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European Journal of Medicinal Chemistry

Volumn 48, Issue , 2012, Pages 192-199

Synthesis and antitumor evaluation of some new 1,3,4-oxadiazole-based heterocycles

(4) Bondock, Samir a,b Adel, Shymaa a Etman, Hassan A a Badria, Farid A c

a Mansoura University (Egypt)

b KING KHALID UNIVERSITY (Saudi Arabia)

c MANSOURA UNIVERSITY (Egypt)

Author keywords

1,3,4 Oxadiazole; Antitumor activity; Pyrazole; Thiazole; Thiophene

Indexed keywords

1,3,4 OXADIAZOLE DERIVATIVE; 2,3 DIHYDROTHIAZOLINE DERIVATIVE; [N [5 1 CYANO 2 (METHYLTHIO) 2 (PHENYLAMINO)VINYL] 1,3,4 OXADIAZOL 2 YL]BENZAMIDE; BLEOMYCIN; N (6 AMINO 7H PYRAZOLO[5,1 C][1,2,4]TRIAZOL 3 YL)BENZAMIDE; N [5 (CYANOMETHYL) 1,3,4 OXADIAZOL 2 YL]BENZAMIDE; N [5 [3 AMINO 1 PHENYL 5 (PHENYLAMINO) 1H PYRAZOL 4 YL] 1,3,4 OXADIAZOL 2 YL]BENZAMIDE; N [5 [3 AMINO 5 (PHENYLAMINO) 1H PYRAZOL 4 YL] 1,3,4 OXADIAZOL 2 YL]BENZAMIDE; N [5 [5 ACETYL 4 AMINO 2 (PHENYLAMINO)THIOPHEN 3 YL] 1,3,4 OXADIAZOL 2 YL]BENZAMIDE; N [5 [CYANO 4 [(1,3 DIPHENYL 1H PYRAZOL 4 YL)METHYLEN 5 OXO 3 PHENYLTHIAZOLIDIN 2 YLIDENE]METHYL] 1,3,4 OXADIAZOL 2 YL]BENZAMIDE; N [5 [CYANO(5 OXO 3 PHENYLTHIAZOLIDIN 2 YL)METHYL] 1,3,4 OXADIAZOL 2 YL]BENZAMIDE; N [5 [CYANO[3,4 DIPHENYLTHIAZOL 2(3H)YLIDENE]METHYL] 1,3,4 OXADIAZOL 2 YL]BENZAMIDE; N [5 [CYANO[4 [(1,5 DIMETHYL 3 OXO 2 PHENYL 2,3 DIHYDRO 1H PYRAZOL 4 YL)METHYLENE] 5 OXO 3 PHENYLTHIAZOLIDIN 2 YLIDENE]METHYL] 1,3,4 OXADIAZOL 2 YL]BENZAMIDE; PYRAZOLE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DETERMINATION; DRUG SCREENING; DRUG SYNTHESIS; DRUG TRANSFORMATION; HUMAN; HUMAN CELL; NATIONAL HEALTH ORGANIZATION; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; HEP G2 CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; OXADIAZOLES; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; VERO CELLS;

EID: 84855988809 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2011.12.013 Document Type: Article

Times cited : (201)

References (47)

1
- 33745208794
- T.M.C. Tan, Y. Chen, K.H. Kong, J. Bai, Y. Li, S.G. Lim, T.H. Ang, and Y. Lam Antivir. Res. 71 2006 7 14
- (2006) Antivir. Res. , vol.71 , pp. 7-14
- Tan, T.M.C.¹ Chen, Y.² Kong, K.H.³ Bai, J.⁴ Li, Y.⁵ Lim, S.G.⁶ Ang, T.H.⁷ Lam, Y.⁸

2
- 33745758352
- S.L. Gaonkar, K.M.L. Rai, and B. Prabhuswamy Eur. J. Med. Chem. 41 2006 841 846
- (2006) Eur. J. Med. Chem. , vol.41 , pp. 841-846
- Gaonkar, S.L.¹ Rai, K.M.L.² Prabhuswamy, B.³

