Progress in the treatment of locally advanced clinically resectable rectal cancer

Clinical Colorectal Cancer

Volumn 10, Issue 4, 2011, Pages 227-237

  Minsky, Bruce D ^a  

^a UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

Author keywords

Combined modality therapy; Local recurrence; Postoperative chemotherapy; Preoperative chemoradiation

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CETUXIMAB; FLUORODEOXYGLUCOSE F 18; FLUOROURACIL; IRINOTECAN; OXALIPLATIN;

ADVANCED CANCER; CANCER ADJUVANT THERAPY; CANCER STAGING; CANCER SURGERY; CHEMORADIOTHERAPY; FOLLOW UP; HEALTH CARE QUALITY; HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PREOPERATIVE TREATMENT; RADIATION DOSE; RECTUM CANCER; REVIEW; TRANSRECTAL ULTRASONOGRAPHY; TREATMENT OUTCOME;

EID: 84855970002     PISSN: 15330028     EISSN: 19380674     Source Type: Journal    
DOI: 10.1016/j.clcc.2011.06.007     Document Type: Review

References (125)

1. J.E. Krook, C.G. Moertel, and L.L. Gunderson Effective surgical adjuvant therapy for high-risk rectal carcinoma N Engl J Med 1991 324709 324715
2. C. Twelves, A. Wong, and M.P. Nowacki Capecitabine as adjuvant treatment for stage III colon cancer N Engl J Med 2005 3522696 3522704
3. M.S. Roh, G.A. Yothers, and M.J. O'Connell The impact of capecitabine and oxaliplatin in the preoperative multimodality treatment in patients with carcinoma of the rectum NSABP R-04 J Clin Oncol 29 suppl 2011 abstract 3503 http://www.asco.org Accessed: June 28, 2011
4. R. Hofheinz, F.K. Wenz, and S. Post Capecitabine (Cape) versus 5-fluorouracil (5-FU) based (neo)adjuvant chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC): long-term results of a randomized, phase III trial J Clin Oncol 29 suppl 2011 abstract 3504 http://www.asco.org Accessed: June 28, 2011
5. T. Andre, C. Boni, and L. Mounedji-Boudiaf Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer N Engl J Med 350 2004 2343 2351 (Pubitemid 38702845)
6. L.B. Saltz, D. Niedzwiecki, and D. Hollis Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer results of CALGB 89803 J Clin Oncol 25 2007 3456 3461 (Pubitemid 47310883)
7. R.S. Midgley, C.G. McConkey, and E.C. Johnstone Phase III randomized trial assessing rofecoxib in the adjuvant setting of colorectal cancer final results of the VICTOR trial J Clin Oncol 28 2010 4575 4580
8. C.J. Allegra, G. Yothers, and M.J. O'Connel Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon results of NSABP protocol C-08 J Clin Oncol 29 2011 11 16
9. D. Sargent, G. Yothers, and E. van Cutsem Use of two-year disease-free survival (DFS) as a primary endpoint in stage III adjuvant colon cancer trials with fluoropyrimidines with or without oxaliplatin or irinotecan: new data from 12,676 patients from MOSAIC, X-ACT, PETACC-3, NSABP C-06 and C-07, and C89803 J Clin Oncol 27 2009 4011
10. J.E. Tepper, M.J. O'Connell, and D. Niedzwiecki Adjuvant therapy in rectal cancer analysis of stage, sex, and local control final report of Intergroup 0114 J Clin Oncol 20 2002 1744 1750 (Pubitemid 34273262)
11. R. Sauer, T. Liersch, and S. Merkel Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years J Clin Oncol 29 suppl 2011 abstract 3516 http://www.asco.org Accessed: June 28, 2011
12. J.A. Meyerhardt, J.E. Tepper, and D. Neidzwiecki Impact of hospital procedure volume on surgical operation and long-term outcomes in high risk curatively resected rectal cancer findings from the Intergroup 0114 study J Clin Oncol 22 2004 166 174 (Pubitemid 41095129)
13. M.S. Roh, L.H. Colangelo, and M.J. O'Connell Pre-operative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum (NSABP-R-03) J Clin Oncol 27 2009 5124 5130
