메뉴 건너뛰기




Volumn 817, Issue , 2012, Pages 35-54

The mouse lymphoma assay

Author keywords

Large and small colonies; Mouse lymphoma; Mutation; TFT; Thymidine kinase; Viability

Indexed keywords

DRUG DERIVATIVE; MUTAGENIC AGENT; THYMIDINE; THYMIDINE KINASE;

EID: 84856004308     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-421-6_3     Document Type: Article
Times cited : (38)

References (69)
  • 1
    • 54049122062 scopus 로고    scopus 로고
    • In Vitro Mammalian Cell Gene Mutation Test
    • OECD Test Guideline OECD Paris
    • OECD (1997) " In Vitro Mammalian Cell Gene Mutation Test", in: OECD Guidelines for the Testing of Chemicals, Test Guideline 476. OECD Paris (http://titania.sourceoecd.org/vl=1382924/cl=17/nw=1/rpsv/cw/vhosts/ oecdjournals/1607310x/v1n4/contp1-1. htm)
    • (1997) OECD Guidelines for the Testing of Chemicals , vol.476
  • 2
    • 84856016882 scopus 로고    scopus 로고
    • International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. Step 4 Guideline, Brussels, July
    • ICH, Topic S2B Genotoxicity: A Standard Battery for Genotoxocity Testing of Pharmaceuticals, International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. Step 4 Guideline, Brussels, July, 1997 (http://www.ich.org/cache/compo/502-272-1.html)
    • (1997) ICH, Topic S2B Genotoxicity: A Standard Battery for Genotoxocity Testing of Pharmaceuticals
  • 3
    • 84856013231 scopus 로고
    • Increase in incidence of leukemia in hybrid mice bearing thymic transplants from a high leukemic strain
    • Law LW (1952) Increase in incidence of leukemia in hybrid mice bearing thymic transplants from a high leukemic strain. Journal of the National Cancer Institute 12 (4):789-805
    • (1952) Journal of the National Cancer Institute , vol.12 , Issue.4 , pp. 789-805
    • Law, L.W.1
  • 4
    • 0001169306 scopus 로고
    • Studies of the culture of leukemic cells in vitro
    • Fischer GA (1958) Studies of the culture of leukemic cells in vitro. Annals of the New York Academy of Sciences 76 (3):673-680
    • (1958) Annals of the New York Academy of Sciences , vol.76 , Issue.3 , pp. 673-680
    • Fischer, G.A.1
  • 5
    • 0028169613 scopus 로고
    • Use of microsatellite DNA polymorphisms on mouse chromosome 11 for in vitro analysis of thymidine kinase gene mutations
    • Liechty MC, Hassanpour Z, Hozier JC and Clive D (1994) Use of microsatellite DNA polymorphisms on mouse chromosome 11 for in vitro analysis of thymidine kinase gene mutations. Mutagenesis 9:423-427 (Pubitemid 24297870)
    • (1994) Mutagenesis , vol.9 , Issue.5 , pp. 423-427
    • Liechty, M.C.1    Hassanpour, Z.2    Hozier, J.C.3    Clive, D.4
  • 6
    • 0015402142 scopus 로고
    • A mutational assay system using the thymidine kinase locus in mouse lym-phoma cells
    • Clive D, Flamm WG, Machesko MR and Bernheim NJ (1972) A mutational assay system using the thymidine kinase locus in mouse lym-phoma cells. Mutation Research 16: 77-87
    • (1972) Mutation Research , vol.16 , pp. 77-87
    • Clive, D.1    Flamm, W.G.2    MacHesko, M.R.3    Bernheim, N.J.4
  • 7
    • 0015691658 scopus 로고
    • Recent developments with the l5178y TK heterozygote mutagen assay system
    • Clive D (1973) Recent Developments with the L5178Y TK Heterozygote Mutagen Assay System. Environmental Health Perspectives 6: 119-125.
