Clinical review of grayanotoxin/mad honey poisoning past and present

Clinical Toxicology

Volumn 46, Issue 5, 2008, Pages 437-442

  Gunduz, Abdulkadir ^a   Turedi, Suleyman ^a,b   Russell, Robert M ^a   Ayaz, Faik Ahmet ^a  

^a KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

^b KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Andromedotoxin; Grayanotoxin; Mad honey; Rhododendron

Indexed keywords

ATROPINE; GRAYANOTOXIN; MUSCARINIC RECEPTOR; PLANT TOXIN; SODIUM CHANNEL;

ASYSTOLE; BRADYCARDIA; CENTRAL NERVOUS SYSTEM; CHOLINERGIC SYSTEM; COMPLETE HEART BLOCK; HEART ARRHYTHMIA; HONEY; HUMAN; HYPOTENSION; INTOXICATION; MAD HONEY POISONING; MORTALITY; PLANT; REVIEW; RHODODENDRON; SYNDROME DELINEATION; TOXIN ANALYSIS; VAGUS NERVE;

DITERPENES; EUROPE; HISTORY, 18TH CENTURY; HISTORY, 19TH CENTURY; HISTORY, ANCIENT; HONEY; HUMANS; NORTH AMERICA; RHODODENDRON; TOXINS, BIOLOGICAL;

ERICACEAE; RHODODENDRON;

EID: 45849094055     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.1080/15563650701666306     Document Type: Review

References (36)

