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Volumn 16, Issue 1, 2012, Pages 85-101

Targeting the Fas/FasL signaling pathway in cancer therapy

Author keywords

Apoptosis; Combined therapy; Fas CD95; FasL CD95L; Resistance; Sensitization; Therapy.

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ADENOVIRUS VECTOR; ADIPONECTIN:FAS LIGAND; ANTINEOPLASTIC AGENT; APO 010; AZACITIDINE; BATIMASTAT; BLEOMYCIN; CARBOPLATIN; CD40:FAS LIGAND; CISPLATIN; CYTOTOXIC T LYMPHOCYTE ASSOCIATED PROTEIN 4:FAS LIGAND; DOXORUBICIN; ETOPOSIDE; FAS ANTIBODY; FAS ANTIGEN; FAS LIGAND; FC RECEPTOR:FAS LIGAND; FLUOROURACIL; GATAPARSEN; MEGAFASL; N ACETYLSARCOSYLGLYCYLVALYL DEXTRO ALLOISOLEUCYLTHREONYLNORVALYLISOLEUCYLARGINYLPROLINE ETHYLAMIDE; PACLITAXEL; PRINOMASTAT; R 125224; RECOMBINANT FAS LIGAND; RECOMBINANT PROTEIN; SC40:FAS LIGAND; SEPANTRONIUM BROMIDE; SINGLE CHAIN FRAGMENT VARIABLE CD7:FAS LIGAND; TOPOTARGET; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84855867670     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2011.628937     Document Type: Review
Times cited : (133)

References (164)
  • 1
    • 0026706261 scopus 로고
    • Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen
    • Oehm A, Behrmann I, Falk W, et al. Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen. J Biol Chem 1992;267:10709-15
    • (1992) J Biol Chem , vol.267 , pp. 10709-15
    • Oehm, A.1    Behrmann, I.2    Falk, W.3
  • 2
    • 0027281373 scopus 로고
    • A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen
    • Itoh N, Nagata S. A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem 1993;268:10932-7 (Pubitemid 23162276)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.15 , pp. 10932-10937
    • Itoh, N.1    Nagata, S.2
  • 3
    • 84855885559 scopus 로고    scopus 로고
    • Fas (TNF receptor superfamily, member 6). Available from Last accessed 6 October 2011
    • Fas (TNF receptor superfamily, member 6). Available from: http://www.ensembl.org/Homo-sapiens/Gene/Summary? g=ENSG00000026103;r=10: 90729553-90775542 [Last accessed 6 October 2011]
  • 5
    • 0027145632 scopus 로고
    • Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family
    • DOI 10.1016/0092-8674(93)90326-L
    • Suda T, Takahashi T, Golstein P, Nagata S. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 1993;75:1169-78 (Pubitemid 24006113)
    • (1993) Cell , vol.75 , Issue.6 , pp. 1169-1178
    • Suda, T.1    Takahashi, T.2    Golstein, P.3    Nagata, S.4
  • 6
    • 0028223847 scopus 로고
    • Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
    • DOI 10.1016/0092-8674(94)90375-1
    • Takahashi T, Tanaka M, Brannan CI, et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 1994;76:969-76 (Pubitemid 24106378)
    • (1994) Cell , vol.76 , Issue.6 , pp. 969-976
    • Takahashi, T.1    Tanaka, M.2    Brannan, C.I.3    Jenkins, N.A.4    Copeland, N.G.5    Suda, T.6    Nagata, S.7
  • 7
    • 84855905435 scopus 로고    scopus 로고
    • Fas ligand (TNF superfamily, member 6). Available from Last accessed 6 October 2011
    • Fas ligand (TNF superfamily, member 6). Available from: http://www.ensembl. org/Homo-sapiens/Gene/Summary?g=ENSG00000117560;r=1: 172628154-172636014 [Last accessed 6 October 2011]
  • 8
    • 0028804857 scopus 로고
    • Metalloproteinase-mediated release of human Fas ligand
    • Kayagaki N, Kawasaki A, Ebata T, et al. Metalloproteinase-mediated release of human Fas ligand. J Exp Med 1995;182:1777-83
    • (1995) J Exp Med , vol.182 , pp. 1777-1783
    • Kayagaki, N.1    Kawasaki, A.2    Ebata, T.3
  • 9
    • 0035863471 scopus 로고    scopus 로고
    • Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity
    • Mitsiades N, Yu WH, Poulaki V, et al. Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity. Cancer Res 2001;61:577-81 (Pubitemid 32128617)
    • (2001) Cancer Research , vol.61 , Issue.2 , pp. 577-581
    • Mitsiades, N.1    Yu, W.-H.2    Poulaki, V.3    Tsokos, M.4    Stamenkovic, I.5
  • 10
    • 77953722976 scopus 로고    scopus 로고
    • The role of FasL and Fas in health and disease
    • Ehrenschwender M, Wajant H. The role of FasL and Fas in health and disease. Adv Exp Med Biol 2009;647:64-93
    • (2009) Adv Exp Med Biol , vol.647 , pp. 64-93
    • Ehrenschwender, M.1    Wajant, H.2
  • 11
    • 0033621336 scopus 로고    scopus 로고
    • Identification and characterization of a ligand-independent oligomerization domain in the extracellular region of the CD95 death receptor
    • DOI 10.1074/jbc.274.53.38241
    • Papoff G, Hausler P, Eramo A, et al. Identification and characterization of a ligand-independent oligomerization domain in the extracellular region of the CD95 death receptor. J Biol Chem 1999;274:38241-50 (Pubitemid 30026900)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.53 , pp. 38241-38250
    • Papoff, G.1    Hausler, P.2    Eramo, A.3    Pagano, M.G.4    Di Leve, G.5    Signore, A.6    Ruberti, G.7
  • 15
    • 0034641898 scopus 로고    scopus 로고
    • CD95's deadly mission in the immune system
    • Krammer PH. CD95's deadly mission in the immune system. Nature 2000;407:789-95
    • (2000) Nature , vol.407 , pp. 789-795
    • Krammer, P.H.1
  • 17
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 18
  • 19
    • 34347222212 scopus 로고    scopus 로고
    • A role for the fas/fasl system in modulating genetic susceptibility to t-cell lymphoblastic lymphomas
    • DOI 10.1158/0008-5472.CAN-06-4006
    • Villa-Morales M, Santos J, Perez-Gomez E, et al. A role for the Fas/FasL system in modulating genetic susceptibility to T-cell lymphoblastic lymphomas. Cancer Res 2007;67:5107-16 (Pubitemid 46997246)
    • (2007) Cancer Research , vol.67 , Issue.11 , pp. 5107-5116
    • Villa-Morales, M.1    Santos, J.2    Perez-Gomez, E.3    Quintanilla, M.4    Fernandez-Piqueras, J.5
  • 20
    • 33645901517 scopus 로고    scopus 로고
    • CD95L/FasL and TRAIL in tumour surveillance and cancer therapy
    • Wajant H. CD95L/FasL and TRAIL in tumour surveillance and cancer therapy. Cancer Treat Res 2006;130:141-65
    • (2006) Cancer Treat Res , vol.130 , pp. 141-165
    • Wajant, H.1
  • 21
    • 35748972927 scopus 로고    scopus 로고
    • From cancer immunosurveillance to cancer immunotherapy
    • DOI 10.1111/j.1600-065X.2007.00566.x
    • Stagg J, Johnstone RW, Smyth MJ. From cancer immunosurveillance to cancer immunotherapy. Immunol Rev 2007;220:82-101 (Pubitemid 350045568)
    • (2007) Immunological Reviews , vol.220 , Issue.1 , pp. 82-101
