Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase i and II inhibitory activity, cytotoxicity, and structure-activity relationship

European Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2011, Pages 3201-3209

  Thapa, Uttam ^a   Thapa, Pritam ^a   Karki, Radha ^a   Yun, Minho ^a   Choi, Jae Hun ^a   Jahng, Yurngdong ^a   Lee, Eunyoung ^b   Jeon, Kyung Hwa ^b   Na, Younghwa ^c   Ha, Eun Mi ^c   Cho, Won Jea ^d   Kwon, Youngjoo ^b   Lee, Eung Seok ^a  

^a Yeungnam University   (South Korea)

^b Ewha Womans University   (South Korea)

^c Catholic University of Daegu   (South Korea)

^d Chonnam National University   (South Korea)

Author keywords

4 chromanone; Cytotoxicity; Terpyridine; Terthiophene; Topoisomerase I and II

Indexed keywords

2 (FURAN 2 YL) 4 (PYRIDIN 2 YL) 5H CHROMENO[4,3 B]PYRIDINE; 2 (FURAN 2 YL) 4 (PYRIDIN 3 YL) 5H CHROMENO[4,3 B]PYRIDINE; 2 (FURAN 2 YL) 4 (THIOPHEN 2 YL) 5H CHROMENO[4,3 B]PYRIDINE; 2 (FURAN 2 YL) 4 PHENYL 5H CHROMENO[4,3 B]PYRIDINE; 2 (PYRIDIN 2 YL) 4 (PYRIDIN 3 YL) 5H CHROMENO[4,3 B]PYRIDINE; 2 (PYRIDIN 2 YL) 4 (THIOPHEN 2 YL) 5H CHROMENO[4,3 B]PYRIDINE; 2 PHENYL 4 (PYRIDIN 2 YL) 5H CHROMENO[4,3 B]PYRIDINE; 2 PHENYL 4 (PYRIDIN 3 YL) 5H CHROMENO[4,3 B]PYRIDINE; 2 PHENYL 4 (THIOPHEN 2 YL) 5H CHROMENO[4,3 B]PYRIDINE; 2 PHENYL 4 (THIOPHEN 3 YL) 5H CHROMENO[4,3 B]PYRIDINE; 2,4 DI(FURAN 2 YL) 5H CHROMENO[4,3 B]PYRIDINE; 2,4 DI(PYRIDIN 2 YL) 5H CHROMENO[4,3 B]PYRIDINE; 2,4 DI(THIOPHEN 2 YL) 5H CHROMENO[4,3 B]PYRIDINE; 2,4 DIPHENYL 5H CHROMENO[4,3 B]PYRIDINE; 4 (FURAN 2 YL) 2 (PYRIDIN 2 YL) 5H CHROMENO[4,3 B]PYRIDINE; 4 (FURAN 2 YL) 2 (THIOPHEN 2 YL) 5H CHROMENO[4,3 B]PYRIDINE; 4 (FURAN 2 YL) 2 PHENYL 5H CHROMENO[4,3 B]PYRIDINE; 4 (FURAN 3 YL) 2 (THIOPHEN 2 YL) 5H CHROMENO[4,3 B]PYRIDINE; 4 (FURAN 3 YL) 2 PHENYL 5H CHROMENO[4,3 B]PYRIDINE; 4 (PYRIDIN 2 YL) 2 (THIOPHEN 2 YL) 5H CHROMENO[4,3 B]PYRIDINE; 4 (PYRIDIN 2 YL) 2 (THIOPHEN 3 YL) 5H CHROMENO[4,3 B]PYRIDINE; 4 PHENYL 2 (PYRIDIN 2 YL) 5H CHROMENO[4,3 B]PYRIDINE; 4 PHENYL 2 (THIOPHEN 2 YL) 5H CHROMENO[4,3 B]PYRIDINE; 5H CHROMENO[4,3 B]PYRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; BENZOPYRANS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MALE; NEOPLASMS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS; TOPOISOMERASE II INHIBITORS;

EID: 79958283748     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.04.029     Document Type: Article

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