Experimental characterization of the effects of acute stresslike doses of hydrocortisone in human neurogenic hyperalgesia models

Pain

Volumn 153, Issue 2, 2012, Pages 420-428

  Michaux, Gilles P N ^a   Magerl, Walter ^b   Anton, Fernand ^a   Treede, Rolf Detlef ^b  

^a UNIVERSITY OF LUXEMBOURG   (Luxembourg)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Capsaicin; Hydrocortisone; Hypothalamic pituitary adrenal axis; Quantitative sensory testing; Secondary hyperalgesia; Windup

Indexed keywords

CAPSAICIN; HYDROCORTISONE; PLACEBO;

ADULT; ALLODYNIA; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FOREARM; HUMAN; HUMAN EXPERIMENT; HYPERALGESIA; HYPERCORTISOLISM; LOW DRUG DOSE; NEUROGENIC HYPERALGESIA; NORMAL HUMAN; PAIN ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; TEMPORAL SUMMATION; VISUAL ANALOG SCALE;

ACUTE DISEASE; ADULT; ANALGESICS; ANTI-INFLAMMATORY AGENTS; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYDROCORTISONE; HYPERALGESIA; MALE; NEURALGIA; STRESS, PSYCHOLOGICAL; YOUNG ADULT;

EID: 84855960544     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2011.10.043     Document Type: Article

References (82)

