Nanoparticle PEBBLE sensors in live cells

Methods in Enzymology

Volumn 504, Issue , 2012, Pages 419-470

  Koo Lee, Yong Eun ^a   Kopelman, Raoul ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

enzyme activity; fluorescence; ion; molecule; nanoparticle; physical property; sensor

Indexed keywords

ANION; CALCIUM ION; CATION; COPPER ION; DISSOLVED OXYGEN; GLUCOSE; HYDROGEN PEROXIDE; IRON; LEAD; MAGNESIUM ION; MERCURY; NANOPARTICLE; OXYGEN; POTASSIUM ION; REACTIVE OXYGEN METABOLITE; SODIUM ION; ZINC ION;

APOPTOSIS; ARTICLE; BIOENGINEERING; CELL DIFFERENTIATION; CELL FUNCTION; CELL STRUCTURE; CHEMICAL ANALYSIS; ELECTRIC FIELD; ENZYME ACTIVITY; EQUIPMENT DESIGN; MOLECULAR PROBE; NANOSENSOR; OPTICS; PEBBLE SENSOR; PH MEASUREMENT; PHOSPHORYLATION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TEMPERATURE MEASUREMENT;

EID: 84855928927     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-391857-4.00021-5     Document Type: Chapter

References (139)

1. E. Allard, and C. Larpent Core-shell type dually fluorescent polymer nanoparticles for ratiometric pH-sensing J. Polym. Sci. A: Polym. Chem. 46 2008 6206 6213
2. J.N. Anker, and R. Kopelman Magnetically modulated optical nanoprobes Appl. Phys. Lett. 82 2003 1102 1104
3. J.N. Anker, C. Behrend, and R. Kopelman Aspherical magnetically modulated optical nanoprobes (MagMOONs) J. Appl. Phys. 93 2003 6698 6700
4. M. Arduini, S. Marcuz, M. Montolli, E. Rampazzo, F. Mancin, S. Gross, L. Armelao, P. Tecilla, and U. Tonellato Turning fluorescent dyes into Cu(II) nanosensors Langmuir 21 2005 9314 9321 (Pubitemid 41433980)
5. 2+ detection Langmuir 23 2007 8632 8636 (Pubitemid 47237863)
6. K. Aslan, I. Gryczynski, J. Malicka, E. Matveeva, J.R. Lakowicz, and C.D. Geddes Metal-enhanced fluorescence: An emerging tool in biotechnology Curr. Opin. Biotechnol. 16 2005 55 62 (Pubitemid 40253579)
7. X. Banquy, F. Suarez, A. Argaw, J.-M. Rabanel, P. Grutter, J.-F. Bouchard, P. Hildgen, and S. Giasson Effect of mechanical properties of hydrogel nanoparticles on macrophage cell uptake Soft Matter 5 2009 3984 3991
8. S.M. Borisov, and I. Klimant Luminescent nanobeads for optical sensing and imaging of dissolved oxygen Microchim. Acta 164 2009 7 15
9. S.M. Borisov, and O.S. Wolfbeis Temperature-sensitive europium(III) probes and their use for simultaneous luminescent sensing of temperature and oxygen Anal. Chem. 78 2006 5094 5101 (Pubitemid 44100646)
10. S.M. Borisov, T. Mayr, and I. Klimant Poly(styrene-block- vinylpyrrolidone) beads as a versatile material for simple fabrication of optical nanosensors Anal. Chem. 80 2008 573 582 (Pubitemid 351206843)
11. S.M. Borisov, G. Nuss, and I. Klimant Red light-excitable oxygen sensing materials based on platinum(II) and palladium(II) benzoporphyrins Anal. Chem. 80 2008 9435 9442
12. 2+ on silica particles Chem. Commun. 24 2003 3026 3027 (Pubitemid 38019256)
13. M. Brasuel, R. Kopelman, T.J. Miller, R. Tjalkens, and M.A. Philbert Fluorescent nanosensors for intracellular chemical analysis: Decyl methacrylate liquid polymer matrix and ion-exchange-based potassium PEBBLE sensors with real-time application to viable rat C6 glioma cells Anal. Chem. 73 2001 2221 2228 (Pubitemid 32880686)
14. M. Brasuel, R. Kopelman, I. Kasman, T.J. Miller, and M.A. Philbert Ion concentrations in live cells from highly selective ion correlations fluorescent nano-sensors for sodium Proc. IEEE Sensors 1 2002 288 292
