In vivo effects of zearalenone on the expression of proteins involved in the detoxification of rat xenobiotics

Environmental Toxicology

Volumn 27, Issue 2, 2012, Pages 98-108

  Duca, Radu Corneliu ^a   Mabondzo, Aloise ^b   Bravin, Frédérique ^a   Delaforge, Marcel ^a  

^a CEA   (France)

^b CEA SACLAY   (France)

Author keywords

Cytochrome P450; Metabolic activities; MRNA; P glycoprotein; QRT PCR; Zearalenone

Indexed keywords

CYTOCHROME P450; METABOLIC ACTIVITY; MRNA; P-GLYCOPROTEIN; Q-RT-PCR; ZEARALENONE;

ANIMALS; BIOCHEMISTRY; CHEMICAL CONTAMINATION; ENZYME ACTIVITY; GENE EXPRESSION; GLYCOPROTEINS; METABOLISM; PHYSIOLOGY; PROTEINS; RATS;

DETOXIFICATION;

AROMATASE; BREAST CANCER RESISTANCE PROTEIN; CALGRANULIN B; CLOFIBRATE; CYTOCHROME P450; CYTOCHROME P450 2B; CYTOCHROME P450 2C; CYTOCHROME P450 2C7; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; CYTOCHROME P450 3A2; DEXAMETHASONE; FLAVONE DERIVATIVE; GLUCURONOSYLTRANSFERASE; GLYCOPROTEIN P; HYDROXYSTEROID DEHYDROGENASE; MESSENGER RNA; PHENOBARBITAL; STEROID REDUCTASE; TRANSFERASE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT; ZEARALENONE;

BIOLOGICAL UPTAKE; DETOXIFICATION; ENZYME ACTIVITY; ESTROGENIC COMPOUND; FUNGUS; GENE EXPRESSION; METABOLISM; ORGANIC ACID; POLYMERASE CHAIN REACTION; PROTEIN; RODENT; STEROID;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; ENZYME ACTIVITY; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC CODE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEROID METABOLISM;

ANIMALS; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; ESTROGENS, NON-STEROIDAL; HYDROXYLATION; LIVER; MALE; METABOLIC DETOXICATION, DRUG; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; P-GLYCOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; XENOBIOTICS; ZEARALENONE;

ANIMALIA; FUSARIUM; RATTUS;

EID: 84855860343     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20617     Document Type: Article

References (42)