1. Z. Ali, R.A. Meyer, and J.N. Campbell Secondary hyperalgesia to mechanical but not heat stimuli following a capsaicin injection in hairy skin Pain 68 1996 401 411 (Pubitemid 27025900)
2. R. Baron, T.R. Tölle, U. Gockel, M. Brosz, and R. Freynhagen A cross-sectional cohort survey in 2100 patients with painful diabetic neuropathy and postherpetic neuralgia: differences in demographic data and sensory symptoms Pain 146 2009 34 40
3. M.S. Bartlett The use of transformations Biometrics 3 1947 39 52
4. U. Baumgärtner, W. Magerl, T. Klein, H.C. Hopf, and R.D. Treede Neurogenic hyperalgesia versus painful hypoalgesia: two distinct mechanisms of neuropathic pain Pain 96 2002 141 151 (Pubitemid 34272290)
5. B.E. Beckwith, K. Lerud, J.R. Antes, and B.W. Reynolds Hydrocortisone reduces auditory sensitivity at high tonal frequencies in adult males Pharmacol Biochem Behav 19 1983 431 433 (Pubitemid 13016740)
6. T. Bisgaard, B. Klarskov, H. Kehlet, and J. Rosenberg Preoperative dexamethasone improves surgical outcome after laparoscopic cholecystectomy: a randomized double-blind placebo-controlled trial Ann Surg 238 2003 651 660 (Pubitemid 38182254)
7. J. Born, W. Kern, G. Fehm-Wolfsdorf, and H.L. Fehm Cortisol effects on attentional processes in man as indicated by event-related potentials Psychophysiology 24 1987 286 292 (Pubitemid 17071801)
8. N.A. Calcutt, and M.M. Backonja Pathogenesis of pain in peripheral diabetic neuropathy Curr Diabetes Rep 7 2007 429 434 (Pubitemid 350284973)
9. E. Charlton Ethical guidelines for pain research in humans. Committee on ethical issues of the international association for the study of pain Pain 63 1995 277 278
10. A. Cintra, C. Molander, and K. Fuxe Colocalization of fos- and glucocorticoid receptor-immunoreactivities is present only in a very restricted population of dorsal horn neurons of the rat spinal cord after nociceptive stimulation Brain Res 632 1993 334 338 (Pubitemid 24015536)
11. J.D. Croxtall, Q. Choudhury, and R.J. Flower Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism Br J Pharmacol 130 2000 289 298 (Pubitemid 30261038)
12. D. Czock, F. Keller, F.M. Rasche, and U. Häussler Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids Clin Pharmacokinet 44 2005 61 98 (Pubitemid 40096038)
13. M. DeLeón, R. Coveñas, G. Chadi, J.A. Narváez, K. Fuxe, and A. Cintra Subpopulations of primary sensory neurons show coexistence of neuropeptides and glucocorticoid receptors in the rat spinal and trigeminal ganglia Brain Res 636 1994 338 342 (Pubitemid 24044652)
14. H. Derendorf, H. Möllmann, J. Barth, C. Möllmann, S. Tunn, and M. Krieg Pharmacokinetics and oral bioavailability of hydrocortisone J Clin Pharmacol 31 1991 473 476
15. M. Devor, R. Govrin-Lippmann, and P. Raber Corticosteroids suppress ectopic neural discharge originating in experimental neuromas Pain 22 1985 127 137 (Pubitemid 15057897)
16. J. Drejer, C. Hendriksen, L.M. Nielsen, C. Binder, C. Hagen, and H. Kehlet Diurnal variations in plasma prolactin, growth hormone, cortisol and blood glucose in labile diabetes mellitus Clin Endocrinol (Oxf) 6 1977 57 64 (Pubitemid 8077312)
17. N.V. Esteban, T. Loughlin, A.L. Yergey, J.K. Zawadzki, J.D. Booth, J.C. Winterer, and D.L. Loriaux Daily cortisol production rate in man determined by stable isotope dilution/mass spectrometry J Clin Endocrinol Metab 72 1991 39 45 (Pubitemid 21921653)
18. J.T. Farrar, J.P. Young, L. LaMoreaux, J.L. Werth, and R.M. Poole Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale Pain 94 2001 149 158 (Pubitemid 33016608)
19. G. Fehm-Wolfsdorf, E. Scheible, H. Zenz, J. Born, and H.L. Fehm Taste thresholds in man are differentially influenced by hydrocortisone and dexamethasone Psychoneuroendocrinology 14 1989 433 440 (Pubitemid 20033111)
20. G. Fehm-Wolfsdorf, U. Soherr, R. Arndt, W. Kern, H.L. Fehm, and D. Nagel Auditory reflex thresholds elevated by stress-induced cortisol secretion Psychoneuroendocrinology 18 1993 579 589 (Pubitemid 23363094)