15. - analysis and biological applications Analyst 128 2003 1262 1267 (Pubitemid 37357602)
16. J.Q. Brown, and M.J. McShane Core-referenced ratiometric fluorescent potassium ion sensors using self-assembled ultrathin films on europium nanoparticles IEEE Sensors J. 5 2005 1197 1205 (Pubitemid 41788484)
17. A. Burns, P. Sengupta, T. Zedayko, B. Baird, and U. Wiesner Core/shell fluorescent silica nanopartictes for chemical sensing: Towards single-particle laboratories Small 2 2006 723 726 (Pubitemid 43745139)
18. Y. Cao, Y.-E.L. Koo, and R. Kopelman Poly (decyl methacrylate)-based fluorescent PEBBLE swarm nanosensors for measuring dissolved oxygen in biosamples Analyst 129 2004 745 750 (Pubitemid 39120521)
19. Y. Cao, Y.-E.L. Koo, S. Koo, and R. Kopelman Ratiometric singlet oxygen nano-optodes and their use for monitoring photodynamic therapy nanoplatforms Photochem. Photobiol. 81 2005 1489 1498 (Pubitemid 43035862)
20. W.C.W. Chan, and S.M. Nie Quantum dot bioconjugates for ultrasensitive nonisotopic detection Science 281 1998 2016 2018 (Pubitemid 28475486)
21. Y.H. Chan, C.F. Wu, F.M. Ye, Y.H. Jin, P.B. Smith, and D.T. Chiu Development of ultrabright semiconducting polymer dots for ratiometric pH sensing Anal. Chem. 83 2011 1448 1455
22. S. Chandra, D. Gross, Y.C. Ling, and G.H. Morrison Quantitative imaging of free and total intracellular calcium in cultured cells Proc. Natl. Acad. Sci. USA 86 1989 1870 1874 (Pubitemid 19087033)
23. A. Changela, K. Chen, Y. Xue, J. Holschen, C.E. Outten, T.V. O'Halloran, and A. Mondragon Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR Science 301 2003 1383 1387 (Pubitemid 37075815)
24. Y.F. Chen, and Z. Rosenzweig Luminescent CdS quantum dots as selective ion probes Anal. Chem. 74 2002 5132 5138
25. Y. Chen, R. Thakar, and P.T. Snee Imparting nanoparticle function with size-controlled amphiphilic polymers J. Am. Chem. Soc. 130 2008 3744 3745 (Pubitemid 351429828)
26. J. Chen, F. Zeng, S. Wu, J. Su, J. Zhao, and Z. Tong A facile approach for cupric ion detection in aqueous media using polyethyleneimine/PMMA core-shell fluorescent nanoparticles Nanotechnology 20 2009 365502
27. Z.L. Cheng, and C.A. Aspinwall Nanometre-sized molecular oxygen sensors prepared from polymer stabilized phospholipid vesicles Analyst 131 2006 236 243
28. B.D. Chithrani, A.A. Ghazani, and W.C.W. Chan Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells Nano Lett. 6 2006 662 668
29. H.A. Clark, S.L.R. Barker, M. Brasuel, M.T. Miller, E. Monson, S. Parus, Z.-Y. Shi, A. Song, B. Thorsrud, R. Kopelman, A. Ade, and W. Meixner Subcellular optochemical nanobiosensors: Probes encapsulated by biologically localised embedding (PEBBLEs) Sens. Act. B: Chem. 51 1998 12 16 (Pubitemid 128433355)
30. H.A. Clark, M. Hoyer, S. Parus, M.A. Philbert, and R. Kopelman Optochemical nanosensors and subcellular applications in living cells Mikrochim. Acta 131 1999 121 128
31. H.A. Clark, M. Hoyer, M.A. Philbert, and R. Kopelman Optical nanosensors for chemical analysis inside single living cells. 1. Fabrication, characterization, and methods for intracellular delivery of PEBBLE sensors Anal. Chem. 71 1999 4831 4836
32. - 2 Photochem. Photobiol. Sci. 9 2010 103 109