1. Gunduz A, Turedi S, Uzun H, Topbas M. Mad honey poisoning. Am J Emerg Med 2006; 24:595-598.
2. Lampe KF. Rhododendrons, mountain laurel, and mad honey. JAMA 1988; 259:2009.
3. Ozhan H, Akdemir R, Yazici M, Gunduz H, Duran S, Uyan C. Cardiac emergencies caused by honey ingestion: a single centre experience. Emerg Med J 2004; 21:742-744.
4. Yavuz H, Ozel A, Akkus I, Erkul I. Honey poisoning in Turkey. Lancet 1991; 337:789-790.
5. Yilmaz O, Eser M, Sahiner A, Altintop L, Yesildag O. Hypotension, bradycardia and syncope caused by honey poisoning. Resuscitation 2006; 68:405-408.
6. Kebler LF. Poisonous honey. Am Pharm Assoc Proc 1896; 44:167-174.
7. ABC of Complementary medicine: Herbal medicine. One Hundred years ego-Honey poisoning (bmj 1899; ii: 674). BMJ 1999; 319:1422.
8. Von Malottki K, Wiechmann HW. Acute life-threatening bradycardia: food poisoning by Turkish wild honey. Dtsch Med Wochenschr 1996; 121:936-938.
9. Gossinger H, Hruby K, Pohl A, Davogg S, Sutterlutti G, Mathis G. Poisoning with andromedotoxin-containing honey. Dtsch Med Wochenschr 1983; 108:1555-1558.
10. Leach DG. Ancient curse of the rhododendron. Am Horticulturist 1972; 51:20-29.
11. Tallent WH, Riethof ML, Horning EC. Studies on the occurrence and structure of acetylandromedol (Andromedotoxin). J Am Chem Soc 1957; 79:4549-4554.
12. Stevens PF. Rhododendron L. In: Davis PF ed. Flora of Turkey and the East Aegean Islands. Edinburgh: Edinburgh University Press; 1978; 6:90-94.
13. Gunduz A, Bostan H, Turedi S, Nuhoglu I, Patan T. Wild flowers and mad honey. Wilderness Environ Med 2007; 18:69-71.
14. Terai T, Osakabe K, Katai M, Sakaguchi K, Narama I, Matsuura T, Katakawa J, Tetsumi T. Preparation of 9-hydroxy grayanotoxin derivatives and their acute toxicity in mice. Chem Pharm Bull (Tokyo) 2003; 51:351-353.
15. Ascioglu M, Ozesmi C, Dogan P, Ozturk F. Effects of acute grayanotoxin-1 administration on hepatic and renal functions in rats. Turk J Med Sci 2000; 30:23-27.
16. Grayanotoxin. U.S Food and Drug Adminstration Web site. Available at: http://www.cfsan.fda.gov/∼mow/chap44.html. Accessed June 13, 2007.
17. White JW, Doner LW. Honey composition and properties. Beesource Web site. Available at: http://www.beesource.com/pov/usda/beekpUSA82.htm. Accessed June 13, 2007.
18. Honey bee. Wikipedia Web site. Available at: http://en.wikipedia.org/ wiki/Honey_bee. Accessed June 13, 2007.
19. Honey. Wikipedia Web site. http://en.wikipedia.org/wiki/Honey. Accessed June 13, 2007.
20. Onat F, Yegen BC, Lawrence R, Oktay A, Oktay S. Site of action of grayanotoxins in mad honey in rats. J Appl Toxicol 1991; 11:199-201.
21. Onat FY, Yegen BC, Lawrence R, Oktay A, Oktay S. Mad honey poisoning in man and rat. Rev Environ Health 1991; 9:3-9.
22. Maejima H, Kinoshita E, Seyama I, Yamaoka K. Distinct site regulating Grayanotoxin binding and unbinding to D4S6 of Nav1.4 sodium channel as revealed by improved estimation of toxin sensitivity. J Biological Chemistry 2003; 278:9464-9471.
23. Oztasan N, Altinkaynak K, Akcay FA, Gocer F, Dane S. Effect of Mad Honey on Blood glucose and lipid levels in rat with streptozocin-induced diabetes. Turk J Vet Anim Sci 2005; 29:1093-1096.
24. Xenophon: Anabasis, or March Up Country. Fordham University Web site. Available at: http://www.fordham.edu/halsall/ancient/xenophon-anabasis. html#BOOK%20II. Accessed June 13, 2007.
25. Mokhlesi B, Leiken JB, Murray P, Corbridge TC. Adult toxicology in critical care: part I: general approach to the intoxicated patient. Chest 2003; 123:577-592.
26. Biberoglu S, Biberoglu K, Komsuoglu B. Mad honey. JAMA 1988; 259:1943.
27. Sutlupinar N, Mat A, Satganoglu Y. Poisoning by toxic honey in Turkey. Arch Toxicol 1993; 67:148-150.
28. Dilber E, Kalyoncu M, Yarifi N, Okten A. A case of mad honey poisoning presenting with convulsion: intoxication instead of alternative therapy. Turk J Med Sci 2002; 32:361-362.
29. Ergun K, Tufekcioglu O, Aras D, Korkmaz S, Pehlivan S. A rare cause of atrioventricular block: Mad Honey intoxication. Int J Cardiol 2005; 99:347-348.
30. Gunduz A, Durmus I, Turedi S, Nuhoglu I, Ozturk S. Mad honey poisoning-related asystole. Emerg Med J 2007; 24:592-593.
31. Burton J. Curious traits of the higher primates, flower power, and raving honey. Sonomapicnic Web site. Available at: http://www.sonomapicnic.com/06/ ravhoney.htm. Accessed June 13, 2007.
32. Scott PM, Coldwell BB, Wiberg GS. Grayanotoxins. Occurrence and analysis in honey and a comparison of toxicities in mice. Food Cosmet Toxicol 1971; 9:179-184.
33. Koca I, Koca AF. Poisoning by mad honey : A brief review. Food Chem Toxicol 2007; 45:1315-318.
34. Adler LS. The ecologic significance of toxic nectar. Oikos 2000; 91:409-420.
35. Esen D, Yildiz O, Kulac S, Sarginci M. Controlling Rhododendron spp. in the Turkish Black Sea Region. Forestry 2006; 79:177-184.
36. Harborne JB. Phytochemical Methods: A guide to modern techniques of plant analysis,Third ed, London:Chapman & Hall; 1998.