21. A.A. Filaretov, A.I. Bogdanov, and N.I. Yarushkina Stress-Induced analgesia. The role of hormones produced by the hypophyseal-adrenocortical system Neurosci Behav Physiol 26 1996 572 578 (Pubitemid 126723369)
22. K.M. Hargreaves, G.P. Mueller, R. Dubner, D. Goldstein, and R.A. Dionne Corticotropin-Releasing factor (CRF) produces analgesia in humans and rats Brain Res 422 1987 154 157 (Pubitemid 17153458)
23. J.F. Herrero, J.M. Laird, and J.A. López-García Wind-Up of spinal cord neurones and pain sensation: much ado about something? Prog Neurobiol 61 2000 169 203 (Pubitemid 30110477)
24. K. Holte, and H. Kehlet Perioperative single-dose glucocorticoid administration: pathophysiologic effects and clinical implications J Am Coll Surg 195 2002 694 712 (Pubitemid 35285405)
25. M. Hornyak, A. Rupp, D. Riemann, B. Feige, M. Berger, and U. Voderholzer Low-Dose hydrocortisone in the evening modulates symptom severity in restless legs syndrome Neurology 70 2008 1620 1622 (Pubitemid 351620318)
26. S. Hunskaar, and K. Hole The formalin test in mice. Dissociation between inflammatory and non-inflammatory pain Pain 30 1987 103 114 (Pubitemid 17094194)
27. T.S. Jensen, and R. Baron Translation of symptoms and signs into mechanisms in neuropathic pain Pain 102 2003 1 8 (Pubitemid 36298856)
28. A. Johansson, J. Hao, and B. Sjölund Local corticosteroid application blocks transmission in normal nociceptive c-fibres Acta Anaesthesiol Scand 34 1990 335 338 (Pubitemid 20310354)
29. M. Karst, K. Salim, S. Burstein, I. Conrad, L. Hoy, and U. Schneider Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial JAMA 290 2003 1757 1762 (Pubitemid 37430626)
30. H. Kehlet Glucocorticoids for peri-operative analgesia: how far are we from general recommendations? Acta Anaesthesiol Scand 51 2007 1133 1135 (Pubitemid 47389702)
31. H. Kehlet, and C. Binder Adrenocortical function and clinical course during and after surgery in unsupplemented glucocorticoid-treated patients Br J Anaesth 45 1973 1043 1048
32. L.J. Kehl, T.M. Trempe, and K.M. Hargreaves A new animal model for assessing mechanisms and management of muscle hyperalgesia Pain 85 2000 333 343 (Pubitemid 30214161)
33. W.S. Kingery A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes Pain 73 1997 123 139 (Pubitemid 27491673)
34. W.S. Kingery, T. Guo, G.S. Agashe, M.F. Davies, J.D. Clark, and M. Maze Glucocorticoid inhibition of neuropathic limb edema and cutaneous neurogenic extravasation Brain Res 913 2001 140 148 (Pubitemid 32817057)
35. T. Klein, W. Magerl, A. Hanschmann, M. Althaus, and R.D. Treede Antihyperalgesic and analgesic properties of the n-methyl-d-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic hyperalgesia Eur J Pain 12 2008 17 29 (Pubitemid 350046361)
36. T. Klein, W. Magerl, R. Rolke, and R.-D. Treede Human surrogate models of neuropathic pain Pain 115 2005 227 233 (Pubitemid 40725278)
37. N. Kotani, T. Kushikata, H. Hashimoto, F. Kimura, M. Muraoka, M. Yodono, M. Asai, and A. Matsuki Intrathecal methylprednisolone for intractable postherpetic neuralgia N Engl J Med 343 2000 1514 1519
38. L.K. Kuehl, G.P. Michaux, S. Richter, H. Schächinger, and F. Anton Increased basal mechanical pain sensitivity but decreased perceptual wind-up in a human model of relative hypocortisolism Pain 149 2010 539 546
39. S.W. Lamberts, H.A. Bruining, and F.H. de Jong Corticosteroid therapy in severe illness N Engl J Med 337 1997 1285 1292 (Pubitemid 27461285)
40. R.H. LaMotte, C.N. Shain, D.A. Simone, and E.F. Tsai Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms J Neurophysiol 66 1991 190 211
41. J.J. Langmayr, A.A. Obwegeser, A.B. Schwarz, I. Laimer, H. Ulmer, and M. Ortler Intrathecal steroids to reduce pain after lumbar disc surgery: a double-blind, placebo-controlled prospective study Pain 62 1995 357 361