14. R. Sauer, H. Becker, and P. Hohenberger Preoperative chemoradiotherapy as compared with postoperative chemoradiotherapy for locally advanced rectal cancer N Engl J Med 351 2004 1731 1740
15. R. Fietkau, C. Rodel, and W. Hohenberger Rectal cancer delivery of radiotherapy in adequate time and with adequate dose is influenced by treatment center, treatment schedule, and gender and is prognostic parameter for local control results of study CAO/ARO/AIO-94 Int J Radiat Oncol Biol Phys 67 2007 1008 1019
16. G.V. Salerno, I.R. Daniels, and B.J. Moran Magnetic resonance imaging prediction of an involved surgical resection margin in low rectal cancer Dis Colon Rectum 52 2009 632 639
17. B. Barbaro, V. Valentini, and C. Coco Tumor vascularity evaluated by transrectal color doppler US in predicting therapy outcome for low-lying rectal cancer Int J Radiat Oncol Biol Phys 63 2005 1304 1308 (Pubitemid 41628022)
18. V. Valentini, A. DePaoli, and M.A. Gambacorta Chemoradiation with infusional 5-FU and ZD1839 (Gefitinib-Iressa) in patients with locally advanced rectal cancer: a phase II trial Int J Radiat Oncol Biol Phys 66 2006 s168 (abstract)
19. N.K. Kim, M.J. Kim, and J.K. Park Preoperative staging of rectal cancer with MRI: accuracy and clinical usefulness Ann Surg Oncol 7 2000 732 737
20. C.S.R. Nahas, T. Akhurst, and H. Yeung Positron emission tomography detection of distant metastatic or synchronous disease in patients with locally advanced rectal cancer receiving preoperative chemoradiation Ann Surg Oncol 15 2008 704 711
21. C. Kristiansen, A. Loft, and A.K. Berthelsen PET/CT and histopathologic response to preoperative chemoradiation therapy in locally advanced rectal cancer Dis Colon Rectum 51 2008 21 25
22. V. Kalff, R. Ware, and A. Heriot Radiation changes do not interfere with postchemoradiation restaging of patients with rectal cancer by FDG PET/CT before curative surgical therapy Int J Radiat Oncol Biol Phys 74 2009 60 66
23. D. Mak, D.L. Joon, and M. Chao The use of PET in assessing tumor response after neoadjuvant chemoradiation for rectal cancer Radiother Oncol 97 2010 205 211
24. F.A. Calvo, L. Cabezon, and C. Gonzalez 18F-FDG PET bio-metabolic monitoring of neoadjuvant therapy effects in rectal cancer: focus on nodal disease characteristics Radiother Oncol 97 2010 212 216
25. B. Barbaro, C. Fiorucci, and C. Tebala Locally advanced rectal cancer: MR imaging in prediction of response after preoperative chemotherapy and radiation therapy Radiology 250 2009 730 739
26. F.A. Calvo, M. Domper, and R. Matute 18F-FDG positron emission tomography staging and restaging in rectal cancer treated with preoperative chemoradiation Int J Radiat Oncol Biol Phys 58 2004 528 535 (Pubitemid 38142480)
27. V.M. Shami, K.S. Parmer, and I. Waxman Clinical impact of endoscopic ultrasound and endoscopic ultrasound-guided fine-needle aspiration in the management of rectal carcinoma Dis Colon Rectum 47 2004 59 65 (Pubitemid 38040246)
28. Y.H. Kim, D.Y. Kim, and T.H. Kim Usefulness of magnetic resonance volumetric evaluation in predicting response to preoperative concurrent chemoradiotherapy in patients with resectable rectal cancer Int J Radiat Oncol Biol Phys 62 2005 761 768
29. L.J. Kuo, M.C. Chern, and M.H. Tsou Interpretation of magnetic resonance imaging for locally advanced rectal carcinoma after preoperative chemoradiation therapy Dis Colon Rectum 48 2005 23 28
