Implication of an Asp residue in the ribonucleolytic activity of hirsutellin A reveals new electrostatic interactions at the active site of ribotoxins

Biochimie

Volumn 94, Issue 2, 2012, Pages 427-433

  Herrero Galán, Elías ^a,b   García Ortega, Lucía ^a   Lacadena, Javier ^a   Martínez Del Pozo, Álvaro ^a   Olmo, Nieves ^a   Gavilanes, José G ^a   Oñaderra, Mercedes ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Sarcin; Cytotoxic protein; Ribonucleases; Ribosome; Ribotoxin

Indexed keywords

ALPHA SARCIN; ASPARAGINE; FUNGAL ENZYME; HIRSUTELLIN A; RIBONUCLEASE; RIBONUCLEOPROTEIN; RIBOTOXIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; GENE MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN CLEAVAGE; RIBOSOME; STATIC ELECTRICITY;

ASPARTIC ACID; CATALYTIC DOMAIN; CLONING, MOLECULAR; ENDORIBONUCLEASES; FUNGAL PROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BIOSYNTHESIS; PROTEIN CONFORMATION; PROTEIN SYNTHESIS INHIBITORS; RECOMBINANT PROTEINS; RIBOSOMES; STATIC ELECTRICITY;

EID: 84855851604     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2011.08.010     Document Type: Article

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