42. W.R. Lariviere, and R. Melzack The role of corticotropin-releasing factor in pain and analgesia Pain 84 2000 1 12
43. S. Lautenbacher, S. Roscher, G. Kohl, H. Vedder, and J. Krieg Corticotropin-Releasing-Hormone lacks analgesic properties: an experimental study in humans, using non-inflammatory pain Pain 83 1999 1 7 (Pubitemid 29446151)
44. H. Logan, S. Lutgendorf, P. Rainville, D. Sheffield, K. Iverson, and D. Lubaroff Effects of stress and relaxation on capsaicin-induced pain J Pain 2 2001 160 170 (Pubitemid 32550238)
45. R.M. Losel, E. Falkenstein, M. Feuring, A. Schultz, H.-C. Tillmann, K. Rossol-Haseroth, and M. Wehling Nongenomic steroid action: controversies, questions, and answers Physiol Rev 83 2003 965 1016 (Pubitemid 36828929)
46. W. Magerl, P.N. Fuchs, R.A. Meyer, and R.D. Treede Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia Brain 124 2001 1754 1764 (Pubitemid 32845437)
47. C. Maier, R. Baron, T.R. Tölle, A. Binder, N. Birbaumer, F. Birklein, J. Gierthmühlen, H. Flor, C. Geber, V. Huge, E.K. Krumova, G.B. Landwehrmeyer, W. Magerl, C. Maihöfner, H. Richter, R. Rolke, A. Scherens, A. Schwarz, C. Sommer, V. Tronnier, N. Ueyler, M. Valet, G. Wasner, and R.D. Treede Quantitative sensory testing in the German research network on neuropathic pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes Pain 150 2010 439 450
48. G.B. Makara, and J. Haller Non-Genomic effects of glucocorticoids in the neural system. Evidence, mechanisms and implications Prog Neurobiol 65 2001 367 390 (Pubitemid 32781669)
49. S. McKean, X. Kochilas, R. Kelleher, and M. Dockery Use of intravenous steroids at induction of anaesthesia for adult tonsillectomy to reduce post-operative nausea and vomiting and pain: a double-blind randomized controlled trial Clin Otolaryngol 31 2006 36 40
50. J.A. O'Hare, F. Abuaisha, and M. Geoghegan Prevalence and forms of neuropathic morbidity in 800 diabetics Ir J Med Sci 163 1994 132 135 (Pubitemid 24103995)
51. R.C. Oldfield The assessment and analysis of handedness: the edinburgh inventory Neuropsychologia 9 1971 97 113
52. J.L. Pedersen, S. Moiniche, and H. Kehlet Topical glucocorticoid has no antinociceptive or anti-inflammatory effect in thermal injury Br J Anaesth 72 1994 379 382 (Pubitemid 24117959)
53. P. Poisbeau, C. Patte-Mensah, A.F. Keller, M. Barrot, J.D. Breton, O.E. Luis-Delgado, M.J. Freund-Mercier, A.G. Mensah-Nyagan, and R. Schlichter Inflammatory pain upregulates spinal inhibition via endogenous neurosteroid production J Neurosci 25 2005 11768 11776 (Pubitemid 43098469)
54. D.D. Price, F.M. Bush, S. Long, and S.W. Harkins A comparison of pain measurement characteristics of mechanical visual analogue and simple numerical rating scales Pain 56 1994 217 226 (Pubitemid 24067851)
55. D.D. Price, J. Mao, H. Frenk, and D.J. Mayer The n-methyl-d-aspartate receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man Pain 59 1994 165 174 (Pubitemid 24348901)
56. P. Putman, and K. Roelofs Effects of single cortisol administrations on human affect reviewed: coping with stress through adaptive regulation of automatic cognitive processing Psychoneuroendocrinology 36 2011 439 448
57. M. Qin, J.J. Wang, R. Cao, H. Zhang, L. Duan, B. Gao, Y.F. Xiong, L.W. Chen, and Z.R. Rao The lumbar spinal cord glial cells actively modulate subcutaneous formalin induced hyperalgesia in the rat Neurosci Res 55 2006 442 450 (Pubitemid 43866257)
58. S. Richter, A. Schulz, C.M. Zech, M.S. Oitzl, N.P. Daskalakis, T.D. Blumenthal, and H. Schächinger Cortisol rapidly disrupts prepulse inhibition in healthy men Psychoneuroendocrinology 36 2011 109 114
59. L. Romundstad, H. Breivik, G. Niemi, A. Helle, and A. Stubhaug Methylprednisolone intravenously 1 day after surgery has sustained analgesic and opioid-sparing effects Acta Anaesthesiol Scand 48 2004 1223 1231 (Pubitemid 39490854)
