Randomized, Multicenter, Phase IIB Study of Preoperative Chemoradiotherapy in T3 Mid-Distal Rectal Cancer: Raltitrexed + Oxaliplatin + Radiotherapy Versus Cisplatin + 5-Fluorouracil + Radiotherapy

International Journal of Radiation Oncology Biology Physics

Volumn 70, Issue 2, 2008, Pages 403-412

  Valentini, Vincenzo ^a   Coco, Claudio ^a   Minsky, Bruce D ^c   Gambacorta, Maria Antonietta ^a   Cosimelli, Maurizio ^d   Bellavita, Rita ^h   Morganti, Alessio G ^b   La Torre, Giuseppe ^a   Trodella, Lucio ^e   Genovesi, Domenico ^f   Portaluri, Maurizio ^g   Maurizi Enrici, Riccardo ⁱ   Barbera, Fernando ^j   Maranzano, Ernesto ^k   Lupattelli, Marco ^h  

^a CATHOLIC UNIVERSITY   (Italy)

^b Department of Radiation Therapy   (Italy)

^c UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^d REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^e Department of Radiation Therapy ^*  (Italy)

^f UNIVERSITY OF CHIETI   (Italy)

^g Ospedale di Brindisi   (Italy)

^h UNIVERSITY OF PERUGIA   (Italy)

ⁱ SAPIENZA UNIVERSITY OF ROME   (Italy)

^j UNIVERSITY OF BRESCIA   (Italy)

^k Ospedale Civile   (Italy)

more..

Author keywords

Preoperative chemoradiotherapy; Rectal cancer; Sphincter saving; TRG; Tumor downstaging

Indexed keywords

PATHOLOGY; RADIOTHERAPY; TOXICITY;

PREOPERATIVE CHEMORADIOTHERAPY; TUMOR DOWNSTAGING;

TUMORS;

CISPLATIN; FLUOROURACIL; NONSTEROID ANTIINFLAMMATORY AGENT; OXALIPLATIN; RALTITREXED;

ACUTE TOXICITY; ADULT; AGED; ALOPECIA; ANEMIA; ANUS SPHINCTER; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER REGRESSION; CANCER SURGERY; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DYSESTHESIA; EXTERNAL BEAM RADIOTHERAPY; FEMALE; HUMAN; HUMAN TISSUE; LEUKOPENIA; LIVER FUNCTION TEST; LYMPHADENECTOMY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MULTIPLE CYCLE TREATMENT; NAUSEA AND VOMITING; NEPHROTOXICITY; OTOTOXICITY; PARESTHESIA; PERIPHERAL NEUROPATHY; PREOPERATIVE CARE; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; PROCTITIS; RADIATION DOSE; RADIATION INJURY; RANDOMIZED CONTROLLED TRIAL; RECTUM CARCINOMA; RECTUM RESECTION; SIDE EFFECT; SKIN TOXICITY; SURGICAL TECHNIQUE; THROMBOCYTOPENIA; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

ADENOCARCINOMA; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CISPLATIN; COMBINED MODALITY THERAPY; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROURACIL; HUMANS; MALE; MIDDLE AGED; ORGANOPLATINUM COMPOUNDS; PROSPECTIVE STUDIES; QUINAZOLINES; RADIOTHERAPY DOSAGE; RECTAL NEOPLASMS; THIOPHENES;

EID: 38149009730     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2007.06.025     Document Type: Article

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