    • (1973) Environmental Health Perspectives , vol.6 , pp. 119-125
    • Clive, D.1
  • 8
    • 0019413371 scopus 로고
    • The utilization of trifluorothymidine (TFT) to select for thymidine kinase-deficient (TK(-/-)) mutants from L5178Y/TK(+/-) mouse lymphoma cells
    • Moore-Brown MM, Clive D, Howard BE et al. (1981) The utilization of trifluorothymidine (TFT) to select for thymidine kinase-deficient (TK-/-) mutants from L5178Y/TK+/-mouse lymphoma cells. Mutation Research 85: 363-378 (Pubitemid 11059819)
    • (1981) Mutation Research , vol.85 , Issue.5 , pp. 363-378
    • Moore-Brown, M.M.1    Clive, D.2    Howard, B.E.3
  • 10
    • 0022262801 scopus 로고
    • Analysis of trifluorothymidine-resistant (TFT(r)) mutants of L5178Y/TK(+/-) mouse lymphoma cells
    • Moore MM, Clive D, Hozier JC et al. (1985) Analysis of trifluorothymidine-resistant (TFTr) mutants of L5178Y/TK+/-mouse lymphoma cells. Mutation Research 151:161-174 (Pubitemid 15023098)
    • (1985) Mutation Research , vol.151 , Issue.1 , pp. 161-174
    • Moore, M.M.1    Clive, D.2    Hozier, J.C.3
  • 11
    • 0016423549 scopus 로고
    • Laboratory procedure for assessing specific locus mutations at the TK locus in cultured l5178y mouse lymphoma cells
    • Clive D and Spector JFS (1975) Laboratory procedure for assessing specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells. Mutation Research 31: 17-29.
    • (1975) Mutation Research , vol.31 , pp. 17-29
    • Clive, D.1    Spector, J.F.S.2
  • 12
    • 0017737028 scopus 로고
    • Evidence for chemically induced structural gene mutations at the thymidine kinase locus in cultured L5178Y mouse lymphoma cells
    • Clive D and Voytek P (1977) Evidence for chemically-induced structural gene mutations at the thymidine kinase locus in cultured L5178Y mouse lymphoma cells. Mutation Research 44: 269-278. (Pubitemid 8162863)
    • (1977) Mutation Research , vol.44 , Issue.2 , pp. 269-278
    • Clive, D.1    Voytek, P.2
  • 13
    • 0018327785 scopus 로고
    • - mouse lymphoma mutagen assay system
    • Clive D, Johnson KO, Spector JFS et al. (1979) Validation and characterization of the L5178Y/TK+/-mouse lymphoma mutagen assay system. Mutation Research 59: 61-108 (Pubitemid 9070607)
    • (1979) Mutation Research , vol.59 , Issue.1 , pp. 61-108
    • Clive, D.1    Johnson, K.O.2    Spector, J.F.S.3
  • 14
    • 0021015467 scopus 로고
    • A comparison of the agar cloning and microtitration techniques for assaying cell survival and mutation frequency in L5178Y mouse lymphoma cells
    • Cole J, Arlett CF, Green MHL et al. (1983) A comparison of the agar cloning and microti-tration techniques for assaying cell survival and mutation frequency in L5178Y mouse lym-phoma cells. Mutation Research 111: 371-386 (Pubitemid 14211273)
    • (1983) Mutation Research , vol.111 , Issue.3 , pp. 371-386
    • Cole, J.1    Arlett, C.F.2    Green, M.H.L.3
  • 15
    • 0023744752 scopus 로고
    • Evaluation of the l5178y mouse lymphoma cell mutagenesis assay: Methods used and chemicals evaluated
    • Mitchell AD, Myhr BC, Rudd CJ et al. (1988) Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Methods used and chemicals evaluated. Environmental Mutagen-esis 12: 1-18
    • (1988) Environmental Mutagen-esis , vol.12 , pp. 1-18
    • Mitchell, A.D.1    Myhr, B.C.2    Rudd, C.J.3
  • 16
    • 0023760848 scopus 로고
    • Evaluation of the l5178y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at SRI international
    • Mitchell AD, Rudd CJ and Caspary WJ (1988) Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at SRI international. Environmental Mutagenesis 12: 37-101
