Inhibition of hypoxia-induced [ 3H]glycine release from chicken retina by the glycine transporter type-1 (GlyT-1) inhibitors NFPS and Org-24461

Experimental Eye Research

Volumn 94, Issue 1, 2012, Pages 6-12

  Harsing, Laszlo G ^a   Albert, Mihaly ^b   Matyus, Peter ^a   Szenasi, Gabor ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b EGIS PHARMACEUTICALS LTD   (Hungary)

Author keywords

Chicken retina; Glycine transporter; Glycine transporter inhibitors; Ischemia

Indexed keywords

AMINO ACID RECEPTOR AFFECTING AGENT; GLUCOSE; GLYCINE; GLYCINE TRANSPORTER; GLYCINE TRANSPORTER 1; N [3 (4 FLUOROPHENYL) 3 (4 PHENYLPHENOXY)PROPYL]SARCOSINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; ORG 24461; OXYGEN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHICKEN; CONTROLLED STUDY; ELECTROSTIMULATION; GLIA CELL; HYPOXIA; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA; RETINA GANGLION CELL;

ANIMALS; ANOXIA; CHICKENS; ELECTRIC STIMULATION; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLYCINE; GLYCINE PLASMA MEMBRANE TRANSPORT PROTEINS; ISCHEMIA; RETINA; SARCOSINE;

EID: 84855853459     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2011.10.010     Document Type: Article

References (59)