30. B. Barbaro, A. Schulsinger, and V. Valentini The accuracy of transrectal ultrasound in predicting the pathological stage of low-lying rectal cancer after preoperative chemoradiation therapy Int J Radiat Oncol Biol Phys 43 1999 1043 1047 (Pubitemid 29144792)
31. J.G. Guillem, D.B. Chessin, and J. Shia Clinical examination following preoperative chemoradiation for rectal cancer is not a reliable surrogate endpoint J Clin Oncol 23 2005 3475 3479
32. R.J. Stephens, L.C. Thompson, and P. Quirke Impact of short-course preoperative radiotherapy for rectal cancer on patient's quality of life: data from the Medical Research Council CR07/National Cancer Institute of Canada Clinical Trials Group C016 randomized clinical trial J Clin Oncol 27 2010 4233 4239
33. K. Bujko, M.P. Nowacki, and A. Nasierowska-Guttmejer Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomized trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy Radiother Oncol 72 2004 15 24 (Pubitemid 38952855)
34. K. Bujko, M.P. Nowacki, and A. Nasierowska-Guttmejer Long term results of a randomized trial comparing preoperative short-course radiotherapy with preperative conventionally fractionated chemoradiation for rectal cancer Br J Surg 93 2006 1215 1223 (Pubitemid 44547018)
35. S. Ngan, R. Fischer, and D. Goldstein A randomized trial comparing local recurrence (LR) rates between short course (SC) and long course (LC) radiotherapy (RT) for clinical T3 rectal cancer: An Intergroup (TROG, AGITG, CSSANZ, RACS) J Clin Oncol 28 suppl 2010 abstract 3509 http://www.asco.org Accessed: June 28, 2011
36. D. Sebag-Montefiore, R.J. Stephens, and R. Steele Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicenter, randomised trial Lancet 373 2009 811 820
37. T.H. van Dijk, K. Havenga, and J. Beukema Short-course radiation therapy, neoadjuvant bevacizumab, capecitabine and oxaliplatin, and radical resection of primary tumor and metastasis in primary stage IV rectal cancer: a phase II multicenter study of the Dutch Colorectal Cancer Group J Clin Oncol 28 suppl 2010 abstract 3638 http://www.asco.org Accessed: June 28, 2011
38. J.F. Bosset, L. Collette, and E. Bardet Chemotherapy with preoperative radiotherapy in rectal cancer N Engl J Med 355 2006 1114 1123 (Pubitemid 44394918)
39. J.P. Gerard, T. Conroy, and F. Bonnetain Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203 J Clin Oncol 28 2006 4620 4625 (Pubitemid 46630960)
40. L. Collette, J.F. Bosset, and M. den Dulk Patients with curative resection of cT3-4 rectal cancer after preoperative radiotherapy or radiochemotherapy: does anybody benefit from adjuvant fluorouracil-based chemotherapy? A trial of the European Organisation for Research and Treatment of Cancer Radiation Oncology Group J Clin Oncol 25 2007 4379 4386 (Pubitemid 350013843)
41. F. Bonnetain, J.F. Bosset, and J.P. Gerard An analysis of preoperative chemoradiotherapy with 5FU/leucovorin for T3-4 rectal cancer on survival in a pooled analysis of EORTC 22921 and FFCD 9203 trials: surrogacy in question? J Clin Oncol 29 suppl 2011 abstract 3506 http://www.asco.org Accessed: June 28, 2011
42. P. Khrizman, J.C. Niland, and A. ter Veer Postoperative adjuvant chemotherapy (CTX) use in patients (pts) with stage II/III rectal cancer treated with neoadjuvant therapy: a National Comprehensive Cancer Network (NCCN) analysis J Clin Oncol 29 suppl 2011 abstract 3515 http://www.asco.org Accessed: June 28, 2011
43. G.L. Beets, M. Mass, and P.J. Nelemans Evaluation of response after chemoradiation for rectal cancer as a predictive factor for the benefit of adjuvant chemotherapy: a pooled analysis of 2724 individual patients J Clin Oncol 29 suppl 4 2011 abstract 361 http://www.asco.org Accessed: June 28, 2011
