Methylprednisolone and ketorolac rapidly reduce hyperalgesia around a skin burn injury and increase pressure pain thresholds

Acta Anaesthesiologica Scandinavica

Volumn 51, Issue 9, 2007, Pages 1138-1146

  Stubhaug, A ^a   Romundstad, L ^a   Kaasa, T ^a   Breivik, H ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

Allodynia; Cross over study; Double blind study; Ketorolac; Methylprednisolone; Pressure pain detection threshold; Pressure pain tolerance threshold; Randomized; Secondary hyperalgesia

Indexed keywords

KETOROLAC; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE; PLACEBO;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; BURN; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HYPERALGESIA; MALE; PAIN THRESHOLD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN INFLAMMATION;

ADULT; ANALGESIA; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BURNS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; GLUCOCORTICOIDS; HUMANS; HYPERALGESIA; KETOROLAC; MALE; METHYLPREDNISOLONE; PAIN THRESHOLD; PROSPECTIVE STUDIES; TIME FACTORS;

EID: 34548279914     PISSN: 00015172     EISSN: 13996576     Source Type: Journal    
DOI: 10.1111/j.1399-6576.2007.01415.x     Document Type: Article

References (42)

1. Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet 2006 367 : 1618 25.
2. Breivik H, Curatolo M, Niemi G et al. How to implement an acute postoperative pain service - an update. In : Breivik H, Shipley M, eds. Pain. Best Practice and Research Compendium. London : Elsevier, 2007 : 253 67.
3. Takeda K, Sawamura S, Sekiyama H, Tamai H, Hanaoka K. Effect of methylprednisolone on neuropathic pain and spinal glial activation in rats. Anesthesiology 2004 100 : 1249 57.
4. Warncke T, Stubhaug A, Jorum E. Ketamine, an NMDA receptor antagonist, suppresses spatial and temporal properties of burn-induced secondary hyperalgesia in man: a double-blind, cross-over comparison with morphine and placebo. Pain 1997 72 : 99 106.
5. Romundstad L, Stubhaug A, Niemi G, Rosseland LA, Breivik H. Adding propacetamol to ketorolac increases the tolerance to painful pressure. Eur J Pain 2006 10 : 177 83.
6. Samad TA, Moore KA, Sapirstein A et al. Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 2001 410 : 471 5.
7. Simmons DL, Botting RM, Hla T. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev 2004 56 : 387 437.
8. Woolf CJ, Salter MW. Neuronal plasticity: increasing the gain in pain. Science 2000 288 : 1765 9.
9. Ahmadi S, Lippross S, Neuhuber WL, Zeilhofer HU. PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons. Nat Neurosci 2002 1 : 34 40.
10. Aasbø V, Ræder JC, Grøgaard B. Betamethasone reduces postoperative pain and nausea after ambulatory surgery. Anesth Analg 1998 87 : 319 23.
11. Romundstad L, Breivik H, Niemi G, Helle A, Stubhaug A. Methylprednisolone intravenously 1 day after surgery has sustained analgesic and opioid-sparing effects. Acta Anaesthesiol Scand 2004 48 : 1223 31.
12. Afman CE, Welge JA, Steward DL. Steroids for post-tonsillectomy pain reduction: meta analysis of randomized controlled trials. Otolaryngol Head Neck Surg 2006 134 : 181 6.
13. Schleimer RP. An overview of glucocorticoid anti-inflammatory actions. Eur J Clin Pharmacol 1993 45 : S3 7 discussion S43-4.
14. Ferreira SH, Cunha FQ, Lorenzetti BB et al. Role of lipocortin-1 in the anti-hyperalgesic actions of dexamethasone. Br J Pharmacol 1997 121 : 883 8.
15. Svennson CI, Yaksh TI. The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing. Annu Rev Pharmacol Toxicol 2002 42 : 553 83.
16. Zhu X, Conklin D, Eisenach JC. Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain. Pain 2003 104 : 15 23.
17. Zhu X, Eisenach JC. Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury. Anesthesiology 2003 99 : 1175 9.
18. Koppert W, Wehrfritz A, Korber N et al. The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans. Pain 2004 108 : 148 53.
