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Volumn 28, Issue 10, 2011, Pages 1405-1423

Screening of plant toxins in food, feed and botanicals using full-scan high-resolution (Orbitrap) mass spectrometry

Author keywords

animal feed; chromatography LC MS; dietary supplements; honey; LC MS; natural toxicants; natural toxicants alkaloids; plants

Indexed keywords

ADDITIVES; ALKALOIDS; CHEMICAL DETECTION; CHROMATOGRAPHY; DATA ACQUISITION; DIETARY SUPPLEMENTS; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; MASS SPECTROMETRY; MATRIX ALGEBRA; MEDICINE; POSITIVE IONS; TEA; TOXIC MATERIALS;

EID: 84855920652     PISSN: 19440049     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/19440049.2011.603704     Document Type: Review
Times cited : (81)

References (46)
  • 1
    • 67650454711 scopus 로고    scopus 로고
    • Quantitative-qualitative data acquisition using a benchtop Orbitrap mass spectrometer
    • Bateman, KP, Kellmann, M, Muenster, H, Papp, R and Taylor, L. 2009. Quantitative-qualitative data acquisition using a benchtop Orbitrap mass spectrometer. J Am Soc Mass Spectrom, 20: 1441-1450.
    • (2009) J Am Soc Mass Spectrom , vol.20 , pp. 1441-1450
    • Bateman, K.P.1    Kellmann, M.2    Muenster, H.3    Papp, R.4    Taylor, L.5
  • 3
    • 84855959605 scopus 로고    scopus 로고
    • Bundesinstitut für Risikobewertung (BfR), Bfr Opinion No. 043/2010, 3 September. BfR. Available from
    • Bundesinstitut für Risikobewertung (BfR). 2010. Cases of poisoning through grayanotoxins in rhododendron honey originating from the Turkish Black Sea Region. Bfr Opinion No. 043/2010, 3 September. BfR. Available from: http://www.bfr.bund.de/cm/349/cases_of_poisoning_through_grayanotoxins_in_rhododendron_honey_originating_from_the_turkish_black_sea_region.pdf
    • (2010) Cases of poisoning through grayanotoxins in rhododendron honey originating from the Turkish Black Sea Region
  • 4
    • 0142216466 scopus 로고    scopus 로고
    • Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliine
    • Chou, MW, Wang, YP, Yan, J, Yang, JC, Beger, RD, Williams, LD, Doerge, DR and Fu, PP. 2003. Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliine. Toxicol Lett, 145: 239-247.
    • (2003) Toxicol Lett , vol.145 , pp. 239-247
    • Chou, M.W.1    Wang, Y.P.2    Yan, J.3    Yang, J.C.4    Beger, R.D.5    Williams, L.D.6    Doerge, D.R.7    Fu, P.P.8
  • 5
    • 0037229943 scopus 로고    scopus 로고
    • Aristolochic acid and 'Chinese herbs nephropathy', a review of the evidence to date
    • Cosyns, JP. 2003. Aristolochic acid and 'Chinese herbs nephropathy', a review of the evidence to date. Drug Safety, 26: 33-48.
    • (2003) Drug Safety , vol.26 , pp. 33-48
    • Cosyns, J.P.1
  • 7
    • 84855940259 scopus 로고    scopus 로고
    • Besluit van 19 januari 2001, houdende vaststelling van het Warenwetbesluit kruidenpreparaten
    • Dutch Commodities Act Decree 'Herbal preparations'
    • Dutch Commodities Act Decree 'Herbal preparations'. 2001. Besluit van 19 januari 2001, houdende vaststelling van het Warenwetbesluit kruidenpreparaten. Staatsblad, 2001: 56
    • (2001) Staatsblad , vol.2001 , pp. 56
  • 8
    • 0037041903 scopus 로고    scopus 로고
    • Honey from plants containing pyrrolizidine alkaloids: a potential threat to health
    • Edgar, JA, Roeder, E and Molyneux, RJ. 2002. Honey from plants containing pyrrolizidine alkaloids: a potential threat to health. J Agric Food Chem, 50: 2719-2730.
