Analysis of large and small colony L5178Y tk(-/-) mouse lymphoma mutants by loss of heterozygosity (LOH) and by whole chromosome 11 painting: Detection of recombination

Mutagenesis

Volumn 13, Issue 5, 1998, Pages 461-474

  Liechty, Melissa C ^a   Scalzi, Jane M ^a   Sims, Kenneth R ^a   Crosby Jr , Herbert ^a   Spencer, Diane L ^b   Davis, Lisa M ^a   Caspary, William J ^b   Hozier, John C ^a  

^a Applied Genetics Laboratories Inc   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MICROSATELLITE DNA;

ANEUPLOIDY; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL GROWTH; CELL MUTANT; CHROMOSOME 11; CHROMOSOME PAINTING; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DNA RECOMBINATION; HETEROZYGOSITY LOSS; LYMPHOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANEUPLOIDY; ANIMALS; CELL DIVISION; CHROMOSOME ABERRATIONS; CHROMOSOME PAINTING; CLONE CELLS; LEUKEMIA L5178; LOSS OF HETEROZYGOSITY; MICE; MUTATION; NEOPLASM PROTEINS; RECOMBINATION, GENETIC; SEQUENCE DELETION; THYMIDINE KINASE;

ANIMALIA;

EID: 0031671608     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/13.5.461     Document Type: Article

References (74)

