메뉴 건너뛰기




Volumn 827, Issue , 2012, Pages 3-12

Historical overview of rho GTPases

Author keywords

Adhesion; Cytoskeleton; GAP; GDI; GEF; Signal transduction; Trafficking; Transcription

Indexed keywords

BACTERIAL TOXIN; GUANINE NUCLEOTIDE BINDING PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; VIRUS PROTEIN;

EID: 84855897077     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-442-1_1     Document Type: Review
Times cited : (46)

References (78)
  • 1
    • 34648844192 scopus 로고    scopus 로고
    • Taking Rho GTPases to the next level: The cellular functions of atypical Rho GTPases
    • DOI 10.1016/j.yexcr.2007.07.022, PII S0014482707003588
    • Aspenstrom, P., Ruusala, A., and Pacholsky, D. (2007) Taking Rho GTPases to the next level: the cellular functions of atypical Rho GTPases. Exp Cell Res 313, 3673-9. (Pubitemid 47464235)
    • (2007) Experimental Cell Research , vol.313 , Issue.17 , pp. 3673-3679
    • Aspenstrom, P.1    Ruusala, A.2    Pacholsky, D.3
  • 2
    • 77958198472 scopus 로고    scopus 로고
    • Rnd proteins: Multifunctional regulators of the cytoskeleton and cell cycle progression
    • Riou, P., Villalonga, P., and Ridley, A. J. (2010) Rnd proteins: multifunctional regulators of the cytoskeleton and cell cycle progression. Bioessays 32, 986-92.
    • (2010) Bioessays , vol.32 , pp. 986-992
    • Riou, P.1    Villalonga, P.2    Ridley, A.J.3
  • 3
    • 0021830154 scopus 로고
    • A novel rasrelated gene family
    • Madaule, P., and Axel, R. (1985) A novel rasrelated gene family. Cell 41, 31-40.
    • (1985) Cell , vol.41 , pp. 31-40
    • Madaule, P.1    Axel, R.2
  • 4
    • 0023293818 scopus 로고
    • Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae
    • Madaule, P., Axel, R., and Myers, A. M. (1987) Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae . Proc Natl Acad Sci USA 84, 779-83.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 779-83
    • Madaule, P.1    Axel, R.2    Myers, A.M.3
  • 5
    • 0025363198 scopus 로고
    • Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity
    • Johnson, D. I., and Pringle, J. R. (1990) Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity. J Cell Biol 111, 143-52.
    • (1990) J Cell Biol , vol.111 , pp. 143-152
    • Johnson, D.I.1    Pringle, J.R.2
  • 7
    • 0028913197 scopus 로고
    • Isolation and sequencing of two cDNA clones encoding Rho proteins from the fi ssion yeast S chizosaccharomyces pombe
    • Nakano, K., and Mabuchi, I. (1995) Isolation and sequencing of two cDNA clones encoding Rho proteins from the fi ssion yeast S chizosaccharomyces pombe . Gene 155, 119-22.