33. D.B. Cordes, S. Gamsey, and B. Singaram Fluorescent quantum dots with boronic acid substituted viologens to sense glucose in aqueous solution Angew. Chem. Int. Ed. 45 2006 3829 3832 (Pubitemid 44098934)
34. K. Cui, X. Lu, W. Cui, J. Wu, X. Chen, and Q. Lu Fluorescent nanoparticles assembled from a poly(ionic liquid) for selective sensing of copper ions Chem. Commun. 47 2011 920 922
35. P.J. Cywinski, A.J. Moro, S.E. Stanca, C. Biskup, and G.J. Mohr Ratiometric porphyrin-based layers and nanoparticles for measuring oxygen in biosamples Sens. Act. B: Chem. 135 2009 472 477
36. A.M. Derfus, W.C.W. Chan, and S.N. Bhatia Intracellular delivery of quantum dots for live cell labeling and organelle tracking Adv. Mater. 16 2004 961 966
37. H. Duan, and S. Nie Cell-penetrating quantum dots based on multivalent and endosome-disrupting surface coatings J. Am. Chem. Soc. 129 2007 3333 3338
38. J.M. Dubach, D.I. Harjes, and H.A. Clark Fluorescent ion-selective nanosensors for intracellular analysis with improved lifetime and size Nano Lett. 7 2007 1827 1831 (Pubitemid 47140468)
39. J.M. Dubach, D.I. Harjes, and H.A. Clark Ion-selective nano-optodes incorporating quantum dots J. Am. Chem. Soc. 129 2007 8418 8419 (Pubitemid 47066494)
40. L. Fedrizzi, D. Lim, and E. Carafoli Calcium and signal transduction Biochem. Mol. Biol. Educ. 36 2008 175 180 (Pubitemid 351861141)
41. L.A. Finney, and T.V. O'Halloran Transition metal speciation in the cell: Insights from the chemistry of metal ion receptors Science 300 2003 931 936 (Pubitemid 36548870)
42. 2+ ions based on dual fluorescent ligand-coated polymer nanoparticles Chem. Eur. J. 15 2009 8319 8330
43. J.E. Fuller, G.T. Zugates, L.S. Ferreira, H.O. Ow, N.N. Nguyen, U.B. Wiesner, and R.S. Langer Intracellular delivery of core-shell fluorescent silica nanoparticles Biomaterials 29 2008 1526 1532
44. K.M. Gattas-Asfura, and R.M. Leblane Peptide-coated CdS quantum dots for the optical detection of copper(II) and silver(I) Chem. Commun. 21 2003 2684 2685 (Pubitemid 37392832)
45. 2 -sensitive CdSe/ZnS quantum dots Angew. Chem. Int. Ed. 47 2008 1676 1679
46. C. Gota, K. Okabe, T. Funatsu, Y. Harada, and S. Uchiyama Hydrophilic fluorescent nanogel thermometer for intracellular thermometry J. Am. Chem. Soc. 131 2009 2766 2767
47. F. Gouanvé, T. Schuster, E. Allard, R. Meallet-Renault, and C. Larpent Fluorescence quenching upon binding of copper ions in dye-doped and ligand-capped polymer nanoparticles: A simple way to probe the dye accessibility in nano-sized templates Adv. Funct. Mater. 17 2007 2746 2756 (Pubitemid 350012677)
48. A. Graefe, S.E. Stanca, S. Nietzsche, L. Kubicova, R. Beckert, C. Biskup, and G.J. Mohr Development and critical evaluation of fluorescent chloride nanosensors Anal. Chem. 80 2008 6526 6531
49. K.B. Guice, M.E. Caldorera, and M.J. McShane Nanoscale internally referenced oxygen sensors produced from self-assembled nanofilms on fluorescent nanoparticles J. Biomed. Opt. 10 2005 064031
50. V.J. Hammond, J.W. Aylott, G.M. Greenway, P. Watts, A. Webster, and C. Wiles An optical sensor for reactive oxygen species: Encapsulation of functionalised silica nanoparticles into silicate nanoprobes to reduce fluorophore leaching Analyst 133 2008 71 75 (Pubitemid 350265600)
