Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR

Science

Volumn 301, Issue 5638, 2003, Pages 1383-1387

  Changela, Anita ^a   Chen, Kui ^a   Xue, Yi ^a   Holschen, Jackie ^a   Outten, Caryn E ^a   O'Halloran, Thomas V ^a   Mondragón, Alfonso ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; ESCHERICHIA COLI; HYDROGEN BONDS; SENSITIVITY ANALYSIS;

THERMODYNAMIC CALIBRATION;

GENES;

METAL ION; METALLOPROTEIN;

COPPER; GENE;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DIMERIZATION; GENE EXPRESSION REGULATION; GENETIC REGULATION; HYDROGEN BOND; METAL BINDING; PRIORITY JOURNAL; PROTEIN FAMILY; RNA TRANSCRIPTION; SENSOR; THERMODYNAMICS; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; COPPER; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA-BINDING PROTEINS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HELIX-TURN-HELIX MOTIFS; HYDROGEN BONDING; HYDROPHOBICITY; LIGANDS; METALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PROMOTER REGIONS (GENETICS); PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SEQUENCE ALIGNMENT; THERMODYNAMICS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; ZINC;

ESCHERICHIA COLI;

EID: 0043192605     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1085950     Document Type: Article

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41. We thank C. Fahrni, L. A. Finney, H. A. Godwin, E. Kawamoto, and J. L. Wolford for helpful discussions. Supported by NIH GM51350 (to A.M.), NIH GM38784 (T.V.O.), NIH F32 DK61868 (K.C.), and the National Research Service Award Institutional Training Grant in Molecular Biophysics (NIH GM08382) (A.C. and C.E.O.). We acknowledge the use of instruments in the Keck Biophysics Facility at Northwestern University. Support from the R.H. Lurie Comprehensive Cancer Center of Northwestern University to the Structural Biology Facility is acknowledged. Portions of this work were performed at the DuPont-Northwestern-Dow Collaborative Access Team (DND-CAT) Synchrotron Research Center at the Advanced Photon Source (APS) and at the Stanford Synchrotron Radiation Laboratory (SSRL). DND-CAT is supported by DuPont, Dow, the state of Illinois, and the NSF, and use of the APS is supported by the U.S. Department of Energy (DOE). SSRL is operated by the DOE, Office of Basic Energy Sciences. The SSRL Biotechnology Program is supported by the NIH and the DOE. Coordinates and structure factors have been deposited in the Protein Data Bank with accession numbers 1Q05, 1Q06, 1Q07, 1Q08, 1Q09, and 1Q0A.