1. Aubrey K.R., Vandenberg R.J. N[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy) propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport. Br. J. Pharmacol. 2001, 134:1429-1436.
2. Aubrey K.R., Vandenberg R.J., Clements J.D. Dynamics of forward and reverse transport by glial glycine transporter, Glyt1b. Biophys. J. 2005, 89:1657-1668.
3. Brown A., Carlyle I., Clark J., Hamilton W., Gibson S., McGarry G., McEachen S., Rae D., Thorn S., Walker G. Discovery and SAR of Org 24598-a selective glycine uptake inhibitor. Bioorg. Med. Chem. Lett. 2001, 11:2007-2009.
4. Bridges T.M., Williams R., Lindsley C.W. Design of potent GlyT1 inhibitors: invitro and invivo profiles. Curr. Opin. Mol. Ther. 2008, 10:591-601.
5. Bull N.D., Barnett N.L. Retinal glutamate transporter activity persists under stimulated ischemic conditions. J.Neurosci. Res. 2004, 78:590-599.
6. Casson R.J. Possible role of excitotoxicity in the pathology of glaucoma. Clin. Experiment. Ophthalmol. 2006, 34:54-63.
7. Chidlow G., Wood J.P.M., Casson R.J. Pharmacological manipulation for glaucoma. Drugs 2007, 67:725-759.
8. Colleoni S., Jensen A.A., Landucci E., Fumagalli E., Conti P., Pinto A., De Amici M., Pellegrini-Giampietro D.E., De Michelli C., Mennini T., Gobbi M. Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrollo[3,4-d]-isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reuptake. J.Pharmacol. Exp. Ther. 2008, 326:646-656.
9. Cubelos B., Gimenez C., Zafra F. Localization of the GLYT1 glycine transporter at glutamatergic synapses in the rat brain. Cereb. Cortex 2005, 15:448-459.
10. Danysz W., Parson C.G. N-Methyl-d-aspartate receptors: physiological significance and possible therapeutic applications. Pharmacol. Rev. 1998, 50:597-664.
11. Dijk F., Kamphuis W. An immunocytochemical study on specific amacrine cell subpopulations in the rat retina after ischemia. Brain Res. 2004, 1026:205-217.
12. Du J.L., Xu L., Yang X.L. Glycine receptors and transporters on bullfrog retinal Muller cells. Neuroreport 2002, 13:1653-1656.
13. Dumitrescu O.N., Protti D.A., Majumdar S., Zeilhofer H.U., Wässle H. Ionotropic glutamate receptors of amacrine cells of the mouse retina. Vis. Neurosci. 2006, 23:79-90.
14. El-Asrar A.M., Morse P.H., Maimone D., Torczynski E., Reder A.T. MK-801 protects retinal neurons from hypoxia and the toxicity of glutamate and aspartate. Invest. Ophthalmol. Vis. Sci. 1992, 33:3463-3468.
15. Famiglietti E.V., Kolb H. Abistratified amacrine cell and synaptic circuitry in the inner plexiform layer of the retina. Brain Res. 1975, 84:293-300.
16. Fujita H., Sato K., Wen T.-C., Peng Y., Sakanaka M. Differential expression of glycine transporter 1 and three glutamate transporter mRNA in the hippocampus of gerbils with transient forebrain ischemia. J.Cereb. Blood Flow Metab. 1999, 19:604-615.
17. Gadea A., Lopez E., Lopez-Colome A.M. Characterization of glycine transport in cultured Muller glial cells from the retina. Glia 1999, 4:273-279.
18. Grunert U., Wässle H. Immunocytochemical localization of glycine receptors in the mammalian retina. J.Comp. Neurol. 1993, 335:523-537.
19. Guo L., Salt T.E., Maass A., Luong V., Moss S.E., Fitzke F.W., Cordeiro M.F. Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis invivo. Invest. Ophthalmol. Vis. Sci. 2006, 47:626-633.
20. Hama Y., Katshuki H., Tochikawa Y., Suminaka C., Kume T., Akaike A. Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage invivo. Neurosci. Res. 2006, 56:279-285.
21. Harsing L.G., Gacsalyi I., Schmidt E., Szabo G., Sziray N., Sebban C., Tesolin-Decros B., Matyus P., Spedding M., Levay G. The glycine transporter 1 inhibitor NFPS and Org-24461: a pharmacological study. Pharmacol. Biochem. Behav. 2003, 74:811-825.
22. Harsing L.G., GiglerI G., Moricz K., Agoston M., Marko B., Szabo G., Szenasi G., Juranyi Z. Antiischemic effects of Org-24461 and NFPS, two glycine transporter type-1 inhibitors. Soc. Neurosci. Abstr. 2005, 669.16.
23. Harsing L.G., Juranyi Z., Gacsalyi I., Tapolcsanyi P., Czompa A., Matyus P. Glycine transporter type-1 and its inhibitors. Curr. Med. Chem. 2006, 13:1017-1044.
24. Harsing L.G., Szabo G., Barkoczy J., Matyus P. Anew series of sarcosine-containing glycine transporter-1 (GlyT-1) inhibitors. Soc. Neurosci. Abstr. 2010, 547.6.
25. Herdon H.J., Godfrey F.M., Brown A.M., Coulton S., Evans J.R., Cairns W.J. Pharmacological assessment of the role of glycine transporter GlyT-1 in mediating high affinity glycine uptake by rat cerebral cortex and cerebellum synaptosomes. Neuropharmacology 2001, 41:88-96.
26. Ivanova E., Muller U., Wässle H. Characterization of the glycinergic input to bipolar cells of the mouse retina. Eur. J. Neurosci. 2006, 23:350-364.
27. Izumi Y., Shimamoto K., Benz A.M., Hammarman S.B., Olney J.W., Zorumski C.F. Glutamate transporters and retinal excitotoxicity. Glia 2002, 39:58-69.
28. Johnson J.W., Ascher P. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 1987, 325:529-531.
29. Kalbaugh T.L., Zhang J., Diamond J.S. Coagonist release modulates NMDA receptor subtype contributions at synaptic inputs to retinal ganglion cells. J.Neurosci. 2009, 29:1469-1479.