    • Stagg, J.1    Johnstone, R.W.2    Smyth, M.J.3
  • 22
    • 37549061827 scopus 로고    scopus 로고
    • Creating immune privilege: Active local suppression that benefits friends, but protects foes
    • Mellor AL, Munn DH. Creating immune privilege: active local suppression that benefits friends, but protects foes. Nat Rev Immunol 2008;8:74-80
    • (2008) Nat Rev Immunol , vol.8 , pp. 74-80
    • Mellor, A.L.1    Munn, D.H.2
  • 25
    • 0036791130 scopus 로고    scopus 로고
    • A novel splice variant of the Fas gene in patients with cutaneous T-cell lymphoma
    • van Doorn R, Dijkman R, Vermeer MH, et al. A novel splice variant of the Fas gene in patients with cutaneous T-cell lymphoma. Cancer Res 2002;62:5389-92
    • (2002) Cancer Res , vol.62 , pp. 5389-5392
    • Van Doorn, R.1    Dijkman, R.2    Vermeer, M.H.3
  • 27
    • 78649766263 scopus 로고    scopus 로고
    • Modulation of the Fas-apoptosis-signalling pathway by functional polymorphisms at Fas, FasL and Fadd and their implication in T-cell lymphoblastic lymphoma susceptibility
    • Villa-Morales M, Gonzalez-Gugel E, Shahbazi MN, et al. Modulation of the Fas-apoptosis-signalling pathway by functional polymorphisms at Fas, FasL and Fadd and their implication in T-cell lymphoblastic lymphoma susceptibility. Carcinogenesis 2010;31:2165-71
    • (2010) Carcinogenesis , vol.31 , pp. 2165-2171
    • Villa-Morales, M.1    Gonzalez-Gugel, E.2    Shahbazi, M.N.3
  • 28
    • 79952636511 scopus 로고    scopus 로고
    • Structural alterations of the FAS gene in cutaneous T-cell lymphoma (CTCL)
    • Wu J, Siddiqui J, Nihal M, et al. Structural alterations of the FAS gene in cutaneous T-cell lymphoma (CTCL). Arch Biochem Biophys 2010;508:185-91
    • (2010) Arch Biochem Biophys , vol.508 , pp. 185-191
    • Wu, J.1    Siddiqui, J.2    Nihal, M.3
  • 30
    • 35548953686 scopus 로고    scopus 로고
    • An elaborate pathway required for Ras-mediated epigenetic silencing
    • DOI 10.1038/nature06251, PII NATURE06251
    • Gazin C, Wajapeyee N, Gobeil S, et al. An elaborate pathway required for Ras-mediated epigenetic silencing. Nature 2007;449:1073-7 (Pubitemid 350014604)
    • (2007) Nature , vol.449 , Issue.7165 , pp. 1073-1077
    • Gazin, C.1    Wajapeyee, N.2    Gobeil, S.3    Virbasius, C.-M.4    Green, M.R.5
  • 31
    • 77949496219 scopus 로고    scopus 로고
    • Downregulation of Fas gene expression in Sezary syndrome is associated with promoter hypermethylation
    • Jones CL, Wain EM, Chu CC, et al. Downregulation of Fas gene expression in Sezary syndrome is associated with promoter hypermethylation. J Invest Dermatol 2010;130:1116-25
    • (2010) J Invest Dermatol , vol.130 , pp. 1116-1125
    • Jones, C.L.1    Wain, E.M.2    Chu, C.C.3
  • 32
    • 0034795875 scopus 로고    scopus 로고
    • Hypermethylation of the tumor necrosis factor receptor superfamily 6 (APT1, Fas, CD95/Apo-1) gene promoter at rel/nuclear factor kappaB sites in prostatic carcinoma
    • Santourlidis S, Warskulat U, Florl AR, et al. Hypermethylation of the tumor necrosis factor receptor superfamily 6 (APT1, Fas, CD95/Apo-1) gene promoter at rel/nuclear factor kappaB sites in prostatic carcinoma. Mol Carcinog 2001;32:36-43
    • (2001) Mol Carcinog , vol.32 , pp. 36-43
    • Santourlidis, S.1    Warskulat, U.2    Florl, A.R.3
  • 33
    • 0037752001 scopus 로고    scopus 로고
    • Epigenetic changes in tumor Fas levels determine immune escape and response to therapy
    • DOI 10.1016/S1535-6108(02)00095-8
    • Maecker HL, Yun Z, Maecker HT, Giaccia AJ. Epigenetic changes in tumor Fas levels determine immune escape and response to therapy. Cancer Cell 2002;2:139-48 (Pubitemid 41039114)
    • (2002) Cancer Cell , vol.2 , Issue.2 , pp. 139-148
    • Maecker, H.L.1    Yun, Z.2    Maecker, H.T.3    Giaccia, A.J.4
  • 35
    • 33847682187 scopus 로고    scopus 로고
    • Up-regulation of Fas (CD95) expression in tumour cells in vivo
    • DOI 10.1111/j.1365-2567.2006.02521.x
    • Peshes-Yaloz N, Rosen D, Sondel PM, et al. Up-regulation of Fas (CD95) expression in tumour cells in vivo. Immunology 2007;120:502-11 (Pubitemid 46365008)
    • (2007) Immunology , vol.120 , Issue.4 , pp. 502-511
    • Peshes-Yaloz, N.1    Rosen, D.2    Sondel, P.M.3    Krammer, P.H.4    Berke, G.5
  • 38
    • 79952575635 scopus 로고    scopus 로고
    • Decoy receptor 3: A pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer
    • Lin WW, Hsieh SL. Decoy receptor 3: a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer. Biochem Pharmacol 2011;81:838-47
    • (2011) Biochem Pharmacol , vol.81 , pp. 838-847
    • Lin, W.W.1    Hsieh, S.L.2
  • 39
    • 78650794472 scopus 로고    scopus 로고
    • Cell death and hepatocarcinogenesis: Dysregulation of apoptosis signaling pathways
    • Schattenberg JM, Schuchmann M, Galle PR. Cell death and hepatocarcinogenesis: dysregulation of apoptosis signaling pathways. J Gastroenterol Hepatol 2011;26(Suppl 1):213-19
    • (2011) J Gastroenterol Hepatol , vol.26 , Issue.SUPPL. 1 , pp. 213-219
    • Schattenberg, J.M.1    Schuchmann, M.2    Galle, P.R.3
  • 40
    • 0037616595 scopus 로고    scopus 로고
    • Loss of FADD protein expression results in a biased Fas-signaling pathway and correlates with the development of tumoral status in thyroid follicular cells
    • DOI 10.1038/sj.onc.1206399
    • Tourneur L, Mistou S, Michiels FM, et al. Loss of FADD protein expression results in a biased Fas-signaling pathway and correlates with the development of tumoral status in thyroid follicular cells. Oncogene 2003;22:2795-804 (Pubitemid 36609593)
    • (2003) Oncogene , vol.22 , Issue.18 , pp. 2795-2804
    • Tourneur, L.1    Mistou, S.2    Michiels, F.-M.3    Devauchelle, V.4    Renia, L.5    Feunteun, J.6    Chiocchia, G.7
  • 41
    • 0035855626 scopus 로고    scopus 로고
    • Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer
    • DOI 10.1038/sj.onc.1204750
    • Fulda S, Kufer MU, Meyer E, et al. Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer. Oncogene 2001;20:5865-77 (Pubitemid 32937956)
    • (2001) Oncogene , vol.20 , Issue.41 , pp. 5865-5877
    • Fulda, S.1    Kufer, M.U.2    Meyer, E.3    Van Valen, F.4    Dockhorn-Dworniczak, B.5    Debatin, K.-M.6
  • 42
    • 0034662625 scopus 로고    scopus 로고
    • Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis
    • Hopkins-Donaldson S, Bodmer JL, Bourloud KB, et al. Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Cancer Res 2000;60:4315-19 (Pubitemid 32103601)