1. Acuna,G., Wurgler,F.E. and Sengstag,C. (1994) Reciprocal mitotic recombination is the predominant mechanism for the loss of a heterozygous gene in Saccharomyces cerevisiae. Environ. Mol. Mutagen., 24, 307-316.
2. Applegate,M.L., Moore,M.M., Broder,C.C., Burrell,A., Juhn,G., Kasweck, K.L., Lin,P.-F., Wadhams,A. and Hozier,J.C. (1990) Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells. Proc. Natl Acad. Sci. USA, 87, 51-55.
3. Amacher,D.E., Paillet,S.C., Turner,G.N., Ray,V.A. and Salsburg,D.S. (1980) Point mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells. II. Test validation and interpretation. Mutat. Res., 72, 447-474.
4. Auletta,A.E., Dearfield,K.L. and Cimino,M.C. (1993) Mutagenicity test schemes and guidelines: U.S. EPA Office of Pollution Prevention and Toxics and Office of Pesticide Programs. Environ. Mol. Mutagen., 21,38-45.
5. Baird,P.N., Pritchard,J. and Colwell,U.K. (1994) Molecular genetic analysis of chromosome 11p in familial Wilms tumor. Br. J. Cancer, 69, 1072-1077.
6. Baker,B.S., Carpenter,A.T.C. and Gatti,M. (1987) On the biological effects of mutants producing aneuploidy in Drosaphila. In Vig,B.K. and Sandberg,A.A. (eds), Aneuploidy, Part A: Incidence and Etiology. Wiley Liss, New York, NY, pp. 273-296.
7. Bianchi,A.B., Navone,N.M., Aldaz,C.M. and Conti,C.J. (1991) Overlapping loss of heterozygosity by mitotic recombination on mouse chromosome 7F1-ter in skin carcinogenesis. Proc. Natl Acad. Sci. USA, 88, 7590-7594.
8. Blazak,W.F., Stewart,B.E., Galperin,I., Allen,K.L., Rudd,C.J., Mitchell,A.D. and Caspary,W.J. (1986a) Chromosome analysis of trifluorothymidineresistant L5178Y mouse lymphoma cell colonies. Environ. Mutagen., 8, 229-240.
9. Blazak,W., Stewart,B., Galperin,I., Allen,K., Rudd,C., Mitchell,A. and Caspary,W. (1986b) Stable dicentric chromosomes induced by chemical mutagens in L5178Y mouse lymphoma cells. Mutat. Res., 173, 263-266.
10. Blazak,W.F., Los,F.J., Rudd,C.J. and Caspary.W.J. (1989) Chromosome analysis of small and large L5178Y mouse lymphoma cell colonies. Comparison of trifluorothymidine-resistant and unselected cell colonies from mutagen-treated and control cultures. Mutat. Res., 224, 197-208.
11. Bremner,R. and Balmain,A. (1990) Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell, 61, 407-417.
12. Chen,L.-C., Matsumura,K., Deng,G., Kurisu,W., Ljung,B.-M., Lerman,M.I., Waldman,F.M. and Smith,H.S. (1994) Deletion of two separate regions on chromosome 3p in breast cancers. Cancer Res., 54, 3021-3024.
13. Clive,D. (1985) Mutagenicity in drug development: interpretation and significance of test results. Regulatory Toxicol. Pharmacol., 5, 79-100.
14. Clive,D., Flamm,W.G., Machesko,M.R. and Bernheim,N.J. (1972) A mutational assay system using the thymidine kinase locus in mouse lymphoma cells. Mutat. Res., 16, 77-87.
15. +/- mouse lymphoma mutagen assay system. Mutat. Res., 59, 61-108.
16. +/- mouse lymphoma cells. Mutagenesis, 5, 191-197.
17. Copeland,N.G., Jenkins,N.A., Gilbert,D.J., Eppig,J.T. Maltais,L.J., Miller,J.C., Dietrich,W.F., Weaver,A., Lincoln,S.E., Steen,R.G., Stein,L.D., Nadeau,J.H., and Lander,E.S. (1993a) A genetic linkage map of the mouse: current applications and future prospects. Science, 262, 57-66.
18. Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Nadeau,J.H., Eppig,J.T., Maltais, L.J., Miller,J.C., Dietrich,W.F., Steen,R.G., Lincoln,S.E., Weave,A., Joyce, D.C., Merchant,M., Wessel,M., Katz,H., Stein,L.D., Reeve,M.P., Daly,M.J., Dredge,R.D., Marquis,A., Goodman,N. and Lander,E.S. (1993b) Genome maps IV: the mouse. Science, 262, 67-82.
19. Coppes,M.J., Bonetta,L., Huang,A., Hoban,P., Chilton-MacNeill,S., Campbell, C.E., Weksberg,R., Yeger,H., Reeve,A.E. and Williams,B.R. (1992) Loss of heterozygosity mapping in Wilms tumor indicates the involvement of three distinct regions and a limited role for nondisjunction or mitotic recombination. Genes Chromosomes Cancer, 5, 326-334.
20. Dietrich,W.F., Miller,J., Katz,H., Joyce,D., Stean,R., Lincoln,S., Daly,M., Reeve,M.P., Goodman,N., Dracopoli,N. and Lander,E.S. (1992) In O'Brien,S.J. (ed.), Genetic Maps 1992. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, Vol. 4, pp. 110-142.
21. Dietrich,W.F., Miller,J., Steen,R., Merchant,M.A., Damron-Boles,D., Husain,Z., Dredge,R., Daly,M.J., Ingalls,K.A., O'Connor,T.J., Evans,C.A., DeAngelis,M.M., Levinson,D.A., Kruglyak,L., Goodman,N., Copeland, N.G., Jenkins,N.A., Hawkins,T.L., Stein,L., Page,D.C. and Lander,E.S. (1996) A comprehensive genetic map of the mouse genome. Nature, 380, 149-152.
