The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues

Biochemistry

Volumn 50, Issue 14, 2011, Pages 3004-3013

  Plantinga, Matthew J ^a,c   Korennykh, Alexei V ^a,c   Piccirilli, Joseph A ^a   Correll, Carl C ^a,b,c  

^a UNIVERSITY OF CHICAGO   (United States)

^b ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^c MEMORIAL HEALTH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVE SITE RESIDUES; BIOMOLECULAR INTERFACES; CATALYTIC ACTIVITY; ENDONUCLEASES; ENZYME SPECIFICITY; KINETIC PROOFREADING MECHANISMS; LYSINE RESIDUES; MECHANISTIC MODELS; PROTEIN MUTATIONS; QUANTITATIVE ANALYSIS; RNA INTERFACE; RNA RECOGNITION; RNA SUBSTRATE; SITE-SPECIFIC;

AMINO ACIDS; CATALYST ACTIVITY; CELL DEATH; CONTACTS (FLUID MECHANICS); ENZYMES; NUCLEIC ACIDS; RNA;

SUBSTRATES;

ALPHA SARCIN; LYSINE; RESTRICTOCIN; RICIN; RNA;

ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN MOTIF; PROTEIN RNA BINDING; QUANTITATIVE ANALYSIS;

ALGORITHMS; AMINO ACID SUBSTITUTION; ANIMALS; BASE SEQUENCE; BINDING SITES; BIOCATALYSIS; CATALYTIC DOMAIN; FUNGAL PROTEINS; KINETICS; MODELS, MOLECULAR; MUTATION; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RIBONUCLEASES; RNA; SUBSTRATE SPECIFICITY;

EID: 79953727280     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1018336     Document Type: Article

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