    • (2000) Cancer Research , vol.60 , Issue.16 , pp. 4315-4319
    • Hopkins-Donaldson, S.1    Bodmer, J.-L.2    Bourloud, K.B.3    Brognara, C.B.4    Tschopp, J.5    Gross, N.6
  • 43
    • 42549092626 scopus 로고    scopus 로고
    • Acquired resistance to Fas/CD95 ligation in U937 cells is associated with multiple molecular mechanisms
    • Blomberg J, Ruuth K, Santos D, Lundgren E. Acquired resistance to Fas/CD95 ligation in U937 cells is associated with multiple molecular mechanisms. Anticancer Res 2008;28(2A):593-9 (Pubitemid 351578898)
    • (2008) Anticancer Research , vol.28 , Issue.A2 , pp. 593-599
    • Blomberg, J.1    Ruuth, K.2    Santos, D.3    Lundgren, E.4
  • 46
    • 49149130029 scopus 로고    scopus 로고
    • The Fas death signaling pathway connecting reactive oxygen species generation and FLICE inhibitory protein down-regulation
    • Wang L, Azad N, Kongkaneramit L, et al. The Fas death signaling pathway connecting reactive oxygen species generation and FLICE inhibitory protein down-regulation. J Immunol 2008;180:3072-80
    • (2008) J Immunol , vol.180 , pp. 3072-3080
    • Wang, L.1    Azad, N.2    Kongkaneramit, L.3
  • 51
    • 0029096804 scopus 로고
    • Local Fas/APO-1 (CD95) ligand-mediated tumor cell killing in vivo
    • Rensing-Ehl A, Frei K, Flury R, et al. Local Fas/APO-1 (CD95) ligand-mediated tumor cell killing in vivo. Eur J Immunol 1995;25:2253-8
    • (1995) Eur J Immunol , vol.25 , pp. 2253-2258
    • Rensing-Ehl, A.1    Frei, K.2    Flury, R.3
  • 52
    • 30344460536 scopus 로고    scopus 로고
    • Exosomes derived from genetically modified DC expressing FasL are anti-inflammatory and immunosuppressive
    • DOI 10.1016/j.ymthe.2005.09.015, PII S1525001605016217
    • Kim SH, Bianco N, Menon R, et al. Exosomes derived from genetically modified DC expressing FasL are anti-inflammatory and immunosuppressive. Mol Ther 2006;13:289-300 (Pubitemid 43056894)
    • (2006) Molecular Therapy , vol.13 , Issue.2 , pp. 289-300
    • Kim, S.H.1    Bianco, N.2    Menon, R.3    Lechman, E.R.4    Shufesky, W.J.5    Morelli, A.E.6    Robbins, P.D.7
  • 53
    • 16844363920 scopus 로고    scopus 로고
    • Fas/FasL interaction: A novel immune therapy approach with immobilized biologicals
    • DOI 10.1002/med.20025
    • Scholz M, Cinatl J. Fas/FasL interaction: a novel immune therapy approach with immobilized biologicals. Med Res Rev 2005;25:331-42 (Pubitemid 40489665)
    • (2005) Medicinal Research Reviews , vol.25 , Issue.3 , pp. 331-342
    • Scholz, M.1    Cinatl, J.2
  • 55
    • 79951683621 scopus 로고    scopus 로고
    • Protective effects of HFE7A, mouse anti-human/mouse Fas monoclonal antibody against acute and lethal hepatic injury induced by Jo2
    • Yoshida H, Watanabe K, Takahashi S, Ichikawa K. Protective effects of HFE7A, mouse anti-human/mouse Fas monoclonal antibody against acute and lethal hepatic injury induced by Jo2. Cytotechnology 2010;62:313-23
    • (2010) Cytotechnology , vol.62 , pp. 313-323
    • Yoshida, H.1    Watanabe, K.2    Takahashi, S.3    Ichikawa, K.4
  • 58
    • 69549130818 scopus 로고    scopus 로고
    • Highly frequent anti-idiotype antibody in cynomolgus monkeys developed against mouse-derived regions of anti-Fas antibody humanized by complementarity determining region grafting
    • Saito-Yabe M, Yoshigae Y, Takasaki W, et al. Highly frequent anti-idiotype antibody in cynomolgus monkeys developed against mouse-derived regions of anti-Fas antibody humanized by complementarity determining region grafting. Br J Pharmacol 2009;158:548-57
    • (2009) Br J Pharmacol , vol.158 , pp. 548-557
    • Saito-Yabe, M.1    Yoshigae, Y.2    Takasaki, W.3
  • 59
    • 0035266408 scopus 로고    scopus 로고
    • Target cell-restricted triggering of the CD95 (APO-1/Fas) death receptor with bispecific antibody fragments
    • Jung G, Grosse-Hovest L, Krammer PH, Rammensee HG. Target cell-restricted triggering of the CD95 (APO-1/Fas) death receptor with bispecific antibody fragments. Cancer Res 2001;61:1846-8 (Pubitemid 32691997)
    • (2001) Cancer Research , vol.61 , Issue.5 , pp. 1846-1848
    • Jung, G.1    Grosse-Hovest, L.2    Krammer, P.H.3    Rammensee, H.-G.4
  • 60
    • 39449129555 scopus 로고    scopus 로고
    • Construction of optimized bispecific antibodies for selective activation of the death receptor CD95
    • DOI 10.1158/0008-5472.CAN-07-6175
    • Herrmann T, Grosse-Hovest L, Otz T, et al. Construction of optimized bispecific antibodies for selective activation of the death receptor CD95. Cancer Res 2008;68:1221-7 (Pubitemid 351272242)
    • (2008) Cancer Research , vol.68 , Issue.4 , pp. 1221-1227
    • Herrmann, T.1    Grosse-Hovest, L.2    Otz, T.3    Krammer, P.H.4    Rammensee, H.-G.5    Jung, G.6
  • 61
    • 0032550366 scopus 로고    scopus 로고
    • Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity
    • DOI 10.1084/jem.187.8.1205
    • Schneider P, Holler N, Bodmer JL, et al. Conversion of membrane-bound Fas (CD95) ligand to its soluble form is associated with downregulation of its 52. proapoptotic activity and loss of liver toxicity. J Exp Med 1998;187:1205-13 (Pubitemid 28189110)
    • (1998) Journal of Experimental Medicine , vol.187 , Issue.8 , pp. 1205-1213
    • Schneider, P.1    Holler, N.2    Bodmer, J.-L.3    Hahne, M.4    Frei, K.5    Fontana, A.6    Tschopp, J.7
  • 62
    • 0035318305 scopus 로고    scopus 로고
    • Extracellular matrix interacts with soluble CD95L: Retention and enhancement of cytoxicity
    • DOI 10.1038/86336
    • Aoki K, Kurooka M, Chen JJ, et al. Extracellular matrix interacts with soluble CD95L: retention and enhancement of cytotoxicity. Nat Immunol 2001;2:333-7 (Pubitemid 33706344)
    • (2001) Nature Immunology , vol.2 , Issue.4 , pp. 333-337
    • Aoki, K.1    Kurooka, M.2    Chen, J.-J.3    Petryniak, J.4    Nabel, E.G.5    Nabel, G.J.6
  • 64
    • 50849154466 scopus 로고    scopus 로고
    • Single-chain TNF, a TNF derivative with enhanced stability and antitumoral activity
    • Krippner-Heidenreich A, Grunwald I, Zimmermann G, et al. Single-chain TNF, a TNF derivative with enhanced stability and antitumoral activity. J Immunol 2008;180:8176-83
    • (2008) J Immunol , vol.180 , pp. 8176-8183
    • Krippner-Heidenreich, A.1    Grunwald, I.2    Zimmermann, G.3
  • 67
    • 55949109417 scopus 로고    scopus 로고
    • Abundant Fas expression by gastrointestinal stromal tumours may serve as a therapeutic target for MegaFasL