3
- 30344436995
- A.S. Aboraia, H.M. Abdel-Rahman, N.M. Mahfouz, and M.A. Gendy Bioorg. Med. Chem. 14 2006 1236 1246
- (2006) Bioorg. Med. Chem. , vol.14 , pp. 1236-1246
- Aboraia, A.S.¹ Abdel-Rahman, H.M.² Mahfouz, N.M.³ Gendy, M.A.⁴

4
- 33644831848
- Y. Li, J. Liu, H. Zhang, X. Yang, and Z. Liu Bioorg. Med. Chem. Lett. 16 2006 2278 2282
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 2278-2282
- Li, Y.¹ Liu, J.² Zhang, H.³ Yang, X.⁴ Liu, Z.⁵

5
- 27944463018
- C. Loetchutinat, F. Chau, and S. Mankhetkorn Chem. Pharm. Bull. 51 2003 728 730
- (2003) Chem. Pharm. Bull. , vol.51 , pp. 728-730
- Loetchutinat, C.¹ Chau, F.² Mankhetkorn, S.³

6
- 1542471130
- A.H. Abadi, A.A.H. Eissa, and G.S. Hassan Chem. Pharm. Bull. 51 2003 838 844
- (2003) Chem. Pharm. Bull. , vol.51 , pp. 838-844
- Abadi, A.H.¹ Eissa, A.A.H.² Hassan, G.S.³

7
- 0035818922
- B.G. Szczepankiewicz, G. Liu, H.-S. Jae, A.S. Tasker, I.W. Gunawardana, T.W. von Geldern, S.L. Gwaltney, J.R. Wu-Wong, L. Gehrke, W.J. Chiou, R.B. Credo, J.D. Alder, M.A. Nukkala, N.A. Zielinski, K. Jarvis, K.W. Mollison, D.J. Frost, J.L. Bauch, Y.H. Hui, A.K. Claiborne, Q. Li, and S.H. Rosenberg J. Med. Chem. 44 2001 4416 4430
- (2001) J. Med. Chem. , vol.44 , pp. 4416-4430
- Szczepankiewicz, B.G.¹ Liu, G.² Jae, H.-S.³ Tasker, A.S.⁴ Gunawardana, I.W.⁵ Von Geldern, T.W.⁶ Gwaltney, S.L.⁷ Wu-Wong, J.R.⁸ Gehrke, L.⁹ Chiou, W.J.¹⁰ Credo, R.B.¹¹ Alder, J.D.¹² Nukkala, M.A.¹³ Zielinski, N.A.¹⁴ Jarvis, K.¹⁵ Mollison, K.W.¹⁶ Frost, D.J.¹⁷ Bauch, J.L.¹⁸ Hui, Y.H.¹⁹ Claiborne, A.K.²⁰ Li, Q.²¹ Rosenberg, S.H.²² more..

8
- 67649950035
- D. Kumar, S. Sundaree, E.O. Johnson, and K. Shah Bioorg. Med. Chem. Lett. 19 2009 4492 4494
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 4492-4494
- Kumar, D.¹ Sundaree, S.² Johnson, E.O.³ Shah, K.⁴

9
- 17444374605
- M.T. Khan, M.I. Choudhary, K.M. Khan, M. Rani, and A.U. Rahman Bioorg. Med. Chem. 13 2005 3385 3395
- (2005) Bioorg. Med. Chem. , vol.13 , pp. 3385-3395
- Khan, M.T.¹ Choudhary, M.I.² Khan, K.M.³ Rani, M.⁴ Rahman, A.U.⁵

10
- 33646041582
- J.T. Palmer, B.L. Hirschbein, H. Cheung, J. McCarter, J.W. Janc, W.Z. Yu, and G. Wesolowski Bioorg. Med. Chem. Lett. 16 2006 2909 2914
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 2909-2914
- Palmer, J.T.¹ Hirschbein, B.L.² Cheung, H.³ McCarter, J.⁴ Janc, J.W.⁵ Yu, W.Z.⁶ Wesolowski, G.⁷

