Antifungal, cytotoxic and SAR studies of a series of N-alkyl, N-aryl and N-alkylphenyl-1,4-pyrrolediones and related compounds

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 9, 2011, Pages 2823-2834

  Sortino, M ^a,b   Garibotto, F ^a,b   Cechinel Filho, V ^c   Gupta, M ^d   Enriz, R ^b   Zacchino, S ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^b UNIVERSIDAD NACIONAL DE SAN LUIS   (Argentina)

^c UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

^d UNIVERSIDAD DE PANAMÁ   (Panama)

Author keywords

Antifungal; DFT calculations; Maleimides; SAR (structure activity relationships)

Indexed keywords

2 METHYL N BUTYLPHENYL 4 HYDROXY 2,3 DEHYDRO GAMMA LACTAME; 2 METHYL N PHENETHYL 4 HYDROXY 2,3 DEHYDRO GAMMA LACTAME; 2 METHYL N PROPYLPHENYL 4 HYDROXY 2,3 DEHYDRO GAMMA LACTAME; 2,3 DIPHENYL N BENZYLMALEIMIDE; 2,3 DIPHENYL N BUTYLPHENYLMALEIMIDE; 2,3 DIPHENYL N PHENETHYLMALEIMIDE; 2,3 DIPHENYL N PROPYLPHENYLMALEIMIDE; 3 METHYL N BUTYLPHENYL 4 HYDROXY 2,3 DEHYDRO GAMMA LACTAME; 3 METHYL N PHENETHYL 4 HYDROXY 2,3 DEHYDRO GAMMA LACTAME; 3 METHYL N PROPYLPHENYL 4 HYDROXY 2,3 DEHYDRO GAMMA LACTAME; MALEIMIDE DERIVATIVE; N (3',4' DIMETHOXYPHENYL)MALEIMIDE; N (3',4' METHYLENEDIOXYPHENYL)MALEIMIDE; N BUTYLPHENYL 4 HYDROXY 2,3 DEHYDRO GAMMA LACTAME; N BUTYLPHENYLSUCCINIMIDE; N PHENETHYL 4 HYDROXY 2,3 DEHYDRO GAMMA LACTAME; N PHENYL 4 HYDROXY 2,3 DEHYDRO GAMMA LACTAME; N PHENYLALKYLSUCCINIMIDE; N PROPYLPHENYL 4 HYDROXY 2,3 DEHYDRO GAMMA LACTAME; N PROPYLPHENYLSUCCINIMIDE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG SELECTIVITY; DRUG SYNTHESIS; FUNGICIDAL ACTIVITY; FUNGISTASIS; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION;

FUNGI;

EID: 79955470995     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.03.038     Document Type: Article

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