    • Rikhof B, van der Graaf WT, Meijer C, et al. Abundant Fas expression by gastrointestinal stromal tumours may serve as a therapeutic target for MegaFasL. Br J Cancer 2008;99:1600-6
    • (2008) Br J Cancer , vol.99 , pp. 1600-1606
    • Rikhof, B.1    Van Der Graaf, W.T.2    Meijer, C.3
  • 68
    • 76749170208 scopus 로고    scopus 로고
    • Radiation and anticancer drugs can facilitate mitochondrial bypass by CD95/Fas via c-FLIP downregulation
    • Verbrugge I, Maas C, Heijkoop M, et al. Radiation and anticancer drugs can facilitate mitochondrial bypass by CD95/Fas via c-FLIP downregulation. Cell Death Differ 2010;17:551-61
    • (2010) Cell Death Differ , vol.17 , pp. 551-561
    • Verbrugge, I.1    Maas, C.2    Heijkoop, M.3
  • 69
    • 79951833543 scopus 로고    scopus 로고
    • APO010, a synthetic hexameric CD95 ligand, induces human glioma cell death in vitro and in vivo
    • Eisele G, Roth P, Hasenbach K, et al. APO010, a synthetic hexameric CD95 ligand, induces human glioma cell death in vitro and in vivo. Neuro-oncol 2011;13:155-64
    • (2011) Neuro-oncol , vol.13 , pp. 155-164
    • Eisele, G.1    Roth, P.2    Hasenbach, K.3
  • 70
    • 84855884904 scopus 로고    scopus 로고
    • TopoTarget A/S ClinicalTrials.gov 2007 Available from Last accessed 6 October 2011
    • TopoTarget A/S. A Phase I Dose Finding Study of APO010 in Patients With Solid Tumors. ClinicalTrials.gov 2007 Available from: http://clinicaltrials. gov/ct2/results?term=apo010 [Last accessed 6 October 2011]
    • A Phase i Dose Finding Study of APO010 in Patients with Solid Tumors
  • 73
    • 33645509276 scopus 로고    scopus 로고
    • CD7-restricted activation of Fas-mediated apoptosis: A novel therapeutic approach for acute T-cell leukemia
    • Bremer E, ten Cate B, Samplonius DF, et al. CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia. Blood 2006;107:2863-70
    • (2006) Blood , vol.107 , pp. 2863-2870
    • Bremer, E.1    Ten Cate, B.2    Samplonius, D.F.3
  • 74
    • 79959556991 scopus 로고    scopus 로고
    • Selective elimination of pathogenic synovial fluid T-cells from rheumatoid arthritis and juvenile idiopathic arthritis by targeted activation of Fas-apoptotic signaling
    • Bremer E, Abdulahad WH, de Bruyn M, et al. Selective elimination of pathogenic synovial fluid T-cells from rheumatoid arthritis and juvenile idiopathic arthritis by targeted activation of Fas-apoptotic signaling. Immunol Lett 2011;138:161-8
    • (2011) Immunol Lett , vol.138 , pp. 161-168
    • Bremer, E.1    Abdulahad, W.H.2    De Bruyn, M.3
  • 76
    • 34249692537 scopus 로고    scopus 로고
    • Rituximab-induced inhibition of antiapoptotic cell survival pathways: Implications in chemo/immunoresistance, rituximab unresponsiveness, prognostic and novel therapeutic interventions
    • DOI 10.1038/sj.onc.1210365, PII 1210365
    • Bonavida B. Rituximab-induced inhibition of antiapoptotic cell survival pathways: implications in chemo/immunoresistance, rituximab unresponsiveness, prognostic and novel therapeutic interventions. Oncogene 2007;26:3629-36 (Pubitemid 46842700)
    • (2007) Oncogene , vol.26 , Issue.25 , pp. 3629-3636
    • Bonavida, B.1
  • 77
    • 38849092640 scopus 로고    scopus 로고
    • CTLA-4. FasL induces early apoptosis of activated T cells by interfering with anti-apoptotic signals
    • Orbach A, Rachmilewitz J, Parnas M, et al. CTLA-4. FasL induces early apoptosis of activated T cells by interfering with anti-apoptotic signals. J Immunol 2007;179:7287-94
    • (2007) J Immunol , vol.179 , pp. 7287-7294
    • Orbach, A.1    Rachmilewitz, J.2    Parnas, M.3
  • 79
    • 78650214751 scopus 로고    scopus 로고
    • CD40.FasL and CTLA-4.FasL fusion proteins induce apoptosis in malignant cell lines by dual signaling
    • Orbach A, Rachmilewitz J, Shani N, et al. CD40.FasL and CTLA-4.FasL fusion proteins induce apoptosis in malignant cell lines by dual signaling. Am J Pathol 2010;177:3159-68
    • (2010) Am J Pathol , vol.177 , pp. 3159-3168
    • Orbach, A.1    Rachmilewitz, J.2    Shani, N.3
  • 80
    • 84876079719 scopus 로고    scopus 로고
    • Engineering death receptor ligands for cancer therapy
    • Epub ahead of print doi:10.1016/j.canlet.2010.12.019
    • Wajant H, Gerspach J, Pfizenmaier K. Engineering death receptor ligands for cancer therapy. Cancer Lett 2011 [Epub ahead of print] doi:10.1016/j.canlet. 2010.12.019
    • (2011) Cancer Lett
    • Wajant, H.1    Gerspach, J.2    Pfizenmaier, K.3
  • 85
    • 67650360785 scopus 로고    scopus 로고
    • Release of HMGB1 in response to proapoptotic glioma killing strategies: Efficacy and neurotoxicity
    • Candolfi M, Yagiz K, Foulad D, et al. Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity. Clin Cancer Res 2009;15:4401-14
    • (2009) Clin Cancer Res , vol.15 , pp. 4401-4414
    • Candolfi, M.1    Yagiz, K.2    Foulad, D.3
  • 86
    • 77954847993 scopus 로고    scopus 로고
    • Efficient and selective tumor cell lysis and induction of apoptosis in melanoma cells by a conditional replication-competent CD95L adenovirus
    • Fecker LF, Schmude M, Jost S, et al. Efficient and selective tumor cell lysis and induction of apoptosis in melanoma cells by a conditional replication-competent CD95L adenovirus. Exp Dermatol 2010;19:e56-66
    • (2010) Exp Dermatol , vol.19
    • Fecker, L.F.1    Schmude, M.2    Jost, S.3
  • 87
    • 0037384316 scopus 로고    scopus 로고
    • Quantification and characterization of the bystander effect in prostate cancer cells following adenovirus-mediated FasL expression
    • DOI 10.1038/sj.cgt.7700576
    • Hyer ML, Sudarshan S, Schwartz DA, et al. Quantification and characterization of the bystander effect in prostate cancer cells following adenovirus-mediated FasL expression. Cancer Gene Ther 2003;10:330-9 (Pubitemid 36423115)
    • (2003) Cancer Gene Therapy , vol.10 , Issue.4 , pp. 330-339
    • Hyer, M.L.1    Sudarshan, S.2    Schwartz, D.A.3    Hannun, Y.4    Dong, J.-Y.5    Norris, J.S.6
  • 89
    • 34848886660 scopus 로고    scopus 로고
    • Fas ligand delivery by a prostate-restricted replicative adenovirus enhances safety and antitumor efficacy
    • DOI 10.1158/1078-0432.CCR-07-0342
    • Li X, Liu YH, Zhang YP, et al. Fas ligand delivery by a prostate-restricted replicative adenovirus enhances safety and antitumor efficacy. Clin Cancer Res 2007;13:5463-73 (Pubitemid 47510374)
    • (2007) Clinical Cancer Research , vol.13 , Issue.18 , pp. 5463-5473