30. Kalesnyikas G., Tuulos T., Uusitalo H., Jolkkonen J. Neurodegeneration and cellular stress in the retina and optic nerve in rat cerebral ischemia and hypoperfusion models. Neuroscience 2008, 155:937-947.
31. Kallo I., Jekkel C., Hrabovszky E., Juranyi Zs., Vida B., Jarasi A., Wilheim T., Harsing L.G., Liposits Z. Immunohistochemical and in situ hybridization studies on glycine transporter 1 after transient ischemia in the rat forebrain. Neurochem. Int. 2008, 52:799-808.
32. Kolb H., Famiglietti E.V. Rod and cone pathways in the inner plexiform layer of the cat retina. Science 1974, 186:47-49.
33. Kapus G., Kertesz Sz., Gigler G., Simo A., Vegh M., Barkoczy J., Harsing L.G., Szabo G., Levay G. Comparison of the AMPA antagonist action of new 2,3-benzodiazepines invitro and their neuroprotective effects invivo. Pharm. Res. 2004, 21:317-323.
34. Koulen P., Sassoe-Pognetto M., Grunert U., Wässle H. Selective clustering of GABAA and glycine receptors in the mammalian retina. J.Neurosci. 1996, 16:2127-2140.
35. Lee S., Zhong Y., Yang X. Expression of glycine receptor and transporter on bullfrog retinal Muller cells. Neurosci. Lett. 2005, 387:75-79.
36. Lee E.J., Mann L.B., Rickman D.W., Lim E.J., Chun M.H., Grzywacz N.M. AII amacrine cells in the distal inner nuclear layer of the mouse retina. J.Comp. Neurol. 2006, 494:651-662.
37. Lukasiewicz P.D., Roeder R.C. Evidence for glycine modulation of excitatory synaptic inputs to retinal ganglion cells. J.Neurosci. 1995, 15:4592-4601.
38. MacNeil M.A., Masland R.H. Extreme diversity among amacrine cells: implication for function. Neuron 1998, 20:971-982.
39. Majumdar S., Heinze L., Haverkamp S., Ivanova E., Wässle H. Glycine receptors of A-type ganglion cells of the mouse retina. Vis. Neurosci. 2007, 24:1-17.
40. Marc R.E., Liu W.-L. (3H)Glycine-accumulating neurons of the human retina. J.Comp. Neurol. 1985, 232:241-260.
41. Masland R.H. The fundamental plan of the retina. Nat. Neurosci. 2001, 4:877-886.
42. Menger N., Pow D.V., Wässle H. Glycinergic amacrine cells of the rat retina. J.Comp. Neurol. 1998, 401:34-46.
43. Osborne N.N., Cazevieille C., Wood J.P., Nash M.S., Pergrande G., Block F., Kosinski C., Sshwarz M. Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist. Gen. Pharmacol. 1998, 30:255-263.
44. Pang I.H., Wexler E.M., Nawy S., Desantis L., Kapin M.A. Protection by eliprodil against excitotoxicity in cultured rat retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 1999, 40:1170-1176.
45. Pang J.-J., Abd-El-Barr M.M., Gao F., Bramblett D.E., Paul D.L., Wu S.M. Relative contributions of rod and cone bipolar cell inputs to AII amacrine cell light responses in the mouse retina. J.Physiol. 2007, 580:397-410.
46. Pena-Rangel M.T., Riesgo-Escovar J.R., Sanchez-Chavez G., Salcedo R. Glycine transporters (glycine transporter 1 and glycine transporter 2) are expressed in retina. Neuroreport 2008, 19:1295-1299.
47. 3H)glycine-accumulating amacrine cells in the cat retina. J.Comp. Neurol. 1985, 233:473-480.
48. Pow D.V., Hendrickson A.E. Distribution of the glycine transporter glyt-1 in mammalian and nonmammalian retinae. Vis. Neurosci. 1999, 16:231-239.
49. Reed B.T., Sullivan S.J., Tsai G., Coyle J.T., Esguerra M., Miller R.F. The glycine transporter GlyT1 controls N-methyl-d-aspartic acid receptor coagonist occupancy in the mouse retina. Eur. J. Neurosci. 2009, 30:2308-2317.
50. Sassoe-Pognetto M., Wässle H., Grunert U. Glycinergic synapses in the rod pathway of the rat retina: cone bipolar cells express the α1 subunit of the glycine receptor. J.Neurosci. 1994, 14:5131-5146.
51. Schmidt K.-G., Bergert H., Funk R.H.W. Neurodegenerative diseases of the retina and potential for protection and recovery. Curr. Neuropharmacol. 2008, 6:164-178.
52. Shen W., Jiang Z. Characterization of glycinergic synapses in vertebrate retinas. J.Biomed. Sci. 2007, 14:5-13.
53. Szabo L. Differential effect of GlyT1 inhibitors on the development of ischemic cerebral infarction. J.Cereb. Blood Flow Metab. 2005, 25(S15).
54. Thomsen C. Glycine transporter inhibitors as novel antipsychotics. Drug Discov. Today Ther. Strat. 2006, 3:539-545.
55. Vaney D.I., Nelson J.C., Pow D.W. Neurotransmitter coupling through gap junctions in the retina. J.Neurosci. 1998, 18:10594-10602.
56. Vizi E.S. Role of high-affinity receptors and membrane transporters in nonsynaptic communication and drug action in the central nervous system. Pharmacol. Rev. 2000, 53:63-89.
57. Wässle H., Heinze L., Ivanova I., Majumdar S., Weiss J., Harvey R.J., Havenkamp S. Glycinergic transmission in the mammalian retina. Front. Mol. Neurosci. 2009, 2:6-20.
58. Weiss J., O'Sullivan G.A., Heinze L., Chen H.-X., Betz H., Wässle H. Glycinergic input of small-field amacrine cells in the retinas of wildtype and glycine receptor deficient mice. Mol. Cell. Neurosci. 2008, 37:40-55.
59. Zafra F., Aragon C., Oliveras L., Danbolt N.C., Gimenez C., Storm-Mathisen J. Glycine transporters are differently expressed among CNS cells. J.Neurosci. 1995, 15:3952-3969.