51. O. Harush-Frenkel, E. Rozentur, S. Benita, and Y. Altschuler Surface charge of nanoparticles determines their endocytic and transcytotic pathway in polarized MDCK cells Biomacromolecules 9 2008 435 443 (Pubitemid 351298461)
52. R.P. Haugland The Handbook: A Guide to Fluorescent Probes and Labeling Technologies 10th edn. 2005 Molecular Probes Inc. Eugene
53. X. He, H. Liu, Y. Li, S. Wang, Y. Li, N. Wang, J. Xiao, X. Xu, and D. Zhu Gold nanoparticle-based fluorometric and colorimetric sensing of copper(II) ions Adv. Mater. 17 2005 2811 2815 (Pubitemid 41797801)
54. - detection in aqueous solution and living cells J. Mater. Chem. 20 2010 10755 10764
55. S. Hornig, C. Biskup, A. Grafe, J. Wotschadlo, T. Liebert, G.J. Mohr, and T. Heinze Biocompatible fluorescent nanoparticles for pH-sensoring Soft Matter 4 2008 1169 1172 (Pubitemid 351693269)
56. H. Jin, D.A. Heller, R. Sharma, and M.S. Strano Size-dependent cellular uptake and expulsion of single-walled carbon nanotubes: Single particle tracking and a generic uptake model for nanoparticles ACS Nano 3 2009 149 158
57. L.B. Josefsen, J.W. Aylott, A. Beeby, P. Warburton, J.P. Boyle, C. Peers, and R.W. Boyle Porphyrin-nanosensor conjugates. New tools for the measurement of intracellular response to reactive oxygen species Photochem. Photobiol. Sci. 9 2010 801 811
58. S.-H. Kim, B. Kim, V.K. Yadavalli, and M.V. Pishko Encapsulation of enzyme within polymer spheres to create optical nanosensors for oxidative stress Anal. Chem. 77 2005 6828 6833 (Pubitemid 41547275)
59. K. Kim, M. Lee, H. Park, J.H. Kim, S. Kim, H. Chung, K. Choi, I.S. Kim, B.L. Seong, and I.C. Kwon Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging J. Am. Chem. Soc. 128 2006 3490 3491
60. J.H. Kim, S. Lee, K. Park, H.Y. Nam, S.Y. Jang, I. Youn, K. Kim, H. Jeon, R. Park, I. Kim, K. Choi, and I.C. Kwon Protein-phosphorylation-responsive polymeric nanoparticles for imaging protein kinase activities in single living cells Angew. Chem. Int. Ed. 46 2007 5779 5782 (Pubitemid 47172211)
61. J.H. Kim, S. Lee, K. Kim, H. Jeon, R.W. Park, I.S. Kim, K. Choi, and I.C. Kwon Polymeric nanoparticles for protein kinase activity Chem. Commun. 13 2007 1346 1348 (Pubitemid 46465975)
62. G. Kim, Y.E. Koo Lee, H. Xu, M.A. Philbert, and R. Kopelman Nanoencapsulation method for high selectivity sensing of hydrogen peroxide inside live cells Anal. Chem. 82 2010 2165 2169
63. M. King, and R. Kopelman Development of a hydroxyl radical ratiometric nanoprobe Sens. Act. B: Chem. 90 2003 76 81
64. J. Kneipp, H. Kneipp, B. Wittig, and K. Kneipp Novel optical nanosensors for probing and imaging live cells Nanomedicine 6 2010 214 226
65. Y.-E. Koo Lee, and R. Kopelman Optical nanoparticle Sensors for quantitative intracellular imaging WIREs Nanomed. Nanobiotechnol. 1 2009 98 110
66. Y.-E. Koo Lee, and R.T. Kopelman Targeted hydrogel nanoparticles for imaging, surgery and therapy of cancer R.K. Prud'homme, S. Svenson, Multifunctional Nanoparticles for Drug Delivery: Imaging, Targeting and Delivery 2011 Springer New York (in press)
67. Y.-E. Koo Lee, R. Smith, and R. Kopelman Nanoparticle PEBBLE sensors in live cells and in vivo Annu. Rev. Anal. Chem. 2 2009 57 76
68. Y.-E. Koo Lee, D.A. Orringer, and R. Kopelman Polymer-based nanosensors for medical applications P. Broz, Polymer-Based Nanostructures: Medical Applications 2010 RSC Publishing Cambridge, UK 333 353
