Down-regulation of NF-κB signalling by polyphenolic compounds prevents endotoxin-induced liver injury in a rat model

Innate Immunity

Volumn 18, Issue 1, 2012, Pages 70-79

  Bharrhan, Sushma ^a   Chopra, Kanwaljit ^b   Arora, Sunil K ^c   Toor, Jaideep S ^c   Rishi, Praveen ^a  

^a PANJAB UNIVERSITY   (India)

^b PANJAB UNIVERSITY   (India)

^c POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Endotoxin; liver injury; nuclear factor kappa B (NF B); polyphenols; tumor necrosis factor alpha (TNF )

Indexed keywords

CATECHIN; ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; QUERCETIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EXPERIMENTAL MODEL; FEMALE; LIVER INJURY; NONHUMAN; RAT;

ANIMALS; ANTIOXIDANTS; CATECHIN; DISEASE MODELS, ANIMAL; ENDOTOXINS; FEMALE; HUMANS; LIVER DISEASES; NF-KAPPA B; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; POLYPHENOLS; QUERCETIN; RATS; RATS, WISTAR; SEPSIS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 84855996006     PISSN: 17534259     EISSN: 17534267     Source Type: Journal    
DOI: 10.1177/1753425910393369     Document Type: Article

References (49)

1. Cadenas S, Cadenas AM. Fighting the stranger-antioxidant protection against endotoxin toxicity. Toxicology. 2002 ; 180: 45-63 (Pubitemid 35248092)
2. Victor VM, Rocha M, Esplugues JV, De la Fuente M. Role of free radicals in sepsis: antioxidant therapy. Curr Pharm Design. 2005 ; 11: 3141-3158 (Pubitemid 41149930)
3. Victor VM, Rocha M, De la Fuente M. Immune cells: free radicals and antioxidants in sepsis. Int Immunopharmacol. 2004 ; 4: 327-347 (Pubitemid 38375967)
4. Victor VM, Minano M, Guayerbas N, Del Rio M, Medina S, De la Fuente M. Effects of endotoxic shock in several functions of murine peritoneal macrophages. Mol Cell Biochem. 1998 ; 189: 25-31 (Pubitemid 28556544)
5. Victor VM, De la Fuente M. Changes in the superoxide production and other macrophage functions could be related to the mortality of mice with endotoxin-induced oxidative stress. Physiol Res. 2003 ; 52: 101-110 (Pubitemid 36356267)
6. Hertog MGL, Hollman PCH. Potential health effects of the dietary flavonol quercetin. Eur J Clin Nutr. 1996 ; 50: 63-71 (Pubitemid 26068005)
7. Jovanovic SV, Steenken S, Simic MG, Hara Y Flavonoids in health and disease. Rice-Evans C Packer L, ed. New York: Marcel Dekker ; 1998: 137-161.
8. Rice-Evans C. Flavonoid antioxidants. Curr Med Chem. 2001 ; 8: 797-807 (Pubitemid 32427907)
9. Bravo L. Polyphenols: chemistry, dietary sources, metabolism and nutritional significance. Nutr Rev. 1998 ; 56: 317-333 (Pubitemid 28532456)
10. Huk I, Brovkovich V, Nanobash V, Weigel G, Neumayer C, Partyka L. Bioflavonoid quercetin scavenges superoxide and increases nitric oxide concentration in ischemia-reperfusion injury: an experimental study. Br J Surg. 1998 ; 85: 1080-1085 (Pubitemid 28360771)
11. Duarte J, Galisteo M, Ocete MA, Perez-Vizcaino F, Zarzuelo A, Tamargo J. Effect of chronic quercetin treatment on hepatic oxidative status in spontaneously hypersensitive rats. Mol Cell Biochem. 2001 ; 221: 155-160 (Pubitemid 33640572)
12. Peres W, Tunon MJ, Mato S, Collado PS, Marroni N, Gonzalez-Gallego J. Hepatoprotective effects of the flavonoid quercetin in rats with biliary obstruction. J Hepatol. 2000 ; 33: 742-750