    • (2002) J Agric Food Chem , vol.50 , pp. 2719-2730
    • Edgar, J.A.1    Roeder, E.2    Molyneux, R.J.3
  • 9
    • 49049114683 scopus 로고    scopus 로고
    • Scientific opinion. Pyrrolizidine alkaloids as undesirable substances in animal feed
    • European Food Safety Authority (EFSA). 2007. Scientific opinion. Pyrrolizidine alkaloids as undesirable substances in animal feed. EFSA J, 447: 1-51.
    • (2007) EFSA J , vol.447 , pp. 1-51
  • 10
    • 61449097026 scopus 로고    scopus 로고
    • Scientific opinion. Glucosinolates as undesirable substances in animal feed
    • European Food Safety Authority (EFSA). 2008a. Scientific opinion. Glucosinolates as undesirable substances in animal feed. EFSA J, 590: 1-76.
    • (2008) EFSA J , vol.590 , pp. 1-76
  • 11
    • 61449097026 scopus 로고    scopus 로고
    • Scientific opinion. Tropane alkaloids (from Datura sp.) as undesirable substances in animal feed
    • European Food Safety Authority (EFSA). 2008b. Scientific opinion. Tropane alkaloids (from Datura sp.) as undesirable substances in animal feed. EFSA J, 691: 1-55.
    • (2008) EFSA J , vol.691 , pp. 1-55
  • 12
    • 77955661221 scopus 로고    scopus 로고
    • Compendium of botanicals that have been reported to contain toxic, addictive, psychotropic or other substances of concern on request of EFSA
    • Available from: http://www.efsa.europa.eu/en/supporting/doc/280rax1.pdf
    • European Food Safety Authority (EFSA). 2009. Compendium of botanicals that have been reported to contain toxic, addictive, psychotropic or other substances of concern on request of EFSA. EFSA J, 7(9): 281 Available from: http://www.efsa.europa.eu/en/supporting/doc/280rax1.pdf
    • (2009) EFSA J , vol.7 , Issue.9 , pp. 281
  • 13
    • 84855929014 scopus 로고    scopus 로고
    • European Food Safety Authority (EFSA), Available from
    • European Food Safety Authority (EFSA). 2010a. EFSA call for scientific data on opium alkaloids in poppy seeds. Available from: http://www.efsa.europa.eu/en/dataclosed/call/datex101020.htm/
    • (2010) EFSA call for scientific data on opium alkaloids in poppy seeds
  • 14
    • 84855923071 scopus 로고    scopus 로고
    • EFSA Panel on Additives and Products or Substances Used in Animal Feed (FEEDAP) statement on the preparation of guidance for the assessment of plant/herbal products and their constituents used as feed additives
    • Available from: http://www.efsa.europa.eu/en/efsajournal/doc/1694.pdf
    • European Food Safety Authority (EFSA). 2010b. EFSA Panel on Additives and Products or Substances Used in Animal Feed (FEEDAP) statement on the preparation of guidance for the assessment of plant/herbal products and their constituents used as feed additives. EFSA J, 8(7): 1694 Available from: http://www.efsa.europa.eu/en/efsajournal/doc/1694.pdf
    • (2010) EFSA J , vol.8 , Issue.7 , pp. 1694
  • 15
    • 84937161657 scopus 로고    scopus 로고
    • EU directive 2002/32/EC on undesirable substances in animal feed. Consolidated document including amendments of the original directive (2002/32/EC)
    • European Union, [cited 2011 Mar]. Available from
    • European Union. 2002. EU directive 2002/32/EC on undesirable substances in animal feed. Consolidated document including amendments of the original directive (2002/32/EC). Off J. L 140: 10; [cited 2011 Mar]. Available from: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CONSLEG:2002L0032:20100302:EN:PDF/
    • (2002) Off J , vol.140 L , pp. 10
  • 16
    • 45849094055 scopus 로고    scopus 로고
    • Clinical review of grayanotoxin/mad honey poisoning past and present
    • Gunduz, A, Turedi, SAC, Russell, RM and Ayaz, FA. 2008. Clinical review of grayanotoxin/mad honey poisoning past and present. Clin Toxicol, 46: 437-442.
    • (2008) Clin Toxicol , vol.46 , pp. 437-442
    • Gunduz, A.1    Turedi, S.A.C.2    Russell, R.M.3    Ayaz, F.A.4
  • 17
    • 36549024989 scopus 로고    scopus 로고
    • From waste products to ecochemicals: fifty years research of plant secondary metabolism
    • Hartmann, T. 2007. From waste products to ecochemicals: fifty years research of plant secondary metabolism. Phytochemistry, 68: 2831-2846.