69. Y.E. Koo Lee, E. Ulbrich, G. Kim, H. Hah, C. Strollo, W. Fan, R. Gurjar, S.M. Koo, and R. Kopelman Near infrared luminescent oxygen nanosensors with nanoparticle matrix tailored sensitivity Anal. Chem. 82 2010 8446 8455
70. Y.-E.L. Koo, Y. Cao, R. Kopelman, S.M. Koo, M. Brasuel, and M.A. Philbert Real-time measurements of dissolved oxygen inside live cells by ormosil (organically modified silicate) fluorescent PEBBLE nanosensors Anal. Chem. 76 2004 2498 2505 (Pubitemid 38585715)
71. J.D. Krooswyk, C.M. Tyrakowski, and P.T. Snee Multivariable response of semiconductor nanocrystal-dye sensors: The case of pH J. Phys. Chem. C 114 2010 21348 21352
72. J.R. Lakowicz Principles of Fluorescence Spectroscopy 3rd edn. 2006 Springer New York
73. D. Lee, S. Khaja, J.C. Velasquez-Castano, M. Dasari, C. Sun, J. Petros, W.R. Taylor, and N. Murthy In vivo imaging of hydrogen peroxide with chemiluminescent nanoparticles Nat. Mater. 6 2007 765 769 (Pubitemid 47515311)
74. S. Lee, E.-J. Cha, K. Park, S.-Y. Lee, J.-K. Hong, I.-C. Sun, S.Y. Kim, K. Choi, I.C. Kwon, K. Kim, and C.-H. Ahn A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination Angew. Chem. Int. Ed. 47 2008 2804 2807
75. C.-K. Lim, Y.-D. Lee, J. Na, J.M. Oh, S. Her, K. Kim, K. Choi, S. Kim, and I.C. Kwon Chemiluminescence-generating nanoreactor formulation for near-infrared imaging of hydrogen peroxide and glucose level in vivo Adv. Funct. Mater. 20 2010 2644 2648
76. 2+ ions and temperatures working in purely aqueous media Anal. Chem. 83 2011 2775 2785
77. B.L. Ma, M.Y. Xu, F. Zeng, L. Huang, and S. Wu Micelle nanoparticles for FRET-based ratiometric sensing of mercury ions in water, biological fluids and living cells Nanotechnology 22 2011 065501
78. R. Makino, T. Tanaka, T. Iizuka, Y. Ishimura, and S. Kanegasaki Stoichiometric conversion of oxygen to superoxide anion during the respiratory burst in neutrophils J. Biol. Chem. 261 1986 11444 11447
79. 2+ Chem. Commun. 20 2004 2344 2345 (Pubitemid 39545921)
80. R. Meallet-Renault, A. Herault, J.J. Vachon, R.B. Pansu, S. Amigoni-Gerbier, and C. Larpent Fluorescent nanoparticles as selective Cu(II) sensors Photochem. Photobiol. Sci. 5 2006 300 310 (Pubitemid 43363049)
81. I.L. Medintz, M.H. Stewart, S.A. Trammell, K. Susumu, J.B. Delehanty, B.C. Mei, J.S. Melinger, J.B. Blanco-Canosa, P.E. Dawson, and H. Mattoussi Quantum-dot/dopamine bioconjugates function as redox coupled assemblies for in vitro and intracellular pH sensing Nat. Mater. 9 2010 676 684
82. E. Monson, M. Brasuel, M. Philbert, and R. Kopelman PEBBLE nanosensors for in vitro bioanalysis T. Vo-Dinh, Biomedical Photonics Handbook 2003 CRC Press Boca Raton 1 14
83. M. Montalti, L. Prodi, and N. Zaccheroni Fluorescence quenching amplication in silica nanosensors for metal ions J. Mater. Chem. 15 2005 2810 2814 (Pubitemid 41048679)
84. A. Myc, I.J. Majoros, T.P. Thomas, and J.R. Baker Dendrimer-based targeted delivery of an apoptotic sensor in cancer cells Biomacromolecules 8 2007 13 18 (Pubitemid 46140467)
85. N. Nakayama-Ratchford, S. Bangsaruntip, X.M. Sun, K. Welsher, and H.J. Dai Noncovalent functionalization of carbon nanotubes by fluorescein- polyethylene glycol: Supramolecular conjugates with pH-dependent absorbance and fluorescence J. Am. Chem. Soc. 129 2007 2448 2449 (Pubitemid 46364046)