11
- 0033755004
- R.N. Warrener Eur. J. Org. Chem. 65 2000 3363 3380
- (2000) Eur. J. Org. Chem. , vol.65 , pp. 3363-3380
- Warrener, R.N.¹

12
- 0242441508
- M. Guan, Z.Q. Bian, Y.F. Zhou, F.Y. Li, Z.J. Li, and C.H. Huang Chem. Commun. 9 2003 2708 2709
- (2003) Chem. Commun. , vol.9 , pp. 2708-2709
- Guan, M.¹ Bian, Z.Q.² Zhou, Y.F.³ Li, F.Y.⁴ Li, Z.J.⁵ Huang, C.H.⁶

13
- 29044438582
- C.R.W. Guimaraes, D.L. Boger, and W.L. Jorgensen J. Am. Chem. Soc. 127 2005 17377 17384
- (2005) J. Am. Chem. Soc. , vol.127 , pp. 17377-17384
- Guimaraes, C.R.W.¹ Boger, D.L.² Jorgensen, W.L.³

14
- 33751506541
- D.-M. Cheng, F.-Y. Ma, and X. Liu Opt. Laser Technol. 39 2007 720 723
- (2007) Opt. Laser Technol. , vol.39 , pp. 720-723
- Cheng, D.-M.¹ Ma, F.-Y.² Liu, X.³

15
- 33845576409
- H. Tang, N. Song, Z. Gao, X. Chen, X. Fan, Q. Xiang, and Q. Zhou Polymer 48 2007 129 138
- (2007) Polymer , vol.48 , pp. 129-138
- Tang, H.¹ Song, N.² Gao, Z.³ Chen, X.⁴ Fan, X.⁵ Xiang, Q.⁶ Zhou, Q.⁷

16
- 0028904010
- B. Oussaid, L. Moeini, B. Martin, D. Villemin, and B. Garrigues Synth. Commun. 25 1995 1451 1459
- (1995) Synth. Commun. , vol.25 , pp. 1451-1459
- Oussaid, B.¹ Moeini, L.² Martin, B.³ Villemin, D.⁴ Garrigues, B.⁵

17
- 0034900980
- X.C. Wang, Z. Li, Z.H. Zhang, and Y.X. Da Synth. Commun. 31 2001 1907 1911
- (2001) Synth. Commun. , vol.31 , pp. 1907-1911
- Wang, X.C.¹ Li, Z.² Zhang, Z.H.³ Da, Y.X.⁴

18
- 0036251314
- X.C. Wang, Z. Li, B.G. Wei, and J.Y. Yang Synth. Commun. 32 2002 1097 1103
- (2002) Synth. Commun. , vol.32 , pp. 1097-1103
- Wang, X.C.¹ Li, Z.² Wei, B.G.³ Yang, J.Y.⁴

19
- 0026334801
- S.K. Srivastava, R.B. Pathak, and S.C. Bahel J. Indian Chem. Soc 68 1991 113 114
- (1991) J. Indian Chem. Soc , vol.68 , pp. 113-114
- Srivastava, S.K.¹ Pathak, R.B.² Bahel, S.C.³

20
- 41349099104
- A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, T. Murray, and M.J. Thun Cancer J. Clin. 58 2008 71 96
- (2008) Cancer J. Clin. , vol.58 , pp. 71-96
- Jemal, A.¹ Siegel, R.² Ward, E.³ Hao, Y.⁴ Xu, J.⁵ Murray, T.⁶ Thun, M.J.⁷

21
- 0004097423
- fifth ed. W.B. Saunders Philadelphia, PA (Chapter 1)
- C.M. Haskell Cancer Treatment fifth ed. 2001 W.B. Saunders Philadelphia, PA (Chapter 1)
- (2001) Cancer Treatment
- Haskell, C.M.¹