    • (1995) Gene , vol.155 , pp. 119-122
    • Nakano, K.1    Mabuchi, I.2
  • 8
    • 0027755363 scopus 로고
    • Cloning and characterization of seven novel Dictyostelium discoideum rac-related genes belonging to the rho family of GTPases
    • DOI 10.1016/0378-1119(93)90448-C
    • Bush, J., Franek, K., and Cardelli, J. (1993) Cloning and characterization of seven novel Dictyostelium discoideum rac-related genes belonging to the rho family of GTPases. Gene 136, 61-8. (Pubitemid 24049223)
    • (1993) Gene , vol.136 , Issue.1-2 , pp. 61-68
    • Bush, J.1    Franek, K.2    Cardelli, J.3
  • 9
    • 0035282887 scopus 로고    scopus 로고
    • The Dictyostelium discoideum family of Rho-related proteins
    • Rivero, F., Dislich, H., Glockner, G., and Noegel, A. A. (2001) The Dictyostelium discoideum family of Rho-related proteins. Nucleic Acids Res 29, 1068-79. (Pubitemid 32186192)
    • (2001) Nucleic Acids Research , vol.29 , Issue.5 , pp. 1068-1079
    • Rivero, F.1    Dislich, H.2    Glockner, G.3    Noegel, A.A.4
  • 10
    • 0037458579 scopus 로고    scopus 로고
    • Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis
    • DOI 10.1074/jbc.M208609200
    • Fransson, A., Ruusala, A., and Aspenstrom, P. (2003) Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. J Biol Chem 278, 6495-502. (Pubitemid 36800910)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.8 , pp. 6495-6502
    • Fransson, A.1    Ruusala, A.2    Aspenstrom, P.3
  • 11
    • 33845868501 scopus 로고    scopus 로고
    • Evolution of the Rho family of Ras-like GTPases in eukaryotes
    • DOI 10.1093/molbev/msl145
    • Boureux, A., Vignal, E., Faure, S., and Fort, P. (2007) Evolution of the Rho family of ras-like GTPases in eukaryotes. Mol Biol Evol 24, 203-16. (Pubitemid 46026295)
    • (2007) Molecular Biology and Evolution , vol.24 , Issue.1 , pp. 203-216
    • Boureux, A.1    Vignal, E.2    Faure, S.3    Fort, P.4
  • 12
    • 0037081677 scopus 로고    scopus 로고
    • The Rho GTPase family: A Racs to Wrchs story
    • Wherlock, M., and Mellor, H. (2002) The Rho GTPase family: a Racs to Wrchs story. J Cell Sci 115, 239-40. (Pubitemid 34145173)
    • (2002) Journal of Cell Science , vol.115 , Issue.2 , pp. 239-240
    • Wherlock, M.1    Mellor, H.2
  • 13
  • 14
    • 78650503825 scopus 로고    scopus 로고
    • A novel testis-specifi c GTPase serves as a link to proteasome biogenesis: Functional characterization of RhoS/RSA-14-44 in spermatogenesis
    • Zhang, N., Liang, J., Tian, Y., Yuan, L., Wu, L., Miao, S., Zong, S., and Wang, L. (2010) A novel testis-specifi c GTPase serves as a link to proteasome biogenesis: functional characterization of RhoS/RSA-14-44 in spermatogenesis. Mol Biol Cell 21, 4312-4324.
    • (2010) Mol Biol Cell , vol.21 , pp. 4312-4324
    • Zhang, N.1    Liang, J.2    Tian, Y.3    Yuan, L.4    Wu, L.5    Miao, S.6    Zong, S.7    Wang, L.8
  • 15
    • 0034175883 scopus 로고    scopus 로고
    • Plant GTPases: The Rhos in bloom
    • DOI 10.1016/S0962-8924(00)01728-1, PII S0962892400017281
    • Valster, A. H., Hepler, P. K., and Chernoff, J. (2000) Plant GTPases: the Rhos in bloom. Trends Cell Biol 10, 141-6. (Pubitemid 30171308)
    • (2000) Trends in Cell Biology , vol.10 , Issue.4 , pp. 141-146
    • Valster, A.H.1    Hepler, P.K.2    Chernoff, J.3
  • 16
    • 0024449589 scopus 로고
    • The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells
    • Chardin, P., Boquet, P., Madaule, P., Popoff, M. R., Rubin, E. J., and Gill, D. M. (1989) The mammalian G protein rhoC is ADPribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfi laments in Vero cells. EMBO J 8, 1087-92. (Pubitemid 19273274)
    • (1989) EMBO Journal , vol.8 , Issue.4 , pp. 1087-1092
    • Chardin, P.1    Boquet, P.2    Madaule, P.3    Popoff, M.R.4    Rubin, E.J.5    Gill, D.M.6
  • 17
    • 17844406602 scopus 로고    scopus 로고
    • Bacterial cytotoxins: Targeting eukaryotic switches
    • DOI 10.1038/nrmicro1150
    • Aktories, K., and Barbieri, J. T. (2005) Bacterial cytotoxins: targeting eukaryotic switches. Nat Rev Microbiol 3, 397-410. (Pubitemid 40590382)
    • (2005) Nature Reviews Microbiology , vol.3 , Issue.5 , pp. 397-410
    • Aktories, K.1    Barbieri, J.T.2
  • 18
    • 0025195876 scopus 로고
    • Microinjection of recombinant p21rho induces rapid changes in cell morphology
    • Paterson, H. F., Self, A. J., Garrett, M. D., Just, I., Aktories, K., and Hall, A. (1990) Microinjection of recombinant p21rho induces rapid changes in cell morphology. J Cell Biol 111, 1001-7.