    • (1988) Environmental Mutagenesis , vol.12 , pp. 37-101
    • Mitchell, A.D.1    Rudd, C.J.2    Caspary, W.J.3
  • 17
    • 0023717999 scopus 로고
    • Evaluation of the l5178y mouse lym-phoma cell mutagenesis assay: Interlaboratory reproducibility and assessment
    • Caspary WJ, Daston DS, Myhr BC, et al. (1988) Evaluation of the L5178Y mouse lym-phoma cell mutagenesis assay: Interlaboratory reproducibility and assessment. Environmental Mutagenesis 12: 195-229
    • (1988) Environmental Mutagenesis , vol.12 , pp. 195-229
    • Caspary, W.J.1    Daston, D.S.2    Myhr, B.C.3
  • 18
    • 0023804533 scopus 로고
    • Evaluation of the l5178y mouse lymphoma cell mutagenesis assay: Quality-control guidelines and response categories
    • Caspary WJ, Lee YJ, Poulton S, et al. (1988) Evaluation of the L5178y mouse lymphoma cell mutagenesis assay: Quality-control guidelines and response categories. Environmental Mutagenesis 12: 19-36
    • (1988) Environmental Mutagenesis , vol.12 , pp. 19-36
    • Caspary, W.J.1    Lee, Y.J.2    Poulton, S.3
  • 19
    • 0023746946 scopus 로고
    • Evaluation of the l5178y mouse lymphoma cell mutagen-esis assay: Intralaboratory results for sixty-three coded chemicals tested at litton bionetics, inc
    • Myhr BC and Caspary WJ (1988) Evaluation of the L5178Y mouse lymphoma cell mutagen-esis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environmental Mutagenesis 12:103-194
    • (1988) Environmental Mutagenesis , vol.12 , pp. 103-194
    • Myhr, B.C.1    Caspary, W.J.2
  • 20
    • 0021931636 scopus 로고
    • Cytogenetic characterization of the L5178Y TK(+/-) 3.7.2C mouse lymphoma cell line
    • Sawyer J, Moore MM, Clive D and Hozier J (1985) Cytogenetic characterization of the L5178Y TK+/-3.7.2C mouse lymphoma cell line. Mutation Research 147: 243-253 (Pubitemid 15235249)
    • (1985) Mutation Research , vol.147 , Issue.5 , pp. 243-253
    • Sawyer, J.1    Moore, M.M.2    Clive, D.3    Hozier, J.4
  • 22
    • 0010393211 scopus 로고
    • The mouse lymphoma assay may be used as a chromosome aberration assay
    • Clive D, Turner NT, Krehl R and Eyre J (1985) The mouse lymphoma assay may be used as a chromosome aberration assay. Environmental Mutagenesis 7 (suppl. 3):33
    • (1985) Environmental Mutagenesis , vol.7 , Issue.SUPPL. 3 , pp. 33
    • Clive, D.1    Turner, N.T.2    Krehl, R.3    Eyre, J.4
  • 33
    • 33947304753 scopus 로고    scopus 로고
    • Microarray analysis distinguished differential gene expression patterns from large and small colony thymidine kinase mutants of l5178y mouse lymphoma cells
    • Han T, Wang J, Tong W, et al. (2006) Microarray analysis distinguished differential gene expression patterns from large and small colony Thymidine kinase mutants of L5178Y mouse lymphoma cells. BMC Bioinformatics 7 (Suppl 2):S9
    • (2006) BMC Bioinformatics , vol.7 , Issue.SUPPL. 2
    • Han, T.1    Wang, J.2    Tong, W.3
  • 34
    • 0019945050 scopus 로고
    • Quantitation of small colony trifluorothymidine-resistant mutants of L5178Y/TK(+/-) mouse lymphoma cells in RPMI-1640 medium
    • Moore MM and Howard BE (1982) Quantitation of small colony trifluorothymi-dine-resistant mutants of L5178Y/TK+/-mouse lymphoma cells in RPMI-1640 medium. Mutation Research 104:287-294 (Pubitemid 12080308)
    • (1982) Mutation Research , vol.104 , Issue.4-5 , pp. 287-294
    • Moore, M.M.1    Howard, B.E.2
  • 35
    • 0023010822 scopus 로고
    • Genotoxic effects in cultured mammalian cells produced by low pH treatment conditions and increased ion concentrations