19. Møiniche S, Pedersen JL, Kehlet H. Topical ketorolac has no antinociceptive or anti-inflammatory effect in thermal injury. Burns 1994 20 : 483 6.
20. Petersen KL, Brennum J, Dahl JB. Experimental evaluation of the analgesic effect of ibuprofen on primary and secondary hyperalgesia. Pain 1997 70 : 167 74.
21. Kumar K, Polston GR, Wallace MS. The effect of intravenous ketorolac on capsaicin-induced deep tissue hyperalgesia. Anesth Analg 2006 103 : 696 702.
22. Jones B, Kenward MG. Design and Analysis of Cross-Over Trials. London : Chapman & Hall, 1989 : 192 9.
23. Verbeke G, Molenberghs G. Linear mixed models in practice: a SAS-oriented approach. In : Verbeke G, Molenberghs G, eds. Lecture Notes in Statistics. New York : Springer-Verlag, 1997 : 2 27.
24. Littell RC, Pendergast J, Natarajan R. Modelling covariance structure in the analysis of repeated measures data. Stat Med 2000 19 : 1793 819.
25. Brown H, Prescott R. Advantages of mixed models in cross-over trials. In : Barnett V, ed. Statistics in Practice: Applied Mixed Models in Medicine. Indianapolis, IN : Wiley, 1999 : 261 2.
26. Hochberg Y, Tamhane AC. Multiple Comparison Procedures. New York : Wiley, 1990.
27. Snedecor GW, Cochran WG. Statistical Methods, 7th edn. Ames, IA : Iowa State University Press, 1980.
28. Mathews JNS, Altman DG, Campbell MJ, Royston P. Analysis of serial measurements in medical research. Br Med J 1990 300 : 230 5.
29. Brennum J, Kjeldsen M, Jensen K, Jensen TS. Measurements of human pressure-pain thresholds on fingers and toes. Pain 1989 38 : 211 7.
30. Stubhaug A, Breivik H, Eide PK, Kreunen M, Foss A. Mapping of punctate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery. Acta Anaesthesiol Scand 1997 41 : 1124 32.
31. Petersen KL, Brennum J, Olesen J. Evaluation of pericranial myofascial nociception by pressure algometry. Reproducibility and factors of variation. Cephalalgia 1992 12 : 33 7.
32. Gerdes D, Christ M, Haseroth K, Notzon A, Falkenstein E, Wehling M. Specific, nongenomic actions of steroid hormones. Annu Rev Physiol 1997 59 : 365 93.
33. Falkenstein E, Tillmann HC, Christ M, Feuring M, Wehling M. Multiple actions of steroid hormones - a focus on rapid, nongenomic effects. Pharmacol Rev 2000 52 : 513 56.
34. Di S, Malcher-Lopes R, Marcheselli VL, Bazan NG, Tasker JG. Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and gamma-aminobutyric acid inputs to hypothalamic magnocellular neurons. Endocrinology 2005 146 : 4292 301.
35. Werner MU, Lassen B, Kehlet H. Analgesic effects of dexamethasone in burn injury. Reg Anesth Pain Med 2002 27 : 254 60.
36. De Kock M, Lavand'homme P, Waterloos H. The short-lasting analgesia and long-term antihyperalgesic effect of intrathecal clonidine in patients undergoing colonic surgery. Anesth Analg 2005 101 : 566 72.
37. Bianchi M, Panerai AE. Effects of lornoxicam, piroxicam, and meloxicam in a model of thermal hindpaw hyperalgesia induced by formalin injection in rat tail. Pharmacol Res 2002 45 : 101 5.
38. Burian M, Geisslinger G. COX-dependent mechanisms involved in the antinociceptive action of NSAIDs at central and peripheral sites. Pharmacol Ther 2005 107 : 139 54.
39. Takeda K, Sawamura S, Tamai H, Sekiyama H, Hanaoka K. Role for cyclooxygenase 2 in the development and maintenance of neuropathic pain and spinal glial activation. Anesthesiology 2005 103 : 837 44.
40. Ma W, Eisenach JC. Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain. Eur J Neurosci 2002 15 : 1037 47.
41. Isselee H, De Laat A, Bogaerts K, Lysens R. Long-term fluctuations of pressure pain thresholds in healthy men, normally menstruating women and oral contraceptive users. Eur J Pain 2001 5 : 27 37.
42. Barden J, Edwards JE, Moore RA, McQuay HJ. Ibuprofen 400 mg is effective in women, and women are well represented in trials. BMC Anesthesiol 2002 2 : 6.