44. V. Valentini, C. Aristei, and B. Glimelius Multidisciplinary rectal cancer management: 2nd European Rectal Cancer Consensus Conference Radiother Oncol 92 2009 148 163
45. A. Nissan, A. Stojadinovic, and J. Shia Predictors of recurrence in patients with T2 and early T3, N0 adenocarcinoma of the rectum treated with surgery alone J Clin Oncol 24 2006 4078 4084 (Pubitemid 46622282)
46. F.L. Green, A.K. Stewart, and H.J. Norton New tumor-node-metastasis staging system for node-positive (stage III) rectal cancer: an analysis J Clin Oncol 22 2004 1778 1784 (Pubitemid 41095167)
47. J.H. Kim, G.L. Beets, and M.J. Kim High-resolution MR imaging for nodal staging in rectal cancer: are there any criteria in addition to the size? Eur J Radiol 52 2004 78 83 (Pubitemid 39233657)
48. J.G. Guillem, J. Diaz-Gonzalez, and B.D. Minsky cT3N0 rectal cancer: potential overtreatment with preoperative chemoradiotherapy is warranted J Clin Oncol 26 2008 368 373 (Pubitemid 351171686)
49. W.M. Mendenhall, K.I. Bland, and W.R. Rout Clinically resectable adenocarcinoma of the rectum treated with preoperative irradiation and surgery Dis Colon Rectum 31 1988 287 290
50. A. Cercek, M.R. Weiser, and K.A. Goodman Complete pathologic response in the primary of rectal or colon cancer treated with FOLFOX without radiation J Clin Oncol 28 suppl 2010 abstract 3649 http://www.asco.org Accessed: June 28, 2011
51. E. Kapiteijn, C.A.M. Marijnen, and I.D. Nagtegaal Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer New Engi J Med 345 2001 638 646
52. Swedish Rectal Cancer Trial: Improved survival with preoperative radiotherapy in resectable rectal cancer N Engi J Med 336 1997 980 987
53. R. Sauer, and C. Roedel The author's reply N Engl J Med 2005 352510 352511
54. G.M. Nash, A. Weiss, and R. Dasgupta Close distal margin and rectal cancer recurrence after sphincter-preserving rectal resection Dis Colon Rectum 53 2010 1365 1373
55. H.G. Moore, E. Riedel, and B.D. Minsky Adequacy of 1-cm distal margin after restorative rectal cancer resection with sharp mesorectal excision and preoperative combined modality therapy Ann Surg Oncol 10 2003 80 85
56. I.D. Nagtegaal, and P. Quirke What is the role for the circumferential margin in the modern treatment of rectal cancer? J Clin Oncol 26 2008 303 312
57. I.D. Nagtegaal, C.J.H. van de Velde, and C.A.M. Marijnen Low rectal cancer: a call for a change of approach in abdominoperineal resection J Clin Oncol 23 2005 9257 9264
58. J.G. Guillem, D.B. Chessin, and J. Shia A prospective pathologic analysis using whole mount sections of rectal cancer following preoperative combined modality therapy Implications for sphincter preservation Ann Surg 245 2007 88 93 (Pubitemid 46035440)
59. G. Branagan, H. Chave, and C. Fuller Can magnetic resonance imaging predict circumferential margins and TNM stage in rectal cancer? Dis Colon Rectum 47 2004 1317 1322 (Pubitemid 39180207)
60. S. Burton, G. Brown, and I. Daniels MRI identified prognostic features of tumors in distal sigmoid, rectosigmoid, and upper rectum: treatment with radiotherapy and chemotherapy Int J Radiat Oncol Biol Phys 65 2006 445 451
61. H. Rutten, D. Sebag-Montefiore, and R. Glynne-Jones Capecitabine, oxaliplatin, radiotherapy, and excision (CORE) in patients with MRI-defined locally advanced rectal adenocarcinoma: results of an international multicenter phase II study J Clin Oncol 24 suppl 2006 abstract 3258 http://www.asco.org Accessed: June 28, 2011