22. Evans,H.H., Mencl,J., Horng,M.-F., Ricanati,M., Sanchez,C. and Hozier,J. (1986) Locus specificity in the mutability of L5178Y mouse lymphoma cells: the role of multilocus lesions. Proc. Natl Acad. Sci. USA, 83, 4379-4383.
23. Evans,H.H., Mencl,J., Ricanati,M., Horng,M.-F., Chaudhry,M.A., Jiang,Q., Hozier,J. and Liechty,M. (1996) Induction of multilocus mutations at the Tk1 locus after X irradition of L5178Y cells at different times in the mitotic cycle. Radiat. Res., 146, 131-138.
24. Garriott,M.L., Casciano.D.A., Schechtman,L.M. and Probst,G.S. (1995) International workshop on mouse lymphoma assay testing practices and data interpretations: Portland, Oregon, May 7,1994. Environ. Mol. Mutagen., 25, 162-164.
25. -/- mutants: extent of damage as determined by microsatellite DNA polymorphisms (abstract). Environ. Mol. Mutagen., 25, 19.
26. Gollahon,L.S., Chen,A. and Aldaz,CM. (1995) Loss of heterozygosity at chromosome 1q loci in rat mammary tumors. Mol. Carcinogen., 12, 7-13.
27. Gudas,J.M., Fridovich-Keil,J.L., Datta,M.W., Bryan,J. and Pardee,A.B. (1992) Characterization of the murine thymidine kinase-encoding gene and analysis of transcription start point heterogeneity. Gene, 118, 205-216.
28. Hahn,P.J., Giddings,L., Longo,J., Lane,M.J., Scalzi,J. and Hozier,J. (1992) Double-minute chromosomes as megabase cloning vehicles. Genet. Anal. Tech.Appl.,9, 17-25.
29. Hearne,C.M., McAleer,M.A., Love,J.M., Aitman,T.J., Cornall,R.J., Ghosh,S., Knight,A.M., Prins,J.-B. and Todd,T.A. (1991) Additional microsatellite markers for mouse genome mapping. Mamm. Genome., 1, 273-282.
30. -/- mouse lymphoma mutagenesis assay system. Mutat. Res., 84, 169-181.
31. +/- 3.7.2C mouse-lymphoma cell line. Mutat. Res., 105, 451-456.
32. -/-mutants early in their clonal history. Annls NY Acad. Sci., 401, 423-425.
33. -/- mutants early in their clonal history. Mutat. Res., 147, 237-242.
34. -/- mutants. Mutat. Res., 214, 195-199.
35. Hozier,J.C., Scalzi,J., Sawyer,J., Carley,N., Applegate,M., Clive,D. and Moore,M. (1991) Localization of the mouse thymidine kinase gene to the distal portion of chromosome 11. Genomics, 10, 827-830.
36. Hozier,J., Applegate,M. and Moore,M.M. (1992) In vitro mammalian muuigenesis as a model for genetic lesions in human cancer. Mutat. Res., 270, 201-209.
37. Kirkland,D.J. (1993) Genetic toxicology testing requirements: official and unofficial views from Europe. Environ. Mol. Mutagen., 21, 8-14.
38. -/- mutants in TK6 human lymphoblastoid cultures. Environ. Mol. Mutagen. 14, 149-154.
39. Lane,M.J., Waterbury,P.G., Carroll,W.T., Smardon,A.M., Faldasz,B.D., Peshick,S.M., Mante,S., Huckaby,C.S., Kouri,R.E., Hanlon,D.J., Hahn,P.J., Scalzi,J.M. and Hozier,J.C. (1992) Variation in genomic Alu repeat density as a basis for rapid construction of low resolution physical maps of human chromosomes. Chromosoma, 101, 349-357.
40. Li,C.-Y., Yandell,D.W. and Little,J.B. (1992) Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro. Somatic Cell Mol. Genet., 18, 77-87.
41. Li,C.Y., Yandell,D.W. and Little,J.B. (1994) Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus. Mol. Cell. Biol., 14, 4373-4379.
42. Liber,H.L. and Thilly,W.G. (1982) Mutation assay at the thymidine kinase locus in diploid human lymphoblasts. Mutat. Res., 94, 467-485.
43. Liber,H.L., Yandell,D.W. and Little,J.B. (1989) A comparison of mutation induction at the tk and hprt loci in human lymphoblastoid cells: quantitative differences are due to an additional class of mutations at the autosomal tk locus. Mutat. Res. 216, 9-17.
44. -/- mutants. Mutat. Res., 286, 299-307.
45. Liechty,M.C., Hassanpour,Z., Hozier,J.C. and Clive,D. (1994) Use of microsatellite DNA polymorphisms on mouse chromosome 11 for in vitro analysis of thymidine kinase gene mutations. Mutagenesis, 9, 423-427.
46. Liechty,M.C, Hall,B.K., Scalzi,J.M., Davis,L.M., Caspary,W.J. and Hozier,J.C. (1995) Mouse chromosome-specific painting probes generated from microdissected chromosomes Mamm. Genet., 6, 592-594.
47. Liechty,M.C., Crosby,H.Jr., Murthy,A., Davis,L.M., Caspary,W.J. and Hozier,J.C. (1996) Identification of a heteromorphic microsatellite within the thymidine kinase gene in L5178Y mouse lymphoma cells. Mutat. Res., 371, 265-271.
48. 2 arrest in Chinese hamster ovary cells. Cancer Res., 50, 3761-3766.
49. Love,J.M., Knight,A.M., McAleer,M.A. and Todd,J.A. (1990) Towards Construction of a high resolution map of the mouse genome using PCR-analysed microsatellites. Nucleic Acids Res., 18, 4123-4130.