    • (1990) J Cell Biol , vol.111 , pp. 1001-1007
    • Paterson, H.F.1    Self, A.J.2    Garrett, M.D.3    Just, I.4    Aktories, K.5    Hall, A.6
  • 19
    • 0024376173 scopus 로고
    • Ras Oncogenes in human cancer: A review
    • Bos, J. L. (1989) ras oncogenes in human cancer: a review. Cancer Res 49, 4682-9. (Pubitemid 19213607)
    • (1989) Cancer Research , vol.49 , Issue.17 , pp. 4682-4689
    • Bos, J.L.1
  • 20
    • 0023715225 scopus 로고
    • Inhibition of NIH 3 T3 cell proliferation by a mutant ras protein with preferential affi nity for GDP
    • Feig, L. A., and Cooper, G. M. (1988) Inhibition of NIH 3 T3 cell proliferation by a mutant ras protein with preferential affi nity for GDP. Mol Cell Biol 8, 3235-43.
    • (1988) Mol Cell Biol , vol.8 , pp. 3235-3243
    • Feig, L.A.1    Cooper, G.M.2
  • 21
    • 0026654125 scopus 로고
    • The small GTP-binding protein rac regulates growth factor- induced membrane ruffl ing
    • Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., and Hall, A. (1992) The small GTP-binding protein rac regulates growth factor- induced membrane ruffl ing. Cell 70, 401-10.
    • (1992) Cell , vol.70 , pp. 401-410
    • Ridley, A.J.1    Paterson, H.F.2    Johnston, C.L.3    Diekmann, D.4    Hall, A.5
  • 22
    • 0026778133 scopus 로고
    • The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fi bers in response to growth factors
    • Ridley, A. J., and Hall, A. (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fi bers in response to growth factors. Cell 70, 389-99.
    • (1992) Cell , vol.70 , pp. 389-399
    • Ridley, A.J.1    Hall, A.2
  • 23
    • 0028986034 scopus 로고
    • The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and fi lopodia in Swiss 3 T3 fi broblasts
    • Kozma, R., Ahmed, S., Best, A., and Lim, L. (1995) The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and fi lopodia in Swiss 3 T3 fi broblasts. Mol Cell Biol 15, 1942-52.
    • (1995) Mol Cell Biol , vol.15 , pp. 1942-1952
    • Kozma, R.1    Ahmed, S.2    Best, A.3    Lim, L.4
  • 24
    • 0028961293 scopus 로고
    • Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fi bers, lamellipodia, and fi lopodia
    • Nobes, C. D., and Hall, A. (1995) Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fi bers, lamellipodia, and fi lopodia. Cell 81, 53-62.
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 25
    • 0942268723 scopus 로고    scopus 로고
    • Rho GTPases have diverse effects on the organization of the actin filament system
    • DOI 10.1042/BJ20031041
    • Aspenstrom, P., Fransson, A., and Saras, J. (2004) Rho GTPases have diverse effects on the organisation of the actin fi lament system. Biochem J 377, 327-37. (Pubitemid 38142188)
    • (2004) Biochemical Journal , vol.377 , Issue.2 , pp. 327-337
    • Aspenstrom, P.1    Fransson, A.2    Saras, J.3
  • 28
    • 33646197411 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of RhoA activity in migrating cells
    • Pertz, O., Hodgson, L., Klemke, R. L., and Hahn, K. M. (2006) Spatiotemporal dynamics of RhoA activity in migrating cells. Nature 440, 1069-72.
