Investigation of Ehrlich ascites tumor cell death mechanisms induced by Synadenium umbellatum Pax.

Journal of Ethnopharmacology

Volumn 139, Issue 2, 2012, Pages 319-329

  Da Mota, Mariana Flavia ^a   Benfica, Polyana Lopes ^a   Batista, Aline Carvalho ^a   Martins, Frederico Severino ^a   De Paula, José Realino ^a   Valadares, Marize Campos ^a  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

Author keywords

Apoptosis; Cell death; Ehrlich ascites tumor; Euphorbiaceae; Myelotoxicity; Synadenium umbellatum

Indexed keywords

CALCIUM ION; CASPASE 3; CASPASE 8; CASPASE 9; CYTOTOXIC AGENT; HERBACEOUS AGENT; PHOSPHATIDYLSERINE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW TOXICITY; CALCIUM CELL LEVEL; CELL CYCLE ARREST; CELL DEATH; CELL VIABILITY; COLONY FORMING UNIT GM; CONTROLLED STUDY; CYTOTOXICITY; EHRLICH ASCITES TUMOR CELL; ENZYME ACTIVATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; IMMUNOCYTOCHEMISTRY; MALE; MEDICINAL PLANT; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; SYNADENIUM UMBELLATUM;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CALCIUM; CARCINOMA, EHRLICH TUMOR; CASPASE 3; CASPASE 8; CASPASE 9; CELL CYCLE; CELL SHAPE; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; EUPHORBIACEAE; FLOW CYTOMETRY; GRANULOCYTE-MACROPHAGE PROGENITOR CELLS; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICROSCOPY, FLUORESCENCE; OXIDATIVE STRESS; PHOSPHATIDYLSERINES; PLANT COMPONENTS, AERIAL; PLANTS, MEDICINAL; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED;

EUPHORBIACEAE; SYNADENIUM;

EID: 84856002326     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.04.055     Document Type: Article

References (59)