    • (2007) Phytochemistry , vol.68 , pp. 2831-2846
    • Hartmann, T.1
  • 18
    • 0034830749 scopus 로고    scopus 로고
    • Determination of grayanotoxins in biological samples by LC-MS/MS
    • Holstege, DM, Puschner, B and Le, T. 2001. Determination of grayanotoxins in biological samples by LC-MS/MS. J Agric Food Chem, 49: 1648-1651.
    • (2001) J Agric Food Chem , vol.49 , pp. 1648-1651
    • Holstege, D.M.1    Puschner, B.2    Le, T.3
  • 19
    • 67549139888 scopus 로고    scopus 로고
    • Determination of senkirkine and senecionine in Tussilago farfara using microwave-assisted extraction and pressurized hot water extraction with liquid chromatography tandem mass spectrometry
    • Jiang, Z, Liu, F, Goh, JJL, Yu, L, Li, SFY, Ong, ES and Ong, CN. 2009. Determination of senkirkine and senecionine in Tussilago farfara using microwave-assisted extraction and pressurized hot water extraction with liquid chromatography tandem mass spectrometry. Talanta, 79: 539-546.
    • (2009) Talanta , vol.79 , pp. 539-546
    • Jiang, Z.1    Liu, F.2    Goh, J.J.L.3    Yu, L.4    Li, S.F.Y.5    Ong, E.S.6    Ong, C.N.7
  • 22
    • 77953685262 scopus 로고    scopus 로고
    • Simultaneous determination of various cardiac glycosides by liquid chromatography-hybrid mass spectrometry for the purity assessment of the therapeutic monitored drug digoxin
    • Josephs, RD, Daireaux, A, Westwood, S and Wielgosz, RI. 2010. Simultaneous determination of various cardiac glycosides by liquid chromatography-hybrid mass spectrometry for the purity assessment of the therapeutic monitored drug digoxin. J Chromatogr A, 1217: 4535-4543.
    • (2010) J Chromatogr A , vol.1217 , pp. 4535-4543
    • Josephs, R.D.1    Daireaux, A.2    Westwood, S.3    Wielgosz, R.I.4
  • 23
    • 67650727050 scopus 로고    scopus 로고
    • Full scan MS in comprehensive qualitative and quantitative residue analysis in food and feed matrices: how much resolving power is required?
    • Kellmann, M, Muenster, H, Zomer, P and Mol, H. 2009. Full scan MS in comprehensive qualitative and quantitative residue analysis in food and feed matrices: how much resolving power is required?. J Am Soc Mass Spectrom, 2009: 1464-1476.
    • (2009) J Am Soc Mass Spectrom , vol.2009 , pp. 1464-1476
    • Kellmann, M.1    Muenster, H.2    Zomer, P.3    Mol, H.4
  • 24
    • 33644931644 scopus 로고    scopus 로고
    • Issues related to botanicals
    • Khan, IA. 2006. Issues related to botanicals. Life Sci, 78: 2033-2038.
    • (2006) Life Sci , vol.78 , pp. 2033-2038
    • Khan, I.A.1
  • 25
    • 75749114019 scopus 로고    scopus 로고
    • Rapid determination of aristolochic acids I and II in herbal products and biological samples by ultra-high-pressure liquid chromatography-tandem mass spectrometry
    • Kuo, CH, Lee, CW, Lin, SC, Tsai, IL, Lee, SS, Tseng, YJ, Kang, JJ, Peng, FC and Chu, LW. 2010. Rapid determination of aristolochic acids I and II in herbal products and biological samples by ultra-high-pressure liquid chromatography-tandem mass spectrometry. Talanta, 80: 1672-1680.
    • (2010) Talanta , vol.80 , pp. 1672-1680
    • Kuo, C.H.1    Lee, C.W.2    Lin, S.C.3    Tsai, I.L.4    Lee, S.S.5    Tseng, Y.J.6    Kang, J.J.7    Peng, F.C.8    Chu, L.W.9
  • 26
    • 33645760258 scopus 로고    scopus 로고
    • Combination of TLC and HPLC-MS/MS methods. Approach to a rational quality control of Chinese star anise
    • Lederer, I, Schulzki, G, Gross, J and Steffe, JP. 2006. Combination of TLC and HPLC-MS/MS methods. Approach to a rational quality control of Chinese star anise. J Agric Food Chem, 2006: 1970-1974.