    • (2006) Nature , vol.440 , pp. 1069-10672
    • Pertz, O.1    Hodgson, L.2    Klemke, R.L.3    Hahn, K.M.4
  • 29
    • 24344482090 scopus 로고    scopus 로고
    • Localized RhoA activation as a requirement for the induction of membrane ruffling
    • DOI 10.1091/mbc.E04-12-1076
    • Kurokawa, K., and Matsuda, M. (2005) Localized RhoA activation as a requirement for the induction of membrane ruffl ing. Mol Biol Cell 16, 4294-303. (Pubitemid 41262897)
    • (2005) Molecular Biology of the Cell , vol.16 , Issue.9 , pp. 4294-4303
    • Kurokawa, K.1    Matsuda, M.2
  • 30
    • 79952092131 scopus 로고    scopus 로고
    • Multiples roles of RhoA during T cell transendothelial migration
    • Heasman, S. J., and Ridley, A. J. (2010) Multiples roles of RhoA during T cell transendothelial migration. Small GTPases 1, 174-9.
    • (2010) Small GTPases , vol.1 , pp. 174-179
    • Heasman, S.J.1    Ridley, A.J.2
  • 31
    • 0025295180 scopus 로고
    • Purifi cation and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTPbinding protein
    • Ueda, T., Kikuchi, A., Ohga, N., Yamamoto, J., and Takai, Y. (1990) Purifi cation and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTPbinding protein. J Biol Chem 265, 9373-80.
    • (1990) J Biol Chem , vol.265 , pp. 9373-9380
    • Ueda, T.1    Kikuchi, A.2    Ohga, N.3    Yamamoto, J.4    Takai, Y.5
  • 32
    • 0025965647 scopus 로고
    • Regulation of binding of rhoB p20 to membranes by its specific regulatory protein, GDP dissociation inhibitor
    • Isomura, M., Kikuchi, A., Ohga, N., and Takai, Y. (1991) Regulation of binding of rhoB p20 to membranes by its specifi c regulatory protein, GDP dissociation inhibitor. Oncogene 6, 119-24. (Pubitemid 21923990)
    • (1991) Oncogene , vol.6 , Issue.1 , pp. 119-124
    • Isomura, M.1    Kikuchi, A.2    Ohga, N.3    Takai, Y.4
  • 33
    • 21744432683 scopus 로고    scopus 로고
    • GDIs: Central regulatory molecules in Rho GTPase activation
    • DOI 10.1016/j.tcb.2005.05.001, PII S0962892405001273
    • DerMardirossian, C., and Bokoch, G. M. (2005) GDIs: central regulatory molecules in Rho GTPase activation. Trends Cell Biol 15, 356-63. (Pubitemid 40943524)
    • (2005) Trends in Cell Biology , vol.15 , Issue.7 , pp. 356-363
    • DerMardirossian, C.1    Bokoch, G.M.2
  • 34
    • 0026044409 scopus 로고
    • Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product
    • Hart, M. J., Eva, A., Evans, T., Aaronson, S. A., and Cerione, R. A. (1991) Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. Nature 354, 311-4. (Pubitemid 21896884)
    • (1991) Nature , vol.354 , Issue.6351 , pp. 311-314
    • Hart, M.J.1    Eva, A.2    Evans, T.3    Aaronson, S.A.4    Cerione, R.A.5
  • 36
    • 34548472221 scopus 로고    scopus 로고
    • GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
    • DOI 10.1016/j.tcb.2007.05.001, PII S0962892407001572
    • Cote, J. F., and Vuori, K. (2007) GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. Trends Cell Biol 17, 383-93. (Pubitemid 47375099)
    • (2007) Trends in Cell Biology , vol.17 , Issue.8 , pp. 383-393
    • Cote, J.-F.1    Vuori, K.2
  • 37
    • 0024541333 scopus 로고
    • Identification of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins
    • Garrett, M. D., Self, A. J., van Oers, C., and Hall, A. (1989) Identifi cation of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins. J Biol Chem 264, 10-3. (Pubitemid 19027566)
    • (1989) Journal of Biological Chemistry , vol.264 , Issue.1 , pp. 10-13
    • Garrett, M.D.1    Self, A.J.2    Van Oers, C.3    Hall, A.4
  • 39
    • 33846969965 scopus 로고    scopus 로고
    • Current knowledge of the large RhoGAP family of proteins