13. Wadsworth TL, Koop DR. Effects of Gingko biloba extract (Egb 761) and quercetin on lipopolysaccharide-induced release of nitric oxide. Chem Biol Interact. 2001 ; 137: 43-58 (Pubitemid 32772760)
14. Dias AS, Porawski M, Alonso M, Marroni N, Collado PS, Gonzalez-Gallego J. Quercetin decreases oxidative stress, NF-κB activation and iNOS overexpression in liver of streptozotocin-induced diabetic rats. J Nutr. 2005 ; 135: 2299-2304 (Pubitemid 41429581)
15. Tieppo J, Cuevas MJ, Vercelino R, Tunon MJ, Marroni NP, Gonzalez-Gallego J. Quercetin administration ameliorates pulmonary complications of cirrhosis in rats. J Nutr. 2009 ; 139: 1339-1346
16. Manjeet KR, Ghosh B. Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-alpha production in murine macrophages. Int J Immunopharmacol. 1999 ; 21: 435-443 (Pubitemid 29306925)
17. Liu J, Li X, Yue Y, Li J, He T, He Y. The inhibitory effect of quercetin on IL-6 production by LPS-stimulated neutrophils. Cell Mol Immunol. 2005 ; 2: 455-460
18. Kim BH, Lee IJ, Lee HY, et al. Quercetin 3-O-beta-(20-galloyl)- glucopyranoside inhibits endotoxin LPS-induced IL-6 expression and NF-kappa B activation in macrophages. Cytokine. 2007 ; 39: 207-215 (Pubitemid 47599974)
19. Okoko T, Oruambo IF. Inhibitory activity of quercetin and its metabolite on lipopolysaccharide-induced activation of macrophage U937 cells. Food Chem Toxicol. 2009 ; 47: 809-812
20. Rice-Evans C, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med. 1996 ; 20: 933-956 (Pubitemid 26157509)
21. Wang H, Provan GJ, Helliwell K. Tea flavonoids: their functions, utilization and analysis. Trends Food Sci Technol. 2000 ; 11: 152-160 (Pubitemid 32122540)
22. Chen JH, Tipoe GL, Liong EC, et al. Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide-derived prooxidants. Am J Clin Nutr. 2004 ; 80: 742-751 (Pubitemid 41115541)
23. Zhen MC, Wang Q, Huang XH, et al. Green tea polyphenol epigallocatechin-3-gallate inhibits oxidative damage and preventive effects on carbon-tetrachloride-induced hepatic fibrosis. J Nutr Biochem. 2007 ; 18: 795-805 (Pubitemid 350138426)
24. Zhong Z, Froh M, Lehnert M, et al. Polyphenols from Camellia sinensis attenuate experimental cholestasis-induced liver fibrosis in rats. Am J Physiol. 2003 ; 285: G1004 - G1013
25. Yuan GJ, Gong ZJ, Sun XM, Zheng SH, Li X. Tea polyphenols inhibit expressions of iNOS and TNF-α and prevent lipopolysaccharide-induced liver injury in rats. Hepatobiliary Pancreat Dis Int. 2006 ; 5: 262-267 (Pubitemid 43826920)
26. Giakoustidis A, Giakoustidis DE, Iliadis S, et al. Attenuation of intestinal ischemia/reperfusion-induced liver and lung injury by intraperitoneal administration of (-)-epigallocatechin-3-gallate. Free Radic Res. 2006 ; 40: 103-110 (Pubitemid 43023791)
27. Chanana V, Majumdar S, Rishi P. Involvement of caspase-3, lipid peroxidation and TNF-alpha in causing apoptosis of macrophages by coordinately expressed Salmonella phenotype under stress conditions. Mol Immunol. 2007 ; 44: 1551-1558
28. Rishi P, Kaur H, Tirkey N, et al. Are the increases in local tumour necrosis factor and lipid peroxidation observed in pre-starved mice infected with Salmonella typhimurium markers of increased liver damage?. Microbes Infect. 2006 ; 8: 1695-1701 (Pubitemid 44128891)
29. Green LC, Wagner DA, Glogowski J, Shipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite and 15N nitrate in biological fluids. Anal Biochem. 1982 ; 126: 131-138 (Pubitemid 13203451)