62. S.H. Baik, N.K. Kim, and Y.C. Lee Prognostic significance of circumferential resection margin following total mesorectal excision and adjuvant chemoradiotherapy in patients with rectal cancer Ann Surg Oncol 14 2007 462 469 (Pubitemid 46175290)
63. D. Sebag-Montefiore, R. Steele, and P. Quirke Routine short course pre-operative radiotherapy or selective post-op chemoradiotherapy for resectable rectal cancer? Preliminary results of the MRC CR07 randomised trial J Clin Oncol 24 2006 abstract 3511 http://www.asco.org Accessed: June 28, 2011
64. C.A.M. Marijnen, I.D. Nagtegaal, and E. Kapiteijn Radiotherapy does not compensate for positive resection margins in rectal cancer patients: report of a multicenter randomomized trial Int J Radiat Oncol Biol Phys 55 2003 1311 1320 (Pubitemid 36338299)
65. Y. Kundel, R. Brenner, and O. Purim Is local excision after complete pathological response to neoadjuvant chemoradiation for rectal cancer an acceptable treatment option? Dis Colon Rectum 53 2010 1624 1631
66. A. Habr-Gama, B. Santinho, and P.M. de Souza Low rectal cancer Impact of radiation and chemotherapy on surgical treatment Dis Colon Rectum 41 1998 1087 1096 (Pubitemid 28432448)
67. M. Gavioli, A. Bagni, and I. Piccagli Usefulness of endorectal ultrasound after preoperative radiotherapy in rectal cancer Dis Colon Rectum 43 2000 1075 1083
68. S.P. Hiotis, S.M. Weber, and A.M. Cohen Assessing the predictive value of clinical complete response to neoadjuvant therapy for rectal cancer: an analysis of 488 patients J Am Coll Surg 194 2002 131 136 (Pubitemid 34118868)
69. A. Dzik-Jurask, C. Domenig, and M. George Diffusion MRI for prediction of response of rectal cancer to chemoradiation Lancet 360 2002 307 308 (Pubitemid 34874724)
70. R. Glynne-Jones, M. Wallace, and J.I. Livingstone Complete clinical response after preoeprative chemoradiation in rectal cancer: is a "wait and see" policy justified? Dis Colon Rectum 51 2008 10 20
71. T. Borschitz, D. Wachtlin, and M. Mohler Neoadjuvant chemoradiation and local excision for T2-3 rectal cancer Ann Surg Oncol 15 2008 712 720
72. J. Garcia-Aguilar, Q. Shi, and C.R. Thomas Pathologic complete response (pCR) to neoadjuvant chemoradiation (CRT) of uT2UN0 rectal cancer (RC) treated by local excision (LE) Results of the ACOSOG Z6041 trial J Clin Oncol 28 suppl 2010 abstract 3510 http://www.asco.org Accessed: June 28, 2011
73. G.G. Callender, P. Das, and M. Rodriguez-Bigas Local excision after preoperative chemoradiation results is an equivalent outcome to total mesorectal excision in selected patients with T3 rectal cancer Ann Surg Oncol 17 2010 441 447
74. L. Cionini, and S. Lonardi Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized Phase III trial J Clin Oncol 29 2011 2773 2780
75. J.P. Gerard, D. Azria, and S. Gourgou-Bourgade Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III ACCORD 12/0405 PRODIGE 2 J Clin Oncol 28 2010 1638 1644
76. C. Roedel, H. Becker, and R. Fietkau Preoperative chemoradiotherapy and postoperative chemotherapy with 5-fluorouracil and oxaliplatin versus 5-fluorouracil alone in locally advanced rectal cancer: first results of the German CAO/ARO/AIO-04 randomized phase III trial J Clin Oncol 29 suppl 2011 abstract LBA3505 http://www.asco.org Accessed: June 28, 2011
77. C.G. Willett, D. Duda, and E. di Tomaso Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study J Clin Oncol 27 2009 3020 3026
78. E. van Cutsem, I. Lang, and G. D'haens KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab: the CRYSTAL experience J Clin Oncol 26 suppl 2008 abstract 2 http://www.asco.org Accessed: June 28, 2011