    • Li, X.1    Liu, Y.-H.2    Zhang, Y.-P.3    Zhang, S.4    Pu, X.5    Gardner, T.A.6    Jeng, M.-H.7    Kao, C.8
  • 90
    • 0033032347 scopus 로고    scopus 로고
    • Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule pas ligand to predetermined brain cell types, and abolish peripheral liver toxicity
    • Morelli AE, Larregina AT, Smith-Arica J, et al. Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of 86. the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity. J Gen Virol 1999;80:571-83 (Pubitemid 29101210)
    • (1999) Journal of General Virology , vol.80 , Issue.3 , pp. 571-583
    • Morelli, A.E.1    Larregina, A.T.2    Smith-Arica, J.3    Dewey, R.A.4    Southgate, T.D.5    Ambar, B.6    Fontana, A.7    Castro, M.G.8    Lowenstein, P.R.9
  • 92
    • 0031666610 scopus 로고    scopus 로고
    • Efficient Fas-ligand gene expression in rodent liver after intravenous injection of a recombinant adenovirus by the use of a Cre-mediated switching system
    • Okuyama T, Fujino M, Li XK, et al. Efficient Fas-ligand gene expression in rodent liver after intravenous injection of a recombinant adenovirus by the use of a Cre-mediated switching system. Gene Ther 1998;5:1047-53 (Pubitemid 28401306)
    • (1998) Gene Therapy , vol.5 , Issue.8 , pp. 1047-1053
    • Okuyama, T.1    Fujino, M.2    Li, X.-K.3    Funeshima, N.4    Kosuga, M.5    Saito, I.6    Suzuki, S.7    Yamada, M.8
  • 93
    • 0034200933 scopus 로고    scopus 로고
    • Restricted expression of an adenoviral vector encoding Fas ligand (CD95L) enhances safety for cancer gene therapy
    • Aoki K, Akyurek LM, San H, et al. Restricted expression of an adenoviral vector encoding Fas ligand (CD95L) enhances safety for cancer gene therapy. Mol Ther 2000;1(6):555-65
    • (2000) Mol Ther , vol.1 , Issue.6 , pp. 555-565
    • Aoki, K.1    Akyurek, L.M.2    San, H.3
  • 94
    • 0035191647 scopus 로고    scopus 로고
    • A complex adenovirus vector that delivers FASL-GFP with combined prostate-specific and tetracycline-regulated expression
    • DOI 10.1006/mthe.2001.0478
    • Rubinchik S, Wang D, Yu H, et al. A complex adenovirus vector that delivers FASL-GFP with combined prostate-specific and tetracycline-regulated expression. Mol Ther 2001;4:416-26 (Pubitemid 33100279)
    • (2001) Molecular Therapy , vol.4 , Issue.5 , pp. 416-426
    • Rubinchik, S.1    Wang, D.2    Yu, H.3    Fan, F.4    Luo, M.5    Norris, J.S.6    Dong, J.-Y.7
  • 96
    • 0036209678 scopus 로고    scopus 로고
    • Spatial and temporal control of transgene expression through ultrasound-mediated induction of the heat shock protein 70B promoter in vivo
    • DOI 10.1089/104303402317322267
    • Smith RC, Machluf M, Bromley P, et al. Spatial and temporal control of transgene expression through ultrasound-mediated induction of the heat shock protein 70B promoter in vivo. Hum Gene Ther 2002;13:697-706 (Pubitemid 34280484)
    • (2002) Human Gene Therapy , vol.13 , Issue.6 , pp. 697-706
    • Smith, R.C.1    Machluf, M.2    Bromley, P.3    Atala, A.4    Walsh, K.5
  • 97
    • 43949093802 scopus 로고    scopus 로고
    • Combination of Fasl and GM-CSF confers synergistic antitumor immunity in an in vivo model of the murine Lewis lung carcinoma
    • Ho MY, Sun GH, Leu SJ, et al. Combination of Fasl and GM-CSF confers synergistic antitumor immunity in an in vivo model of the murine Lewis lung carcinoma. Int J Cancer 2008;123:123-33
    • (2008) Int J Cancer , vol.123 , pp. 123-133
    • Ho, M.Y.1    Sun, G.H.2    Leu, S.J.3
  • 98
    • 77957743211 scopus 로고    scopus 로고
    • FasL and FADD delivery by a glioma-specific and cell cycle-dependent HSV-1 amplicon virus enhanced apoptosis in primary human brain tumors
    • Ho IA, Ng WH, Lam PY. FasL and FADD delivery by a glioma-specific and cell cycle-dependent HSV-1 amplicon virus enhanced apoptosis in primary human brain tumors. Mol Cancer 2010;9:270
    • (2010) Mol Cancer , vol.9 , pp. 270
    • Ho, I.A.1    Ng, W.H.2    Lam, P.Y.3
  • 99
    • 65049090448 scopus 로고    scopus 로고
    • Retrovirally transduced murine T lymphocytes expressing FasL mediate effective killing of prostate cancer cells
    • Symes JC, Siatskas C, Fowler DH, Medin JA. Retrovirally transduced murine T lymphocytes expressing FasL mediate effective killing of prostate cancer cells. Cancer Gene Ther 2009;16:439-52
    • (2009) Cancer Gene Ther , vol.16 , pp. 439-452
    • Symes, J.C.1    Siatskas, C.2    Fowler, D.H.3    Medin, J.A.4
  • 100
    • 79851473784 scopus 로고    scopus 로고
    • Microbial-based therapy of cancer: Current progress and future prospects
    • Bernardes N, Seruca R, Chakrabarty AM, Fialho AM. Microbial-based therapy of cancer: current progress and future prospects. Bioeng Bugs 2010;1:178-90
    • (2010) Bioeng Bugs , vol.1 , pp. 178-190
    • Bernardes, N.1    Seruca, R.2    Chakrabarty, A.M.3    Fialho, A.M.4
  • 102
    • 77649181792 scopus 로고    scopus 로고
    • Death receptors: Targets for cancer therapy
    • Mahmood Z, Shukla Y. Death receptors: targets for cancer therapy. Exp Cell Res 2010;316:887-99
    • (2010) Exp Cell Res , vol.316 , pp. 887-899
    • Mahmood, Z.1    Shukla, Y.2
  • 103
    • 67649472428 scopus 로고    scopus 로고
    • Novel role of thiadiazolidine derivatives in inducing cell death through Myc-Max, Akt, FKHR, and FasL pathway
    • Raghavendra PB, Pathak N, Manna SK. Novel role of thiadiazolidine derivatives in inducing cell death through Myc-Max, Akt, FKHR, and FasL pathway. Biochem Pharmacol 2009;78:495-503
    • (2009) Biochem Pharmacol , vol.78 , pp. 495-503
    • Raghavendra, P.B.1    Pathak, N.2    Manna, S.K.3
  • 104
    • 41849127108 scopus 로고    scopus 로고
    • Paclitaxel (Taxol)-induced apoptosis in human epithelioid sarcoma cell lines is enhanced by upregulation of CD95 ligand (FasL/Apo-1L)
    • Heikaus S, Matuszek KS, Suschek CV, et al. Paclitaxel (Taxol)-induced apoptosis in human epithelioid sarcoma cell lines is enhanced by upregulation of CD95 ligand (FasL/Apo-1L). J Cancer Res Clin Oncol 2008;134:689-95
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 689-695
    • Heikaus, S.1    Matuszek, K.S.2    Suschek, C.V.3
  • 105
    • 0036104828 scopus 로고    scopus 로고
    • Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor
    • DOI 10.1038/nm0402-349
    • Volpert OV, Zaichuk T, Zhou W, et al. Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor. Nat Med 2002;8:349-57 (Pubitemid 34407029)
    • (2002) Nature Medicine , vol.8 , Issue.4 , pp. 349-357
