Dehydroepiandrosterone inhibits the activation and dysfunction of endothelial cells induced by high glucose concentration

Steroids

Volumn 77, Issue 3, 2012, Pages 233-240

  Huerta García, Elizabeth ^a   Ventura Gallegos, José Luis ^b,c   Victoriano, Ma Elena Crescencio ^a   Montiél Dávalos, Angélica ^a,d   Tinoco Jaramillo, Gerardo ^e   López Marure, Rebeca ^a  

^a INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

^b INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^d INSTITUTO NACIONAL DE CANCEROLOGÍA   (Mexico)

^e INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

Author keywords

Dehydroepiandrosterone; Endothelial cells; High glucose; Inflammation; Oxidative stress

Indexed keywords

CD31 ANTIGEN; CELL ADHESION MOLECULE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; PRASTERONE; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL ACTIVATION; CELL ADHESION; CONTROLLED STUDY; DIABETES MELLITUS; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; OXIDATIVE STRESS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ANTIGENS, CD31; CELL ADHESION; CELLS, CULTURED; DEHYDROEPIANDROSTERONE; E-SELECTIN; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GLUCOSE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; I-KAPPA B PROTEINS; INTERCELLULAR ADHESION MOLECULE-1; MONOCYTES; NF-KAPPA B; NITRIC OXIDE; OXIDATIVE STRESS; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; U937 CELLS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84855892569     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2011.11.010     Document Type: Article

References (31)