86. L.J. Nielsen, L.F. Olsen, and V.C. Ozalp Aptamers embedded in polyacrylamide nanoparticles: A tool for in vivo metabolite sensing ACS Nano 4 2010 4361 4370
87. M. Oishi, A. Tamura, T. Nakamura, and Y. Nagasaki A smart nanoprobe based on fluorescence-quenching PEGylated nanogels containing gold nanoparticles for monitoring the response to cancer therapy Adv. Func. Mater. 19 2009 827 834
88. E.J. Park, M. Brasuel, C. Behrend, M.A. Philbert, and R. Kopelman Ratiometric optical PEBBLE nanosensors for real-time magnesium ion concentrations inside viable cells Anal. Chem. 75 2003 3784 3791 (Pubitemid 36962112)
89. J.F. Peng, X.X. He, K.M. Wang, W. Tan, Y. Wang, and Y. Liu Noninvasive monitoring of intracellular pH change induced by drug stimulation using silica nanoparticle sensors Anal. Bioanal. Chem. 388 2007 645 654 (Pubitemid 46709849)
90. H. Peng, M.I.J. Stich, J. Yu, L.-N. Sun, L.H. Fischer, and O.S. Wolfbeis Luminescent europium(III) nanoparticles for sensing and imaging of temperature in the physiological range Adv. Mater. 22 2010 716 719
91. H.-S. Peng, S.H. Huang, and O.S. Wolfbeis Ratiometric fluorescent nanoparticles for sensing temperature J. Nanoparticle Res. 12 2010 2729 2733
92. H.-S. Peng, J.A. Stolwijk, L.-N. Sun, J. Wegener, and O.S. Wolfbeis A nanogel for ratiometric fluorescent sensing of intracellular pH values Angew. Chem. Int. Ed. 49 2010 4246 4249
93. A.K. Poulsen, A.M. Scharff-Poulsen, and L.F. Olsen Horseradish peroxidase embedded in polyacrylamide nanoparticles enables optical detection of reactive oxygen species Anal. Biochem. 366 2007 29 36 (Pubitemid 46764297)
94. E. Rampazzo, E. Brasola, S. Marcuz, F. Mancin, P. Tecilla, and U. Tonellato Surface modification of silica nanoparticles: A new strategy for the realization of self-organized fluorescent chemosensors J. Mater. Chem. 15 2005 2687 2696 (Pubitemid 41048663)
95. A. Ray, Y.-E. Koo Lee, T. Epstein, G. Kim, and R. Kopelman Two-photon nano-PEBBLE sensors: Subcellular pH measurements Analyst 136 2011 3616 3622
96. R. Roots, and S. Okada Estimation of life times and diffusion distances involved in the X-ray induced DNA strand breaks or killing of mammalian cells Radiat. Res. 64 1975 306 320
97. S.M. Rozenzhak, M.P. Kadakia, T.M. Caserta, T.R. Westbrook, M.O. Stone, and R.R. Naik Cellular internalization and targeting of semiconductor quantum dots Chem. Commun. 17 2005 2217 2219 (Pubitemid 40685997)
98. + -selective nanospheres: Maximizing response range and minimizing response time Analyst 131 2007 1282 1291
99. M.J. Ruedas-Rama, and E.A.H. Hall Azamacrocycle activated quantum dot for zinc ion detection Anal. Chem. 80 2008 8260 8268
100. - Analyst 133 2008 1556 1566
101. M.J. Ruedas-Rama, and E.A.H. Hall Multiplexed energy transfer mechanisms in a dual-function quantum dot for zinc and manganese Analyst 134 2009 159 169
102. M.J. Ruedas-Rama, A. Orte, E.A.H. Hall, J.M. Alvarez-Pez, and E.M. Talavera Quantum dot photoluminescence lifetime-based pH nanosensor Chem. Commun. 47 2011 2898 2900
103. K.E. Sapsford, L. Berti, and I.L. Medintz Materials for fluorescence resonance energy transfer analysis: Beyond traditional donor-acceptor combinations Angew. Chem. Int. Ed. 45 2006 4562 4588 (Pubitemid 44106071)