    • Volpert, O.V.1    Zaichuk, T.2    Zhou, W.3    Reiher, F.4    Ferguson, T.A.5    Stuart, P.M.6    Amin, M.7    Bouck, N.P.8
  • 106
    • 84855885553 scopus 로고    scopus 로고
    • ClinicalTrials.gov Available from Last accessed 6 October 2011
    • ClinicalTrials.gov Available from: http://clinicaltrials.gov/ct2/results? term=ABT-510 [Last accessed 6 October 2011]
  • 109
    • 79955015045 scopus 로고    scopus 로고
    • Understanding rituximab function and resistance: Implications for tailored therapy
    • Amoroso A, Hafsi S, Militello L, et al. Understanding rituximab function and resistance: implications for tailored therapy. Front Biosci 2011;16:770-82
    • (2011) Front Biosci , vol.16 , pp. 770-782
    • Amoroso, A.1    Hafsi, S.2    Militello, L.3
  • 110
    • 77955465161 scopus 로고    scopus 로고
    • Aerosol therapy for the treatment of osteosarcoma lung metastases: Targeting the Fas/FasL pathway and rationale for the use of gemcitabine
    • Gordon N, Kleinerman ES. Aerosol therapy for the treatment of osteosarcoma lung metastases: targeting the Fas/FasL pathway and rationale for the use of gemcitabine. J Aerosol Med Pulm Drug Deliv 2010;23:189-96
    • (2010) J Aerosol Med Pulm Drug Deliv , vol.23 , pp. 189-196
    • Gordon, N.1    Kleinerman, E.S.2
  • 111
    • 62749191287 scopus 로고    scopus 로고
    • The role of MMP7 and its cross-talk with the FAS/FASL system during the acquisition of chemoresistance to oxaliplatin
    • Almendro V, Ametller E, Garcia-Recio S, et al. The role of MMP7 and its cross-talk with the FAS/FASL system during the acquisition of chemoresistance to oxaliplatin. PLoS One 2009;4:e4728
    • (2009) PLoS One , vol.4
    • Almendro, V.1    Ametller, E.2    Garcia-Recio, S.3
  • 112
    • 77951553358 scopus 로고    scopus 로고
    • Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis
    • Bousserouel S, Kauntz H, Gosse F, et al. Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis. Int J Oncol 2010;36:1485-90
    • (2010) Int J Oncol , vol.36 , pp. 1485-1490
    • Bousserouel, S.1    Kauntz, H.2    Gosse, F.3
  • 113
    • 84855885552 scopus 로고    scopus 로고
    • ClinicalTrials.gov Available from Last accessed 6 October 2011
    • ClinicalTrials.gov Available from: http://clinicaltrials.gov/ct2/results? term=ag3340 [Last accessed 6 October 2011]
  • 114
    • 84855885551 scopus 로고    scopus 로고
    • ClinicalTrials.gov Available from Last accessed 6 October 2011
    • ClinicalTrials.gov Available from: http://clinicaltrials.gov/ct2/results? term=bisphosphonates&cond=cancer [Last accessed 6 October 2011]
  • 115
    • 84855887469 scopus 로고    scopus 로고
    • ClinicalTrials.gov Available from: Last accessed 6 October 2011
    • ClinicalTrials.gov Available from: http://clinicaltrials.gov/ct2/results? term=AE-941 [Last accessed 6 October 2011]
  • 118
    • 63749094012 scopus 로고    scopus 로고
    • Randomized Phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates
    • Fizazi K, Lipton A, Mariette X, et al. Randomized Phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates. J Clin Oncol 2009;27:1564-71
    • (2009) J Clin Oncol , vol.27 , pp. 1564-1571
    • Fizazi, K.1    Lipton, A.2    Mariette, X.3
  • 119
    • 77953695968 scopus 로고    scopus 로고
    • Chemoradiotherapy with or without AE-941 in stage III non-small cell lung cancer: A randomized Phase III trial
    • Lu C, Lee JJ, Komaki R, et al. Chemoradiotherapy with or without AE-941 in stage III non-small cell lung cancer: a randomized Phase III trial. J Natl Cancer Inst 2010;102:859-65
    • (2010) J Natl Cancer Inst , vol.102 , pp. 859-865
    • Lu, C.1    Lee, J.J.2    Komaki, R.3
  • 120
    • 77952647070 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors: A critical appraisal of design principles and proposed therapeutic utility
    • Dorman G, Cseh S, Hajdu I, et al. Matrix metalloproteinase inhibitors: a critical appraisal of design principles and proposed therapeutic utility. Drugs 2010;70:949-64
    • (2010) Drugs , vol.70 , pp. 949-964
    • Dorman, G.1    Cseh, S.2    Hajdu, I.3
  • 121
    • 78751558489 scopus 로고    scopus 로고
    • Differential regulation of MMP7 in colon cancer cells resistant and sensitive to oxaliplatin-induced cell death
    • Ametller E, Garcia-Recio S, Pastor-Arroyo EM, et al. Differential regulation of MMP7 in colon cancer cells resistant and sensitive to oxaliplatin-induced cell death. Cancer Biol Ther 2011;11:4-13
    • (2011) Cancer Biol Ther , vol.11 , pp. 4-13
    • Ametller, E.1    Garcia-Recio, S.2    Pastor-Arroyo, E.M.3
  • 122
    • 77955071563 scopus 로고    scopus 로고
    • Cisplatin augments FAS-mediated apoptosis through lipid rafts
    • Huang CR, Jin ZX, Dong L, et al. Cisplatin augments FAS-mediated apoptosis through lipid rafts. Anticancer Res 2010;30:2065-71
    • (2010) Anticancer Res , vol.30 , pp. 2065-2071
    • Huang, C.R.1    Jin, Z.X.2    Dong, L.3
  • 123
    • 77951665350 scopus 로고    scopus 로고
    • Cisplatin-induced apoptosis involves a Fas-ROCK-ezrin-dependent actin remodelling in human colon cancer cells
    • Rebillard A, Jouan-Lanhouet S, Jouan E, et al. Cisplatin-induced apoptosis involves a Fas-ROCK-ezrin-dependent actin remodelling in human colon cancer cells. Eur J Cancer 2010;46:1445-55
    • (2010) Eur J Cancer , vol.46 , pp. 1445-1455
    • Rebillard, A.1    Jouan-Lanhouet, S.2    Jouan, E.3
  • 124
    • 77950641684 scopus 로고    scopus 로고
    • In vitro and in vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts
    • Mollinedo F, de la Iglesia-Vicente J, Gajate C, et al. In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts. Clin Cancer Res 2010;16:2046-54
    • (2010) Clin Cancer Res , vol.16 , pp. 2046-2054
    • Mollinedo, F.1    De La Iglesia-Vicente, J.2    Gajate, C.3
  • 126
    • 79959724636 scopus 로고    scopus 로고
    • Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor
    • Huang L, Ramirez JC, Frampton GA, et al. Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor. Lab Invest 2011;91:1007-17
    • (2011) Lab Invest , vol.91 , pp. 1007-1017
    • Huang, L.1    Ramirez, J.C.2    Frampton, G.A.3
  • 127
    • 77649207635 scopus 로고    scopus 로고
    • Theaflavins target Fas/caspase-8 and Akt/pBad pathways to induce apoptosis in p53-mutated human breast cancer cells
    • Lahiry L, Saha B, Chakraborty J, et al. Theaflavins target Fas/caspase-8 and Akt/pBad pathways to induce apoptosis in p53-mutated human breast cancer cells. Carcinogenesis 2010;31:259-68