    • (2006) J Agric Food Chem , vol.2006 , pp. 1970-1974
    • Lederer, I.1    Schulzki, G.2    Gross, J.3    Steffe, J.P.4
  • 27
    • 77950042977 scopus 로고    scopus 로고
    • Comparison of QuEChERS sample preparation methods for the analysis of pesticide residues in fruits and vegetables
    • Lehotay, SJ, Son, KA, Kwon, H, Koesukwiwata, U, Fud, W, Mastovska, K, Hoh, E and Leepipatpiboon, N. 2010. Comparison of QuEChERS sample preparation methods for the analysis of pesticide residues in fruits and vegetables. J Chromatogr A, 1217: 2548-2560.
    • (2010) J Chromatogr A , vol.1217 , pp. 2548-2560
    • Lehotay, S.J.1    Son, K.A.2    Kwon, H.3    Koesukwiwata, U.4    Fud, W.5    Mastovska, K.6    Hoh, E.7    Leepipatpiboon, N.8
  • 28
    • 77950371647 scopus 로고    scopus 로고
    • UPLC-PDA-TOFMS based chemical profiling approach to rapidly evaluate chemical consistency between traditional and dispensing granule decoctions of traditional medicine combinatorial formulae
    • Li, SL, Song, JZ, Qiao, CF, Zhou, Y and Xu, HX. 2010. UPLC-PDA-TOFMS based chemical profiling approach to rapidly evaluate chemical consistency between traditional and dispensing granule decoctions of traditional medicine combinatorial formulae. J Pharmaceut Biomed Anal, 52: 468-478.
    • (2010) J Pharmaceut Biomed Anal , vol.52 , pp. 468-478
    • Li, S.L.1    Song, J.Z.2    Qiao, C.F.3    Zhou, Y.4    Xu, H.X.5
  • 30
    • 70449864863 scopus 로고    scopus 로고
    • Direct analysis of psychoactive tryptamine and harmala alkaloids in the Amazonian botanical medicine ayahuasca by liquid chromatography-electrospray ionization-tandem mass spectrometry
    • McIlhenny, EH, Pipkin, KE, Standish, LJ, Wechkin, HA, Strassman, R and Barker, SA. 2009. Direct analysis of psychoactive tryptamine and harmala alkaloids in the Amazonian botanical medicine ayahuasca by liquid chromatography-electrospray ionization-tandem mass spectrometry. J Chromatogr A, 1216: 8960-8968.
    • (2009) J Chromatogr A , vol.1216 , pp. 8960-8968
    • McIlhenny, E.H.1    Pipkin, K.E.2    Standish, L.J.3    Wechkin, H.A.4    Strassman, R.5    Barker, S.A.6
  • 31
    • 58149139363 scopus 로고    scopus 로고
    • Toward a generic extraction method for simultaneous determination of pesticides, mycotoxins, plant toxins, and veterinary drugs in feed and food matrixes
    • Mol, HGJ, Plaza-Bolaños, P, Zomer, P, de Rijk, TC, Stolker, AAM and Mulder, PPJ. 2008. Toward a generic extraction method for simultaneous determination of pesticides, mycotoxins, plant toxins, and veterinary drugs in feed and food matrixes. Anal Chem, 80: 9450-9459.
    • (2008) Anal Chem , vol.80 , pp. 9450-9459
    • Mol, H.G.J.1    Plaza-Bolaños, P.2    Zomer, P.3    de Rijk, T.C.4    Stolker, A.A.M.5    Mulder, P.P.J.6
  • 32
    • 33846895151 scopus 로고    scopus 로고
    • Screening and confirmation criteria for hormone residue analysis using liquid chromatography accurate mass time-of-flight, Fourier transform ion cyclotron resonance and Orbitrap mass spectrometry techniques
    • Nielen, MWF MC, van Engelen, MC, Zuiderent, R and Ramaker, R. 2007. Screening and confirmation criteria for hormone residue analysis using liquid chromatography accurate mass time-of-flight, Fourier transform ion cyclotron resonance and Orbitrap mass spectrometry techniques. Analyt Chim Acta, 586: 122-129.