    • DOI 10.1002/em.2860080611
    • Brusick D (1986) Genotoxic effects in cultured mammalian cells produced by low ph treatment conditions and increased ion concentrations. Environmental Mutagenesis 8:879-886 (Pubitemid 17188042)
    • (1986) Environmental Mutagenesis , vol.8 , Issue.6 , pp. 879-886
    • Brusick, D.1
  • 39
    • 0025354122 scopus 로고
    • Towards construction of a high resolution map of the mouse genome using pcr-analysed microsatellites
    • Love JM, Knight AM, McAleer MA and Todd JA (1990) Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellites. Nucl. Acids Res. 18:4123-4130
    • (1990) Nucl. Acids Res. , vol.18 , pp. 4123-4130
    • Love, J.M.1    Knight, A.M.2    Ma, M.3    Todd, J.A.4
  • 40
    • 0030596059 scopus 로고    scopus 로고
    • Identification of a heteromorphic microsatellite within the thymidine kinase gene in L5178Y mouse lymphoma cells
    • DOI 10.1016/S0165-1218(96)90115-9, PII S0165121896001267
    • Liechty MC, Crosby H, Murthy A, Davis LM, Caspary WJ and Hozier JC (1996) Identification of a heteromorphic microsatellite within the thymidine kinase gene in L5178Y mouse lym-phoma cells. Mutation Research 371:265-271 (Pubitemid 27036289)
    • (1996) Mutation Research - Genetic Toxicology , vol.371 , Issue.3-4 , pp. 265-271
    • Liechty, M.C.1    Crosby Jr., H.2    Murthy, A.3    Davis, L.M.4    Caspary, W.J.5    Hozier, J.C.6
  • 41
    • 0025147998 scopus 로고
    • Molecular aspects of chemical mutagenesis in L5178Y/tk(+/-) mouse lymphoma cells
    • Clive D, Glover P, Applegate M and Hozier J (1990) Molecular aspects of chemical muta-genesis in L5178Y/tk+/-mouse lymphoma cells. Mutagenesis 5:191-197 (Pubitemid 20274558)
    • (1990) Mutagenesis , vol.5 , Issue.2 , pp. 191-197
    • Clive, D.1    Glover, P.2    Applegate, M.3    Hozier, J.4
  • 43
    • 0020450142 scopus 로고
    • +- 3.7.2C mouse-lymphoma cell line
    • Hozier J, Sawyer J, Clive D and Moore M (1982) Cytogenetic distinction between the TK+ and TK-chromosomes in the L5178Y TK+/-3.7.2C mouse-lymphoma cell line. Mutation Research 105:451-456 (Pubitemid 13247397)
    • (1982) Mutation Research , vol.105 , Issue.6 , pp. 451-456
    • Hozier, J.1    Sawyer, J.2    Clive, D.3    Moore, M.4
  • 44
    • 0021932482 scopus 로고
    • Chromosome 11 aberrations in small colony L5178Y TK(-/-) mutants early in their clonal history
    • +/- mutants early in their clonal history. Mutation Research 147:237-242 (Pubitemid 15235248)
    • (1985) Mutation Research , vol.147 , Issue.5 , pp. 237-242
    • Hozier, J.1    Sawyer, J.2    Clive, D.3    Moore, M.M.4
  • 45
    • 0022260616 scopus 로고
    • In situ analysis of trifluorothymidine-resistant (TFT) mutants of L5178Y/TK(+/-) mouse lymphoma cells
    • r) mutants of L5178Y/TK+/-mouse-lymphoma cells. Mutation Research 151 147-159 (Pubitemid 15023097)
    • (1985) Mutation Research , vol.151 , Issue.1 , pp. 147-159
    • Moore, M.M.1    Clive, D.2    Howard, B.E.3
  • 46
    • 0022262801 scopus 로고
    • Analysis of trifluorothymidine-resistant (TFT(r)) mutants of L5178Y/TK(+/-) mouse lymphoma cells
    • Moore MM, Clive D, Hozier JC, Howard. BE, Batson AG, Turner NT and Sawyer J. (1985) Analysis of trifluorothymidine-resistant (TFT ¢) mutants of L5178Y TK+/-mouse lymphoma cells. Mutation Research 151:161-174 (Pubitemid 15023098)
    • (1985) Mutation Research , vol.151 , Issue.1 , pp. 161-174
    • Moore, M.M.1    Clive, D.2    Hozier, J.C.3
  • 47
    • 0022612736 scopus 로고
    • Chromosome analysis of trifluorothymidine-resistant L5178Y mouse lymphoma cell colonies