    • (2010) Carcinogenesis , vol.31 , pp. 259-268
    • Lahiry, L.1    Saha, B.2    Chakraborty, J.3
  • 129
    • 0035279153 scopus 로고    scopus 로고
    • Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis
    • DOI 10.1038/sj.onc.1204141
    • Fulda S, Meyer E, Friesen C, et al. Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis. Oncogene 2001;20:1063-75 (Pubitemid 32238855)
    • (2001) Oncogene , vol.20 , Issue.9 , pp. 1063-1075
    • Fulda, S.1    Meyer, E.2    Friesen, C.3    Susin, S.A.4    Kroemer, G.5    Debatin, K.-M.6
  • 130
    • 79953046542 scopus 로고    scopus 로고
    • FAS and NF-kappaB signalling modulate dependence of lung cancers on mutant EGFR
    • Bivona TG, Hieronymus H, Parker J, et al. FAS and NF-kappaB signalling modulate dependence of lung cancers on mutant EGFR. Nature 2011;471:523-6
    • (2011) Nature , vol.471 , pp. 523-526
    • Bivona, T.G.1    Hieronymus, H.2    Parker, J.3
  • 131
    • 75749132740 scopus 로고    scopus 로고
    • The extrinsic apoptosis pathway and its prognostic impact in ovarian cancer
    • Duiker EW, van der Zee AG, de Graeff P, et al. The extrinsic apoptosis pathway and its prognostic impact in ovarian cancer. Gynecol Oncol 2010;116:549-55
    • (2010) Gynecol Oncol , vol.116 , pp. 549-555
    • Duiker, E.W.1    Van Der Zee, A.G.2    De Graeff, P.3
  • 132
    • 79951947295 scopus 로고    scopus 로고
    • Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia
    • Tsumuraya T, Ishikawa C, Machijima Y, et al. Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia. Biochem Pharmacol 2011;81:713-22
    • (2011) Biochem Pharmacol , vol.81 , pp. 713-722
    • Tsumuraya, T.1    Ishikawa, C.2    MacHijima, Y.3
  • 133
    • 53049109359 scopus 로고    scopus 로고
    • Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation
    • Zhang G, Park MA, Mitchell C, et al. Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation. Clin Cancer Res 2008;14:5385-99
    • (2008) Clin Cancer Res , vol.14 , pp. 5385-5399
    • Zhang, G.1    Park, M.A.2    Mitchell, C.3
  • 134
    • 63149169896 scopus 로고    scopus 로고
    • Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: Role of calmodulin
    • Pawar P, Ma L, Byon CH, et al. Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: role of calmodulin. Clin Cancer Res 2009;15:1288-96
    • (2009) Clin Cancer Res , vol.15 , pp. 1288-1296
    • Pawar, P.1    Ma, L.2    Byon, C.H.3
  • 135
    • 77954930632 scopus 로고    scopus 로고
    • IAPs: From caspase inhibitors to modulators of NF-kappaB, inflammation and cancer
    • Gyrd-Hansen M, Meier P. IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. Nat Rev Cancer 2010;10:561-74
    • (2010) Nat Rev Cancer , vol.10 , pp. 561-574
    • Gyrd-Hansen, M.1    Meier, P.2
  • 136
    • 79953655787 scopus 로고    scopus 로고
    • Impacting tumor cell-fate by targeting the inhibitor of apoptosis protein survivin
    • Kelly RJ, Lopez-Chavez A, Citrin D, et al. Impacting tumor cell-fate by targeting the inhibitor of apoptosis protein survivin. Mol Cancer 2011;10:35
    • (2011) Mol Cancer , vol.10 , pp. 35
    • Kelly, R.J.1    Lopez-Chavez, A.2    Citrin, D.3
  • 137
    • 79953108690 scopus 로고    scopus 로고
    • Epigenetics in cancer: What's the future?
    • 228
    • Boumber Y, Issa JP. Epigenetics in cancer: what's the future? Oncology (Williston Park) 2011;25:220-6; 228
    • (2011) Oncology (Williston Park) , vol.25 , pp. 220-226
    • Boumber, Y.1    Issa, J.P.2
  • 139
    • 79953840339 scopus 로고    scopus 로고
    • Reduction of Fas/CD95 promoter methylation, upregulation of Fas protein, and enhancement of sensitivity to apoptosis in cutaneous T-cell lymphoma
    • Wu J, Wood GS. Reduction of Fas/CD95 promoter methylation, upregulation of Fas protein, and enhancement of sensitivity to apoptosis in cutaneous T-cell lymphoma. Arch Dermatol 2011;147:443-9
    • (2011) Arch Dermatol , vol.147 , pp. 443-449
    • Wu, J.1    Wood, G.S.2
  • 141
    • 84855885556 scopus 로고    scopus 로고
    • ClinicalTrials.gov Available from Last accessed 6 October 2011
    • ClinicalTrials.gov Available from: http://clinicaltrials.gov/ct2/results? term=azacitidine [Last accessed 6 October 2011]
  • 142
    • 84855885555 scopus 로고    scopus 로고
    • ClinicalTrials.gov Available from Last accessed 6 October 2011
    • ClinicalTrials.gov Available from: http://clinicaltrials.gov/ct2/results? term=decitabine [Last accessed 6 October 2011]
  • 143
    • 77955393899 scopus 로고    scopus 로고
    • Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca2+de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway
    • Park MA, Mitchell C, Zhang G, et al. Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca2+de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway. Cancer Res 2010;70:6313-24
    • (2010) Cancer Res , vol.70 , pp. 6313-6324
    • Park, M.A.1    Mitchell, C.2    Zhang, G.3
  • 144
  • 145
    • 36749029400 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis through both mitochondrial and Fas (Cd95) signaling in head and neck squamous carcinoma cells
    • DOI 10.1158/1535-7163.MCT-04-0344
    • Gillenwater AM, Zhong M, Lotan R. Histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis through both mitochondrial and Fas (Cd95) signaling in head and neck squamous carcinoma cells. Mol Cancer Ther 2007;6:2967-75 (Pubitemid 350206775)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.11 , pp. 2967-2975
    • Gillenwater, A.M.1    Zhong, M.2    Lotan, R.3
  • 147
    • 11844298984 scopus 로고    scopus 로고
    • Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP
    • DOI 10.1038/sj.cdd.4401507
    • Watanabe K, Okamoto K, Yonehara S. Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP. Cell Death Differ 2005;12:10-18 (Pubitemid 40090024)
    • (2005) Cell Death and Differentiation , vol.12 , Issue.1 , pp. 10-18
    • Watanabe, K.1    Okamoto, K.2    Yonehara, S.3
  • 149
    • 0038494686 scopus 로고    scopus 로고
    • Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein
    • DOI 10.1182/blood-2002-12-3794
    • Aron JL, Parthun MR, Marcucci G, et al. Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein. Blood 2003;102:652-8 (Pubitemid 36841988)
    • (2003) Blood , vol.102 , Issue.2 , pp. 652-658
    • Aron, J.L.1    Parthun, M.R.2    Marcucci, G.3    Kitada, S.4    Mone, A.P.5    Davis, M.E.6    Shen, T.7    Murphy, T.8    Wickham, J.9    Kanakry, C.10    Lucas, D.M.11    Reed, J.C.12    Grever, M.R.13    Byrd, J.C.14