22
- 0036080202
- S. Eckhardt Curr. Med. Chem. Anti Canc. Agents 2 2002 419 439
- (2002) Curr. Med. Chem. Anti Canc. Agents , vol.2 , pp. 419-439
- Eckhardt, S.¹

23
- 0035416117
- K.H. Altmann Curr. Opin. Chem. Biol. 5 2001 424 431
- (2001) Curr. Opin. Chem. Biol. , vol.5 , pp. 424-431
- Altmann, K.H.¹

24
- 0036080040
- M. Wartmann, and K.H. Altmann Curr. Med. Chem. Anti Canc. Agents 2 2002 123 148
- (2002) Curr. Med. Chem. Anti Canc. Agents , vol.2 , pp. 123-148
- Wartmann, M.¹ Altmann, K.H.²

25
- 0035342380
- M.E. O'Dwyer, and B.J. Druker Curr. Cancer Drug Targets 1 2001 49 57
- (2001) Curr. Cancer Drug Targets , vol.1 , pp. 49-57
- O'Dwyer, M.E.¹ Druker, B.J.²

26
- 79955577303
- S. Bondock, W. Khalifa, and A.A. Fadda Eur. J. Med. Chem. 46 2011 2555 2561
- (2011) Eur. J. Med. Chem. , vol.46 , pp. 2555-2561
- Bondock, S.¹ Khalifa, W.² Fadda, A.A.³

27
- 77955551619
- S. Bondock, W. Fadaly, and M.A. Metwally Eur. J. Med. Chem. 45 2010 3692 3701
- (2010) Eur. J. Med. Chem. , vol.45 , pp. 3692-3701
- Bondock, S.¹ Fadaly, W.² Metwally, M.A.³

28
- 70449640310
- S. Bondock, W. Fadaly, and M.A. Metwally Eur. J. Med. Chem. 44 2009 4813 4818
- (2009) Eur. J. Med. Chem. , vol.44 , pp. 4813-4818
- Bondock, S.¹ Fadaly, W.² Metwally, M.A.³

29
- 53149130600
- S. Bondock, R. Rabie, H.A. Etman, and A.A. Fadda Eur. J. Med. Chem. 43 2008 2122 2129
- (2008) Eur. J. Med. Chem. , vol.43 , pp. 2122-2129
- Bondock, S.¹ Rabie, R.² Etman, H.A.³ Fadda, A.A.⁴

30
- 34250159079
- S. Bondock, W. Khalifa, and A.A. Fadda Eur. J. Med. Chem. 42 2007 948 954
- (2007) Eur. J. Med. Chem. , vol.42 , pp. 948-954
- Bondock, S.¹ Khalifa, W.² Fadda, A.A.³

31
- 38949217946
- S. Bondock, A.E. Tarhoni, and A.A. Fadda Monatsh Chem. 139 2008 153 159
- (2008) Monatsh Chem. , vol.139 , pp. 153-159
- Bondock, S.¹ Tarhoni, A.E.² Fadda, A.A.³

32
- 34250850198
- S. Bondock, A.E. Tarhoni, and A.A. Fadda Phosphorus Sulfur Silicon 182 2007 1915 1936
- (2007) Phosphorus Sulfur Silicon , vol.182 , pp. 1915-1936
- Bondock, S.¹ Tarhoni, A.E.² Fadda, A.A.³

33
- 79951712195
- S. Bondock, A.E. Tarhoni, and A.A. Fadda Curr. Org. Chem. 15 2011 753 781
- (2011) Curr. Org. Chem. , vol.15 , pp. 753-781
- Bondock, S.¹ Tarhoni, A.E.² Fadda, A.A.³

34
- 0003450582
- Academic Press London
- R.B. Silverman The Organic Chemistry of Drug Design and Drug Action 1992 Academic Press London 263
- (1992) The Organic Chemistry of Drug Design and Drug Action , pp. 263
- Silverman, R.B.¹