    • Blazak WF, Stewart BE, Galperin I, Allen KL, Rudd CJ, Mitchell AD and Caspary WJ (1986) Chromosome analysis of trifluorothymidine-resistant L5178Y mouse lymphoma cell colonies. Environmental Mutagenesis 8:229-240 (Pubitemid 16093364)
    • (1986) Environmental Mutagenesis , vol.8 , Issue.2 , pp. 229-240
    • Blazak, W.F.1    Stewart, B.E.2    Galperin, I.3
  • 49
    • 54149117788 scopus 로고    scopus 로고
    • Arsenic trioxide mutational spectrum analysis in the mouse lymphoma assay
    • Soriano C, Creus A and Marcos R (2008) Arsenic trioxide mutational spectrum analysis in the mouse lymphoma assay. Mutation Research 646:1-7
    • (2008) Mutation Research , vol.646 , pp. 1-7
    • Soriano, C.1    Creus, A.2    Marcos, R.3
  • 50
    • 0018778606 scopus 로고
    • Identification and partial characterization of new antigens from simian virus 40-transformed mouse cells
    • Chang C, Simmons DT, Martin MA and Mora PT (1979) Identification and partial characterization of new antigens from simian virus 40-transformed mouse cells. J Virol 31:463-471 (Pubitemid 9233893)
    • (1979) Journal of Virology , vol.31 , Issue.2 , pp. 463-471
    • Chang, C.1    Simmons, D.T.2    Martin, M.A.3    Mora, P.T.4
  • 51
    • 0018769971 scopus 로고
    • Simian virus 40-transformed cells express new species of proteins precipitable by anti-simian virus 40 tumor serum
    • Kress M, May E, Cassingena R and May P (1979) Simian virus 40-transformed cells express new species of proteins precipitable by anti-simian virus 40 tumor serum. J. Virol. 31:472-483 (Pubitemid 9233894)
    • (1979) Journal of Virology , vol.31 , Issue.2 , pp. 472-483
    • Kress, M.1    May, E.2    Cassingena, R.3    May, P.4
  • 52
    • 0018348655 scopus 로고
    • T antigen is bound to a host protein in SV40 transformed cells
    • Lane DP and Crawford LV (1979) T antigen is bound to a host protein in SV40-transformed cells. Nature 278, 261-263 (Pubitemid 9129076)
    • (1979) Nature , vol.278 , Issue.5701 , pp. 261-263
    • Lane, D.P.1    Crawford, L.V.2
  • 53
    • 0018760324 scopus 로고
    • Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40 transformed cells and uninfected embryonal carcinoma cells
    • Linzer DIH and Levine AJ (1979) Characterization of a 54 K dalton cellular SV40 tumor antigen resent in SV40-transformed cells and in infected embryonal carcinoma cells. Cell 17: 43-52. (Pubitemid 9188209)
    • (1979) Cell , vol.17 , Issue.1 , pp. 43-52
    • Linzer, D.I.H.1    Levine, A.J.2
  • 54
    • 0018348936 scopus 로고
    • Identification of new polypeptide species (48-55K) immunoprecipitable by antiserum to purified large T antigen and present in SV40-infected and -transformed cells
    • Melero JA, Stitt DT, Mangel WF and Carroll RB (1979) Identification of new polypeptide species (48-55 K) immunoprecipitable by anti-serum to purified large T antigen and present in simian virus 40-infected and transformed cells. J. Virol. 93:466-480. (Pubitemid 9145500)
    • (1979) Virology , vol.93 , Issue.2 , pp. 466-480
    • Melero, J.A.1    Stitt, D.T.2    Mangel, W.F.3    Carroll, R.B.4
  • 55
    • 0018743916 scopus 로고
    • Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse
    • DOI 10.1073/pnas.76.5.2420
    • DeLeo A, Jay G, Appella E, Dubois GC, Law LW and Old LJ (1979) Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proceedings of the National Academy of Sciences, USA 76:2420-2424 (Pubitemid 9185501)
    • (1979) Proceedings of the National Academy of Sciences of the United States of America , vol.76 , Issue.5 , pp. 2420-2424