104. K. Sarkar, K. Dhara, M. Nandi, P. Roy, A. Bhaumik, and P. Banerjeeet Selective zinc(II)-ion fluorescence sensing by a functionalized mesoporous material covalently grafted with a fluorescent chromophore and consequent biological applications Adv. Funct. Mater. 19 2009 223 234
105. K. Sasaki, Z.Y. Shi, R. Kopelman, and H. Masuhara Three-dimensional pH microprobing with an optically-manipulated fluorescent particle Chem. Lett. 25 1996 141 142
106. E. Schmälzlin, J.T. van Dongen, I. Klimant, B. Marmodée, M. Steup, J. Fisahn, P. Geigenberger, and H.G. Löhmannsröben An optical multifrequency phase-modulation method using microbeads for measuring intracellular oxygen concentrations in plants Biophys. J. 89 2005 1339 1345
107. A. Schulz, J. Wotschadlo, T. Heinze, and G.J. Mohr Fluorescent nanoparticles for ratiometric pH-monitoring in the neutral range J. Mater. Chem. 20 2010 1475 1482
108. A. Schulz, R. Woolley, T. Tabarin, and C. McDonagh Dextran-coated silica nanoparticles for calcium-sensing Analyst 136 2011 1722 1727
109. 2+ in living cells Eur. J. Inorg. Chem. 6 2010 843 847
110. Y.C. Shiang, C.C. Huang, and H.T. Chang Gold nanodot-based luminescent sensor for the detection of hydrogen peroxide and glucose Chem. Commun. 23 2009 3437 3439
111. J.R. Slotkin, L. Chakrabarti, H.N. Dai, R.S. Carney, T. Hirata, B.S. Bregman, G.I. Gallicano, J.G. Corbin, and T.F. Haydar In vivo quantum dot labeling of mammalian stem and progenitor cells Dev. Dyn. 236 2007 3393 3401 (Pubitemid 350276395)
112. P.T. Snee, R.C. Somers, G. Nair, J.P. Zimmer, M.G. Bawendi, and D.G. Nocera A ratiometric CdSe/ZnS nanocrystal pH sensor J. Am. Chem. Soc. 128 2006 13320 13321 (Pubitemid 44582992)
113. H. Son, H.Y. Lee, J.M. Lim, D. Kang, W.S. Han, S.S. Lee, and J.H. Jung A highly sensitive and selective turn-on fluorogenic and chromogenic sensor based on BODIPY-functionalized magnetic nanoparticles for detecting lead in living cells Chem. Eur. J. 16 2010 11549 11553
114. S.E. Stanca, S. Nietzsche, W. Fritzsche, C.G. Cranfield, and C. Biskup Intracellular ion monitoring using a gold-core polymer-shell nanosensor architecture Nanotechnology 21 2010 055501
115. J.P. Sumner, and R. Kopelman Alexa Fluor 488 as an iron sensing molecule and its application in PEBBLE nanosensors Analyst 130 2005 528 533 (Pubitemid 40523252)
116. J.P. Sumner, J.W. Aylott, E. Monson, and R. Kopelman A fluorescent PEBBLE nanosensor for intracellular free zinc Analyst 127 2002 11 16 (Pubitemid 34081624)
117. 2+ sensitive PEBBLE fluorescent nanosensors using Ds Red as the recognition element Sens. Act. B: Chem. 113 2005 760 767 (Pubitemid 43184119)
118. H. Sun, A.M. Scharff-Poulsen, H. Gu, and K. Almdal Synthesis and characterization of ratiometric, pH sensing nanoparticles with covalently attached fluorescent dyes Chem. Mater. 18 2006 3381 3384
119. H. Sun, A.M. Scharff-Poulsen, H. Gu, I. Jakobsen, J.M. Kossmann, W.B. Frommer, and K. Almdal Phosphate sensing by fluorescent reporter proteins embedded in polyacrylamide nanoparticles ACS Nano 2 2008 19 24 (Pubitemid 351585760)
120. H. Sun, T.L. Andresen, R.V. Benjaminsen, and K. Almdal Polymeric nanosensors for measuring the full dynamic pH range of endosomes and lysosomes in mammalian cells J. Biomed. Nanotechnol. 5 2009 676 682