50. Mȧnnens,M., Slater,R.M., Heyting.C., Bliek,J., de Kraker,J., Coad,N., de Pagter-Holthuizen,P. and Pearson,P.L. (1988) Molecular nature of genetic changes resulting in loss of heterozygosity of chromosome 11 in Wilms' tumours. Hum. Genet., 81, 41-48.
51. Mitchell,A.D. (1997) Alternate hypothesis for the bimodal size distribution of mutant colonies of L5178Y mouse lymphoma cells. Environ. Mol. Mutagen., 29, 431-433.
52. +/- mouse lymphoma specific gene and chromosomal mutation assay: a phase III report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat. Res., 394, 177-303.
53. +/- mouse lymphoma cells. Mutat. Res.. 151, 161-174.
54. Moore,M.M., Brock,K.H., DeMarini D.M. and Doerr,C.L. (1987) Differential recovery of induced mutants at the tk and hprt loci in mammalian cells. In Banbury Report 28: Mammalian Cell Mutagenesis. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 93-108.
55. Moore,M.M., Harrington-Brock,K., Doerr,C.L. and Dearfield,K.L. (1989) Differential mutant quantitation at the mouse lymphoma tk and CHO hprt loci. Mutagenesis, 4, 394-403.
56. +/- mouse lymphoma cells. Mutat. Res., 85, 363-378.
57. Mori,N., Yokota,J., Oshimura,M., Cavenee,W.K., Mizoguchi,H., Nogushi,M., Shimosato,Y, Sugimura,T. and Terada.M. (1989) Concordant deletions of chromosome 3p and loss of heterozygosity for chromosomes 13 and 17 in small cell lung carcinoma. Cancer Res., 49, 5130-5135.
58. Muncke,M. and Francke,U. (1987) The physical map of Mus musculus chromosome 11 reveals evolutionary relationships with different syntenic groups of genes in Homo sapiens. J. Mol. Evol., 25, 134-140.
59. +/- mouse lympboma assay. Environ. Mol. Mutagen, 27, 75-78.
60. Rudd,C.J., Daston,D.S. and Caspary,W.J. (1990) Spontaneous mutation rates in mammalian cells: effect of differential growth rates and phenotypic lag. Genetics, 126, 435-442.
61. +/- mouse lymphoma cell line. Mutat. Res., 147, 243-253.
62. Spencer,D.L. and Caspary,W.J. (1994) In situ and suspension protocols for chemically-induced mutation at the tk locus in L5178Y MOLY cells: dose response and colony size distribution. Mutat. Res., 322, 291-300.
63. Spencer,D.L., Hines,K.C. and Caspary,W.J. (1994) An in situ protocol for measuring the expression of chemically-induced mutations in mammalian cells. Mutat. Res. 312, 85-97.
64. +/- cell line is heterozygous for a codon 170 mutation in the p53 tumor suppressor gene. Mutat. Res., 373, 157-165.
65. Tennant,R.W., Margolin,B.H., Shelby,M.D., Zeiger,E., Haseman,J.K., Spalding,J., Caspary,W., Resnick,M., Stasiewicz,S., Anderson,B. and Minor,R. (1987) Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays. Science, 236, 933-941.
66. Ushijima,T., Makino,H., Okonogi,H., Hosoya,Y., Sugimura,T. and Nagao,M. (1995) Mutation, loss of heterozygosity, and recombination of the p53 gene in mouse forestomach tumors induced by 2-amino-3,4-dimethylimidazo[4,5-flquinoline. Mol. Carcinogen., 12, 23-30.
67. van der Hout,A.H., van den Berg,E., van der Vlies,P., Dijkhuizen,T., Storkel,S., Oosterhuis,J.W., de Jong,B. and Buys,C.H. (1993) Loss of heterozygosity at the short arm of chromosome 3 in renal-cell cancer correlated with the cytological tumor type. Int. J. Cancer, 53, 353-357.
68. Watkins-Chow,D., Roller,C.H., Newhouse,M.M., Buchberg,A.M. and Camper,S.A. (1996) Mouse chromosome 11. Mamm. Genet., 6, S201-S220.
69. Weinert,T.A. and Hartwell,L.H. (1988) The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science, 241, 317-322.
70. Xia,F., Amundson,S.A., Nickoloff,J.A. and Liber,H.L. (1994) Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation. Mol. Cell. Biol., 14, 5850-5857.
71. Yandell,D.E.W., Dryja,T.P. and Little,J.B. (1986) Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations. Somat. Cell Mol. Genet., 12, 255-263.
72. Yang-Feng,T.L., Han,H., Chen,K.C, Li,S.B., Claus,E.B., Carcangiu.M.L., Chambers,S.K., Chambers,J.T. and Schwartz,P.E. (1993) Allelic loss in ovarian cancer. Int. J. Cancer, 54, 546-551.
73. Zeiger,E., Haseman,J.K., Shelby,M.D., Margolin,B.H. and Tennant,R.W. (1990) Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: confirmation of earlier results with 41 additional chemicals. Environ. Mol. Mutagen., 16, 1-14.
74. Zhu,X., Dunn,J.M., Goddard,A.D., Squire,J.A., Becker,A., Phillips,R.A. and Gallie,B.L. (1992) Mechanisms of loss of heterozygosity in retinoblastoma. Cytogenet. Cell Genet., 59, 248-252.