    • DOI 10.1042/BC20060086
    • Tcherkezian, J., and Lamarche-Vane, N. (2007) Current knowledge of the large RhoGAP family of proteins. Biol Cell 99, 67-86. (Pubitemid 46242033)
    • (2007) Biology of the Cell , vol.99 , Issue.2 , pp. 67-86
    • Tcherkezian, J.1    Lamarche-Vane, N.2
  • 40
    • 13444252631 scopus 로고    scopus 로고
    • GEF means go: Turning on Rho GTPases with guanine nucleotide-exchange factors
    • DOI 10.1038/nrm1587
    • Rossman, K. L., Der, C. J., and Sondek, J. (2005) GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol 6, 167-80. (Pubitemid 40215811)
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.2 , pp. 167-180
    • Rossman, K.L.1    Der, C.J.2    Sondek, J.3
  • 41
    • 0030759770 scopus 로고    scopus 로고
    • Crystal structure of a small G protein in complex with the GTPase- activating protein rhoGAP
    • DOI 10.1038/41805
    • Rittinger, K., Walker, P. A., Eccleston, J. F., Nurmahomed, K., Owen, D., Laue, E., Gamblin, S. J., and Smerdon, S. J. (1997) Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP. Nature 388, 693-7. (Pubitemid 27366443)
    • (1997) Nature , vol.388 , Issue.6643 , pp. 693-697
    • Rittinger, K.1    Walker, P.A.2    Eccleston, J.F.3    Nurmahomed, K.4    Owen, D.5    Laue, E.6    Gamblin, S.J.7    Smerdon, S.J.8
  • 42
    • 0034619877 scopus 로고    scopus 로고
    • Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
    • DOI 10.1038/35047014
    • Worthylake, D. K., Rossman, K. L., and Sondek, J. (2000) Crystal structure of Rac1 in complex with the guanine nucleotide exchange egion of Tiam1. Nature 408, 682-8. (Pubitemid 32015977)
    • (2000) Nature , vol.408 , Issue.6813 , pp. 682-688
    • Worthylake, D.K.1    Rossman, K.L.2    Sondek, J.3
  • 43
    • 0343750716 scopus 로고    scopus 로고
    • The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI
    • DOI 10.1038/72392
    • Scheffzek, K., Stephan, I., Jensen, O. N., Illenberger, D., and Gierschik, P. (2000) The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI. Nat Struct Biol 7, 122-6. (Pubitemid 30082509)
    • (2000) Nature Structural Biology , vol.7 , Issue.2 , pp. 122-126
    • Scheffzek, K.1    Stephan, I.2    Jensen, O.N.3    Illenberger, D.4    Gierschik, P.5
  • 46
    • 0027235324 scopus 로고
    • A non-receptor tyrosine kinase that inhibits the GTPase activity of p21(cdc42)
    • DOI 10.1038/363364a0
    • Manser, E., Leung, T., Salihuddin, H., Tan, L., and Lim, L. (1993) A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. Nature 363, 364-7. (Pubitemid 23161535)
    • (1993) Nature , vol.363 , Issue.6427 , pp. 364-367
    • Manser, E.1    Leung, T.2    Salihuddin, H.3    Tan, L.4    Lim, L.5
  • 47
    • 0028078824 scopus 로고
    • A brain serine/threonine protein kinase activated by Cdc42 and Rac1
    • DOI 10.1038/367040a0
    • Manser, E., Leung, T., Salihuddin, H., Zhao, Z. S., and Lim, L. (1994) A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367, 40-6. (Pubitemid 24038530)
    • (1994) Nature , vol.367 , Issue.6458 , pp. 40-46
    • Manser, E.1    Leung, T.2    Salihuddin, H.3    Zhao, Z.-S.4    Lim, L.5
  • 48
    • 0030968580 scopus 로고    scopus 로고
    • Rho GTPases and signaling networks
    • Van Aelst, L., and D'Souza-Schorey, C. (1997) Rho GTPases and signaling networks. Genes Dev 11, 2295-322. (Pubitemid 27408529)
    • (1997) Genes and Development , vol.11 , Issue.18 , pp. 2295-2322
    • Van Aelst, L.1    D'Souza-Schorey, C.2
  • 50
    • 0034253536 scopus 로고    scopus 로고
    • The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    • Joberty, G., Petersen, C., Gao, L., and Macara, I. G. (2000) The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol 2, 531-9.
