Direct analysis of psychoactive tryptamine and harmala alkaloids in the Amazonian botanical medicine ayahuasca by liquid chromatography-electrospray ionization-tandem mass spectrometry

Journal of Chromatography A

Volumn 1216, Issue 51, 2009, Pages 8960-8968

  McIlhenny, Ethan H ^a   Pipkin, Kelly E ^a   Standish, Leanna J ^b   Wechkin, Hope A ^c   Strassman, Rick ^d,e   Barker, Steven A ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b BASTYR UNIVERSITY   (United States)

^c Evergreen Hospital Medical Center   (United States)

^d UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^e Cottonwood Research Foundation ^*  (United States)

Author keywords

Ayahuasca; Dimethyltryptamine; Direct injection; Harmala Alkaloids; LC MS MS

Indexed keywords

DEGREE OF SPECIFICITY; DIRECT ANALYSIS; DIRECT INJECTION; ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY; EXTRACTION PROCEDURE; FORENSIC EXAMINATIONS; INTERNAL STANDARDS; LC/MS/MS; LOW LIMITS OF DETECTIONS; MATRIX EFFECTS; RAPID DETECTION; TRYPTAMINES;

CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DEUTERIUM; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONIZATION; MASS SPECTROMETERS; MASS SPECTROMETRY; PARTICLE DETECTORS; SUGAR (SUCROSE);

ELECTROSPRAY IONIZATION;

1,2,3,4 TETRAHYDRO 2 METHYL BETA CARBOLINE; 5 METHOXY N,N DIMETHYLTRYPTAMINE; ALKALOID DERIVATIVE; BUFOTENINE; HARMALINE; HARMALOL; HARMINE; HARMOL; HERBACEOUS AGENT; N METHYLTRYPTAMINE; N,N DIMETHYLTRYPTAMINE; N,N DIMETHYLTRYPTAMINE N OXIDE; TETRAHYDROHARMINE; TRYPTAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; AYAHUASCA; CONTROLLED STUDY; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; ETHNOBOTANY; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS;

ALKALOIDS; BANISTERIOPSIS; BRAZIL; CHROMATOGRAPHY, LIQUID; MOLECULAR WEIGHT; PLANTS, MEDICINAL; PSYCHOTROPIC DRUGS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TIME FACTORS; TRYPTAMINES;

BANISTERIOPSIS CAAPI;

EID: 70449864863     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2009.10.088     Document Type: Article

References (33)

1. Schultes R.E. Botanical Museum Leaflets, vol. 18 (1957), Harvard University p. 1
2. Schultes R.E., and Hofmann A. The Botany and Chemistry of Hallucinogens (1980), Charles C. Thomas, Springfield, Illinois
3. McKenna D.J., Towers G.H.N., and Abbott F. J. Ethnopharmacol. 10 (1984) 195
4. McKenna D.J., and Towers G.H.N. J. Psychoactive Drugs 16 (1984) 347
5. McKenna D.J., Luna L.E., and Towers G.H.N. In: von Reis S., and Schultes R.E. (Eds). Ethnobotany: Evolution of a Discipline (1995), Dioscorides Press, Portland, OR 349
6. McKenna D.J. Pharmacol. Therap. 102 (2004) 111
7. Callaway J.C., Raymon L.P., Hearn W.L., McKenna D.J., Grob C.S., Brito G.S., and Mash D.C. J. Anal. Tox. 20 (1996) 492
8. Rivier L., and Lindgren J.E. Econ. Bot. 26 (1971) 101
9. Hashimoto Y., and Kawanishi K. Phytochemistry 14 (1975) 1633
10. Hashimoto Y., and Kawanishi K. Phytochemistry 15 (1976) 1559
11. J. Riba, Human pharmacology of ayahuasca, Doctoral Thesis, Universitat Autonoma de Barcelona, 2003.
12. Riba J., Valle M., Urbano G., Yritia M., Morte A., and Barbanoj M.J. J. Pharmacol. Exper. Ther. 306 (2003) 73
13. Callaway J.C., McKenna D.J., Grob C.S., Brito G.S., Raymon L.P., Poland R.E., Andrade E.N., Andrade E.O., and Mash D.C. J. Ethnopharmacol. 65 (1999) 243
14. Ott J. J. Psychoactive Drugs 31 (1999) 171
15. Riba J., and Barbanoj M.J. J. Psychoactive Drugs 37 (2005) 219
16. McKenna D.J. In: Metzner R. (Ed). Ayahuasca: Hallucinogens, Consciousness, and the Spirit of Nature (1999), Thunder's Mouth Press, New York 243
17. Supreme Court of the United States. Certiorari To The United States Court Of Appeals For The Tenth Circuit. No. 04-1084. Alberto R. Gonzales, Attorney General et al., Petitioners V.O. Centro Espirita Beneficente Uniao Do Vegetal et al. (http://www.erowid.org/chemicals/ayahuasca/ayahuasca_law23.pdf), 2006.
18. Gable R.S. Addiction 102 (2007) 24
19. Moura D.J., Richter M.F., Boeira J.B., Henriques J.A.P., and Saffi J. Mutagenesis 22 (2007) 293
20. Andritzky W. J. Psychoactive Drugs 21 (1989) 77
21. Mabit J., Giove R., and Vega J. In: Winkelman M., and Andritzky W. (Eds). Yearbook of Cross-Cultural Medicine and Psychotherapy (1996), VMB Press, Berlin 257
22. Callaway J.C., Airaksinen M.M., McKenna D.J., Brito G.S., and Grob C.S. Psychopharmacology 116 (1994) 385
23. Hallikainen T., Saito H.M., Lachman J., Volavka T., Pohjalainen O.P., Ryynanen J., Kauhanenm J., Syvalahti E., and Hietala J. J. Tiihonen. Mol. Psychol. 4 (1999) 385
24. Mantere T., Tupala E., Hall H., Sarkioja T., Rasanen P., Bergstorm K., and Callaway J.C. J. Tiihonen. Am. J. Psychol. 159 (2002) 599
25. Tiihonen J., Kiukka J.T., Bergstorm K.A., Karhu J., Viinamaki H., Lehtonen J., Hallikainen T., Yang J., and Hakola P. Eur. J. Nucl. Med. 24 (1997) 1253
26. Barker S.A., Monti J.A., and Christian S.T. Biochem. Pharmacol. 29 (1980) 1049
27. Kawanishi K., Uhara Y., and Hasimoto Y. J. Nat. Prod. 45 (1982) 637
28. Callaway J.C., Brito G.S., and Neves E.S. J. Psychoactive Drugs 37 (2005) 145
29. Schultes R.E. J. Psychoactive Drugs 14 (1982) 205
30. Santos R.G., Landeira-Fernandez J., Strassman R.J., Motta V., and Cruz A.P.M. J. Ethnopharmacol. 112 (2007) 507
31. Gambelunghe C., Aroni K., Rossi R., Moretti L., and Bacci M. M. Biomed. Chromatogr. 22 (2008) 1056
32. Pires A.P.S., De Oliveira C.D.R., Moura S., Dorr F.A., Silva W.A.E., and Yonamine M. Phytochem. Anal. 20 (2009) 149
33. Kawanishi K., Saiki K., Tomita H., Tachibana Y., Farnsworth N.R., and Bohlke M. Adv. Mass Spectrom. 14 (1998) (D053560/1)