    • (2007) Analyt Chim Acta , vol.586 , pp. 122-129
    • Nielen, M.W.F.M.C.1    van Engelen, M.C.2    Zuiderent, R.3    Ramaker, R.4
  • 35
    • 33747020099 scopus 로고    scopus 로고
    • Optimized LC/MS/MS analysis of morphine and codeine in poppy seed and evaluation of their fate during food processing as a basis for risk analysis
    • Sproll, C, Perz, RC and Lachenmeier, DW. 2006. Optimized LC/MS/MS analysis of morphine and codeine in poppy seed and evaluation of their fate during food processing as a basis for risk analysis. J Agric Food Chem, 54: 5292-5298.
    • (2006) J Agric Food Chem , vol.54 , pp. 5292-5298
    • Sproll, C.1    Perz, R.C.2    Lachenmeier, D.W.3
  • 36
    • 70349792407 scopus 로고    scopus 로고
    • Application of an LC-MS/MS based multi-mycotoxin method for the semi-quantitative determination of mycotoxins occurring in different types of food infected by moulds
    • Sulyok, M, Krska, R and Schuhmacher, R. 2010. Application of an LC-MS/MS based multi-mycotoxin method for the semi-quantitative determination of mycotoxins occurring in different types of food infected by moulds. Food Chem, 119: 408-416.
    • (2010) Food Chem , vol.119 , pp. 408-416
    • Sulyok, M.1    Krska, R.2    Schuhmacher, R.3
  • 37
    • 0028128236 scopus 로고
    • Liquid chromatography coupled with mass spectrometry in the analysis of alkaloids
    • Verpoorte, R and Niessen, WMA. 1994. Liquid chromatography coupled with mass spectrometry in the analysis of alkaloids. Phytochem Anal, 5: 217-232.
    • (1994) Phytochem Anal , vol.5 , pp. 217-232
    • Verpoorte, R.1    Niessen, W.M.A.2
  • 38
    • 70350157233 scopus 로고    scopus 로고
    • A simple method for screening and quantification of ricinine in feed with HPLC and LC-MS
    • Wang, Z, Li, D, Zhou, Z, Li, B and Yang, W. 2009. A simple method for screening and quantification of ricinine in feed with HPLC and LC-MS. J Chromatogr Sci, 47: 585-588.
    • (2009) J Chromatogr Sci , vol.47 , pp. 585-588
    • Wang, Z.1    Li, D.2    Zhou, Z.3    Li, B.4    Yang, W.5
  • 39
    • 79952020241 scopus 로고    scopus 로고
    • Toxicity of pyrrolizidine alkaloids to humans and ruminants
    • Wiedenfeld, H and Edgar, J. 2011. Toxicity of pyrrolizidine alkaloids to humans and ruminants. Phytochem Rev, 10: 137-151.
    • (2011) Phytochem Rev , vol.10 , pp. 137-151
    • Wiedenfeld, H.1    Edgar, J.2
  • 40
    • 77954860105 scopus 로고    scopus 로고
    • Rapid and global detection and characterization of aconitum alkaloids in Yin Chen Si Ni Tang, a traditional Chinese medical formula, by ultra performance liquid chromatography-high resolution mass spectrometry and automated data analysis
    • Yan, G, Sun, H, Sun, W, Zhao, L, Meng, X and Wang, X. 2010. Rapid and global detection and characterization of aconitum alkaloids in Yin Chen Si Ni Tang, a traditional Chinese medical formula, by ultra performance liquid chromatography-high resolution mass spectrometry and automated data analysis. J Pharmaceut Biomed Anal, 53: 421-431.
    • (2010) J Pharmaceut Biomed Anal , vol.53 , pp. 421-431
    • Yan, G.1    Sun, H.2    Sun, W.3    Zhao, L.4    Meng, X.5    Wang, X.6
  • 41
    • 33845916049 scopus 로고    scopus 로고
    • Analysis of phenolic compounds in rhubarbs using liquid chromatography coupled with electrospray ionization mass spectrometry
    • Ye, M, Han, J, Chen, H, Zheng, J and Guo, D. 2007. Analysis of phenolic compounds in rhubarbs using liquid chromatography coupled with electrospray ionization mass spectrometry. J Am Soc Mass Spectrom, 18: 82-91.
