Design, synthesis, and evaluation of novel ethambutol analogues

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 5, 2008, Pages 1607-1611

  Yendapally, Raghunandan ^a   Lee, Richard E ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Anti tuberculosis; Antibiotic; Tuberculosis

Indexed keywords

ETHAMBUTOL;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG HALF LIFE; DRUG SCREENING; DRUG SYNTHESIS; LIPOPHILICITY; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS;

ANTITUBERCULAR AGENTS; DRUG DESIGN; ETHAMBUTOL; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 39849103711     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.065     Document Type: Article

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20. 2O): 0.87 (3H, t, J = 7.56 Hz), 1.21 (3H, s), 1.54-1.71 (2H, m), 2.37 (2H, d, J = 7.56 Hz), 3.17 (1H, sextet), 3.3-3.4 (4H, m), 3.5-3.62 (2H, m), 3.66 (1H, dd, J = 5.37, 13.18 Hz), 3.78 (1H, dd, J = 3.17, 12.93 Hz), 5.16-5.24 (2H, m), 5.68-5.78 (1H, m); ESI-MS: 217.2 (M+1).
21. 90 was determined by visual inspection and defined as the concentration that inhibited 90% of growth.