30. Baeuerle PA, Baltimore D. NF-κB: ten years after. Cell. 1996 ; 87: 13-20
31. Ghosh S, May MJ, Kopp EB. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol. 1998 ; 16: 225-260 (Pubitemid 28183365)
32. Stancovski I, Baltimore D. NF-κB activation: the IκB kinase revealed?. Cell. 1997 ; 91: 299-302
33. Guha M, Mackman N. LPS induction of gene expression in human monocytes. Cell Signal. 2001 ; 13: 85-94 (Pubitemid 32222977)
34. Tian B, Brasier AR. Identification of a nuclear factor κB-dependent gene network. Recent Prog Horm Res. 2003 ; 58: 95-130 (Pubitemid 37339306)
35. Zhong Z, Froh M, Connor HD, et al. Prevention of hepatic ischemia-reperfusion injury by green tea extract. Am J Physiol. 2002 ; 283: G957 - G964
36. Su GL. Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. Am J Physiol. 2002 ; 283: G256 - G265
37. Yang F, Villiers WJS, McClain C, Varilek GW. Green tea polyphenols block endotoxin-induced tumor necrosis factor production and lethality in a murine model. J Nutr. 1998 ; 128: 2334-2340 (Pubitemid 29012980)
38. Hirose K, Longo DL, Oppenheim JJ, Matsushima K. Over expression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin-1, tumor necrosis factor, selected anti cancer drugs, and ionizing radiation. FASEB J. 1993 ; 7: 361-368 (Pubitemid 23067786)
39. Salah N, Miller NJ, Paganga G, Tijburg L, Bolwell GP, Rice-Evans C. Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants. Arch Biochem Biophys. 1995 ; 322: 339-346
40. Chen T, Zamora R, Zuckerbraun B, Billiar TR. Role of nitric oxide in liver injury. Curr Mol Med. 2003 ; 3: 519-526 (Pubitemid 37168596)
41. Laskin DL, Rodriguez del Valle M, Heck DE, et al. Hepatic nitric oxide production following acute endotoxemia in rats is mediated by increased inducible nitric oxide synthase gene expression. Hepatology. 1995 ; 22: 223-234
42. Matata BM, Galinanes M. Peroxynitrite is an essential component of cytokines production mechanism in human monocytes through modulation of nuclear factor-kappa B DNA binding activity. J Biol Chem. 2002 ; 277: 2330-2335 (Pubitemid 34968820)
43. Song K, Chen Y, Go'ke R, et al. Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression. J Exp Med. 2000 ; 191: 1095-1104
44. Chanana V, Majumdar S, Rishi P. Tumour necrosis factor-α mediated apoptosis in murine macrophages by Salmonella enterica serovar Typhi under oxidative stress. FEMS Immunol Med Microbiol. 2006 ; 47: 278-2786
45. Rishi P, Mavi SK, Bharrhan S, Shukla G, Tewari R. Protective efficacy of probiotic alone or in conjunction with a prebiotic in Salmonella-induced liver damage. FEMS Microbiol Ecol. 2009 ; 69: 222-230
46. Jo HY, Kim Y, Nam SY, et al. The inhibitory effect of quercitrin gallate on iNOS expression induced by lipopolysaccharide in Balb/c mice. J Vet Sci. 2008 ; 9: 267-272
47. Lin YL, Lin JK. (-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB. Mol Pharmacol. 1997 ; 52: 465-472
48. Mu MM, Chakravortty D, Sugiyama T, et al. The inhibitory action of quercetin on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells. J Endotoxin Res. 2001 ; 7: 431-438 (Pubitemid 34048526)
49. Kim BH, Cho SM, Reddy AM, Kim YS, Min KR, Kim Y. Down-regulatory effect of quercitrin gallate on nuclear factor-κB-dependent inducible nitric oxide synthase expression in lipopolysaccharide-stimulated macrophages RAW 264.7. Biochem Pharmacol. 2005 ; 69: 1577-1583 (Pubitemid 40719494)