79. R.D. Hofheinz, B. von Gerstenberg-Helldorf, and F. Wenz Phase I trial of capecitabine and weekly irinotecan in combination with radiotherapy for neoadjuvant therapy of rectal cancer J Clin Oncol 23 2005 1350 1357
80. P. Das, E.H. Lin, and S. Bhatia Preoperative chemoradiotherapy with capecitabine versus protracted infusion 5-fluorouracil for rectal cancer: a matched-pair analysis Int J Radiat Oncol Biol Phys 66 2006 1378 1383
81. K.Y. Chung, B. Minsky, and D. Schrag Phase I trial of preoperative cetuximab with concurrent continuous infusion 5-fluorouracil and pelvic radiation in patients with local-regionally advanced rectal cancer J Clin Oncol 24 suppl 2006 abstract 3560 http://www.asco.org Accessed: June 28, 2011
82. C. Rodel, D. Arnold, and M. Hipp Phase I-II trial of cetuximab, capecitabine, oxaliplatin, and radiotherapy as preoperative treatment in rectal cancer Int J Radiat Oncol Biol Phys 70 2008 1081 1086 (Pubitemid 351296110)
83. A. Dewdney, D. Cunningham, and J. Tabernero EXPERT-C: a randomized phase II European multicenter trial of neoadjuvant chemotherapy (capecitabine/ oxaliplatin) and chemoradiation (CRT) with or without cetuximab followed by total mesorectal excision (TME) in patients with MRI-defined high-risk rectal cancer J Clin Oncol 29 suppl 4 2011 abstract 360 http://www.asco.org Accessed: June 28, 2011
84. I. Chau, G. Brown, and D. Cunningham Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging defined poor risk rectal cancer J Clin Oncol 24 2006 668 674 (Pubitemid 46630432)
85. C. Fernandez-Martos, J. Aparicio, and A. Salud Multicenter randomized phase II study of chemoradiation (CRT) followed by surgery (S) and chemotherapy (CT) versus induction chemotherapy followed by CRT and S in high-risk rectal cancer GCR-3 final efficacy and safety results J Clin Oncol 27 suppl 2009 abstract 4103 http://www.asco.org Accessed: June 28, 2011
86. D.E. Stein, N.N. Mahmoud, and P.R. Anne Longer time interval between completion of neoadjuvant chemoradiation and surgical resection does not improve downstaging of rectal carcinoma Dis Colon Rectum 46 2003 448 453 (Pubitemid 36428037)
87. J.G. Guillem, D.B. Chessin, and A.M. Cohen Long term oncologic outcome following preoperative combined modality therapy and total mesorectal excision of locally advanced rectal cancer Ann Surg 241 2005 829 838 (Pubitemid 40604929)
88. C. Capirci, V. Valentini, and L. Cionini Prognostic value of pathologic complete response after neoadjuvant therapy in locally advanced rectal cancer: long-term analysis of 566 ypCR patients Int J Radiat Oncol Biol Phys 72 2008 99 107
89. S.G. Yeo, D.Y. Kim, and T.H. Kim Pathologic complete response of primary tumor following preoperative chemoradiotherapy for locally advanced rectal cancer Long term outcomes and prognostic significance of pathologic nodal status (KROG 09-01) Ann Surg 252 2010 998 1004
90. M. Maas, P.J. Nelemans, and V. Valentini Long term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data Lancet Oncol 11 2010 835 844
91. J. Shia, M. McManus, and J.G. Guillem Significance of acellular mucin pools in rectal carcinoma after neoadjuvant radiotherapy Am J Surg Pathol 35 2011 127-4
92. M.G. Haddock, R.C. Miller, and H. Nelson Combined modality therapy including intraoperative electron irradiation for locally recurrent colorectal cancer Int J Radiat Oncol Biol Phys 79 2011 143 150
93. P.M. Wilson, M.J. LaBonte, and H.J. Lenz Molecular markers in the treatment of metastatic colorectal cancer Cancer J 16 2010 262 272
94. F. Bertolini, C. Bengala, and L. Losi Prognostic and predictive value of baseline and posttreatment molecular marker expression in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy Int J Radiat Oncol Biol Phys 68 2007 1455 1461 (Pubitemid 47176800)