1. T.S. Abondanza, C.R. Oliveira, C.M. Barbosa, F.E. Pereira, R.L. Cunha, A.C. Caires, J.V. Comasseto, M.L. Queiroz, M.C. Valadares, and C. Bincoletto Bcl-2 expression and apoptosis induction in human HL60 leukaemic cells treated with a novel organotellurium(IV) compound RT-04 Food and Chemical Toxicology 46 2008 2540 2545
2. P. Abreu, S. Matthew, T. González, D. Costa, M.A. Segundo, and E. Fernandes Anti-inflammatory and antioxidant activity of a medicinal tincture from Pedilanthus tithymaloides Life Sciences 78 2006 1578 1585 (Pubitemid 43259465)
3. Z. Amirghofran, M. Bahmani, A. Azadmehr, and K. Javidnia Induction of apoptosis in leukemia cell lines by Linum persicum and Euphorbia cheiradenia Journal of Cancer Research and Clinical Oncology 132 2006 427 432
4. M.J. Balunas, and D. Kinghorn Drug discovery from medicinal plants Life Sciences 78 2005 431 441 (Pubitemid 41653493)
5. E. Bedner, X. Li, W. Gorczyca, M.R. Melamed, and Z. Darzynkiewicz Analysis of apoptosis by laser scanning cytometry Cytometry 35 1999 181 195 (Pubitemid 29104396)
6. S. Block, P. Gerkens, O. Peulen, O. Jolois, M.P. Mingeot-Leclercq, M.C. De Pauw-Gillet, and J. Quetin-Leclercq Induction of apoptosis in human promyelocytic leukemia cells by a natural trachylobane diterpene Anticancer Research 25 2005 363 368 (Pubitemid 40470131)
7. A.P.A. Boleti, C.A. Ventura, G.Z. Justo, R.A. Silva, A.C.T. Sousa, C.V. Ferreira, T. Yano, and M.L.R. Macedo Pouterin, a novel potential cytotoxic lectin-like protein with apoptosis-inducing activity in tumorigenic mammalian cells Toxicon 51 2008 1321 1330 (Pubitemid 351787342)
8. J. Chandra, A. Samali, and S. Orrenius Triggering and modulation of apoptosis by oxidative stress Free Radical Biology & Medicine 29 2000 323 333
9. A.P. Cunha Farmacognosia e fitoquímica 2005 Fundaão Calouste Gulbenkian Lisboa 670 pp.
10. L.C. Cunha, F.S. Azeredo, A.C.V. Mendona, M.S. Vieira, L.L. Pucci, C. Marize, Valadares, H.O.G. Freitas, A.A.S. Sena, and R.S. Lino Junior Avaliaão da toxicidade aguda e subaguda, em ratos, do extrato etanólico das folhas e do látex de Synadenium umbellatum Pax. Brazilian Journal of Pharmacognosy 19 2A 2009 403 411
11. N.N. Danial, and S.J. Korsmeyer Cell death: critical control points Cell 116 2004 205 219 (Pubitemid 38167313)
12. G. Deep, and R. Agarwal New combination therapies with cell cycle agents Current Opinion in Investigational Drugs 9 2008 591 604 (Pubitemid 351777163)
13. N. Duarte, C. Ramalhete, A. Varga, J. Molnár, and M.J. Ferreira Multidrug resistance modulation and apoptosis induction of cancer cells by terpenic compounds isolated from Euphorbia species Anticancer Research 29 2009 4467 4472
14. B.S. El-Menshawi, W. Fayad, K. Mahmoud, S.M. El-Hallouty, M. El-Manawaty, M.H. Olofsson, and S. Linder Screening of natural products for therapeutic activity against solid tumors Indian Journal of Experimental Biology 48 2010 258 264
15. M.O. Fatope, L. Zeng, J.E. Ohayaga, G. Shi, and J.L. McLaughlin Selectively cytotoxic diterpenes from Euphorbia poisonii Journal of Medicinal Chemistry 39 1996 1005 1008 (Pubitemid 26067632)
16. R. Franco, R. Sánchez-Olea, E.M. Reyes-Reyes, and M.I. Panayiotidis Environmental toxicity, oxidative stress and apoptosis: Ménage à Trois Mutation Research 674 2009 3 22
17. E. Galeano, E. Nieto, A.I. García-Pérez, M.D. Delgado, M. Pinilla, and P. Sancho Effects of the antitumoural dequalinium on NB4 and K562 human leukemia cell lines mitochondrial implication in cell death Leukemia Research 29 2005 1201 1211 (Pubitemid 41169237)
18. P. Giridharan, S.T. Somasundaram, K. Perumal, R.A. Vishwakarma, N.P. Karthikeyan, R. Velmurugan, and A. Balakrishnan Novel substituted methylenedioxy lignan suppresses proliferation of cancer cells by inhibiting telomerase and activation of c-myc and caspases leading to apoptosis British Journal of Cancer 87 2002 98 105
19. L. Gribaldo, S. Casati, A.F. Castoldi, and A. Pessina Comparison of in vitro drug-sensitivity of human granulocyte-macrophage progenitors from two different origins: umbilical cord blood and bone marrow Experimental Hematology 27 1999 1593 1598 (Pubitemid 29526743)