    • (2000) Nat Cell Biol , vol.2 , pp. 531-539
    • Joberty, G.1    Petersen, C.2    Gao, L.3    MacAra, I.G.4
  • 51
    • 0037222950 scopus 로고    scopus 로고
    • Cell polarity: Par6, aPKC and cytoskeletal crosstalk
    • DOI 10.1016/S0955-0674(02)00005-4
    • Etienne-Manneville, S., and Hall, A. (2003) Cell polarity: Par6, aPKC and cytoskeletal crosstalk. Curr Opin Cell Biol 15, 67-72. (Pubitemid 36044717)
    • (2003) Current Opinion in Cell Biology , vol.15 , Issue.1 , pp. 67-72
    • Etienne-Manneville, S.1    Hall, A.2
  • 52
    • 17144377069 scopus 로고    scopus 로고
    • RhoE function is regulated by ROCK I-mediated phosphorylation
    • DOI 10.1038/sj.emboj.7600612
    • Riento, K., Totty, N., Villalonga, P., Garg, R., Guasch, R., and Ridley, A. J. (2005) RhoE function is regulated by ROCK I-mediated phosphorylation. EMBO J 24, 1170-80. (Pubitemid 40516600)
    • (2005) EMBO Journal , vol.24 , Issue.6 , pp. 1170-1180
    • Riento, K.1    Totty, N.2    Villalonga, P.3    Garg, R.4    Guasch, R.5    Ridley, A.J.6
  • 54
    • 0035878110 scopus 로고    scopus 로고
    • Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1
    • DOI 10.1101/gad.894301
    • Tao, W., Pennica, D., Xu, L., Kalejta, R. F., and Levine, A. J. (2001) Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev 15, 1796-807. (Pubitemid 32905637)
    • (2001) Genes and Development , vol.15 , Issue.14 , pp. 1796-1807
    • Tao, W.1    Pennica, D.2    Xu, L.3    Kalejta, R.F.4    Levine, A.J.5
  • 55
    • 0030267458 scopus 로고    scopus 로고
    • Rho: Theme and variations
    • Ridley, A. J. (1996) Rho: theme and variations. Curr Biol 6, 1256-64. (Pubitemid 27004910)
    • (1996) Current Biology , vol.6 , Issue.10 , pp. 1256-1264
    • Ridley, A.J.1
  • 56
    • 0038737042 scopus 로고    scopus 로고
    • Actin dynamics control SRF activity by regulation of its coactivator MAL
    • DOI 10.1016/S0092-8674(03)00278-2
    • Miralles, F., Posern, G., Zaromytidou, A. I., and Treisman, R. (2003) Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 113, 329-42. (Pubitemid 36556115)
    • (2003) Cell , vol.113 , Issue.3 , pp. 329-342
    • Miralles, F.1    Posern, G.2    Zaromytidou, A.-I.3    Treisman, R.4
  • 57
    • 9944251987 scopus 로고    scopus 로고
    • Rho GTPases in human cancer: An unresolved link to upstream and downstream transcriptional regulation
    • DOI 10.1016/j.bbcan.2004.10.002, PII S0304419X04000654
    • Benitah, S. A., Valeron, P. F., van Aelst, L., Marshall, C. J., and Lacal, J. C. (2004) Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation. Biochim Biophys Acta 1705, 121-32. (Pubitemid 39592900)
    • (2004) Biochimica et Biophysica Acta - Reviews on Cancer , vol.1705 , Issue.2 , pp. 121-132
    • Benitah, S.A.1    Valeron, P.F.2    Van Aelst, L.3    Marshall, C.J.4    Lacal, J.C.5
  • 58
    • 0038554077 scopus 로고    scopus 로고
    • Biology of the p21- activated kinases
    • Bokoch, G. M. (2003) Biology of the p21- activated kinases. Annu Rev Biochem 72, 743-81.