    • (2007) J Am Soc Mass Spectrom , vol.18 , pp. 82-91
    • Ye, M.1    Han, J.2    Chen, H.3    Zheng, J.4    Guo, D.5
  • 42
    • 58149492552 scopus 로고    scopus 로고
    • Studies on the aconitine-type alkaloids in the roots of Aconitum Carmichaeli Debx. by HPLC/ESIMS/MSn
    • Yue, H, Pi, Z, Song, F, Liu, Z, Cai, Z and Liu, S. 2009. Studies on the aconitine-type alkaloids in the roots of Aconitum Carmichaeli Debx. by HPLC/ESIMS/MSn. Talanta, 77: 1800-1807.
    • (2009) Talanta , vol.77 , pp. 1800-1807
    • Yue, H.1    Pi, Z.2    Song, F.3    Liu, Z.4    Cai, Z.5    Liu, S.6
  • 43
    • 67650360041 scopus 로고    scopus 로고
    • Rapid separation and identification of furocoumarins in Angelica dahurica by high-performance liquid chromatography with diode-array detection, time-of-flight mass spectrometry and quadrupole ion trap mass spectrometry
    • Zhang, H, Gong, C, Lv, L, Xu, Y, Zhao, L, Zhu, Z, Chai, Y and Zhang, G. 2009. Rapid separation and identification of furocoumarins in Angelica dahurica by high-performance liquid chromatography with diode-array detection, time-of-flight mass spectrometry and quadrupole ion trap mass spectrometry. Rapid Comm Mass Spectrom, 23: 2167-2175.
    • (2009) Rapid Comm Mass Spectrom , vol.23 , pp. 2167-2175
    • Zhang, H.1    Gong, C.2    Lv, L.3    Xu, Y.4    Zhao, L.5    Zhu, Z.6    Chai, Y.7    Zhang, G.8
  • 44
    • 78049280983 scopus 로고    scopus 로고
    • A new approach for simultaneous screening and quantification of toxic pyrrolizidine alkaloids in some potential pyrrolizidine alkaloid-containing plants by using ultra performance liquid chromatography-tandem quadrupole mass spectrometry
    • Zhou, Y, Li, N, Choi, FFK, Qiao, CF, Song, JZ, Li, SL, Liu, X, Cai, ZW, Fu, PP and Xu, HX. 2010. A new approach for simultaneous screening and quantification of toxic pyrrolizidine alkaloids in some potential pyrrolizidine alkaloid-containing plants by using ultra performance liquid chromatography-tandem quadrupole mass spectrometry. Analyt Chim Acta, 681: 33-40.
    • (2010) Analyt Chim Acta , vol.681 , pp. 33-40
    • Zhou, Y.1    Li, N.2    Choi, F.F.K.3    Qiao, C.F.4    Song, J.Z.5    Li, S.L.6    Liu, X.7    Cai, Z.W.8    Fu, P.P.9    Xu, H.X.10
  • 45
    • 37249025797 scopus 로고    scopus 로고
    • Development and validation of a liquid chromatography/electrospray ionization time-of-flight mass spectrometry method for relative and absolute quantification of steroidal alkaloids in Fritillaria species
    • Zhou, JL, Li, P, Li, HJ, Jiang, Y, Ren, MT and Liu, Y. 2008. Development and validation of a liquid chromatography/electrospray ionization time-of-flight mass spectrometry method for relative and absolute quantification of steroidal alkaloids in Fritillaria species. J Chromatogr A, 1177: 126-137.
    • (2008) J Chromatogr A , vol.1177 , pp. 126-137
    • Zhou, J.L.1    Li, P.2    Li, H.J.3    Jiang, Y.4    Ren, M.T.5    Liu, Y.6
  • 46
    • 70349778830 scopus 로고    scopus 로고
    • Herbal medicine analysis by liquid chromatography/time-of-flight mass spectrometry
    • Zhou, JL, Qi, LW and Li, P. 2009. Herbal medicine analysis by liquid chromatography/time-of-flight mass spectrometry. J Chromatogr A, 1216: 7582-7594.
    • (2009) J Chromatogr A , vol.1216 , pp. 7582-7594
    • Zhou, J.L.1    Qi, L.W.2    Li, P.3


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