121. M. Suzuki, Y. Husimi, H. Komatsu, K. Suzuki, and K.T. Douglas Quantum dot FRET biosensors that respond to pH, to proteolytic or nucleolytic cleavage, to DNA synthesis, or to a multiplexing combination J. Am. Chem. Soc. 130 2008 5720 5725 (Pubitemid 351600504)
122. B. Tang, L. Cao, K. Xu, L. Zhuo, J. Ge, Q. Li, and L. Yu A new nanobiosensor for glucose with high sensitivity and selectivity in serum based on fluorescence resonance energy transfer (FRET) between CdTe quantum dots and Au nanoparticles Chem. Eur. J. 14 2008 3637 3644
123. II : Exploring the covalent strategy Chem. Eur. J. 13 2007 2238 2245 (Pubitemid 46941880)
124. K.M. Tyner, R. Kopelman, and M.A. Philbert "Nanosized voltmeter" enables cellular-wide electric field mapping Biophys. J. 93 2007 1163 1174 (Pubitemid 47330896)
125. F. Vetrone, R. Naccache, A. Zamarron, A.J. de la Fuente, F. Sanz-Rodriguez, L.M. Maestro, E.M. Rodriguez, D. Jaque, J.G. Sole, and J.A. Capobianco Temperature sensing using fluorescent nanothermometers ACS Nano 4 2010 3254 3258
126. 2+ homeostasis Nat. Methods 6 2009 737 740
127. X.J. Wang, C. Boschetti, M.J. Ruedas-Rama, A. Tunnacliffe, and E.A.H. Hall Ratiometric pH-dot ANSors Analyst 135 2010 1585 1591
128. G. Wang, A.S. Stender, W. Sun, and N. Fang Optical imaging of non-fluorescent nanoparticle probes in live cells Analyst 135 2010 215 221
129. X.-D. Wang, H.H. Gorris, J.A. Stolwijk, R.J. Meier, D.B.M. Groegel, J. Wegener, and O.S. Wolfbeis Self-referenced RGB colour imaging of intracellular oxygen Chem. Sci. 2 2011 901 906
130. S. Wang, B. Li, L. Zhang, L. Liu, and Y. Wang Photoluminescent and oxygen sensing properties of core-shell nanospheres based on a covalently grafted ruthenium(II) complex Appl. Organometal. Chem. 25 2011 21 26
131. D. Wang, T. Liu, J. Yin, and S. Liu Stimuli-responsive fluorescent poly(N-isopropylacrylamide) microgels labeled with phenylboronic acid moieties as multifunctional ratiometric probes for glucose and temperatures Macromolecules 44 2011 2282 2290
132. P. Watson, A.T. Jonesb, and D.J. Stephens Intracellular trafficking pathways and drug delivery: Fluorescence imaging of living and fixed cells Adv. Drug Deliv. Rev. 57 2005 43 61 (Pubitemid 39424063)
133. L.A. Woods, P.R. Powell, T.L. Paxon, and A.G. Ewing Analysis of mammalian cell cytoplasm with electrophoresis in nanometer inner diameter capillaries Electroanalysis 17 2005 1192 1197 (Pubitemid 41024947)
134. C. Wu, B. Bull, K. Christensen, and J. McNeill Ratiometric single-nanoparticle oxygen sensors for biological imaging Angew. Chem. Int. Ed. 48 2009 2741 2745
135. W. Wu, T. Zhou, J. Shen, and S. Zhou Optical detection of glucose by CdS quantum dots immobilized in smart microgels Chem. Commun. 14 2009 4390 4392
136. H. Xu, J.W. Aylott, R. Kopelman, T.J. Miller, and M.A. Philbert A real-time ratiometric method for the determination of molecular oxygen inside living cells using sol-gel-based spherical optical nanosensors with applications to rat C6 glioma Anal. Chem. 73 2001 4124 4133 (Pubitemid 32830852)
137. H. Xu, J.W. Aylott, and R. Kopelman Fluorescent nano-PEBBLE sensors designed for intracellular glucose imaging Analyst 127 2002 1471 1477 (Pubitemid 35398763)
138. 2+ sensors with thermo-enhanced detection sensitivity Langmuir 25 2009 11367 11374
139. + sensors fabricated from thermoresponsive poly(N- isopropylacrylamide) microgels labeled with crown ether moieties J. Phys. Chem. B 114 2010 12213 12220