95. D. Unsal, A. Under, and N. Akyuerk Matrix metalloproteinase-9 expression correlated with tumor response in patients with locally advanced rectal cancer undergoing preoperative chemoradiotherapy Int J Radiat Oncol Biol Phys 67 2007 196 203
96. P.G. Johnston Prognostic markers of local relapse in rectal cancer: are we any further forward? J Clin Oncol 24 2006 4049 4050 (Pubitemid 46622276)
97. J.G. Kuremsky, J.E. Tepper, and H.L. McLeod Biomarkers for response to neoadjuvant chemoradiation for rectal cancer Int J Radiat Oncol Biol Phys 74 2009 673 688
98. A. Konski, T. Li, and E. Sigurdson Use of molecular imaging to predict clinical outcome in patients with rectal cancer after preoperative chemotherapy and radiation Int J Radiat Oncol Biol Phys 74 2009 55 59
99. J. Meyer, B. Czito, and F.F. Yin Advanced radiation therapy technologies in the treatment of rectal and anal cancer: intensity-modulated photon therapy and proton therapy Clin Colorectal Cancer 6 2007 348 356 (Pubitemid 46340200)
100. J.J. Aristu, L. Arbea, and J. Rodriguez Phase I-II trial of concurrent capecitabine and oxaliplatin with preoperative intensity modulated radiotherapy in patients with locally advanced rectal cancer Int J Radiat Oncol Biol Phys 71 2008 748 755
101. H. Tatsuzaki, M.M. Urie, and C.G. Willett 3-D comparative study of proton vs. x-ray radiation therapy for rectal cancer Int J Radiat Oncol Biol Phys 22 1991 369 374
102. M.D. Callister, G.A. Ezzell, and L.L. Gunderson IMRT reduces the dose to small bowel and other pelvic organs in the preoperative treatment of rectal cancer Int J Radiat Oncol Biol Phys 66s290 2006 (abstr)
103. S. Roels, W. Duthoy, and K. Haustermans Definition and delineation of the clinical target volume for rectal cancer Int J Radiat Oncol Biol Phys 65 2006 1129 1142
104. R.J. Myerson, M.C. Garofalo, and I. El Naqa Elective clinical target volumes for conformal therapy in anorectal cancer: a radiation therapy oncology group consensus panel contouring atlas Int J Radiat Oncol Biol Phys 74 2009 824 830
105. M. Mohiuddin, K. Winter, and E. Mitchell Randomized phase II study of neoadjuvant combined modality chemoradiation for distal rectal cancer: Radiation Therapy Oncology Group trial 0012 J Clin Oncol 24 2006 650 655 (Pubitemid 46630429)
106. L. Ruo, J.G. Guillem, and B.D. Minsky Preoperative radiation with or without chemotherapy and full-thickness transanal excision for selected T2 and T3 distal rectal cancers Int J Colorectal Dis 17 2002 54 58 (Pubitemid 41398993)
107. S.R. Schell, R.A. Zlotecki, and W.M. Mendenhall Transanal excision of locally advanced rectal cancers downstaged using neoadjuvant chemoradiotherapy J Am Coll Surg 194 2002 584 591 (Pubitemid 34496653)
108. M.J. Hershman, A.S. Myint, and C.A. Makin Multi-modality approach in curative local treatment of early rectal carcinomas Colorectal Dis 5 2003 445 450 (Pubitemid 37080652)
109. F. Stipa, G. Lucandri, and M. Ferri Local excision of rectal cancer with transanal endoscopic microsurgery (TEM) Anticancer Res 24 2004 1167 1172 (Pubitemid 38624957)
110. M. Caricato, D. Borzomati, and F. Ausanai Complementary use of local excision and transanal endoscopic microsurgery for rectal cancer after neoadjuvant chemoradiation Surg Endosc 20 2006 1203 1207 (Pubitemid 44259041)
111. R.M. Nair, E.M. Siegel, and D.T. Chen Long-term results of transanal excision after neoadjuvant chemoradiation for T2 and T3 adenocarcinomas of the rectum J Gastrointest Surg 12 2008 1797 1806