    • (2003) Annu Rev Biochem , vol.72 , pp. 743-781
    • Bokoch, G.M.1
  • 59
    • 33846117134 scopus 로고    scopus 로고
    • The signaling mechanism of ROS in tumor progression
    • Wu, W. S. (2006) The signaling mechanism of ROS in tumor progression. Cancer Metastasis Rev 25, 695-705.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 695-705
    • Wu, W.S.1
  • 60
    • 0032496326 scopus 로고    scopus 로고
    • Role of rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change
    • DOI 10.1126/science.280.5365.898
    • Kheradmand, F., Werner, E., Tremble, P., Symons, M., and Werb, Z. (1998) Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change. Science 280, 898-902. (Pubitemid 28215599)
    • (1998) Science , vol.280 , Issue.5365 , pp. 898-902
    • Kheradmand, F.1    Werner, E.2    Tremble, P.3    Symons, M.4    Werb, Z.5
  • 61
    • 61849140657 scopus 로고    scopus 로고
    • Myocardinrelated transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis
    • Medjkane, S., Perez-Sanchez, C., Gaggioli, C., Sahai, E., and Treisman, R. (2009) Myocardinrelated transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat Cell Biol 11, 257-68.
    • (2009) Nat Cell Biol , vol.11 , pp. 257-268
    • Medjkane, S.1    Perez-Sanchez, C.2    Gaggioli, C.3    Sahai, E.4    Treisman, R.5
  • 62
    • 0036774217 scopus 로고    scopus 로고
    • Cell-cell adhesion and signaling
    • Braga, V. M. (2002) Cell-cell adhesion and signalling. Curr Opin Cell Biol 14, 546-56.
    • (2002) Curr Opin Cell Biol , Issue.14 , pp. 546-556
    • Braga, V.M.1
  • 63
    • 27644459665 scopus 로고    scopus 로고
    • Possible role of Rho/Rhotekin signaling in mammalian septin organization
    • DOI 10.1038/sj.onc.1208862, PII 1208862
    • Ito, H., Iwamoto, I., Morishita, R., Nozawa, Y., Narumiya, S., Asano, T., and Nagata, K. (2005) Possible role of Rho/Rhotekin signaling in mammalian septin organisation. Oncogene 24, 7064-72. (Pubitemid 41573635)
    • (2005) Oncogene , vol.24 , Issue.47 , pp. 7064-7072
    • Ito, H.1    Iwamoto, I.2    Morishita, R.3    Nozawa, Y.4    Narumiya, S.5    Asano, T.6    Nagata, K.-I.7
  • 64
    • 68549126922 scopus 로고    scopus 로고
    • The cytoskeleton and cancer
    • Hall, A. (2009) The cytoskeleton and cancer. Cancer Metastasis Rev 28, 5-14.
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 5-14
    • Hall, A.1
  • 65
    • 33748994545 scopus 로고    scopus 로고
    • Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking
    • DOI 10.1016/j.tcb.2006.08.006, PII S0962892406002236, Membrane Dynamics
    • Ridley, A. J. (2006) Rho GTPases and actin dynamics in membrane protrusions and vesicle traffi cking. Trends Cell Biol 16, 522-9. (Pubitemid 44444995)
    • (2006) Trends in Cell Biology , vol.16 , Issue.10 , pp. 522-529
    • Ridley, A.J.1
  • 66
    • 77956454496 scopus 로고    scopus 로고
    • Cdc42 and vesicle traffi cking in polarized cells
    • Harris, K. P., and Tepass, U. (2010) Cdc42 and vesicle traffi cking in polarized cells. Traffi c 11, 1272-9.