    • DeLeo, A.B.1    Jay, G.2    Appella, E.3
  • 56
    • 0019898801 scopus 로고
    • Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer
    • DOI 10.1002/ijc.2910300404
    • Crawford LV, Pim DC and Bulbrook RD (1982) Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer. Int. J. Cancer 30: 403-408. (Pubitemid 12003724)
    • (1982) International Journal of Cancer , vol.30 , Issue.4 , pp. 403-408
    • Crawford, L.V.1    Pim, D.C.2    Bulbrook, R.D.3
  • 57
    • 0021616838 scopus 로고
    • UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells
    • Maltzman W and Czyzyk L (1984) UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol. Cell. Biol. 4:1689-1694 (Pubitemid 14008276)
    • (1984) Molecular and Cellular Biology , vol.4 , Issue.9 , pp. 1689-1694
    • Maltzman, W.1    Czyzyk, L.2
  • 58
    • 0021471591 scopus 로고
    • The use of monoclonal antibodies for selection of a low-abundance mrna: P53
    • Benchimol S., Matlashewski G. and Crawford L. (1984) The use of monoclonal antibodies for selection of a low-abundance mRNA: p53. Biochem Soc Trans 12(4):708-711
    • (1984) Biochem Soc Trans , vol.12 , Issue.4 , pp. 708-711
    • Benchimol, S.1    Matlashewski, G.2    Crawford, L.3
  • 59
    • 0001606206 scopus 로고
    • Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells
    • DOI 10.1073/pnas.82.3.790
    • Wolf D and Rotter V (1985) Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells. Proceedings of the National Academy of Sciences USA 82:790-794. (Pubitemid 15142764)
    • (1985) Proceedings of the National Academy of Sciences of the United States of America , vol.82 , Issue.3 , pp. 790-794
    • Wolf, D.1    Rotter, V.2
  • 60
    • 0023153055 scopus 로고
    • Presence of circulating antibodies against cellular protein p53 in a notable proportion of children with B-cell lymphoma
    • DOI 10.1002/ijc.2910390211
    • Caron de Fromentel C, May-Levin F, Mouriesse H, Lemerle J, Chandrasekaran K and May P (1987) Presence of circulating antibodies against cellular protein p53 in a notable proportion of children with B-cell lymphoma. Int. J. Cancer 39:185-189 (Pubitemid 17015278)
    • (1987) International Journal of Cancer , vol.39 , Issue.2 , pp. 185-189
    • De Fromentel, C.C.1    May-Levin, F.2    Mouriesse, H.3
  • 61
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: Positive and negative feedback loops
    • DOI 10.1038/sj.onc.1208615
    • Harris SL and Levine AJ (2005) The p53 pathway: positive and negative feedback loops. Oncogene 24:2899-2908 (Pubitemid 40638098)
    • (2005) Oncogene , vol.24 , Issue.17 , pp. 2899-2908
    • Harris, S.L.1    Levine, A.J.2
  • 62
    • 0034032170 scopus 로고    scopus 로고
    • Regulation of p53 stability and activity in response to genotoxic stress
    • DOI 10.1016/S1383-5742(00)00035-1, PII S1383574200000351
    • Colman MS, Afshar, CA and Barrett JC (2000) Regulation of p53 stability and activity in response to genotoxic stress. Mutation Research/Reviews in Mutation Research 462:179-188. (Pubitemid 30190225)
    • (2000) Mutation Research - Reviews in Mutation Research , vol.462 , Issue.2-3 , pp. 179-188
    • Colman, M.S.1    Afshari, C.A.2    Barrett, J.C.3
  • 63
    • 0035211073 scopus 로고    scopus 로고
    • The p53 functional circuit
    • Jin S and Levine AJ (2001) The p53 functional circuit. J Cell Sci 114:4139-4140. (Pubitemid 33138651)
    • (2001) Journal of Cell Science , vol.114 , Issue.23 , pp. 4139-4140
    • Jin, S.1    Levine, A.J.2
  • 64
    • 33646807832 scopus 로고    scopus 로고
    • The p53 pathway: What questions remain to be explored?