20. N.F. Grymberg, A. Echevarria, J.E. Lima, S.S.R. Pamplona, A.C. Pinto, and M.A.M. Maciel Anti-tumour activity of two 19-nor-clerodane diterpenes, trans-dehydrocrotonin and trans-crotonin, from Croton cajucara Planta Medica 65 1999 687 689
21. 2+ uptake in apoptosis Cell Calcium 40 2006 553 560 (Pubitemid 44660721)
22. K.B. Harikumar, G. Kuttan, and R. Kuttan Phyllanthus amarus inhibits cell growth and induces apoptosis in Dalton's lymphoma ascites cells through activation of caspase-3 and downregulation of Bcl-2 Integrative Cancer Therapies 8 2009 190 194
23. W. Hu, and J.J. Kavanagh Anticancer therapy targeting the apoptotic pathway Oncology 4 2003 721 729 (Pubitemid 37527207)
24. Y.T. Huang, D.M. Huang, S.C. Chueh, C.M. Teng, and J.H. Guh Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells Cancer Letters 231 2006 270 278
25. H. Itokawa, Y. Ichihara, K. Watanabe, and K. Takeya An antitumor principle from Euphorbia lathyris Planta Medica 55 1989 271 272 (Pubitemid 19149103)
26. K. Kannan, and S.K. Jain Oxidative stress and apoptosis Pathophysiology 7 2000 153 163
27. I.S. Kielland, J.M. Dornish, K.E. Malterud, G. Hvistendahl, C. Romming, O.C. Bockman, P. Kolsaker, Y. Stenstrom, and A. Nordal Cytotoxic triterpenoids from the leaves of Euphorbia pulcherrima Planta Medica 62 1996 322 325 (Pubitemid 26272507)
28. G. Kroemer, L. Galluzzi, P. Vandenabeele, J. Abrams, E.S. Alnemeri, E.H. Baehrecke, M.V. Blagosklonny, W.S. El-Deiry, P. Golstein, D.R. Green, M. Hengartner, R.A. Knight, S. Kumar, S.A. Lipton, W. Malorni, G. Nuñez, M.E. Peter, J. Tschopp, J. Yuan, M. Piacentini, B. Zhivotovsky, and G. Melino Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 Cell Death and Differentiation 16 2009 3 11
29. S.M. Kupchan, I. Uchida, A.R. Branfman, R.G. Dailey Jr., and B.Y. Fei Antileukemic principles isolated from Euphorbiaceae plants Science 191 1976 571 572
30. 2+ dependent endonuclease Biochemical Pharmacology 63 2002 225 236
31. J.W.H. Li, and J.C. Vederas Drug discovery and natural products: end of an era or an endless frontier? Science 325 2009 161 165
32. 2+ homeostasis Cancer Chemotherapy and Pharmacology 55 2005 79 90 (Pubitemid 40064499)
33. H. Luo, and A. Wang Induction of apoptosis in K562 cells by jolkinolide B Canadian Journal of Physiology and Pharmacology 84 2006 959 965
34. M.A.M. Maciel, A.C. Pinto, A.C. Arruda, S.G.S.R. Pamplona, F.A. Vanderlinde, A.J. Lapa, A. Echevarria, N.F. Grynberg, I.M.S. Côlus, R.A.F. Farias, A.M.L. Costa, and V.S.N. Rao Ethnopharmacology, phytochemistry and pharmacology: a successful combination in the study of Croton cajucara Journal of Ethnopharmacology 70 2000 41 55 (Pubitemid 30138069)
35. G. Makin, and C. Dive Apoptosis and cancer chemotherapy Trends in Cell Biology 11 11 2001 S22 S26
36. P.R. Melo-Reis, L.S.A. Bezerra, M.A.A.B. Vale, R.F.R. Canhête, and L. Chen-Chen Assessment of the mutagenic and antimutagenic activity of Synadenium umbellatum Pax. latex by micronucleus test in mice Brazilian Journal of Biology 71 2011 169 174
37. T.P. Miller, T.M. Grogan, S. Dahlberg, C.M. Spier, R.M. Braziel, P.M. Banks, K. Foucar, C.R. Kjeldsberg, N. Levy, and B.N. Nathwani Prognostic significance of the Ki-67-associated proliferative antigen in aggressive non-Hodgkin's lymphomas: a prospective Southwest oncology group trial Blood 83 1994 1460 1466 (Pubitemid 24081556)
38. A. Morales, P. Pérez, R. Mendozab, R. Compagnonec, A.I. Suarez, F. Arvelob, J.L. Ramírez, and I. Galindo-Castro Cytotoxic and proapoptotic activity of ent-16b-17a-dihydroxykaurane on human mammary carcinoma cell line MCF-7 Cancer Letters 218 2005 109 116 (Pubitemid 40082707)
39. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays Journal of Immunology Methods 65 1983 55 63 (Pubitemid 14203433)
40. C. Ngamkitidechakul, K. Jaijoy, P. Hansakul, N. Soonthornchareonnon, and S. Sireeratawong Antitumour effects of Phyllanthus emblica L.: induction of cancer cell apoptosis and inhibition of in vivo tumour promotion and in vitro invasion of human cancer cells Phytotherapy Research 24 2010 1405 1413