1. S.W. Lamberts, A.W. van den Beld, and A.J. van der Lely The endocrinology of aging Science 278 1997 419 424 (Pubitemid 27454418)
2. K. Aoki, A. Nakajima, K. Mukasa, E. Osawa, Y. Mori, and H. Sekihara Prevention of diabetes, hepatic injury, and colon cancer with dehydroepiandrosterone J Steroid Biochem Mol Biol 85 2003 469 472 (Pubitemid 37011123)
3. E. Olech, and J.T. Merrill DHEA supplementation: the claims in perspective Cleve Clin J Med 72 2005 965 984
4. R.J. Esper, R.A. Nordaby, J.O. Vilarino, A. Paragano, J.L. Cacharron, and R.A. Machado Endothelial dysfunction: a comprehensive appraisal Cardiovasc Diabetol 5 2006 4 21
5. R. De Caterina Endothelial dysfunctions: common denominators in vascular disease Curr Opin Lipidol 11 2000 9 23 (Pubitemid 30148193)
6. G.M. Reaven Pathophysiology of insulin resistance in human disease Physiol Rev 75 1995 473 486
7. I.A. van den Oever, H.G. Raterman, M.T. Nurmohamed, and S. Simsek Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus Mediators Inflamm 2010 2010 1 15
8. S. Srinivasan, M.E. Hatley, and D.T. Bolick Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells Diabetologia 47 2004 1727 1734 (Pubitemid 40022408)
9. N.R. Madamanchi, A. Vendrov, and M.S. Runge Oxidative stress and vascular disease Arterioscler Thromb Vasc Biol 25 2005 29 38 (Pubitemid 40054251)
10. D.L. Coleman, E.H. Leiter, and E.H. Leiter Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice Diabetes 31 1982 830 833 (Pubitemid 12062875)
11. M.P. Cleary, T. Zabel, and J.L. Sartin Effects of short-term dehydroepiandrosterone treatment on serum and pancreatic insulin in Zucker rats J Nutr 118 1988 382 387 (Pubitemid 18079091)
12. E. Zapata, J.L. Ventura, K. De la Cruz, E. Rodriguez, P. Damián, F. Massó, L.F. Montaño, and R. López-Marure Dehydroepiandrosterone inhibits the proliferation of human umbilical vein endothelial cells by enhancing the expression of p53 and p21, restricting the phosphorylation of retinoblastoma protein, and is androgen- and estrogen-receptor independent FEBS J 272 2005 1343 1353 (Pubitemid 40444925)
13. T.J. Guzik, S. Mussa, D. Gastaldi, J. Sadowski, C. Ratnatunga, R. Pillai, and K.M. Channon Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase Circulation 105 2002 1656 1662 (Pubitemid 34298608)
14. L. Piconi, L. Quagliaro, and A. Ceriello Oxidative stress in diabetes Clin Chem Lab Med 41 2003 1144 1149 (Pubitemid 37265692)
15. K.A. Roebuck Oxidant stress regulation of IL-8 and ICAM-1 gene expression: differential activation and binding of the transcription factors AP-1 and NF-kappaB Int J Mol Med 4 1999 223 230
16. S. Schoonbroodt, V. Ferreira, M. Best-Belpomme, J.R. Boelaert, S. Legrand-Poels, M. Korner, and J. Piette Crucial role of the amino-terminal tyrosine residue 42 and the carboxyl-terminal PEST domain of IκB α in NF-κB activation by an oxidative stress J Immunol 15 2000 4292 4300 (Pubitemid 30215091)
17. C.G. Schalkwijk, and C.D.A. Stehouwer Vascular complications in diabetes mellitus: the role of endothelial dysfunction Clin Sci 109 2005 143 159 (Pubitemid 41117297)
18. S. Kageyama, H. Yokoo, K. Tomita, N. Kageyama-Yahara, R. Uchimido, N. Matsuda, S. Yamamoto, and Y. Hattori High glucose-induced apoptosis in human coronary artery endothelial cells involves up-regulation of death receptors Cardiovasc Diabetol 10 2011 73 84
19. Y. Du, A. Kowluru, and T.S. Kern PP2A contributes to endothelial death in high glucose: inhibition by benfotiamine Am J Physiol Regul Integr Comp Physiol 299 2010 R1610 R1617
20. G. Gutiérrez, C. Mendoza, E. Zapata, A. Montiel, E. Reyes, L.F. Montaño, and R. López-Marure Dehydroepiandrosterone inhibits the TNF-alpha-induced inflammatory response in human umbilical vein endothelial cells Atherosclerosis 190 2007 90 99 (Pubitemid 44932104)
21. R. López-Marure, C. Huesca-Gómez, M.J. Ibarra- Sánchez, A. Zentella, and O. Pérez-Méndez Dehydroepiandrosterone delays LDL oxidation in vitro and attenuates several oxLDL-induced inflammatory responses in endothelial cells Inflamm Allergy Drug Targets 6 2007 174 182 (Pubitemid 47455786)
22. S. Ayhan, C. Tugay, S. Norton, B. Araneo, and M. Siemionow Dehydroepiandrosterone protects the microcirculation of muscle flaps from ischemia-reperfusion injury by reducing the expression of adhesion molecules Plast Reconstr Surg 111 2003 2286 2294 (Pubitemid 36676807)
23. R. Altman, D.D. Motton, R.S. Kota, and J.C. Rutledge Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: roles of PPARalpha and NF-kappaB Vascul Pharmacol 48 2008 76 84
24. T. Barkhausen, B.M. Westphal, C. Pütz, C. Krettek, and M. van Griensven Dehydroepiandrosterone administration modulates endothelial and neutrophil adhesion molecule expression in vitro Crit Care 10 2006 R109 R118
25. J.P. Camporez, E.H. Akamine, A.P. Davel, C.R. Franci, L.V. Rossoni, and C.R. de Oliveira Carvalho Dehydroepiandrosterone protects against oxidative stress-induced endothelial dysfunction in ovariectomized rats J Physiol 589 2011 2585 2596
26. Jia C, Chen X, Li X, Li M, Miao C, Sun B, Fan Z, Ren L. The effect of DHEA treatment on the oxidative stress and myocardial fibrosis induced by Keshan disease pathogenic factors. J Trace Elem Med Biol 2011. PMID:21602037.
27. N. Alvarado-Vásquez, E. Zapata, S. Alcázar-Leyva, F. Massó, and L.F. Montaño Reduced NO synthesis and eNOS mRNA expression in endothelial cells from newborns with a strong family history of type 2 diabetes Diabetes Metab Res Rev 23 2007 559 566 (Pubitemid 350018030)
28. J. Liao, M. Lei, X. Chen, and F. Liu Effect of intermittent high glucose on synthesis of nitric oxide in human umbilical vein endothelial cells and its mechanism Zhong Nan Da Xue Xue Bao Yi Xue Ban 35 2010 295 300
29. Y. Iwasaki, M. Asai, M. Yoshida, T. Nigawara, M. Kambayashi, and N. Nakashima Dehydroepiandrosterone-sulfate inhibits nuclear factor-kappaB- dependent transcription in hepatocytes, possibly through antioxidant effect J Clin Endocrinol Metab 89 2004 3449 3454 (Pubitemid 38951919)
30. H. Offner, G.S. Firestein, D.L. Boyle, R. Pieters, J.M. Frincke, A. Garsd, S.K. White, C.L. Reading, and D.L. Auci An orally bioavailable synthetic analog of an active dehydroepiandrosterone metabolite reduces established disease in rodent models of rheumatoid arthritis J Pharmacol Exp Ther 329 2009 1100 1109
31. A.M. Traish, H.P. Kang, F. Saad, and A.T. Guay Dehydroepiandrosterone (DHEA) - a precursor steroid or an active hormone in human physiology (CME) J Sex Med 8 2011 2960 2982