Simultaneous determination of various cardiac glycosides by liquid chromatography-hybrid mass spectrometry for the purity assessment of the therapeutic monitored drug digoxin

Journal of Chromatography A

Volumn 1217, Issue 27, 2010, Pages 4535-4543

  Josephs, Ralf Dieter ^a   Daireaux, Adeline ^a   Westwood, Steven ^a   Wielgosz, Robert Ian ^a  

^a PAVILLON DE BRETEUIL   (France)

Author keywords

Cardiac glycoside; Digoxin; LC MS MS; Purity; Reference material; Uncertainty

Indexed keywords

AGLYCONES; CANDIDATE REFERENCE MATERIALS; CLINICAL CHEMISTRY; ELECTROSPRAYS; HERBACEOUS PLANTS; IMPURITIES IN; IMPURITY LEVEL; IONISATION; LABORATORY MEDICINES; LABORATORY STUDIES; LC-MS N; LC-MS/MS; LIMITS OF DETECTION; MASS FRACTION; METROLOGY IN CHEMISTRY; PERFORMANCE CHARACTERISTICS; PURE MATERIALS; PURITY ASSESSMENT; REFERENCE MATERIAL; REFERENCE MEASUREMENT SYSTEM; SIMULTANEOUS DETERMINATIONS; TANDEM MASS SPECTROMETRY; WORKING GROUPS;

BIOCHEMISTRY; CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; SUGARS;

IMPURITIES;

ACETYLDIGOXIN; AGLYCONE; CARDIAC GLYCOSIDE; DEACETYLLANATOSIDE A; DEACETYLLANATOSIDE B; DESLANOSIDE; DIGITALIS EXTRACT; DIGITOXIGENIN; DIGITOXIN; DIGOXIGENIN; DIGOXIN; DIGOXIN TETRADIGITOXOSIDE; GITOXIN; LANATOSIDE C; UNCLASSIFIED DRUG;

ARTICLE; DRUG DETERMINATION; DRUG IMPURITY; DRUG MONITORING; DRUG PURITY; ELECTROSPRAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY HYBRID TANDEM MASS SPECTROMETRY; LINEAR SYSTEM; PRIORITY JOURNAL; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, LIQUID; DIGOXIN; DRUG MONITORING; LINEAR MODELS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

DIGITALIS (GENUS);

EID: 77953685262     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.04.060     Document Type: Article

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