    • (2010) Traffi C , vol.11 , pp. 1272-1279
    • Harris, K.P.1    Tepass, U.2
  • 67
    • 77954858290 scopus 로고    scopus 로고
    • Direct modifi cations of Rho proteins: Deconstructing GTPase regulation
    • Visvikis, O., Maddugoda, M. P., and Lemichez, E. (2010) Direct modifi cations of Rho proteins: deconstructing GTPase regulation. Biol Cell 102, 377-89.
    • (2010) Biol Cell , vol.102 , pp. 377-389
    • Visvikis, O.1    Maddugoda, M.P.2    Lemichez, E.3
  • 68
    • 0032577563 scopus 로고    scopus 로고
    • S. typhimurium Encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells
    • DOI 10.1016/S0092-8674(00)81442-7
    • Hardt, W. D., Chen, L. M., Schuebel, K. E., Bustelo, X. R., and Galan, J. E. (1998) S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffl ing and nuclear responses in host cells. Cell 93, 815-26. (Pubitemid 28257587)
    • (1998) Cell , vol.93 , Issue.5 , pp. 815-826
    • Hardt, W.-D.1    Chen, L.-M.2    Schuebel, K.E.3    Bustelo, X.R.4    Galan, J.E.5
  • 69
    • 18744377691 scopus 로고    scopus 로고
    • Bacterial virulence strategies that utilize Rho GTPases
    • Finlay, B. B. (2005) Bacterial virulence strategies that utilize Rho GTPases. Curr Top Microbiol Immunol 291, 1-10. (Pubitemid 40674907)
    • (2005) Current Topics in Microbiology and Immunology , vol.291 , pp. 1-10
    • Finlay, B.B.1
  • 70
    • 0028086441 scopus 로고
    • Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
    • Luo, L., Liao, Y. J., Jan, L. Y., and Jan, Y. N. (1994) Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev 8, 1787-802. (Pubitemid 24265785)
    • (1994) Genes and Development , vol.8 , Issue.15 , pp. 1787-1802
    • Luo, L.1    Joyce Liao, Y.2    Jan, L.Y.3    Jan, Y.N.4
  • 71
    • 0029097186 scopus 로고
    • CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium
    • Eaton, S., Auvinen, P., Luo, L., Jan, Y. N., and Simons, K. (1995) CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium. J Cell Biol 131, 151-64.
    • (1995) J Cell Biol , vol.131 , pp. 151-164
    • Eaton, S.1    Auvinen, P.2    Luo, L.3    Jan, Y.N.4    Simons, K.5
  • 72
    • 0030917227 scopus 로고    scopus 로고
    • The role of RhoA in tissue polarity and frizzled signalling
    • DOI 10.1038/387292a0
    • Strutt, D. I., Weber, U., and Mlodzik, M. (1997) The role of RhoA in tissue polarity and Frizzled signalling. Nature 387, 292-5. (Pubitemid 27220765)
    • (1997) Nature , vol.387 , Issue.6630 , pp. 292-295
    • Strutt, D.I.1    Weber, U.2    Mlodzik, M.3
  • 73
    • 0033771902 scopus 로고    scopus 로고
    • CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
    • Reddien, P. W., and Horvitz, H. R. (2000) CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans . Nat Cell Biol 2, 131-6.
    • (2000) Nat Cell Biol , vol.2 , pp. 131-136
    • Reddien, P.W.1    Horvitz, H.R.2
  • 74
    • 50149083752 scopus 로고    scopus 로고
    • Mammalian Rho GTPases: New insights into their functions from in vivo studies
    • Heasman, S. J., and Ridley, A. J. (2008) Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 9, 690-701.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 690-701
    • Heasman, S.J.1    Ridley, A.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.