1. Agrawal AK, Shapiro BH. 1996. Phenobarbital induction of hepatic CYP2B1 and CYP2B2: Pretranscriptional and post-transcriptional effects of gender, adult age, and phenobarbital dose. Mol Pharmacol 49: 523-531.
2. Agrawal AK, Shapiro BH. 2003. Phenobarbital-imprinted overinduction of adult constituent CYP isoforms. Pharmacology 68: 204-215.
3. Ali N, Sardjono, Yamashita A, Yoshizawa T. 1998. Natural co-occurrence of aflatoxins and Fusarium mycotoxins (fumonisins, deoxynivalenol, nivalenol and zearalenone) in corn from Indonesia. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 15: 377-384.
4. Bennett JW, Klich M. 2003. Mycotoxins. Clin Microbiol Rev 16: 497-516.
5. Bousquet L, Pruvost A, Guyot A-C, Farinotti R, Mabondzo A. 2009. Combination of tenofovir and emtricitabine plus efavirenz: In vitro modulation of ABC transporter and intracellular drug accumulation. Antimicrob Agents Chemother 53: 896-902.
6. Brady JM, Cherrington NJ, Hartley DP, Buist SC, Li N, Klaassen CD. 2002. Tissue distribution and chemical induction of multiple drug resistance genes in rats. Drug Metab Dispos 30: 838-844.
7. Bravin F, Duca RC, Ballaguer P, Delaforge M. 2009. In vitro cytochrome P450 formation of a mono-hydroxylated metabolite of zearalenone exhibiting estrogenic activities: possible occurrence of this metabolite in vivo. Int J Mol Sci 10: 1824-1837.
8. Brunton LL, Lazo JS, Parker KL, Goodman LS, Gilman AG. 2005. Goodman & Gilman's Pharmacological Basis of Therapeutics. New York: McGraw-Hill.
9. Cavret S, Lecoeur S. 2006. Fusariotoxin transfer in animal. Food Chem Toxicol 44: 444-453.
10. Celius T, Haugen TB, Grotmol T, Walther BT. 1999. A sensitive zonagenetic assay for rapid in vitro assessment of estrogenic potency of xenobiotics and mycotoxins. Environ Health Perspect 107: 63-68.
11. Ding X, Lichti K, Staudinger JL. 2006. The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor. Toxicol Sci 91: 448-455.
12. Fan LQ, Brown-Borg H, Brown S, Westin S, Mode A, Corton JC. 2004. PPARalpha activators down-regulate CYP2C7, a retinoic acid and testosterone hydroxylase. Toxicology 203: 41-48.
13. Gaumy JL, Bailly JD, Benard G, Guerre P. 2001. Zéaralénone: Origine et effets chez les animaux d'élevage. Rev Méd Vét (Toulouse) 152: 123-136.
14. Henderson LO, Marti GE, Gaigalas A, Hannon WH, Vogt RF Jr. 1998. Terminology and nomenclature for standardization in quantitative fluorescence cytometry. Cytometry 33: 97-105.
15. INCHEM. 1998. Diazepam. International Programme on Chemical Safety; Poisons Information Monograph 181; Pharmaceutical. Available at.
16. Kuehl P, Zhang J, Lin Y, Lamba J, Assem M, Schuetz J, Watkins PB, Daly A, Wrighton SA, Hall SD, Maurel P, Relling M, Brimer C, Yasuda K, Venkataramanan R, Strom S, Thummel K, Boguski MS, Schuetz E. 2001. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet 27: 383-391.
17. LeCluyse EL. 2001. Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation. Eur J Pharm Sci 13: 343-368.
18. Lewis DFV. 2001. Guide to Cytochromes P450. Structure and Function. London: Taylor & Francis.
19. Malekinejad H, Colenbrander B, Fink-Gremmels J. 2006. Hydroxysteroid dehydrogenases in bovine and porcine granulosa cells convert zearalenone into its hydroxylated metabolites alpha-zearalenol and beta-zearalenol. Vet Res Commun 30: 445-453.
20. Nelson DR. 1999. Cytochrome P450 and the individuality of species. Arch Biochem Biophys 369: 1-10.
21. Olsen M, Pettersson H, Kiessling KH. 1981. Reduction of zearalenone to zearalenol in female rat liver by 3 alpha-hydroxysteroid dehydrogenase. Acta Pharmacol Toxicol 48: 157-161.
22. Omura T, Sato R. 1964. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J Biol Chem 239: 2370-2378.
23. Ortiz de Montellano PR. 1995. Arylhydrazines as probes of hemoprotein structure and function. Biochimie 77: 581-593.
24. Park Y, Li H, Kemper B. 1996. Phenobarbital induction mediated by a distal CYP2B2 sequence in rat liver transiently transfected in situ. J Biol Chem 271: 23725-23728.
25. Penning TM. 2003. Hydroxysteroid dehydrogenases and pre-receptor regulation of steroid hormone action. Hum Reprod Update 9: 193-205.
26. Persson B, Kallberg Y, Oppermann U, Jörnvall H. 2003. Coenzyme-based functional assignments of short-chain dehydrogenases reductases (SDRs). Chem Biol Interact 143/144: 271-278.
27. Peyronneau MA, Renaud JP, Truan G, Urban P, Pompon D, Mansuy D. 1992. Optimization of yeast-expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH-cytochrome P450 reductase and cytochrome b5. Eur J Biochem 207: 109-116.
28. Pfeiffer E, Heyting A, Metzler M. 2007. Novel oxidative metabolites of the mycoestrogen zearalenone in vitro. Mol Nutr Food Res 51: 867-871.
29. Rodriguez-Antona C, Donato MT, Pareja E, Gómez-Lechón MJ, Castell JV. 2001. Cytochrome P-450 mRNA expression in human liver and its relationship with enzyme activity. Arch Biochem Biophys 393: 308-315.
30. Salphati L, Benet LZ. 1998. Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers. Biochem Pharmacol 55: 387-395.
31. Sangare-Tigori B, Moukha S, Kouadio HJ, Betbeder A-M, Dano DS, Creppy EE. 2006. Co-occurrence of aflatoxin B1, fumonisin B1, ochratoxin A and zearalenone in cereals and peanuts from Côte d'Ivoire. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 23: 1000-1007.
32. Sergent T, Parys M, Garsou S, Pussemier L, Schneider YJ, Larondelle Y. 2006. Deoxynivalenol transport across human intestinal Caco-2 cells and its effectts on cellular metabolism at realistic intestinal concentrations. Toxicol Lett 164: 167-176.
33. Shier WT, Shier AC, Xie W, Mirocha CJ. 2001. Structure-activity relationships for human estrogenic activity in zearalenone mycotoxins. Toxicon 39: 1435-1438.
34. Staudinger JL, Madan A, Carol KM, Parkinson A. 2003. Regulation of drug transporter gene expression by nuclear receptors. Drug Metab Dispos 31: 523-527.
35. Sun JH, Zhu HJ, Zheng YF, Zhu XQ. 2004. Study on the transcriptional modulation of cytochrome P450 3A4 expression by zearalenone. Zhonghua Yu Fang Yi Xue Za Zhi 38: 411-414.
36. Takemura H, Shim JY, Sayama K, Tsubura A, Zhu BT, Shimoi K. 2007. Steroid Characterization of the estrogenic activities of zearalenone and zeranol in vivo and in vitro. Biochem Mol Biol 103: 170-177.
37. Vargas EA, Preis RA, Castro L, Silva CMG. 2001. Co-occurrence of aflatoxins B1, B2, G1, G2, zearalenone and fumonisin B1 in Brazilian corn. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 18: 1981-1986.
38. Videmann B, Tep J, Cavret S, Lecoeur S. 2007. Epithelial transport of deoxynivalenol: Involvement of human P-glycoprotein (ABCB1) and multidrug resistance-associated protein 2 (ABCC2). Food Chem Toxicol 45: 1938-1947.
39. Videmann B, Mazallon M, Tep J, Lecoeur S. 2008. Metabolism and transfer of the mycotoxin zearalenone in human intestinal Caco-2 cells. Food Chem Toxicol 46: 3279-3286.
40. Videmann B, Mazallon M, Prouillac C, Delaforge M, Lecoeur S. 2009. ABCC1, ABCC2 and ABCC3 are involved in the transepithelial transport of the myco-estrogen zearalenone and its major metabolites. Toxicol Lett 190: 215-223.
41. Whitehead SA, Lacey M. 2003. Phytoestrogens inhibit aromatase but not 17β-hydroxysteroid dehydrogenase (HSD) type 1 in human granulosa-luteal cells: Evidence for FSH induction of 17β-HSD. Hum Reprod 18: 487-494.
42. Yu Z, Hu D, Li Y. 2004. Effects of zearalenone on mRNA expression and activity of cytochrome P450 1A1 and 1B1 in MCF-7 cells. Ecotoxicol Environ Saf 58: 187-193.