  • 150
    • 84855885554 scopus 로고    scopus 로고
    • ClinicalTrials.gov Available from Last accessed 6 October 2011
    • ClinicalTrials.gov Available from: http://clinicaltrials.gov/ct2/results? term=vorinostat [Last accessed 6 October 2011]
  • 151
    • 84855887470 scopus 로고    scopus 로고
    • ClinicalTrials.gov Available from: Last accessed 6 October 2011
    • ClinicalTrials.gov Available from: http://clinicaltrials.gov/ct2/results? term=romidepsin%2C [Last accessed 6 October 2011]
  • 152
    • 57449103563 scopus 로고    scopus 로고
    • Valproate synergizes with purine nucleoside analogues to induce apoptosis of B-chronic lymphocytic leukaemia cells
    • Bouzar AB, Boxus M, Defoiche J, et al. Valproate synergizes with purine nucleoside analogues to induce apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol 2009;144:41-52
    • (2009) Br J Haematol , vol.144 , pp. 41-52
    • Bouzar, A.B.1    Boxus, M.2    Defoiche, J.3
  • 153
    • 78651347259 scopus 로고    scopus 로고
    • Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells
    • Lee WJ, Chen YR, Tseng TH. Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells. Oncol Rep 2011;25:583-91
    • (2011) Oncol Rep , vol.25 , pp. 583-591
    • Lee, W.J.1    Chen, Y.R.2    Tseng, T.H.3
  • 154
    • 79960698626 scopus 로고    scopus 로고
    • Effect of the histone deacetylase inhibitor SNDX-275 on Fas signaling in osteosarcoma cells and the feasibility of its topical application for the treatment of osteosarcoma lung metastases
    • Koshkina NV, Rao-Bindal K, Kleinerman ES. Effect of the histone deacetylase inhibitor SNDX-275 on Fas signaling in osteosarcoma cells and the feasibility of its topical application for the treatment of osteosarcoma lung metastases. Cancer 2011;117:3457-67
    • (2011) Cancer , vol.117 , pp. 3457-3467
    • Koshkina, N.V.1    Rao-Bindal, K.2    Kleinerman, E.S.3
  • 155
    • 79955763550 scopus 로고    scopus 로고
    • A let-7/Fas double-negative feedback loop regulates human colon carcinoma cells sensitivity to Fas-related apoptosis
    • Geng L, Zhu B, Dai BH, et al. A let-7/Fas double-negative feedback loop regulates human colon carcinoma cells sensitivity to Fas-related apoptosis. Biochem Biophys Res Commun 2011;408:494-9
    • (2011) Biochem Biophys Res Commun , vol.408 , pp. 494-499
    • Geng, L.1    Zhu, B.2    Dai, B.H.3
  • 156
    • 77958061493 scopus 로고    scopus 로고
    • Diazoxide potentiates mesenchymal stem cell survival via NF-kappaB-dependent miR-146a expression by targeting Fas
    • Suzuki Y, Kim HW, Ashraf M, Haider H. Diazoxide potentiates mesenchymal stem cell survival via NF-kappaB-dependent miR-146a expression by targeting Fas. Am J Physiol 2010;299:H1077-82
    • (2010) Am J Physiol , vol.299
    • Suzuki, Y.1    Kim, H.W.2    Ashraf, M.3    Haider, H.4
  • 157
    • 67649217148 scopus 로고    scopus 로고
    • Upregulation of miR-23a-27a-24-2 cluster induces caspase-dependent and -independent apoptosis in human embryonic kidney cells
    • Chhabra R, Adlakha YK, Hariharan M, et al. Upregulation of miR-23a-27a-24-2 cluster induces caspase-dependent and -independent apoptosis in human embryonic kidney cells. PLoS One 2009;4:e5848
    • (2009) PLoS One , vol.4
    • Chhabra, R.1    Adlakha, Y.K.2    Hariharan, M.3
  • 158
    • 77953782181 scopus 로고    scopus 로고
    • MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand
    • Sayed D, He M, Hong C, et al. MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand. J Biol Chem 2010;285:20281-90
    • (2010) J Biol Chem , vol.285 , pp. 20281-90
    • Sayed, D.1    He, M.2    Hong, C.3
  • 159
    • 77955507555 scopus 로고    scopus 로고
    • Peter ME. miR-200c regulates induction of apoptosis through CD95 by targeting FAP-1
    • Schickel R, Park SM, Murmann AE, Peter ME. miR-200c regulates induction of apoptosis through CD95 by targeting FAP-1. Mol Cell 2010;38:908-15
    • (2010) Mol Cell , vol.38 , pp. 908-915
    • Schickel, R.1    Park, S.M.2    Murmann, A.E.3
  • 160
    • 68549106174 scopus 로고    scopus 로고
    • Combination of human Fas (CD95/Apo-1) ligand with adriamycin significantly enhances the efficacy of antitumor response
    • Liu Z, Liu R, Qiu J, et al. Combination of human Fas (CD95/Apo-1) ligand with adriamycin significantly enhances the efficacy of antitumor response. Cell Mol Immunol 2009;6:167-74
    • (2009) Cell Mol Immunol , vol.6 , pp. 167-174
    • Liu, Z.1    Liu, R.2    Qiu, J.3
  • 161
    • 33645497969 scopus 로고    scopus 로고
    • Functional Fas (Cd95/Apo-1) promoter polymorphisms in inbred mouse strains exhibiting different susceptibility to gamma-radiation-induced thymic lymphoma
    • Villa-Morales M, Santos J, Fernandez-Piqueras J. Functional Fas (Cd95/Apo-1) promoter polymorphisms in inbred mouse strains exhibiting different susceptibility to gamma-radiation-induced thymic lymphoma. Oncogene 2006;25:2022-9
    • (2006) Oncogene , vol.25 , pp. 2022-2029
    • Villa-Morales, M.1    Santos, J.2    Fernandez-Piqueras, J.3
  • 162
    • 77949889993 scopus 로고    scopus 로고
    • Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95-induced apoptosis
    • Loeder S, Drensek A, Jeremias I, et al. Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95-induced apoptosis. Int J Cancer 2010;126:2216-28
    • (2010) Int J Cancer , vol.126 , pp. 2216-2228
    • Loeder, S.1    Drensek, A.2    Jeremias, I.3
  • 163
    • 77749332056 scopus 로고    scopus 로고
    • A Phase 1 trial of ABT-510 concurrent with standard chemoradiation for patients with newly diagnosed glioblastoma
    • Nabors LB, Fiveash JB, Markert JM, et al. A Phase 1 trial of ABT-510 concurrent with standard chemoradiation for patients with newly diagnosed glioblastoma. Arch Neurol 2010;67:313-19
    • (2010) Arch Neurol , vol.67 , pp. 313-319
    • Nabors, L.B.1    Fiveash, J.B.2    Markert, J.M.3
  • 164
    • 77949621084 scopus 로고    scopus 로고
    • The thrombospondin-1 mimetic ABT-510 increases the uptake and effectiveness of cisplatin and paclitaxel in a mouse model of epithelial ovarian cancer
    • Campbell NE, Greenaway J, Henkin J, et al. The thrombospondin-1 mimetic ABT-510 increases the uptake and effectiveness of cisplatin and paclitaxel in a mouse model of epithelial ovarian cancer. Neoplasia 2010;12:275-83
    • (2010) Neoplasia , vol.12 , pp. 275-283
    • Campbell, N.E.1    Greenaway, J.2    Henkin, J.3


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