Humanization of the mouse anti-fas antibody HFE7A and crystal structure of the humanized HFE7A fab fragment

Biological and Pharmaceutical Bulletin

Volumn 25, Issue 12, 2002, Pages 1537-1545

  Haruyama, Hideyuki ^a   Ito, Shuichiro ^a   Miyadai, Kenji ^a   Takahashi, Tohru ^a   Kawaida, Reimi ^a   Takayama, Tomoko ^a   Hanzawa, Hiroyuki ^a   Hata, Tadashi ^a   Yamaguchi, Junko ^a   Yoshida Kato, Hiroko ^a   Ichikawa, Kimihisa ^a   Ohsumi, Jun ^a   Yonehara, Shin ^b   Serizawa, Nobufusa ^a  

^a DAIICHI SANKYO CO   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Antibody humanization; Apoptosis; CDR grafting; Fas; X ray crystal structure

Indexed keywords

FAS ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY HFE7A; UNCLASSIFIED DRUG; ANTI FAS MONOCLONAL ANTIBODY; ANTI-FAS MONOCLONAL ANTIBODY;

ANTIBODY STRUCTURE; ANTIGEN BINDING; APOPTOSIS; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; HIGH TEMPERATURE; PROTEIN EXPRESSION; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY COMBINING SITE; BINDING COMPETITION; CELL STRAIN COS1; CELL SURVIVAL; CERCOPITHECUS; CHEMISTRY; CRYSTALLIZATION; DRUG EFFECT; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; MOUSE; PHYSIOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; BINDING SITES, ANTIBODY; BINDING, COMPETITIVE; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; COS CELLS; CRYSTALLIZATION; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; MOLECULAR SEQUENCE DATA;

EID: 10844291694     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.25.1537     Document Type: Article

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