35
- 0007973598
- M.R.H. Elmoghayar, S.O. Abdalla, and M.Y.A.S. Nasr J. Heterocycl. Chem. 21 1984 781 784
- (1984) J. Heterocycl. Chem. , vol.21 , pp. 781-784
- Elmoghayar, M.R.H.¹ Abdalla, S.O.² Nasr, M.Y.A.S.³

36
- 33748985512
- S.A. Ryndina, A.V. Kadushkin, N.P. Soloveva, and V.G. Granik Russ. Chem. Bull. 51 2002 854 859
- (2002) Russ. Chem. Bull. , vol.51 , pp. 854-859
- Ryndina, S.A.¹ Kadushkin, A.V.² Soloveva, N.P.³ Granik, V.G.⁴

37
- 62549093538
- V. Padmavathi, A.V.N. Mohan, P. Thriveni, and A. Shazia Eur. J. Med. Chem. 44 2009 2313 2321
- (2009) Eur. J. Med. Chem. , vol.44 , pp. 2313-2321
- Padmavathi, V.¹ Mohan, A.V.N.² Thriveni, P.³ Shazia, A.⁴

38
- 33750996715
- Y.M. Elkholy, K.A. Ali, and A.M. Farag J. Heterocycl. Chem. 43 2006 1183 1188
- (2006) J. Heterocycl. Chem. , vol.43 , pp. 1183-1188
- Elkholy, Y.M.¹ Ali, K.A.² Farag, A.M.³

39
- 33746154108
- Y.M. Elkholy, K.A. Ali, and A.M. Farag Lett. Org. Chem. 3 2006 195 200
- (2006) Lett. Org. Chem. , vol.3 , pp. 195-200
- Elkholy, Y.M.¹ Ali, K.A.² Farag, A.M.³

40
- 39049092070
- B. Gottineau, S. Renaux, J. Chenault, and G. Guillaumet Lett. Org. Chem. 2 2005 599 601
- (2005) Lett. Org. Chem. , vol.2 , pp. 599-601
- Gottineau, B.¹ Renaux, S.² Chenault, J.³ Guillaumet, G.⁴

41
- 79961243906
- V. Padmavathi, G.S. Reddy, A.V.N. Mohan, and K. Mahesh ARKIVOC xvii 2008 48 60
- (2008) ARKIVOC , vol.17 , pp. 48-60
- Padmavathi, V.¹ Reddy, G.S.² Mohan, A.V.N.³ Mahesh, K.⁴

42
- 0021061819
- T. Mosmann J. Immunol. Methods 65 1983 55 63
- (1983) J. Immunol. Methods , vol.65 , pp. 55-63
- Mosmann, T.¹

43
- 0022445670
- F. Denizot, and R. Lang J. Immunol. Methods 22 1986 271 277
- (1986) J. Immunol. Methods , vol.22 , pp. 271-277
- Denizot, F.¹ Lang, R.²

44
- 0030720950
- M.I. Thabrew, R.D. Hughes, and I.G. McFarlane J. Pharm. Pharmacol. 49 1997 1132 1135
- (1997) J. Pharm. Pharmacol. , vol.49 , pp. 1132-1135
- Thabrew, M.I.¹ Hughes, R.D.² McFarlane, I.G.³

45
- 0019847498
- J. Gutteridge, D. Rowley, and B. Halliwell Biochem. J. 199 1981 263 265
- (1981) Biochem. J. , vol.199 , pp. 263-265
- Gutteridge, J.¹ Rowley, D.² Halliwell, B.³

46
- 71649093204
- B.F. Abdel-Wahab, A.-A.S. El-Ahl, and F.A. Badria Chem. Pharm. Bull. 57 2009 1348 1351
- (2009) Chem. Pharm. Bull. , vol.57 , pp. 1348-1351
- Abdel-Wahab, B.F.¹ El-Ahl, A.-A.S.² Badria, F.A.³

47
- 36148942860
- F.A. Badria, M. Ameen, and M. Akl Z. Naturforsch. 62c 2007 656 660
- (2007) Z. Naturforsch. , vol.62 C , pp. 656-660
- Badria, F.A.¹ Ameen, M.² Akl, M.³

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