    • Levine AJ, Hu W and Feng Z (2006) The P53 pathway: what questions remain to be explored? Cell Death Differ 13:1027-1036.
    • (2006) Cell Death Differ , vol.13 , pp. 1027-1036
    • Levine, A.J.1    Hu, W.2    Feng, Z.3
  • 66
    • 0031671043 scopus 로고    scopus 로고
    • Identification and chromosomal assignment of two heterozygous mutations in the Trp53 gene in L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells
    • DOI 10.1093/mutage/13.5.427
    • Clark LS, Hart DW, Vojta PJ, Harrington-Brock K, Barrett JC, Moore MM and TIndall KR (1998) Identification and chromosomal assignment of two heterozygous mutations in the Trp53 gene in L5178Y Tk(+/-)-3.7.2C mouse lymphoma cells. Mutagenesis 13:427-434 (Pubitemid 28458725)
    • (1998) Mutagenesis , vol.13 , Issue.5 , pp. 427-434
    • Clark, L.S.1    Hart, D.W.2    Vojta, P.J.3    Harrington-Brock, K.4    Barrett, J.C.5    Moore, M.M.6    Tindall, K.R.7
  • 67
    • 21544473568 scopus 로고    scopus 로고
    • Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens: I. Sensitivity, specificity and relative predictivity
    • DOI 10.1016/j.mrgentox.2005.02.004, PII S1383571805000835
    • Kirkland D, Aardema M, Henderson L and Müller L (2005). Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens: I. Sensitivity, specificity and relative predictivity. Mutation Research 584: 1-256 (Pubitemid 40922793)
    • (2005) Mutation Research - Genetic Toxicology and Environmental Mutagenesis , vol.584 , Issue.1-2 , pp. 1-256
    • Kirkland, D.1    Aardema, M.2    Henderson, L.3    Muller, L.4
  • 68
    • 33747751533 scopus 로고    scopus 로고
    • Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens. II. Further analysis of mammalian cell results, relative predictivity and tumour profiles
    • DOI 10.1016/j.mrgentox.2006.04.017, PII S1383571806001033
    • Kirkland D, Aardema M, Müller L and Hayashi M (2006). Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens: II. Further analysis of mammalian cell results, relative predictivity and tumour profiles. Mutation Research 608: 29-42 (Pubitemid 44280041)
    • (2006) Mutation Research - Genetic Toxicology and Environmental Mutagenesis , vol.608 , Issue.1 , pp. 29-42
    • Kirkland, D.1    Aardema, M.2    Muller, L.3    Hayashi, M.4
  • 69
    • 33847325174 scopus 로고    scopus 로고
    • How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM workshop
    • Kirkland D, Pfuhler S, Tweats D et al. (2007). How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop. Mutation Research 628:31-55
    • (2007) Mutation Research , vol.628 , pp. 31-55
    • Kirkland, D.1    Pfuhler, S.2    Tweats, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.