Quercetin 3-O-β-(2″-galloyl)-glucopyranoside inhibits endotoxin LPS-induced IL-6 expression and NF-κB activation in macrophages

Cytokine

Volumn 39, Issue 3, 2007, Pages 207-215

  Kim, Byung Hak ^a   Lee, In Jeong ^a   Lee, Hwa Young ^a   Han, Sang Bae ^a   Hong, Jin Tae ^a   Ahn, Byeongwoo ^a   Lee, Chong Kil ^a   Kim, Youngsoo ^a  

^a Chungbuk National University   (South Korea)

Author keywords

Endotoxin LPS; IL 6 expression; Macrophages; NF B activation; Quercetin 3 O (2 galloyl) glucopyranoside

Indexed keywords

BETA ACTIN; ENDOTOXIN; GLUCOPYRANOSIDE; I KAPPA B; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PROTEIN P50; QUERCETIN; QUERCETIN 3 O BETA (2'' GALLOYL) GLUCOPYRANOSIDE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANGIOSPERM; ANIMAL CELL; ARTICLE; CELL VIABILITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DNA BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION VECTOR; GEL MOBILITY SHIFT ASSAY; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; NUCLEAR IMPORT; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; WESTERN BLOTTING;

ANIMALS; CELL LINE; GALLIC ACID; GENE EXPRESSION REGULATION; GLUCOSIDES; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; POLYGONACEAE; QUERCETIN;

POLYGONUM LAPATHIFOLIUM;

EID: 35349009092     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2007.08.002     Document Type: Article

References (34)

1. Ulevitch R.J., and Tobias P.S. Recognition of Gram-negative bacteria and endotoxin by the innate immune system. Curr Opin Immunol 11 (1999) 19-22
2. Miyake K. Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. Trends Microbiol 12 (2004) 186-192
3. Palsson-McDermott E.M., and O'Neill L.A. Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology 113 (2004) 153-162
4. Baeuerle P.A., and Baltimore D. NF-κB: ten years after. Cell 87 (1996) 13-20
5. Ghosh S., May M.J., and Kopp E.B. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16 (1998) 225-260
6. Stancovski I., and Baltimore D. NF-κB activation: the IκB kinase revealed?. Cell 91 (1997) 299-302
7. Lee F.S., Peters R.T., Dang L.C., and Maniatis T. MEKK1 activates both IκB kinase α and IκB kinase β. Proc Natl Acad Sci USA 95 (1998) 9319-9324
8. Swantek J.L., Tsen M.F., Cobb M.H., and Thomas J.A. IL-1 receptor-associated kinase modulates host responsiveness to endotoxin. J Immunol 164 (2000) 4301-4306
9. Karin M., and Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu Rev Immunol 18 (2000) 621-663
10. Magnani M., Crinelli R., Bianchi M., and Antonelli A. The ubiquitin-dependent proteolytic system and other potential targets for the modulation of nuclear factor-κB. Curr Drug Targets 1 (2000) 387-399
11. Guha M., and Mackman N. LPS induction of gene expression in human monocytes. Cell Signal 13 (2001) 85-94
12. Tian B., and Brasier A.R. Identification of a nuclear factor κB-dependent gene network. Recent Prog Horm Res 58 (2003) 95-130
13. Kamimura D., Ishihara K., and Hirano T. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol 149 (2003) 1-38
14. Fuller G.M., Bunzel R.J., Woloski B.M., and Nham S.U. Isolation of hepatocyte stimulating factor from human monocytes. Biochem Biophys Res Commun 144 (1987) 1003-1009
15. Noda M., Takeda K., Sugimoto H., Hosoi T., Takechi K., Hara T., et al. Purification and characterization of human fibroblast derived differentiation inducing factor for human monoblastic leukemia cells identical to interleukin-6. Anticancer Res 11 (1991) 961-968
16. Suematsu S., Matsuda T., Aozasa K., Akira S., Nakano N., Ohno S., et al. IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc Natl Acad Sci USA 86 (1989) 7547-7551
17. Kopf M., Baumann H., Freer G., Freudenberg M., Lamers M., Kishimoto T., et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368 (1994) 339-342
18. Yoshida K., Taga T., Saito M., Suematsu S., Kumanogoh A., Tanaka T., et al. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci USA 93 (1996) 407-411
19. Naka T., Nishimoto N., and Kishimoto T. The paradigm of IL-6: from basic science to medicine. Arthritis Res 4 (2002) S233-S242
20. Kim Y., Jang D.S., Park S.H., Yun J., Min B.K., Min K.R., et al. Flavonol glycoside gallate and ferulate esters from Persicaria lapathifolia as inhibitors of superoxide production in human monocytes stimulated by unopsonized zymosan. Planta Med 66 (2000) 72-74
21. Sanlioglu S., Williams C.M., Samavati L., Butler N.S., Wang G., McCray Jr. P.B., et al. Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-α secretion through IKK regulation of NF-κB. J Biol Chem 276 (2001) 30188-30198
22. Hsu H.Y., and Wen M.H. Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression. J Biol Chem 277 (2002) 22131-22139
23. Gao H., Parkin S., Johnson P.F., and Schwartz R.C. C/EBP γ has a stimulatory role on the IL-6 and IL-8 promoters. J Biol Chem 277 (2002) 38827-38837
24. Moon K.Y., Hahn B.S., Lee J., and Kim Y.S. A cell-based assay system for monitoring NF-κB activity in human HaCat transfectant cells. Anal Biochem 292 (2001) 17-21
25. Lee J.H., Koo T.H., Hwang B.Y., and Lee J.J. Kaurane diterpene, kamebakaurin, inhibits NF-κB by directly targeting the DNA-binding activity of p50 and blocks the expression of antiapoptotic NF-κB target genes. J Biol Chem 277 (2002) 18411-18420
26. Shin H.M., Kim M.H., Kim B.H., Jung S.H., Kim Y.S., Park H.J., et al. Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-κB without affecting IκB degradation. FEBS Lett 571 (2004) 50-54
27. Dendorfer U., Oettgen P., and Libermann T.A. Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide. Mol Cell Biol 14 (1994) 4443-4454
28. van der Aa M.A., Mastrobattista E., Oosting R.S., Hennink W.E., Koning G.A., and Crommelin D.J. The nuclear pore complex: the gateway to successful nonviral gene delivery. Pharm Res 23 (2006) 447-459
29. Fagerlund R., Kinnunen L., Kohler M., Julkunen I., and Melen K. NF-κB is transported into the nucleus by importin α3 and importin α4. J Biol Chem 280 (2005) 15942-15951
30. Harel A., and Forbes D.J. Importin β: conducting a much larger cellular symphony. Mol Cell 16 (2004) 319-330
31. Nair M.P., Mahajan S., Reynolds J.L., Aalinkeel R., Nair H., Schwartz S.A., et al. The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor α) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-κB system. Clin Vaccine Immunol 13 (2006) 319-328
32. Wadsworth T.L., McDonald T.L., and Koop D.R. Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-α. Biochem Pharmacol 62 (2001) 963-974
33. Peet G.W., and Li J. IκB kinases α and β show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin. J Biol Chem 274 (1999) 32655-32661
34. Forman H.J., and Torres M. Redox signaling in macrophages. Mol Aspects Med 22 (2001) 189-216