;

EID: 84856011294     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.11.035     Document Type: Article

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