41. I.A.L. Nogueira, A.B.B. Leão, M.S. Vieira, P.L. Benfica, L.C. Cunha, and M.C. Valadares Antitumoral and antiangiogenic activity of Synadenium umbellatum Pax. Journal of Ethnopharmacology 120 2008 474 478 (Pubitemid 50310173)
42. T. Ona, and J. Shibata Advanced dynamic monitoring of cellular status using label-free and non-invasive cell-based sensing technology for the prediction of anticancer drug efficacy Analytical and Bioanalytical Chemistry 398 2010 2505 2533
43. W.B. Ortêncio Medicina popular do Centro Oeste 2nd ed. 1997 Theasaurus Brasília 464 pp.
44. D. Parent-Massin Relevance of clonogenic assays in hematotoxicology Cell Biology and Toxicology 17 2001 87 94 (Pubitemid 32681045)
45. A. Pessina, B. Albella, J. Bueren, P. Brantom, S. Casati, L. Gribaldo, C. Croera, G. Gagliardi, P. Foti, R. Parchment, D. Parent-Massin, Y. Sibiril, and R. Van-Den-Heuvel Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/macrophage (CFU-GM) assay Toxicology In Vitro 15 2001 729 740 (Pubitemid 33043962)
46. A. Pessina, B. Albella, M. Bayo, J. Bueren, P. Brantom, S. Casati, C. Croera, G. Gagliardi, P. Foti, R. Parchment, D. Parent-Massin, G. Schoeters, Y. Sibiril, R. Van-Den-Heuvel, and L. Gribaldo Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics The Journal of Toxicological Sciences 75 2003 355 367 (Pubitemid 37220283)
47. M. Poot, R.H. Pierce, and T.J. Kavanagh Flow cytometric and fluorometric methods of quantifying and characterizing apoptotic cell death M.A. Davis, Apoptosis Methods in Pharmacology and Toxicology 2002 Humana Press Totowa, New Jersey 11 36
48. T. Said, M. Dutot, R. Christon, J.L. Beaudeux, C. Martin, J.M. Warnet, and P. Rat Benefits and side effects of different vegetable oil vectors on apoptosis, oxidative stress, and P2X7 cell death receptor activation Investigative Ophthalmology & Visual Science 48 2007 5000 5006 (Pubitemid 351260909)
49. C. Schluter, M. Duchrow, C. Wohlenberg, M.H.G. Becker, G. Key, H.D. Flad, and J. Gerdes The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins Journal of Cell Biology 123 1993 513 522 (Pubitemid 23324910)
50. R.M. Silverstein, G.C. Bassler, and T.C. Morril Spectrometric Identification of Organic Compounds 5th ed. 1991 John Wiley & Sons, INC Singapore 419 pp.
51. S. Smaili, H. Hirata, R. Ureshino, P.T. Monteforte, A.P. Morales, M.L. Muler, J. Terashima, K. Oseki, T.R. Rosenstock, G.S. Lopes, and C. Bincoletto Calcium and cell death signaling in neurodegeneration and aging Anais da Academia Brasileira de Ciências 81 2009 467 475
52. A. Takahashi, A. Masuda, M. Sun, V.E. Centonze, and B. Herman Oxidative stress-induced apoptosis is associated with alterations in mitochondrial caspase activity and Bcl-2-dependent alterations in mitochondrial pH (pHm) Brain Research Bulletin 62 2004 497 504 (Pubitemid 38253035)
53. W. Uthaisang, V. Reutrakul, C. Krachangchaeng, P. Wilairat, and B. Fadeel VR-3848, a novel peptide derived from Euphorbiaceae, induces mitochondria-dependent apoptosis in human leukemia cells Cancer Letters 28 2004 171 178 (Pubitemid 38624158)
54. M.C. Valadares, and M.L.S. Queiroz The effect of a titanocene dichloride derivative, Ti IV (C5H5)2 NCS2, on the haematopoietic response of Ehrlich tumour-bearing mice European Journal of Pharmacology 439 2002 35 42 (Pubitemid 34286604)
55. M.C. Valadares O uso de cultura clonal de precursores hematopoiéticos na investigaão do potencial mielossupressivo de novas substâncias Revista Eletrônica de Farmácia 1 2004 34 51
56. M. Van Engeland, F.C.S. Ramaekers, B. Schutte, and C.P.M. Reutelingsperger A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture Cytometry 24 1996 131 139 (Pubitemid 26202924)
57. M. Van Engeland, L.J.W. Nieland, F.C.S. Ramaekers, B. Schutte, and C.P.M. Reutelingsperger Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure Cytometry 31 1998 1 9 (Pubitemid 28050057)
58. A.H. Wyllie, J.F.R. Kerr, and A.R. Currie Cell death: the significance of apoptosis International Review of Cytology 68 1980 251 306 (Pubitemid 11219226)
59. Y.B. Zhang, Y.P. Yeb, X.D. Wuc, and H.X. Sun Astilbotriterpenic acid induces growth arrest and apoptosis in HeLa cells through mitochondria-related pathways and reactive oxygen species (ROS) production Chemistry & Biodiversity 6 2009 218 230