112. G. Lezoche, M. Baldarelli, and M. Guerrieri A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery vs. laparoscopic total mesorectal excision after neoadjuvant therapy Surg Endosc 22 2008 352 358
113. J.W. Huh, E.J. Jung, and Y.A. Park Preoperative chemoradiation followed by transanal excision for rectal cancer J Surg Res 148 2008 244 250 (Pubitemid 351915759)
114. M.G. Fakih, A. Rajput, and G.Y. Yang A phase I study of weekly intravelous oxaliplatin in combination with oral daily capecitabine and radiation therapy in the neoadjuvant treatment of rectal adenocarcinoma Int J Radiat Oncol Biol Phys 65 2006 1462 1470 (Pubitemid 44425211)
115. A. Allal, S. Bieri, and P. Gervaz Preoperative concomitant hyperfractionated radiotherapy and gemcitaibine for locally advanced rectal cancers a phase I-II trial Cancer J 11 2005 133 139 (Pubitemid 44698824)
116. G.A.P. Hospers, C.J.A. Punt, and M.E. Tesselaar Preoperative chemoradiotherapy with capecitabine and oxaliplatin in localy advanced rectal cancer: a phase I-II multicenter study of the Dutch Colorectal Cancer Group Ann Surg Oncol 14 2007 2773 2779 (Pubitemid 47460621)
117. J.P. Machiels, L. Duck, and B. Honhon Phase II study of preoperative oxaliplatin, capecitabine, and external beam radiotherapy in patients with rectal cancer: the RadiOxCape study Ann Oncol 16 2005 1898 1905 (Pubitemid 41724278)
118. A. Avallone, P. Delrio, and C. Guida Biweekly oxaliplatin, raltitrexed, 5-fluorouracil and folinic acid combination chemotherapy during preoperative radiation therapy for locally advanced rectal cancer: a phase I-II study Br J Cancer 94 2006 1809 1815 (Pubitemid 43882570)
119. D.P. Ryan, D. Niedzwiecki, and D. Hollis Phase I/II study of preoperative oxaliplatin, fluorouracil, and external-beam radiation therapy in patients with locally advanced rectal cancer: Cancer and Leukemia Group B 89901 J Clin Oncol 24 2006 2557 2562 (Pubitemid 46630634)
120. S. Krishnan, N.A. Janjan, and P.M. Hoff Phase II study of capecitabine (Xeloda) and concomitant boost radiotherapy in patients with locally advanced rectal cancer Int J Radiat Oncol Biol Phys 66 2006 762 771 (Pubitemid 44436703)
121. C.H. Crane, C. Eng, and B.W. Feig Phase II trial of neoadjuvant bevacizumab (BEV), capecitabine (CAP), and radiotherapy (XRT) for locally advanced rectal cancer J Clin Oncol 26 suppl 2008 abstract 4091 http://www.asco.org Accessed: June 28, 2011
122. F. Bertolini, S. Chiara, and C. Bengala Neoadjuvant treatment with single-agent cetuximab followed by 5-FU, cetuximab, and pelvic radiotherapy: a phase II study in locally advanced rectal cancer Int J Radiat Oncol Biol Phys 73 2009 466 472
123. M. Navarro, E. Dotor, and F. Rivera A phase II study of preoperative radiotherapy and concomitant weekly irinotecan in combination with protracted venous infusion 5-fluorouracil for resectable locally advanced rectal cancer Int J Radiat Oncol Biol Phys 66 2006 201 205 (Pubitemid 44175647)
124. S.J. Wong, J. Moughan, and N.J. Meropol Efficacy endpoints of RTOG 0247: a randomized phase II study of neoadjuvant capecitabine (C) and Irinotecan (I) or C and oxaliplatin (O) with concurrent radiation therapy (RT) for locally advanced rectal cancer J Clin Oncol 29 suppl 2011 abstract 3517 http://www.asco.org Accessed: June 28, 2011
125. V. Valentini, C. Coco, and B.D. Minsky Randomized multicenter phase IIB study of preoperative chemoradiotherapy in T3 mid-distal rectal cancer raltitrexed + oxaliplatin + radiotherapy versus cisplatin + 5-fluorouracil radiotherapy Int J Radiat Oncol Biol Phys 70 2008 403 412