60. M. Salem, R.E. Tainsh, J. Bromberg, D.L. Loriaux, and B. Chernow Perioperative glucocorticoid coverage. A reassessment 42 years after emergence of a problem Ann Surg 219 1994 416 425 (Pubitemid 24121456)
61. J. Scholz, and C.J. Woolf The neuropathic pain triad: neurons, immune cells and glia Nat Neurosci 10 2007 1361 1368 (Pubitemid 350014681)
62. M. Shibata, T. Ohkubo, H. Takahashi, and R. Inoki Modified formalin test: characteristic biphasic pain response Pain 38 1989 347 352 (Pubitemid 19251258)
63. D.A. Simone, T.K. Baumann, and R.H. LaMotte Dose-Dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin Pain 38 1989 99 107 (Pubitemid 19184845)
64. P. Skjelbred, and P. Løkken Reduction of pain and swelling by a corticosteroid injected 3 hours after surgery Eur J Clin Pharmacol 23 1982 141 146 (Pubitemid 12068941)
65. E.I. Sokolov Obesity and diabetes mellitus 1997 VSP Utrecht
66. C. Stahn, and F. Buttgereit Genomic and nongenomic effects of glucocorticoids Nat Clin Pract Rheumatol 4 2008 525 533
67. K. Stiasny-Kolster, W. Magerl, W.H. Oertel, J.C. Möller, and R.D. Treede Static mechanical hyperalgesia without dynamic tactile allodynia in patients with restless legs syndrome Brain 127 2004 773 782 (Pubitemid 38478522)
68. A. Stubhaug, L. Romundstad, T. Kaasa, and H. Breivik Methylprednisolone and ketorolac rapidly reduce hyperalgesia around a skin burn injury and increase pressure pain thresholds Acta Anaesthesiol Scand 51 2007 1138 1146 (Pubitemid 47389685)
69. H. Sumikura, O.K. Andersen, A.M. Drewes, and L. Arendt-Nielsen Spatial and temporal profiles of flare and hyperalgesia after intradermal capsaicin Pain 105 2003 285 291 (Pubitemid 37162498)
70. C.I. Svensson, B. Fitzsimmons, S. Azizi, H.C. Powell, X.Y. Hua, and T.L. Yaksh Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization J Neurochem 92 2005 1508 1520 (Pubitemid 40389219)
71. R. Tafler, M.K. Herbert, R.F. Schmidt, and K.H. Weis Small reduction of capsaicin-induced neurogenic inflammation in human forearm skin by the glucocorticoid prednicarbate Agents Actions 38 1993 C31 C34
72. K. Takeda, S. Sawamura, H. Sekiyama, H. Tamai, and K. Hanaoka Effect of methylprednisolone on neuropathic pain and spinal glial activation in rats Anesthesiology 100 2004 1249 1257 (Pubitemid 38541982)
73. A. Tjølsen, O.G. Berge, S. Hunskaar, J.H. Rosland, and K. Hole The formalin test: an evaluation of the method Pain 51 1992 5 17
74. R.D. Treede, and W. Magerl Modern concepts of pain and hyperalgesia: beyond the polymodal c-nociceptor Physiology 10 1995 216
75. S. Tunn, H. Möllmann, J. Barth, H. Derendorf, and M. Krieg Simultaneous measurement of cortisol in serum and saliva after different forms of cortisol administration Clin Chem 38 1992 1491 1494
76. J. Van Hees, and J. Gybels C nociceptor activity in human nerve during painful and non painful skin stimulation J Neurol Neurosurg Psych 44 1981 600 607 (Pubitemid 11018898)
77. C.J. Vierck Mechanisms underlying development of spatially distributed chronic pain (fibromyalgia) Pain 124 2006 242 263
78. M.U. Werner, B. Lassen, and H. Kehlet Analgesic effects of dexamethasone in burn injury Reg Anesth Pain Med 27 2002 254 260 (Pubitemid 34533678)
79. C.J. Woolf, and M.W. Salter Neuronal plasticity: increasing the gain in pain Science 288 2000 1765 1769
80. W. Xie, X. Liu, H. Xuan, S. Luo, X. Zhao, Z. Zhou, and J. Xu Effect of betamethasone on neuropathic pain and cerebral expression of nf-kappab and cytokines Neurosci Lett 393 2006 255 259 (Pubitemid 41821118)
81. E.A. Ziegler, W. Magerl, R.A. Meyer, and R.D. Treede Secondary hyperalgesia to punctate mechanical stimuli. Central sensitization to a-fibre nociceptor input Brain 122 1999 2245 2257
82. O. Zinder, and D.E. Dar Neuroactive steroids: their mechanism of action and their function in the stress response Acta Physiol Scand 167 1999 181 188 (Pubitemid 30019110)